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Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered for 8 weeks. The histopathological changes of the bile duct and liver cells were observed at the 11th week. In six of 8 hamsters (75%) which were treated with DMN and then infected with C. sinensis, the livers developed cholangiocarcinoma at 10 weeks after the infestation of C. sinensis. The features of cholangiocarcinoma lesions were adenomatous or papillary hyperplasia of the bile duct epithelia showing distinct anaplastic changes with mucinous cell metaplasia and necrotic area. In the hamsters which received either DMN or C. sinensis alone, the livers showed only hyperplastic changes of the bile duct epithelial cells. It was suggested that C. sinensis infection and DMN administration could be a synergism on the development of cholangiocarcinoma in Syrian golden hamsters.
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Clonorchis sinensis and Cholangiocarcinoma Eun-Min Kim, Sung-Tae Hong Journal of Korean Medical Science.2025;[Epub] CrossRef
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In-vivo monitoring of development of cholangiocarcinoma induced with C. sinensis and N-nitrosodimethylamine in Syrian golen hamsters using ultrasonography and magnetic resonance imaging: a preliminary study Hyunsik Woo, Joon Koo Han, Jung Hoon Kim, Sung-Tae Hong, Md. Hafiz Uddin, Ja-June Jang European Radiology.2017; 27(4): 1740. CrossRef
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Chang Hwa Jo, Jonghyeon Son, Sulhee Kim, Takashi Oda, Jaehoon Kim, Myoung-Ro Lee, Mamoru Sato, Hyun Tae Kim, Satoru Unzai, Sam-Yong Park, Kwang Yeon Hwang Scientific Reports.2017;[Epub] CrossRef
The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model G. A. Maksimova, M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov Russian Journal of Genetics: Applied Research.2016; 6(4): 454. CrossRef
C3H/He Mice as an Incompatible Cholangiocarcinoma Model by Clonorchis sinensis, Dicyclanil and N-Nitrosodimethylamine Md. Hafiz Uddin, Shunyu Li, Yan Jin, Min-Ho Choi, Ja June Jang, Sung-Tae Hong The Korean Journal of Parasitology.2016; 54(3): 281. CrossRef
Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine Md. Hafiz Uddin, Min-Ho Choi, Woo Ho Kim, Ja-June Jang, Sung-Tae Hong, Xiao-Nong Zhou PLOS Neglected Tropical Diseases.2015; 9(8): e0004008. CrossRef
Genetic diversity of the Chinese liver fluke Clonorchis sinensis from Russia and Vietnam Galina N. Chelomina, Yulia V. Tatonova, Nguyen Manh Hung, Ha Duy Ngo International Journal for Parasitology.2014; 44(11): 795. CrossRef
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Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong Parasitology International.2012; 61(1): 118. CrossRef
Liver Flukes: the Malady Neglected Jae Hoon Lim Korean Journal of Radiology.2011; 12(3): 269. CrossRef
Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory–secretory antigen-fructose-1,6-bisphosphatase Minghui Zheng, Kunhua Hu, Wei Liu, Xuchu Hu, Fengyu Hu, Lisi Huang, Peng Wang, Yue Hu, Yan Huang, Wenfang Li, Chi Liang, Xingfeng Yin, Qingyu He, Xinbing Yu Parasitology Research.2011; 109(3): 737. CrossRef
Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis Shunyu Li, Jung Guk Shin, Pyo Yun Cho, Tae Im Kim, Sung-Tae Hong, Sung-Jong Hong Parasitology Research.2011; 108(5): 1295. CrossRef
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Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Bronwyn E. Campbell, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser Biotechnology Advances.2010; 28(6): 859. CrossRef
Unlocking the Transcriptomes of Two Carcinogenic Parasites, Clonorchis sinensis and Opisthorchis viverrini Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Aaron R. Jex, Cinzia Cantacessi, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser, Malcolm K. Jones PLoS Neglected Tropical Diseases.2010; 4(6): e719. CrossRef
Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim PROTEOMICS.2009; 9(11): 3066. CrossRef
Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory–secretory products of Clonorchis sinensis Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae Parasitology Research.2009; 104(5): 1011. CrossRef
Fifty Years of the Korean Society for Parasitology Seung-Yull Cho The Korean Journal of Parasitology.2009; 47(Suppl): S7. CrossRef
Helminths and malignancy B. J. VENNERVALD, K. POLMAN Parasite Immunology.2009; 31(11): 686. CrossRef
Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells Eun-Min Kim, June-Sung Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae The Korean Journal of Parasitology.2008; 46(3): 127. CrossRef
