All living organisms are destined to die. Cells, the core of those living creatures, move toward the irresistible direction of death. The question of how to die is critical and is very interesting. There are various types of death in life, including natural death, accidental death, questionable death, suicide, and homicide. The mechanisms and molecules involved in cell death also differ depending on the type of death. The dysenteric amoeba, E. histolytica, designated by the German zoologist Fritz Schaudinn in 1903, has the meaning of tissue lysis; i.e., tissue destroying, in its name. It was initially thought that the amoebae lyse tissue very quickly leading to cell death called necrosis. However, advances in measuring cell death have allowed us to more clearly investigate the various forms of cell death induced by amoeba. Increasing evidence has shown that E. histolytica can cause host cell death through induction of various intracellular signaling pathways. Understanding of the mechanisms and signaling molecules involved in host cell death induced by amoeba can provide new insights on the tissue pathology and parasitism in human amoebiasis. In this review, we emphasized on the signaling role of NADPH oxidases in reactive oxygen species (ROS)-dependent cell death by pathogenic E. histolytica.
Citations
Citations to this article as recorded by
Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica Young Ah Lee, Myeong Heon Shin Parasites, Hosts and Diseases.2023; 61(4): 388. CrossRef
Kinesin-13 (Kin-13), a depolymerizer of microtubule (MT), has been known to affect the length of Giardia. Giardia Kin-13 (GlKin-13) was localized to axoneme, flagellar tips, and centrosomes, where phosphorylated forms of Giardia polo-like kinase (GlPLK) were distributed. We observed the interaction between GlKin-13 and GlPLK via co-immunoprecipitation using transgenic Giardia cells expressing Myc-tagged GlKin-13, hemagglutinin-tagged GlPLK, and in vitro-synthesized GlKin-13 and GlPLK proteins. In vitro-synthesized GlPLK was demonstrated to auto-phosphorylate and phosphorylate GlKin-13 upon incubation with [γ-32P]ATP. Morpholino-mediated depletion of both GlKin-13 and GlPLK caused an extension of flagella and a decreased volume of median bodies in Giardia trophozoites. Our results suggest that GlPLK plays a pertinent role in formation of flagella and median bodies by modulating MT depolymerizing activity of GlKin-13.
Citations
Citations to this article as recorded by
Giardia intraflagellar transport protein 88 is involved in flagella formation Hye Rim Yeo, Mee Young Shin, Juri Kim, Soon-Jung Park Parasites, Hosts and Diseases.2025; 63(1): 12. CrossRef
In silico characterisation of a mitotic kinesin-related protein from Leishmania donovani KE16 Suad Gazi AL Kufi, Amjed Qays Ibrahim Alqaisi, Mohammad Mahmoud Farhan Al- Halbosiy, Ikhlass Ali Hussain AlHilaly Asia Pacific Journal of Molecular Biology and Biotechnology.2025; : 62. CrossRef
Optimization of 18 S rRNA metabarcoding for the simultaneous diagnosis of intestinal parasites Dongjun Kang, Jun Ho Choi, Myungjun Kim, Sohyeon Yun, Singeun Oh, Myung-hee Yi, Tai-Soon Yong, Young Ah Lee, Myeong Heon Shin, Ju Yeong Kim Scientific Reports.2024;[Epub] CrossRef
Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park, Björn F. C. Kafsack Microbiology Spectrum.2023;[Epub] CrossRef
Tubulin as a potential molecular target for resveratrol in Giardia lamblia trophozoites, in vitro and in silico approaches José Roberto Vargas-Villanueva, Filiberto Gutiérrez-Gutiérrez, Mariana Garza-Ontiveros, Sendar Daniel Nery-Flores, Lizeth Guadalupe Campos-Múzquiz, Dagoberto Vazquez-Obregón, Raul Rodriguez-Herrera, Lissethe Palomo-Ligas Acta Tropica.2023; 248: 107026. CrossRef
Malaria remains a global health threat. Approximately 97% of the population is at risk in sub-Saharan countries, particularly Nigeria. This study compared the performance of 2 diagnostic methods in assessing malaria endemicity in the rural communities of Ebonyi State, Nigeria. A total of 1,140 study participants were screened for malaria parasite using Rapid Diagnostic Test kits (RDT) in the field, while thick and thin films for microscopy were examined in the laboratory. Our result showed that malaria prevalence was 56.8 by RDT and 38.6% by microscopic test. Age group under 10 years had the highest prevalence of 28.9% (RDT) and 23.6% (microscopy), respectively. The highest prevalence of 19.5% by RDT was recorded in Onicha Local Government Area, while the highest prevalence of 13.4% with microscopy was recorded in Ezza North Local Government Area. The sensitivity and specificity of microscopic examination were both 100%, while those of RDT were 95.5% and 75.9%, respectively.
