Parasites, Hosts and Diseases

"Hassan Ahmed Hassan Ahmed Ismail"

Brief Communications

Implications for selecting persistent hot spots of schistosomiasis from community- and school-based surveys in Blue Nile, North Kordofan, and Sennar States, Sudan: Hassan Ahmed Hassan Ahmed Ismail, Seungman Cha, Yan Jin, Sung-Tae Hong; Parasites Hosts Dis 2023;61(2):216-224.
Published online May 23, 2023; DOI: https://doi.org/10.3347/PHD.23022

Abstract
PDF

In several schistosomiasis-endemic countries, the prevalence has remained high in some areas owing to reinfection despite repeated mass drug administration (MDA) interventions; these areas are referred to as persistent hot spots. Identifying hotspots is critical for interrupting transmission. This study aimed to determine an effective means of identifying persistent hot spots. First, we investigated the differences between Schistosoma haematobium and Schistosoma mansoni prevalence among school-aged children (SAC) estimated by a community-based survey, for which local key informants purposively selected communities, and a randomly sampled school-based survey. A total of 6,225 individuals residing in 60 villages in 8 districts of North Kordofan, Blue Nile, or Sennar States, Sudan participated in a community-based survey in March 2018. Additionally, the data of 3,959 students attending 71 schools in the same 8 districts were extracted from a nationwide school-based survey conducted in January 2017. The community-based survey identified 3 districts wherein the prevalence of S. haematobium or S. mansoni infection among SAC was significantly higher than that determined by the randomly sampled school survey (e.g., S. haematobium in the Sennar district: 10.8% vs. 1.1%, P<0.001). At the state level, the prevalence of schistosomiasis among SAC, as determined by the community-based survey, was consistently significantly higher than that determined by the school-based survey. Purposeful selection of villages or schools based on a history of MDA, latrine coverage, open defecation, and the prevalence of bloody urine improved the ability for identifying persistent hot spots.

3,872 View
147 Download

Association Between the Prevalence of Schistosomiasis in Elementary School Students and Their Parental Occupation in Sudan: Yan Jin, Seungman Cha, Youngjin Kim, Hamdan Mustafa Hamdan, Mousab Siddig Elhag, Hassan Ahmed Hassan Ahmed Ismail, Keon Hoon Lee, Sung-Tae Hong; Korean J Parasitol 2022;60(1):51-56.
Published online February 23, 2022; DOI: https://doi.org/10.3347/kjp.2022.60.1.51

Global efforts to identify groups at high risk for schistosomiasis have mainly concentrated on identifying their geographical distribution. Investigations on the socioeconomic characteristics of high-risk groups are relatively scarce. This study aimed to explore the associations between schistosomiasis among students and their parents’ occupations. A nationwide cross-sectional survey was conducted targeting 105,167 students in 1,772 primary schools across Sudan in 2017. From these students, 100,726 urine and 96,634 stool samples were collected to test for Schistosoma haematobium and S. mansoni infection. A multi-level mixed effect analysis was used with age and sex as fixed factors, and school as a random factor. The odd ratios (ORs) of practicing open defecation among farmers’ children were almost 5 times higher than their counterparts whose parents were government officials (OR=4.97, 95% confidence intervals (CIs): 4.57-5.42, P<0.001). The ORs of contacting water bodies for watering livestock among farmers’ children were more than 4 times higher than those of children whose parents were government officials (OR=4.59, 95% CIs: 4.02-5.24, P<0.001). This study shows that schistosomiasis represents a disease of poverty and that farmers’ children constituted a high-risk group.

Citations

Citations to this article as recorded by

Using zero-inflated and hurdle regression models to analyze schistosomiasis data of school children in the southern areas of Ghana
Kojo Nketia, Dziedzom K. de Souza, Jean Coulibaly
PLOS ONE.2024; 19(7): e0304681. CrossRef
Prevalence and Risk Factors of Schistosomiasis in Sudan: A Systematic Review and Meta-Analysis
Yousef Alsaafin, Ayman Omer, Osama Felemban, Sarra Modawi, Maydolin Ibrahim, Abdullah Mohammed, Ammar Elfaki, Ahmed Abushara, Maryam A SalahEldin
Cureus.2024;[Epub] CrossRef
Identifying the risk factors of schistosomiasis in Indonesia
Christine Christine, Herlina Susanto Sunuh, Fellysca Veronica Margareth Politon, Diana Vanda Daturara Doda
Healthcare in Low-resource Settings.2023;[Epub] CrossRef

5,335 View
217 Download
2 Web of Science
Crossref

Original Articles

Comparison of the Change in the Prevalence and Intensity of Schistosoma haematobium Infection Between High and Low Prevalence Areas of White Nile State, Sudan: Seungman Cha, Sung-Tae Hong, Jin-Su Lee, Hoo Gn Jeong, In-Sun Kwon, Abd Al Wahab Saed, Mousab Siddig Elhag, Hassan Ahmed Hassan Ahmed Ismail, Mutamad Amin, Young-Ha Lee; Korean J Parasitol 2020;58(4):421-430.
Published online August 25, 2020; DOI: https://doi.org/10.3347/kjp.2020.58.4.421

