Warning: fopen(/home/virtual/parasitol/journal/upload/ip_log/ip_log_2025-12.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83
Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Secretions of the biliary mucosa in experimental clonorchiasis
The histological change of the biliary mucosa in clonorchiasis is characterized as adenomatous hyperplasia, and cross-sectioned mucosa looks like intestinal mucosa. In addition to the glandular hyperplasia, the metaplasia of mucin secreting cells is also known. The present study investigated the presence of intestinal secretion from the biliary mucosal cells of rabbits and rats with Clonorchis sinensis infection. The rabbit was infected with 300 and the rat was infected with 100 metacercariae of C. sinensis. A part of the animals were followed up after praziquantel treatment. The rabbit livers were prepared for histochemistry to observe any endocrine secretion and the bile duct mucosa of the mice was processed for the activity of brush border membrane (BBM)-bound enzymes of the small intestine. Immunohistochemistry with the polyclonal antibodies and biotin-streptavidin-peroxidase staining kit showed no positive cells for gastrin and secretin, but a few cells were positive for serotonin. The proliferated biliary mucosa of the mice revealed no activity of disaccharidases and aminopeptidase. Only alkaline phosphatase activity was found both in the control and the infected. The hyperplastic biliary mucosal cells showed no gastrointestinal secretory functions. The serotonin secreting cells may be one of the inflammatory cells.
Citations
Citations to this article as recorded by
Research of the clinical features, risk factors, and surgical diagnosis of intramural stones in patients with gallbladder stones Xiaobing Luo, Hongying Cai, Xiaofeng Wang, Ruihong Ma, Gang Wang, Sangui Wang, Tie Qiao Scientific Reports.2025;[Epub] CrossRef
Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis Byung-Suk Chung, Jeong-Keun Lee, Min-Ho Choi, Myoung Hee Park, Dongil Choi, Sung-Tae Hong The Korean Journal of Parasitology.2009; 47(2): 145. CrossRef
Treatment of severeClonorchiasis sinensisby endoscopic nasobiliary drainage and oral praziquantel Fa-Chao Zhi World Journal of Gastroenterology.2004; 10(14): 2150. CrossRef
Experimental Clonorchiasis in Dogs: CT Findings before and after Treatment Kyoung Ho Lee, Sung Tae Hong, Joon Koo Han, Chang Jin Yoon, Sun Lee, Se Hyung Kim, Byung Ihn Choi Radiology.2003; 228(1): 131. CrossRef
Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits Dongil Choi, Jae Hoon Lim, Seung Kwon Kim, Eung Yeop Kim, Mejeong Lee, Sung-Tae Hong The Korean Journal of Parasitology.1999; 37(2): 77. CrossRef
Correlation of sonographic findings with histopathological changes of the bile ducts in rabbits infected with Clonorchis sinensis S T Hong, K H Park, M Seo, B I Choi, J Y Chai, S H Lee The Korean Journal of Parasitology.1994; 32(4): 223. CrossRef