Citations
Citations to this article as recorded by
Subclinical Plasmodium spp. Infections in a Community Setting in Bangui, Central African Republic Romaric Nzoumbou-Boko, Mireille Cornelia Ingrid Denissio Morissi Nalingbo, Brice Martial Yambiyo, Roger Detol, Ermeland Moussa, Didita Nalinga, Lydie Joella-Venus de la Grace Namsenei-Dankpea, Alexandre Manirakiza, Lawrence Ayong, Yap Boum Research and Reports in Tropical Medicine.2025; Volume 16: 1. CrossRef
Explainable AI for enhanced accuracy in malaria diagnosis using ensemble machine learning models Olushina Olawale Awe, Peter Njoroge Mwangi, Samuel Kotva Goudoungou, Ruth Victoria Esho, Olanrewaju Samuel Oyejide BMC Medical Informatics and Decision Making.2025;[Epub] CrossRef
Ectoparasite species diversity and prevalence in pigs (Sus scrofa domesticus) within delta central senatorial district, Delta State, Nigeria
International Journal of Biosciences (IJB).2025; : 320. CrossRef
Analysis of fractional-order model for the transmission dynamics of malaria via Caputo–Fabrizio and Atangana–Baleanu operators Benedict Celestine Agbata, Raimonda Dervishi, Mehmet Gümüş, Aseel Smerat, Godwin Christopher Ezike Mbah Scientific Reports.2025;[Epub] CrossRef
Estimated distribution of malaria cases among children in sub-Saharan Africa by specified age categories using data from the Global Burden of Diseases 2019 Olorunfemi A. Oshagbemi, Pedro Lopez-Romero, Cornelis Winnips, Katalin R. Csermak, Guoqin Su, Elodie Aubrun Malaria Journal.2023;[Epub] CrossRef
Strongyloides stercoralis infection is not endemic in the Republic of Korea (Korea) with a positivity rate of <1% in stool examination. However, there is a risk of hyperinfection in immunosuppressed individuals. It is necessary to determine the seropositivity of S. stercoralis antibodies in Korea. This study investigated the seropositivity of S. stercoralis antibodies in the southeastern area of Korea. From January 2019 to June 2021, serum samples were collected from participants who visited the study center in the southeastern region of Korea for routine health check-ups. We determined serum levels of specific anti-Strongyloides IgG antibodies in 834 samples by enzyme-linked immunosorbent assay. We observed that 92 samples (11.0%) tested showed a positive response. The age of the participants was 51±10.7 years, and 43.4% of them were men. The antibody positivity rate based on the location of the participants’ residence were 12.3% (Gyoungsangnam-do), 10.2% (Busan), and 10.1% (Ulsan), respectively. Total eosinophil count was associated with positive test results (154.8±152.0 per mm3 versus 202.1±178.9 per mm3, P=0.006). Logistic regression analysis revealed that blood eosinophil count, age above 50 years, and residence in Sacheon were factors associated with the positive status of S. stercoralis antibody. Our finding suggests that it is necessary to test for S. stercoralis in actual clinical settings in Korea.