Abstract
PDF

This study aimed to investigate whether mass drug administration (MDA) intervention has an equivalent effect on reducing the prevalence and intensity of Schistosoma haematobium infection regardless of the baseline values. A repeated cross-sectional survey was performed targeting students of 12 primary schools in Al Jabalain and El Salam districts of White Nile State, Sudan, at both 1 week before and 8 months after the MDA. Prior to the baseline survey, school-aged children in Al Jabalain had received MDA interventions twice in 4 years, while those in El Salam had not. The baseline prevalence was 9.1% in Al Jabalain and 35.2% in El Salam, which were reduced to 1.8% and 5.5% at 8 months after the MDA, respectively. The corresponding reduction rates were 80.3% and 84.4%, not significant difference between both districts. However, changes in the geometric mean intensity (GMI) of egg counts were significantly different between both districts. The baseline GMIs were 14.5 eggs per 10 ml of urine (EP10) in Al Jabalain and 18.5 EP10 in El Salam, which were reduced to 7.1 and 11.2 EP10 after treatment, respectively. The corresponding reduction rates were 51.0% and 39.5%. In conclusion, MDA interventions were found to bring about similar relative reduction in prevalence regardless of the baseline value; however, the relative reduction in infection intensity was more salient in the district with a low baseline value for both prevalence and intensity. This clearly points to the importance of repeated MDA interventions in endemic areas, which will eventually contribute to schistosomiasis elimination.

Citations

Citations to this article as recorded by

Prevalence and Risk Factors of Schistosomiasis in Sudan: A Systematic Review and Meta-Analysis
Yousef Alsaafin, Ayman Omer, Osama Felemban, Sarra Modawi, Maydolin Ibrahim, Abdullah Mohammed, Ammar Elfaki, Ahmed Abushara, Maryam A SalahEldin
Cureus.2024;[Epub] CrossRef
Programmatic Implications for Schistosomiasis Elimination Based on Community-Based Survey in the Blue Nile, North Kordofan, and Sennar States, Sudan
Hassan Ahmed Hassan Ahmed Ismail, Seungman Cha, Yan Jin, Sung-Tae Hong
Life.2023; 13(4): 1049. CrossRef
Implications for selecting persistent hot spots of schistosomiasis from community- and school-based surveys in Blue Nile, North Kordofan, and Sennar States, Sudan
Hassan Ahmed Hassan Ahmed Ismail, Seungman Cha, Yan Jin, Sung-Tae Hong
Parasites, Hosts and Diseases.2023; 61(2): 216. CrossRef
Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting
Sung-Tae Hong
Life.2023; 13(8): 1670. CrossRef
Investigation of Intestinal and Blood Parasites in People Returning to Turkey with a History of Traveling Abroad During the Pandemic
Abdurrahman Ekici, Esra Gürbüz, Ahmet Hakan Ünlü, Rahmi Yıldız, Selahattin Aydemir, Ahmed Galip Halidi, Nuriz Ödemiş, Sinan Karakuş, Şehriban Yürektürk, Mutalip Çiçek, Hasan Yılmaz
Turkish Journal of Parasitology.2022; 46(2): 108. CrossRef
Transmission Dynamics of Schistosoma haematobium among School-Aged Children: A Cohort Study on Prevalence, Reinfection and Incidence after Mass Drug Administration in the White Nile State of Sudan
Yan Jin, Young-Ha Lee, Seungman Cha, In-Uk Choi, Hassan Ahmed Hassan Ahmed Ismail, Mousab Siddig Elhag, Sung-Tae Hong
International Journal of Environmental Research and Public Health.2021; 18(21): 11537. CrossRef
Urinary schistosomiasis and the associated bladder cancer: update
Mohamed S. Zaghloul, Tarek M. Zaghloul, Mai K. Bishr, Brian C. Baumann
Journal of the Egyptian National Cancer Institute.2020;[Epub] CrossRef

5,317 View
104 Download
5 Web of Science
Crossref

Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway: Wei Zhou, Juan-Hua Quan, Fei-Fei Gao, Hassan Ahmed Hassan Ahmed Ismail, Young-Ha Lee, Guang-Ho Cha; Korean J Parasitol 2018;56(2):135-145.
Published online April 30, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.2.135

Abstract
PDF

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little is known about the signaling events in RPE involved in Toxoplasma gondii infection and development. The aim of the study is to screen the host mRNA transcriptional change of 3 inflammation-related gene categories, PI3K/Akt pathway regulatory components, blood vessel development factors and ROS regulators, to prove that PI3K/Akt or mTOR signaling pathway play an essential role in regulating the selected inflammation-related genes. The selected genes include PH domain and leucine- richrepeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glutamate-cysteine ligase (GCL), glutathione S-transferase (GST), and NAD(P)H: quinone oxidoreductase (NQO1). Using reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), we found that T. gondii up-regulates PHLPP2, CK2β, VEGF, GCL, GST, and NQO1 gene expression levels, but down-regulates PHLPP1 and PEDF mRNA transcription levels. PI3K inhibition and mTOR inhibition by specific inhibitors showed that most of these host gene expression patterns were due to activation of PI3K/Akt or mTOR pathways with some exceptional cases. Taken together, our results reveal a new molecular mechanism of these gene expression change dependent on PI3K/Akt or mTOR pathways and highlight more systematical insight of how an intracellular T. gondii can manipulate host genes to avoid host defense.