Proliferative effects of excretory/secretory products from Clonorchis sinensis on the human epithelial cell line HEK293 via regulation of the transcription factor E2F1 Young Ju Kim, Min-Ho Choi, Sung-Tae Hong, Young Mee Bae Parasitology Research.2008; 102(3): 411. CrossRef
Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma Alphonse E Sirica World Journal of Gastroenterology.2008; 14(46): 7033. CrossRef
Molecular cloning and identification of a novel Clonorchis sinensis gene encoding a tegumental protein Zhenwen Zhou, Xuchu Hu, Yan Huang, Huixia Hu, Changling Ma, Xiaoxiang Chen, Fengyu Hu, Jin Xu, Fangli Lu, Zhongdao Wu, Xinbing Yu Parasitology Research.2007; 101(3): 737. CrossRef
Pollutant-induced effects on immunological and physiological interactions in aquatic host–trematode systems: implications for parasite transmission N.J. Morley, J.W. Lewis, D. Hoole Journal of Helminthology.2006; 80(2): 137. CrossRef
Clonorchis sinensis: molecular cloning and functional expression of novel cytosolic malate dehydrogenase Nancai Zheng, Jin Xu, Zhongdao Wu, Jinzhong Chen, Xuchu Hu, Linxia Song, Guang Yang, Chaoneng Ji, Shouyi Chen, Shaohua Gu, Kang Ying, Xinbing Yu Experimental Parasitology.2005; 109(4): 220. CrossRef
Clonorchiasis: an update H.-J. Rim Journal of Helminthology.2005; 79(3): 269. CrossRef
Expression of cyclooxygenase‐2 in cholangiocarcinoma: Correlation with clinicopathological features and prognosis HONG JOO KIM, KYU TAEK LEE, EUN KYUNG KIM, TAE SUNG SOHN, JIN SEOK HEO, SEONG HO CHOI, DONG IL CHOI, JONG KYUN LEE, SEUNG WOON PAIK, JONG CHUL RHEE Journal of Gastroenterology and Hepatology.2004; 19(5): 582. CrossRef
Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis Byung Ihn Choi, Joon Koo Han, Sung Tae Hong, Kyoung Ho Lee Clinical Microbiology Reviews.2004; 17(3): 540. CrossRef
Cellular origin of hepatocellular carcinomas Stewart Sell Seminars in Cell & Developmental Biology.2002; 13(6): 419. CrossRef
Liver fluke-associated cholangiocarcinoma P Watanapa, W B Watanapa British Journal of Surgery.2002; 89(8): 962. CrossRef
Clonorchis sinensis: Molecular Cloning and Characterization of 28-kDa Glutathione S-Transferase Shin-Yong Kang, Il-Young Ahn, Chi-Young Park, Young-Bae Chung, Sung-Tae Hong, Yoon Kong, Seung-Yull Cho, Sung-Jong Hong Experimental Parasitology.2001; 97(4): 186. CrossRef
Analysis of lacI mutations in Big Blue® transgenic mice subjected to parasite-induced inflammation Olga O. Motorna, Holly Martin, Glenda J. Gentile, James M. Gentile Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.2001; 484(1-2): 69. CrossRef
Infectivity and Pathological Changes in Murine Clonorchiasis: Comparison in Immunocompetent and Immunodeficient Mice. Byung-II YOON, Yang-Kyu CHOI, Dae-Yong KIM, Byung-Hwa HYUN, Kyoung-Hwan JOO, Han-Jong RIM, Jae-Hyun LEE Journal of Veterinary Medical Science.2001; 63(4): 421. CrossRef
Molecular cloning and immunological characterization of phosphoglycerate kinase from Clonorchis sinensis Sung-Jong Hong, Kee-Young Seong, Woon-Mok Sohn, Kye-Yong Song Molecular and Biochemical Parasitology.2000; 108(2): 207. CrossRef
Liver and bile duct pathology following Cryptosporidium parvum infection of immunodeficient mice Janet Stephens, Mary Cosyns, Michelle Jones, Anthony Hayward Hepatology.1999; 30(1): 27. CrossRef
Risk factors for biliary tract carcinogenesis R.W. Chapman Annals of Oncology.1999; 10: S308. CrossRef
Enhanced liver cell mutations in trematode-infected Big Blue® transgenic mice James M. Gentile, Glenda J. Gentile, Bonnie Nannenga, Michelle Johnson, Harvey Blankespoor, Regina Montero Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.1998; 400(1-2): 355. CrossRef
Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury Stewart Sell Hepatology.1998; 27(2): 317. CrossRef
Heterogeneity of the “oval-cell” response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimmethylnitrosamine treatment Jae-Hyun Lee, Han-Jong Rim, Stewart Sell Journal of Hepatology.1997; 26(6): 1313. CrossRef
Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis J H Lee, H M Yang, U B Bak, H J Rim The Korean Journal of Parasitology.1994; 32(1): 13. CrossRef
Correlation of sonographic findings with histopathological changes of the bile ducts in rabbits infected with Clonorchis sinensis S T Hong, K H Park, M Seo, B I Choi, J Y Chai, S H Lee The Korean Journal of Parasitology.1994; 32(4): 223. CrossRef
Parasite-associated morbidity: Liver fluke infection and bile duct cancer in Northeast Thailand Paiboon Sithithaworn, Melissa R. Haswell-Elkins, Pisaln Mairiang, Soisungwan Satarug, Eimorn Mairiang, Vanchai Vatanasapt, David B. Elkins International Journal for Parasitology.1994; 24(6): 833. CrossRef
Turnover of biliary epithelial cells in Clonorchis sinensis infected rats S T Hong, W G Kho, W H Kim, J Y Chai, S H Lee The Korean Journal of Parasitology.1993; 31(2): 83. CrossRef