Citations
Citations to this article as recorded by
Screening for strongyloidiasis among selected populations in Taiwan: Prevalence, associated factors, and outcomes Sung-Hsi Huang, Yen-Lin Chen, Hao-Yu Lin, Aristine Cheng, Lih-Yu Chang, Yi-Chia Huang, Po-Hsien Kuo, Yueh-Feng Wen, Chia-Jung Liu, Chia-Hao Chang, Wei-Shun Yang, Kai-Hsiang Chen, Pin-Ru Chu, Chi-Wei Tseng, Yi-Ching Su, Li-Hsin Su, Li-Ta Keng, Chi-Ying Lin Travel Medicine and Infectious Disease.2025; 66: 102866. CrossRef
A silent threat behind bars: Serosurvey and associated risk factors for strongyloidiasis in female inmates and correctional officers Vamilton Alvares Santarém, Gabriel Luís Brucinski Pinto, Isabella Braghin Ferreira, Juliano Ribeiro, Roberto Teixeira de Souza Filho, Dirce Mary Correa Meisel, Ronaldo Cesar Borges Gryschek, Susana Angélica Zevallos Lescano, Rogério Giuffrida, Louise Bach Acta Tropica.2024; 257: 107301. CrossRef
The positive rate of Clonorchis sinensis is the highest among intestinal parasites in the Republic of Korea (Korea). More than 1.2 million people were at risk of C. sinensis infection in Korea in 2012. An intensive control program is being implemented for residents of the 5 major river basins to reduce helminthic infections, including C. sinensis infection. This study evaluated the continuous intensive control program for parasitic diseases including clonorchiasis in areas near the 5 major river basins in Korea over the past 10 years (2011-2020). A total of 335,020 fecal samples (one sample per resident) prepared by the modified sedimentation technic were microscopically examined. Those who expelled helminth eggs were treated with anthelmintics through local health centers and re-examined 3 months later. The overall positive rate of helminths egg was 7.1%. The annual positive rates were dramatically decreased from 14.4% (2011) to 5.9% (2020). The egg positive rate was highest in C. sinensis (5.3%), followed by heterophyid flukes (1.5%) and Trichuris trichiura (0.2%). The prevalence of C. sinensis was significantly higher in males (7.6%) than in females (3.7%), and the highest in the 50–59 years (7.0%) age group. Our results are beneficial to establish prevention and control policies against helminthiases including clonorchiasis in endemic areas in this country.
Citations
Citations to this article as recorded by
Clonorchis sinensis and Cholangiocarcinoma Eun-Min Kim, Sung-Tae Hong Journal of Korean Medical Science.2025;[Epub] CrossRef
Multiparasitism in Spain in a Korean Visiting Friends and Relatives: Case Report and Review of Imported Cases of Clonorchis sinensis in Europe Paola Cociancic, Jacklyn Comas, J. Guillermo Esteban Clinical Case Reports.2025;[Epub] CrossRef
Assessing trends in clonorchiasis incidence via prescription data analysis in South Korea Taeksang Lee, Jun Hyun Lee, Hanna Jin, Yun Kyung Lee, Hyun Beom Song BMC Public Health.2025;[Epub] CrossRef
2023년 국내 장내기생충 감염 조사 명노 이, 정원 주, 선옥 백, 영주 이, 은솔 이, 희일 이 Public Health Weekly Report.2024; 17(28): 1227. CrossRef
Efficacy assessment of miltefosine and curcumin against
Clonorchis sinensis
infection
Soon-Ok Lee, Ki Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Hyeryon Lee, Joo Hwan No, Jin Ho Song, Sung-Jong Hong, Sung Soo Kim, Fu-Shi Quan, Audrey Odom John Antimicrobial Agents and Chemotherapy.2024;[Epub] CrossRef
A novel kit for enrichment of fecal helminth eggs Eunsol Lee, Seon-Ok Back, Young-Ju Lee, Jung-Won Ju, Hee-Il Lee, Myoung-Ro Lee Parasites, Hosts and Diseases.2024; 62(3): 323. CrossRef