Citations

Citations to this article as recorded by

PTEN regulation in virus-associated cancers
Shaian Tavakolian, Zahra Shokati Eshkiki, Abolfazl Akbari, Ebrahim Faghihloo, Seidamir Pasha Tabaeian
Pathology - Research and Practice.2025; 266: 155749. CrossRef
MjTX-II, a Lys49-PLA2 from Bothrops moojeni snake venom, restricts Toxoplasma gondii infection via ROS and VEGF regulation
Samuel Cota Teixeira, Thales Alves de Melo Fernandes, Guilherme de Souza, Alessandra Monteiro Rosini, Aryani Felixa Fajardo Martínez, Angelica Oliveira Gomes, Rosiane Nascimento Alves, Daiana Silva Lopes, Maria Vitoria da Silva, Emidio Beraldo-Neto, Patrí
Chemico-Biological Interactions.2025; 409: 111417. CrossRef
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway
Tao Zhang, Yaogang Zhang, Zihan Yang, Yuan Jiang, Li Sun, Dengliang Huang, Meiyuan Tian, Yinhong Shen, Jun Deng, Jing Hou, Yanyan Ma
Pathogens and Global Health.2023; 117(4): 409. CrossRef
The interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences
Ahmed S. Doghish, Mohamed A. Ali, Mahmoud A. Elrebehy, Hend H. Mohamed, Reda Mansour, Aml Ghanem, Ahmed Hassan, Mohammed S. Elballal, Ola Elazazy, Ahmed E. Elesawy, Sherif S. Abdel Mageed, Yara A. Nassar, Osama A. Mohammed, Ahmed I. Abulsoud
Pathology - Research and Practice.2023; 250: 154790. CrossRef
Mammalian Target of Rapamycin Inhibitor Rapamycin Alleviates 7-Ketocholesterol Induced Inflammatory Responses and Vascular Endothelial Growth Factor Elevation by Regulating MAPK Pathway in Human Retinal Pigment Epithelium Cells
Lin Yang, Peng Yu, Mei Chen, Bo Lei
Journal of Ocular Pharmacology and Therapeutics.2022; 38(2): 189. CrossRef
The host mTOR pathway and parasitic diseases pathogenesis
Sajad Rashidi, Reza Mansouri, Mohammad Ali-Hassanzadeh, Zahra Mojtahedi, Reza Shafiei, Amir Savardashtaki, Nasrin Hamidizadeh, Mohammadreza Karimazar, Paul Nguewa, Raúl Manzano-Román
Parasitology Research.2021; 120(4): 1151. CrossRef
Upregulation of PEDF Predicts a Poor Prognosis and Promotes Esophageal Squamous Cell Carcinoma Progression by Modulating the MAPK/ERK Signaling Pathway
Zui Chen, Di Che, Xiaoqiong Gu, Jiamin Lin, Jing Deng, Ping Jiang, Kaixiong Xu, Banglao Xu, Ting Zhang
Frontiers in Oncology.2021;[Epub] CrossRef
Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition
Christian Rodriguez Rodrigues, María Celeste Nicolao, Maia Chop, Natalia Plá, Mora Massaro, Julia Loos, Andrea C. Cumino
Scientific Reports.2021;[Epub] CrossRef
Ripasudil alleviated the inflammation of RPE cells by targeting the miR-136-5p/ROCK/NLRP3 pathway
Zhao Gao, Qiang Li, Yunda Zhang, Xiaohong Gao, Haiyan Li, Zhigang Yuan
BMC Ophthalmology.2020;[Epub] CrossRef
H3 relaxin protects against calcium oxalate crystal‐induced renal inflammatory pyroptosis
Jiannan Liu, Kelaier Yang, Yinshan Jin, Yadong Liu, Yaodong Chen, Xiaohui Zhang, Shiliang Yu, Erlin Song, Song Chen, Jingbo Zhang, Guanhua Jing, Ruihua An
Cell Proliferation.2020;[Epub] CrossRef
Dipenyleneiodonium Induces Growth Inhibition of Toxoplasma gondii through ROS Induction in ARPE-19 Cells
Pu Reum Sun, Fei Fei Gao, Hei Gwon Choi, Wei Zhou, Jae-Min Yuk, Jaeyul Kwon, Young-Ha Lee, Guang-Ho Cha
The Korean Journal of Parasitology.2019; 57(2): 83. CrossRef
Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii
Michael J. Holmes, Premal Shah, Ronald C. Wek, William J. Sullivan, Ira J. Blader
mSphere.2019;[Epub] CrossRef

11,140 View
182 Download
12 Web of Science
Crossref

IL-12 and IL-23 Production in Toxoplasma gondii- or LPS Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways: Hassan Ahmed Hassan Ahmed Ismail, Byung-Hun Kang, Jae-Su Kim, Jae-Hyung Lee, In-Wook Choi, Guang-Ho Cha, Jae-Min Yuk, Young-Ha Lee; Korean J Parasitol 2017;55(6):613-622.
Published online December 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.6.613

Abstract
PDF

IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these cytokines in T cells. Here, we investigated the roles of PI3K and MAPK pathways in IL-12 and IL-23 production in human Jurkat T cells in response to Toxoplasma gondii and LPS. IL-12 and IL-23 production was significantly increased in T cells after stimulation with T. gondii or LPS. T. gondii and LPS increased the phosphorylation of AKT, ERK1/2, p38 MAPK, and JNK1/2 in T cells from 10 min post-stimulation, and peaked at 30-60 min. Inhibition of the PI3K pathway reduced IL-12 and IL-23 production in T. gondii-infected cells, but increased in LPS-stimulated cells. IL-12 and IL-23 production was significantly reduced by ERK1/2 and p38 MAPK inhibitors in T. gondii- and LPS-stimulated cells, but not in cells treated with a JNK1/2 inhibitor. Collectively, IL-12 and IL-23 production was positively regulated by PI3K and JNK1/2 in T. gondii-infected Jurkat cells, but negatively regulated in LPS-stimulated cells. And ERK1/2 and p38 MAPK positively regulated IL-12 and IL-23 production in Jurkat T cells. These data indicate that T. gondii and LPS induced IL-12 and IL-23 production in Jurkat T cells through the regulation of the PI3K and MAPK pathways; however, the mechanism underlying the stimulation of IL-12 and IL-23 production by T. gondii in Jurkat T cells is different from that of LPS.

Citations

Citations to this article as recorded by

Protective Effect of Low 2-O, 3-O Desulfated Heparin (ODSH) Against LPS-Induced Acute Lung Injury in Mice
Joyce Gonzales, Rahul S. Patil, Thomas P. Kennedy, Nagavedi S. Umapathy, Rudolf Lucas, Alexander D. Verin
Biomolecules.2025; 15(9): 1232. CrossRef
BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells☆
Jianhong Ge, Hongqian Chu, Qianqian Xiao, Weidong Hao, Jing Shang, Tong Zhu, Zhaogang Sun, Xuetao Wei
Environmental Pollution.2021; 273: 116452. CrossRef
Toxoplasma gondiiModulates the Host Cell Responses: An Overview of Apoptosis Pathways
Nour Mammari, Mohamad Adnan Halabi, Souha Yaacoub, Hilda Chlala, Marie-Laure Dardé, Bertrand Courtioux
BioMed Research International.2019; 2019: 1. CrossRef

10,592 View
267 Download
2 Web of Science
Crossref

Genetic Diversity of Schistosoma haematobium Eggs Isolated from Human Urine in Sudan: Juan-Hua Quan, In-Wook Choi, Hassan Ahmed Hassan Ahmed Ismail, Abdoelohab Saed Mohamed, Hoo-Gn Jeong, Jin-Su Lee, Sung-Tae Hong, Tai-Soon Yong, Guang-Ho Cha, Young-Ha Lee; Korean J Parasitol 2015;53(3):271-277.
Published online June 30, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.3.271

Abstract
PDF

The genetic diversity of Schistosoma haematobium remains largely unstudied in comparison to that of Schistosoma mansoni. To characterize the extent of genetic diversity in S. haematobium among its definitive host (humans), we collected S. haematobium eggs from the urine of 73 infected schoolchildren at 5 primary schools in White Nile State, Sudan, and then performed a randomly amplified polymorphic DNA marker ITS2 by PCR-RFLP analysis. Among 73 S. haematobium egg-positive cases, 13 were selected based on the presence of the S. haematobium satellite markers A4 and B2 in their genomic DNA, and used for RFLP analysis. The 13 samples were subjected to an RFLP analysis of the S. haematobium ITS2 region; however, there was no variation in size among the fragments. Compared to the ITS2 sequences obtained for S. haematobium from Kenya, the nucleotide sequences of the ITS2 regions of S. haematobium from 4 areas in Sudan were consistent with those from Kenya (> 99%). In this study, we demonstrate for the first time that most of the S. haematobium population in Sudan consists of a pan-African S. haematobium genotype; however, we also report the discovery of Kenyan strain inflow into White Nile, Sudan.