Age, period, and cohort effects of Clonorchis sinensis infection prevalence in the Republic of Korea: Insights and projections Sung-mok Jung, Heewon Kang, Bong-Kwang Jung, Sejin Ju, Jung-Won Ju, Myoung-Ro Lee, Jong-hun Kim, Sung Hye Kim, Ran Wang PLOS Neglected Tropical Diseases.2024; 18(10): e0012574. CrossRef
Risk factors for Clonorchis sinensis infections and control measures reinforced with focused interviews Soon-Ok Lee, Fuhong Dai, Eun Joo Park, Yun Pyo Hong, Fu-Shi Quan, Jin-Ho Song, Sung-Jong Hong Parasitology Research.2024;[Epub] CrossRef
2022년 유행지역 주민의 장내기생충 감염 조사 명노 이, 정원 주, 선옥 백, 영주 이, 희일 이 Public Health Weekly Report.2023; 16(32): 1131. CrossRef
2022년 국내 자연산 민물고기 간흡충 감염도 조사 명노 이, 정원 주, 선옥 백, 영주 이, 희일 이 Public Health Weekly Report.2023; 16(43): 1455. CrossRef
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea Hwa Sun Kim, Ho-Woo Nam, Hye-Jin Ahn, Dongjae Kim, Yeong Hoon Kim The Korean Journal of Parasitology.2022; 60(4): 261. CrossRef
There have been few reports on extra-enteric infections by Blastocystis STs and none have been molecularly identified in samples from human reproductive organs. We report for the first time the identification of 3 different subtypes of Blastocystis (ST1-3) in vaginal and sperm samples, from patients infected with Trichomonas vaginalis. Blastocystis STs were identified by PCR-sequencing and by phylogenetic inferences using 28 vaginal swab samples and 7 sperm samples from patients trichomoniasis. Blastocystis STs were identified in 6 of 28 vaginal swabs (21.4%) and in 3 of 7 sperm samples (42.8%). In both biological samples, STs 1-3 were found; one vaginal sample showed subtype co-infection with ST1 and ST3. High genetic variation was observed in the sequences obtained and no specific clustering in the phylogenetic trees was detected. Most of the haplotypes identified were placed far from the main dispersal centers. Our finding suggested that incorrect cleaning of the genital area or a contamination by combination of anal and vaginal intercourse.
Citations
Citations to this article as recorded by
Molecular Identification of Blastocystis Subtypes in the Cervix: A Study on Polish Patients Barbara Suchońska, Adam Kaczmarek, Maria Wesołowska, Daniel Młocicki, Rusłan Sałamatin Journal of Clinical Medicine.2025; 14(11): 3928. CrossRef
Genetic Variability of the Internal Transcribed Spacer and Pyruvate:Ferredoxin Oxidoreductase Partial Gene of Trichomonas vaginalis from Female Patients Fernando Martinez-Hernandez, Fabiola Sanchez-Aguillon, Joel Martinez-Ocaña, Nelly Raquel Gonzalez-Arenas, Mirza Romero-Valdovinos, Eduardo Lopez-Escamilla, Pablo Maravilla, Guiehdani Villalobos Microorganisms.2023; 11(9): 2240. CrossRef
Babesia microti is one of the most common causative agents of babesiosis. A sensitive and rapid detection is necessary for screening potentially infected individuals. In this study, B. microti cytochrome c oxidase subunit I (cox1) was selected as the target gene, multiple primers were designed, and optimized by a recombinase-aided amplification (RAA) assay. The optimal primers and probe were labeled with fluorescein. The sensitivity of fluorescent RAA (fRAA) was evaluated using gradient diluents of the cox1 recombinant plasmid and genomic DNA extracted from whole blood of B. microti infected mice. The specificity of fRAA was assessed by other transfusion transmitted parasites. The analytical sensitivity of the fRAA assay was 10 copies of recombinant plasmid per reaction and 10 fg/µl B. microti genomic DNA. No cross-reaction with any other blood-transmitted parasites was observed. Our results demonstrated that the fRAA assay would be rapid, sensitive, and specific for the detection of B. microti.