Citations

Citations to this article as recorded by

Analysis of DNA cox1 barcoding revealed novel haplotype in Schistosoma haematobium isolated from Western Sudan
Ishraga Adam Elzain, Abeer Babiker Idris, Abdul Aziz Karim, Nagla Mohamed Ahmed, Salaheldein G. Elzaki, Semih Yılmaz, Mohamed A. Hassan, Hamid Suliman Abdalla
Scientific Reports.2025;[Epub] CrossRef
Molecular Detection of Urogenital Schistosomiasis in Community Level in Semi-Rural Areas in South-East Gabon
Lady Charlène Kouna, Sandrine Lydie Oyegue-Liabagui, Chenis Nick Atiga, Chérone Nancy Mbani Mpega Ntigui, Roméo Karl Imboumy-Limoukou, Jean Claude Biteghe BI Essone, Steede Seinnat Ontoua, Diamella Nancy Moukodoum, Alain Prince Okouga, Jean Bernard Lekana
Diagnostics.2025; 15(9): 1052. CrossRef
Molecular diagnosis of urogenital schistosomiasis in pre-school children, school-aged children and women of reproductive age at community level in central Senegal
Doudou Sow, Khadime Sylla, Ndeye Marème Dieng, Bruno Senghor, Papa Mouhamadou Gaye, Cheikh B. Fall, Ndiaw Goumballa, Aldiouma Diallo, Jean Louis A. Ndiaye, Philippe Parola, Cheikh Sokhna, Souleymane Doucouré, Babacar Faye
Parasites & Vectors.2023;[Epub] CrossRef
Population genetic structure of Schistosoma haematobium and Schistosoma haematobium × Schistosoma bovis hybrids among school-aged children in Côte d’Ivoire
Etienne K. Angora, Alexane Vangraefschepe, Jean-François Allienne, Hervé Menan, Jean T. Coulibaly, Aboulaye Meïté, Giovanna Raso, Mirko S. Winkler, William Yavo, André O. Touré, Eliézer K. N’Goran, Jakob Zinsstag, Jürg Utzinger, Oliver Balmer, Jérôme Bois
Parasite.2022; 29: 23. CrossRef
Genetic Diversity of Schistosoma haematobium in Sub-Saharan Africa: A Systematic Review
Rabecca Tembo, Panji Nkhoma, Mildred Zulu, Florence Mwaba, John Yabe, Hikabasa Halwiindi, Moses Kamwela, King S Nalubamba, Chummy S Sikasunge, Andrew M Phri
University of Zambia Journal of Agricultural and Biomedical Sciences.2022;[Epub] CrossRef
Detection of Schistosoma DNA in genital specimens and urine: A comparison between five female African study populations originating from S. haematobium and/or S. mansoni endemic areas
P. Pillay, J.A. Downs, J.M. Changalucha, E.A.T. Brienen, C.E. Ramarokoto, P.D.C. Leutscher, B.J. Vennervald, M. Taylor, E.F. Kjetland, L. Van Lieshout
Acta Tropica.2020; 204: 105363. CrossRef

11,750 View
207 Download
8 Web of Science
Crossref

Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR: Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee; Korean J Parasitol 2014;52(6):645-652.
Published online December 23, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.6.645

Abstract
PDF

Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

Citations

Citations to this article as recorded by

Distribution and Fasciola infection rates of Lymnaea snails and cattle in high-salinity areas of Mekong Delta, Vietnam
Dang Thi LOAN, Lam Thanh NGUYEN, Tran Ngoc BICH, Nguyen Thuy Y VI, Yasunobu MATSUMOTO
Journal of Veterinary Medical Science.2025; 87(3): 291. CrossRef
Susceptibility of lymnaeid snails to Fasciola hepatica and Fasciola gigantica (Digenea: Fasciolidae): a systematic review and meta-analysis
Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
PeerJ.2025; 13: e18976. CrossRef
Green vegetable juice as a potential source of human fascioliasis in Korea
Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
One Health.2022; 15: 100441. CrossRef
Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Morphological Characterization of Emerging Cercariae among Lymnaeid Snails from Barangay Cawongan, Padre Garcia, Batangas, Philippines
Gregorio L. Martin I, Esperanza C. Cabrera
Journal of Parasitology Research.2018; 2018: 1. CrossRef
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
The Korean Journal of Parasitology.2018; 56(4): 375. CrossRef
Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
The Korean Journal of Parasitology.2015; 53(5): 641. CrossRef
Ectopic Human <i>Fasciola hepatica</i> Infection by an Adult Worm in the Mesocolon
Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park
The Korean Journal of Parasitology.2015; 53(6): 725. CrossRef

11,798 View
139 Download
9 Web of Science
Crossref

Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU: Hassan Ahmed Hassan Ahmed Ismail, Juan-Hua Quan, Zhou Wei, In-Wook Choi, Guang-Ho Cha, Dae-Whan Shin, Young-Ha Lee, Chang-June Song; Korean J Parasitol 2012;50(1):7-13.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.7

Abstract
PDF

Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2, CCL3, EGR2 and PLAU) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different mice infected with T. gondii. ALDH1A2 mRNA expressions of both mouse strains were markedly increased at day 1-4 postinfection (PI) and then decreased, and its expressions in the spleen and lung were significantly higher in C57BL/6 mice than those of BALB/c mice. BEX2 and CCR3 mRNA expressions of both mouse strains were significantly increased from day 7 PI and peaked at day 15-30 PI (P<0.05), especially high in the spleen liver or small intestine of C57BL/6 mice. EGR2 and PLAU mRNA expressions of both mouse strains were significantly increased after infection, especially high in the spleen and liver. However, their expression patterns were varied depending on the tissue and mouse strain. Taken together, T. gondii-susceptible C57BL/6 mice expressed higher levels of these 5 genes than did T. gondii-resistant BALB/c mice, particularly in the spleen and liver. And ALDH1A2 and PLAU expressions were increased acutely, whereas BEX2, CCL3 and EGR2 expressions were increased lately. Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue.

Citations

Citations to this article as recorded by

Effect of Puerarin, Baicalin and Berberine Hydrochloride on the Regulation of IPEC-J2 Cells Infected with Enterotoxigenic Escherichia coli
Xiaoxi Liu, Fenghua Liu, Yunfei Ma, Huanrong Li, Xianghong Ju, Jianqin Xu
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Gene Silencing of Porcine MUC13 and ITGB5: Candidate Genes towards Escherichia coli F4ac Adhesion
Chuanli Zhou, Zhengzhu Liu, Yang Liu, Weixuan Fu, Xiangdong Ding, Jianfeng Liu, Ying Yu, Qin Zhang, Lucia R. Languino
PLoS ONE.2013; 8(7): e70303. CrossRef

10,066 View
86 Download
Crossref

Brief Communication

Intestinal Parasite Infections in Pigs and Beef Cattle in Rural Areas of Chungcheongnam-do, Korea: Hassan Ahmed Hassan Ahmed Ismail, Hyung-Kyu Jeon, Yong-Man Yu, Changhee Do, Young-Ha Lee; Korean J Parasitol 2010;48(4):347-349.
Published online December 16, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.4.347

Abstract
PDF

The present study was performed to investigate the infection status of intestinal parasites in pigs and beef cattle in rural areas of Chungcheongnam-do, Korea. From November 2009 to April 2010, a total of 241 fecal samples of pigs and beef cattle (136 and 105, respectively) were examined by direct smear and centrifugal sedimentation methods. The overall positive rates of intestinal parasites among pigs and beef cattle were 73.5% and 4.8%, respectively, and the double-infection rate was 10.3% in pigs. Of 136 specimens from pigs, Balantidium coli, Ascaris suum, and Entamoeba spp. infections were found in 88 (64.7%), 24 (17.6%), and 5 cases (3.7%), respectively. Of 105 beef cattle, Entamoeba spp. infections were detected in 5 cases (4.8%). From these results, it is shown that pigs raised on rural farms in Chungcheongnam-do had a high B. coli infection rate and a moderate A. suum infection rate. These results demonstrate that environmentally resistant cysts or eggs could be widespread on the farms examined, and thus an effective hygienic management system is needed to prevent them from serving as the source of infection for human beings.