Citations
Citations to this article as recorded by
Research progress on diagnostic techniques for different Babesia species in persistent infections Zelin Jia, Yuliang Zhang, Donghui Zhao, Haifeng Wang, Ming Yu, Zhilin Liu, Xin Zhang, Jiayu Cui, Xueli Wang Frontiers in Cellular and Infection Microbiology.2025;[Epub] CrossRef
Progress in the application of isothermal amplification technology in the diagnosis of infectious diseases Qingshang Bi, Mengru Liu, Li Yan, Jun Cheng, Qingyang Sun, Yuzhu Dai, Lingli Zou Frontiers in Microbiology.2025;[Epub] CrossRef
Development of a real-time recombinase-aided amplification assay for rapid and sensitive detection of Edwardsiella piscicida Yuchen Dong, Dandan Zhou, Binzhe Zhang, Xiaoying Xu, Jian Zhang Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Effect of food matrix on rapid detection of Vibrio parahaemolyticus in aquatic products based on toxR gene Darong Li, Jiayi Zhao, Weiqing Lan, Yong Zhao, Xiaohong Sun World Journal of Microbiology and Biotechnology.2023;[Epub] CrossRef
This study aimed to examine the distribution of gastrointestinal parasitic infections in domestic pigs in the Republic of Korea. From May 2020 to October 2021, 364 pig fecal samples were collected from 75 farms in 7 Provinces and microscopically examined. A total of 170 (46.7%) pigs were infected with at least one of the following parasites: Balantioides coli, strongyles, Ascaris suum, Trichuris suis, and coccidia. By parasite species, B. coli, strongyles, A. suum, T. suis, and coccidia oocysts or eggs were detected in 144 (39.6%), 24 (6.6%), 14 (3.8%), 4 (1.1%), and 1 (0.3%) samples, respectively. One hundred fifty-four, 15, and 1 cases showed single, double, and triple infections, respectively. Of the swine fecal samples from 75 farms, 69 specimens (92.0%) were infected with 1 or more parasites. All surveyed farms across the country exhibited a positive rate of over 30%, among which the highest positive rate was 65.0% in Chungcheongnam-do, and Jeollabuk-do was followed by 61.9%. Winter showed a statistically lower prevalence than other seasons. This study showed that gastrointestinal parasites are prevalent in pigs in Korea, although the diversity of parasites is low.
Citations
Citations to this article as recorded by
Molecular identification and diversity of gastrointestinal apicomplexan protozoa in pigs in the Republic of Korea Subin Lee, Sang-Hyup Lee, Badriah Alkathiri, Kyung-Duk Min, Dong Hyeon Kwon, Mi-Hye Hwang, Gyu-Tae Jeon, Bok Kyung Ku, Jae-Won Byun, Seung-Hun Lee Scientific Reports.2025;[Epub] CrossRef
Gastrointestinal parasites in pigs in Brazil: prevalence, risk factors, diagnosis, and extension activities Camila Souza Carvalho Class, Renan de Souza Ferreira, Ana Luiza Soares de Araujo, Ingrid da Silva Reis, Breno Torres da Silva, Fabiana Batalha Knackfuss, Laís Lisboa Corrêa, José Arcínio de Assis, Marcelo José Milagres de Almeida, Daniel de Castro Trindad Parasitology Research.2025;[Epub] CrossRef
Integrative use of conventional and DNA metabarcoding methods reveals high diversity, prevalence and intensity of gastrointestinal parasites in pigs from Victoria, Australia Ghazanfar Abbas, Yuet On Lee, Hannah Mitchell, Abdul Ghafar, Mark A. Stevenson, Charles G. Gauci, Leah G. Starick, Regina M. Fogarty, Bernie Gleeson, Dianne E. Phillips, Tao Wang, Robin B. Gasser, Abdul Jabbar Research in Veterinary Science.2025; 196: 105902. CrossRef
Prevalence and diversity of gastrointestinal parasites on pig farms in Kalasin Province, Thailand Sirikanda Thanasuwan, Supawadee Piratae, Keattipong Thaowandee, Chalothon Amporn Veterinary World.2024; : 273. CrossRef