Citations

Citations to this article as recorded by

Detection of Protozoa Intestinal Zoonotic in Madura Cattle in Bangkalan Madura Regency
Agus Sunarso, Poedji Hastutiek, Mufasirin
Journal of Parasite Science.2025; 9(1): 25. CrossRef
Prevalence and sequence diversity of Balantioides coli in pigs in Xinjiang, China
Zhenjie Zhang, Junfei Si, Lingyun Wang, Fuchang Yu, Suhui Hu, Meng Qi
Parasitology Research.2024;[Epub] CrossRef
A survey of gastrointestinal helminth infestation in smallholder backyard pigs and the first molecular identification of the two zoonotic helminths Ascaris suum and Trichuris suis in Myanmar
Saw Bawm, Lat Lat Htun, Hla Myet Chel, Yadanar Khaing, Myint Myint Hmoon, Su Su Thein, Shwe Yee Win, Nyein Chan Soe, Yu Nandi Thaw, Naoki Hayashi, Mar Mar Win, Nariaki Nonaka, Ken Katakura, Ryo Nakao
BMC Veterinary Research.2024;[Epub] CrossRef
Ontological representation, modeling, and analysis of parasite vaccines
Anthony Huffman, Xumeng Zhang, Meghana Lanka, Jie Zheng, Anna Maria Masci, Yongqun He
Journal of Biomedical Semantics.2024;[Epub] CrossRef
Prevalence of gastrointestinal parasites in domestic pigs from family farms in northeastern Argentina
Rumesilda Eliana Alegre, Esteban Joaquin Flores Lacsi, María de los Ángeles Gómez Muñoz, Lucas Daniel Monje, Francisca Milano
Veterinary Parasitology: Regional Studies and Reports.2024; 54: 101080. CrossRef
Prevalence and Genetic Diversity of Entamoeba and Cryptosporidium in Pigs and Wild Boars in Central and Southern Vietnam: Implications for Zoonotic Risks and Surveillance
Le Chi Cao, Devika Muraleedharan, Tran Thi Giang, Vo Minh Tiep, Ngo Thi Minh Chau, Ton Nu Phuong Anh, Le Nguyen Nhat Ha, Nguyen Thi Thu Hoai, Truong Nhat My, Awatef El Moussi, Nourhane Hafza, Le Huu Song, Thirumalaisamy P. Velavan
Foodborne Pathogens and Disease.2024;[Epub] CrossRef
Phylogenetics and Pathogenicity of Balantioides coli Isolates in Vietnamese Weaned Pigs
Duy Tien Do, Mai Tieu Duong, Nam Minh Nguyen, Phuong Le Dinh Nguyen, Hai Ngoc Nguyen
Acta Parasitologica.2022; 67(1): 110. CrossRef
Balantidium coli; Rare and Accidental Finding in the Urine of Pregnant Woman: Case Report
Andargachew Almaw, Ayenew Berhan, Yenealem Solomon, Birhanemaskal Malkamu, Tahir Eyayu, Lemma Workineh, Getachew Mekete, Ashagrachew Tewabe Yayehrad
International Medical Case Reports Journal.2022; Volume 15: 105. CrossRef
First Evidence of Entamoeba Parasites in Australian Wild Deer and Assessment of Transmission to Cattle
Jose L. Huaman, Carlo Pacioni, Lily Kenchington-Evans, Mark Doyle, Karla J. Helbig, Teresa G. Carvalho
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Distribution of Gastrointestinal Parasitic Infection in Domestic Pigs in the Republic of Korea: Nationwide Survey from 2020-2021
Subin Lee, Badriah Alkathiri, Dongmi Kwak, Sang-Myeong Lee, Wan-Kyu Lee, Jae-Won Byun, Seung-Hun Lee
The Korean Journal of Parasitology.2022; 60(3): 207. CrossRef
Molecular Characterization of Entamoeba spp. in Pigs with Diarrhea in Southern China
Pei Wang, Sen Li, Yang Zou, Ru-Yi Han, Ping Wang, De-Ping Song, Cheng-Bin Wang, Xiao-Qing Chen
Animals.2022; 12(14): 1764. CrossRef
Family-Run Pig Farms: Research and Extension Activities for Parasite Control in a Municipality in the State of Rio de Janeiro, Brazil
Camila Class, Renato Silveira, Priscila Fialho, Letícia Silva, Lucas Lobão, Maria Regina Amendoeira, Alynne Barbosa
Pathogens.2022; 11(9): 971. CrossRef
Balantioides coli
Francisco Ponce-Gordo, Juan José García-Rodríguez
Research in Veterinary Science.2021; 135: 424. CrossRef
Review of zoonotic amebiasis: Epidemiology, clinical signs, diagnosis, treatment, prevention and control
Junqiang Li, Zhaohui Cui, Xiaoying Li, Longxian Zhang
Research in Veterinary Science.2021; 136: 174. CrossRef
Prevalence of Balantidium coli (Malmsten, 1857) infection in swine reared in South Italy: A widespread neglected zoonosis
Filippo Giarratana, Luca Nalbone, Ettore Napoli, Vincenzo Lanzo, Antonio Panebianco
Veterinary World.2021; 14(4): 1044. CrossRef
Balantidiasis a Potential Neglected Zoonotic Disease and the Liar Paradox
Napoli E, L Nalbone, Giarratana F
Biosciences Biotechnology Research Asia.2021; 18(1): 5. CrossRef
Gastrointestinal parasites of indigenous pigs (Sus domesticus) in south‐central Nepal
Roshan B. Adhikari, Madhuri Adhikari Dhakal, Santosh Thapa, Tirth R. Ghimire
Veterinary Medicine and Science.2021; 7(5): 1820. CrossRef
Identification of Zoonotic Balantioides coli in Pigs by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and Its Distribution in Korea
Jae-Won Byun, Jung-Hyun Park, Bo-Youn Moon, Kichan Lee, Wan-Kyu Lee, Dongmi Kwak, Seung-Hun Lee
Animals.2021; 11(9): 2659. CrossRef
Balantidium coli in domestic animals: An emerging protozoan pathogen of zoonotic significance
Arslan Ahmed, Muhammad Ijaz, Rana Muhammad Ayyub, Awais Ghaffar, Hammad Nayyar Ghauri, Muhammad Umair Aziz, Sadaqat Ali, Muhammad Altaf, Muhammad Awais, Muhammad Naveed, Yasir Nawab, Muhammad Umar Javed
Acta Tropica.2020; 203: 105298. CrossRef
Copro-prevalence and risk factor assessment of gastrointestinal parasitism in Indian domestic pigs
D. Sharma, N. K. Singh, H. Singh, S. S. Rath
Helminthologia.2020; 57(1): 28. CrossRef
Prevalence and distribution of Entamoeba species in a rural community in northern South Africa
Amidou Samie, Leah Mahlaule, Peter Mbati, Tomoyoshi Nozaki, Ali ElBakri
Food and Waterborne Parasitology.2020; 18: e00076. CrossRef
A SURVEY FOR ZOONOTIC AND OTHER GASTROINTESTINAL PARASITES IN PIG IN BALI PROVINCE, INDONESIA
Ni Komang Aprilina Widisuputri, Lucia Tri Suwanti, Hani Plumeriastuti
Indonesian Journal of Tropical and Infectious Disease.2020; 8(1): 55. CrossRef
Prevalence and diversity of gastrointestinal protozoa in Madura cattle at Bangkalan Regency, East Java, Indonesia
Poedji Hastutiek, Wiwik Misaco Yuniarti, Mufasirin Djaeri, Nunuk Dyah Retno Lastuti, Endang Suprihati, Lucia Tri Suwanti
Veterinary World.2019; 12(2): 198. CrossRef
Prevalence of gastrointestinal helminths and parasites in smallholder pigs reared in the central Free State Province
Ifeoma C. Nwafor, Hester Roberts, Pieter Fourie
Onderstepoort Journal of Veterinary Research.2019;[Epub] CrossRef
Prevalence and Genetic Identification of Three Entamoeba Species in Pigs in Southeastern China
Ting Ji, Hao-Xuan Cao, Ran Wu, Lin-Lin Cui, Guo-Ming Su, Chang Niu, Ning Zhang, Shou-Kun Wang, Dong-Hui Zhou
BioMed Research International.2019; 2019: 1. CrossRef
IDENTIFICATION AND PREVALENCE OF GASTROINTESTINAL PARASITES IN BEEF CATTLE IN SIAK SRI INDRAPURA, RIAU, INDONESIA
Lucia Tri Suwanti
Indonesian Journal of Tropical and Infectious Disease.2019; 7(6): 155. CrossRef
First detection and molecular identification of Entamoeba bovis from Japanese cattle
Makoto Matsubayashi, Yuu Matsuura, Satoko Nukata, Yuusuke Daizi, Tomoyuki Shibahara, Isao Teramoto, Tomohide Matsuo, Shigehiko Uni, Takeshi Hatta, Akira Kaneko, Naotoshi Tsuji, Kazumi Sasai
Parasitology Research.2018; 117(1): 339. CrossRef
First report on the occurance of intestinal Entamoeba spp. In pigs In China
Wen-Chao Li, Jin-zhu Geng, Cheng Chen, Lei Qian, Tao Zhang, Jun-long Liu, Jian-xun Luo, You-fang Gu
Acta Tropica.2018; 185: 385. CrossRef
The First Case of Diarrhoea in Tibetan Sheep, Ovis aries, Caused by Balantidium coli in the Qinghai Tibetan Plateau Area, China
Ying-Na Jian, Ge-Ping Wang, Xiu-Ping Li, Xue-Yong Zhang, Li-Qing Ma
The Korean Journal of Parasitology.2018; 56(6): 603. CrossRef
A survey for potentially zoonotic gastrointestinal parasites of dogs and pigs in Cambodia
Tawin Inpankaew, K. Darwin Murrell, Nongnuch Pinyopanuwat, Chamnan Chhoun, Kuong Khov, Tharin Sem, San Sorn, Sinuon Muth, Anders Dalsgaard
Acta Parasitologica.2015;[Epub] CrossRef
Gastrointestinal parasites of swine raised in different management systems in the State of Rio de Janeiro, Brazil
Alynne S. Barbosa, Otilio M.P. Bastos, Laís V. Dib, Mayara P. de Siqueira, Matheus L. Cardozo, Luiz Claudio Ferreira, William T. Chaves, Ana Beatriz M. Fonseca, Claudia M.A. Uchôa, Maria Regina R. Amendoeira
Pesquisa Veterinária Brasileira.2015; 35(12): 941. CrossRef
Effects of Some Pesticides on Development of Ascaris suum Eggs
Yong-Man Yu, Jin-Won Kim, Won-Seok Na, Young-Nam Youn, In-Wook Choi, Young-Ha Lee
The Korean Journal of Parasitology.2014; 52(1): 111. CrossRef
Presence of Gastrointestinal Parasites in a Tropical Urban Region (Yaoundé, Cameroon)
Gideon Ajeagah, Margaret Wouafo, Guy Ezenguele, Jean Nzukam
Comparative Parasitology.2013; 80(2): 279. CrossRef
Quantitative Evaluation of Viability- and Apoptosis-Related Genes in Ascaris suum Eggs under Different Culture-Temperature Conditions
Yong-Man Yu, You-Hang Cho, Young-Nam Youn, Juan Hua Quan, In-Wook Choi, Young-Ha Lee
The Korean Journal of Parasitology.2012; 50(3): 243. CrossRef
Effect of Temperature on Embryonation of Ascaris suum Eggs in an Environmental Chamber
Min-Ki Kim, Kyoung-Ho Pyo, Young-Sang Hwang, Ki Hwan Park, In Gyun Hwang, Jong-Yil Chai, Eun-Hee Shin
The Korean Journal of Parasitology.2012; 50(3): 239. CrossRef
Effects of Kimchi Extract and Temperature on Embryostasis of Ascaris suum Eggs
Jin-Sung Kim, Dae-Sung Oh, Kyu-Sung Ahn, Sung-Shik Shin
The Korean Journal of Parasitology.2012; 50(1): 83. CrossRef