Comparative Analysis of Ascaris suum and Macracanthorhynchus hirudinaceus Infections in Free-Ranging and Captive Wild Boars (Sus scrofa) in Hungary Csaba Farkas, Alexandra Juhász, Balázs Fekete, Borisz Egri Animals.2024; 14(6): 932. CrossRef
Parasites burden in peri-urban free-roaming pigs in Gert Sibande District Municipality, Mpumalanga Province, South Africa P Munzhelele, NPS Sibeko, JW Oguttu, CA Mbajiorgu, FO Fasina Journal of the South African Veterinary Association.2024; 95(1): 55. CrossRef
Prevalence of intestinal parasites in humans and domestic animals in Jirel community, Dolakha, Nepal Pitambar Dhakal, Medhavi Dhakal, Dipa Dhakal, Pramita Shakya, Barsha Singh, Rabina Gupta Kalwar, Rekha Shahi, Sophiya Pandey, Darwin Niraula, Anita Karki, Mukesh Kumar Mahato, Semsal Tamang, Basanti Chhetri, Muna Thapa, Rameshwor Parajuli, Janak Raj Subed Journal of Family Medicine and Primary Care.2024; 13(8): 3408. CrossRef
Turtle leeches have not been recorded in Korea, although they occur in geographically adjacent countries including China and Japan. This study describes a turtle leech, Ozobranchus jantseanus (Clitellata: Ozobranchidae), found from Reeve’s turtle (Mauremys reevesii) in Korea. Of the 143 Reeve’s turtles collected from the freshwater reservoir in Jinju City, Gyeongsangnam-do, Korea, 95 unidentified leeches were found in 8 (5.6%) individuals. The leeches had 22 somites with 11 pairs of externally exposed branchiae, body-sized posterior suckers, and spines on the dorsal surface. We identified these leeches as Ozobranchus jantseanus Oka, 1912 (Clitellata: Ozobranchidae). This species of turtle leeches found in Korea may fill the gap in the biodiversity of East Asian annulus.
Citations
Citations to this article as recorded by
The impact of the legal designation and collection system on the abandonment and surrender of non-native common
snapping turtle (Chelydra serpentina) in South Korea Eun Jin Park, Hakyung Kang, Chul Hoon Kim, Jong-Yoon Im, Yikweon Jang, Kyo Soung Koo Environmental Biology Research.2024; 42(1): 46. CrossRef
Gustavo Ponce-Garcia, Olga K. Villanueva-Segura, Karina Garza-Elizondo, Heriberto M. Villegas-Ramirez, Ildefonso Fernandez-Salas, Iram P. Rodriguez-Sanchez, Felipe Dzul-Manzanilla, Adriana E. Flores-Suarez
Korean J Parasitol 2022;60(3):217-221. Published online June 30, 2022
The head louse Pediculus humanus capitis (De Geer) is a hematophagous ectoparasite that inhabits the human scalp. The infestations are asymptomatic; however, skin irritation from scratching occasionally may cause secondary bacterial infections. The present study determined the presence and frequency of the knockdown resistance (kdr) mutation T929I in 245 head lice collected from Mexico, Peru, and Canada. Head lice were collected manually using a comb in the private head lice control clinic. Allele mutation at T9291 was present in 100% of the total sampled populations (245 lice) examined. In addition, 4.89% of the lice were homozygous susceptible, whereas 6.93% heterozygous and 88.16% homozygous were resistant, respectively. This represents the second report in Mexico and Quebec and fist in Lima.
Citations
Citations to this article as recorded by
Population genetics as a tool to understand invasion dynamics and insecticide resistance in indoor urban pest insects Warren Booth Current Opinion in Insect Science.2024; 62: 101166. CrossRef
Toxicity of 6-gingerol and Cymbopogon citratus against Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae): Mortality, detoxifying enzymes, and morphological ultrastructure alterations in lice Rizal Subahar, Rizqy Hadyansyah, Rachmanin Aldilla, Yulhasri Yulhasri, Rawina Winita, Surya Dwira, Gulshan Fahmi El Bayani Research in Veterinary Science.2024; 177: 105364. CrossRef
First
Prev
