Parasites, Hosts and Diseases

"Saeed Nazifi"

Original Articles

Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis: Shabnam Tadayon, Seyed Mostafa Razavi, Saeed Nazifi; Korean J Parasitol 2016;54(6):719-724.
Published online December 31, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.6.719

Abstract
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The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including IFN-γ, TNF-α, IL-4, IL-6, acute phase protein (α1-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with 5×10⁴ sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. IFN-γ, TNF-α, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines (IFN-γ, TNF-α, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.

Citations

Citations to this article as recorded by

Isolation of a Novel Caprine Eimeria christenseni Strain (GC) in Canary Islands and Analysis of Parasitological, Clinical, and Pathological Findings on Experimentally Infected Goat Kids
Emilio Barba, José Manuel Molina, Francisco Rodríguez, Otilia Ferrer, María Carmen Muñoz, Liliana M. R. Silva, María Cristina Del Río, José Adrián Molina, Anja Taubert, Carlos Hermosilla, Antonio Ruiz
Animals.2025; 15(2): 139. CrossRef
Acute phase response and oxidative stress in coccidiosis: A review in domestic animals
Seyed Mostafa Razavi, Mohammad Sajjad Soltan, Kiarash Abbasian, Ali Karami, Saeed Nazifi
Veterinary Parasitology.2024; 331: 110286. CrossRef
The role of genetics in determining resistance to coccidiosis in goats a review of current research and future directions
Tejswini Sontakke, Ashwini Biradar, Dinesh Nalage
Molecular Biology Reports.2023; 50(7): 6171. CrossRef
Effects of riboflavin and Bacillus subtilis on internal organ development and intestinal health of Ross 708 male broilers with or without coccidial challenge
Sabin Poudel, Li Zhang, George T. Tabler, Jun Lin, Wei Zhai
Poultry Science.2021; 100(4): 100973. CrossRef
Oxidative stress linked to changes of cholinesterase and adenosine deaminase activities in experimentally infected chicken chicks with Eimeria spp
Luiz Gustavo Griss, Gabriela M. Galli, Mateus Fracasso, Anielen D. Silva, Bruno Fortuoso, Maria Rosa C. Schetinger, Vera M. Morch, Marcel M. Boiago, Anderson Gris, Ricardo E. Mendes, Matheus D. Baldissera, Lenita M. Stefani, Aleksandro S. da Silva
Parasitology International.2019; 71: 11. CrossRef

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Changing Patterns of Acute Phase Proteins and Inflammatory Mediators in Experimental Caprine Coccidiosis: Mohammad Hashemnia, Azizollah Khodakaram-Tafti, Seyed Mostafa Razavi, Saeed Nazifi; Korean J Parasitol 2011;49(3):213-219.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.213

Abstract
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This experiment was conducted to assess the changing patterns and relative values of acute phase proteins and inflammatory cytokines in experimental caprine coccidiosis. Eighteen newborn kids were allocated to 3 equal groups. Two groups, A and B, were inoculated with a single dose of 1×10³ and1×10⁵ sporulated oocysts of Eimeria arloingi, respectively. The third group, C, received distilled water as the control. Blood samples were collected from the jugular vein of each kid in both groups before inoculation and at days 7, 14, 21, 28, 35, and 42 post-inoculation (PI), and the levels of haptoglobin (Hp), serum amyloid A (SAA), TNF-α, and IFN-γ were measured. For histopathological examinations, 2 kids were selected from each group, euthanized, and necropsied on day 42 PI. Mean Hp concentrations in groups A and B (0.34 and 0.68 g/L) at day 7 PI were 3.2 and 6.3 times higher than the levels before inoculation. The mean SAA concentrations in groups A and B (25.6 and 83.5 ?g/ml) at day 7 PI were 4.2 and 13.7 times higher than the levels before inoculation. The magnitude and duration of the Hp and SAA responses correlated well with the inoculation doses and the severity of the clinical signs and diarrhea in kids. These results were consistent with the histopathological features, which showed advanced widespread lesions in group B. In both groups, significant correlations were observed for TNF-α and IFN-γ with SAA and Hp, respectively. In conclusion, Hp and SAA can be useful non-specific diagnostic indicators in caprine coccidiosis.

Citations

Citations to this article as recorded by

Global prevalence of Eimeria species in goats: a systematic review and meta-analysis
Endris A. Ali, Abdul Ghafar, Juan C. Angeles-Hernandez, Muhammad Yaseen, Charles G. Gauci, Ian Beveridge, Sandra Baxendell, Abdul Jabbar
Frontiers in Veterinary Science.2025;[Epub] CrossRef
Acute phase response and oxidative stress in coccidiosis: A review in domestic animals
Seyed Mostafa Razavi, Mohammad Sajjad Soltan, Kiarash Abbasian, Ali Karami, Saeed Nazifi
Veterinary Parasitology.2024; 331: 110286. CrossRef
DEVELOPMENT OF A QUANTITATIVE IMMUNOASSAY FOR SERUM HAPTOGLOBIN AS A PUTATIVE DISEASE MARKER IN THE SOUTHERN WHITE RHINOCEROS (CERATOTHERIUM SIMUM SIMUM)
Henrik H. Petersen, Rikke Stenbak, Camilla Blaabjerg, Anne K.H. Krogh, Mads F. Bertelsen, Peter Buss, Peter M.H. Heegaard
Journal of Zoo and Wildlife Medicine.2022;[Epub] CrossRef
Assessment of the Immune Response of Clinically Infected Calves to Cryptosporidium parvum Infection
Wael El-Deeb, Olimpia Iacob, Mahmoud Fayez, Ibrahim Elsohaby, Abdulrahman Alhaider, Hermine V. Mkrtchyan, Abdelazim Ibrahim, Naser Alhumam
Agriculture.2022; 12(8): 1151. CrossRef
Comparative study on plasma fibrinogen and ceruloplasmin concentrations during pregnancy and postpartum period in Bulgarian native goats
I. Fasulkov, M. Karadaev, D. Zapryanova, T. Mircheva, N. Vasilev, F. Ceciliani
BULGARIAN JOURNAL OF VETERINARY MEDICINE.2022; 25(4): 603. CrossRef
Acute phase biomarkers of diseases in small ruminants: an overview
P.T. Iliev, T.M. Georgieva
BULGARIAN JOURNAL OF VETERINARY MEDICINE.2019; 22(1): 1. CrossRef
Haptoglobin and serum amyloid A in goats with clinical form of caprine arthritis-encephalitis
Michał Czopowicz, Olga Szaluś-Jordanow, Marcin Mickiewicz, Agata Moroz, Lucjan Witkowski, Iwona Markowska-Daniel, Tadeusz Stefaniak, Emilia Bagnicka, Jarosław Kaba
Small Ruminant Research.2017; 156: 73. CrossRef
Agreement between commercial assays for haptoglobin and serum amyloid A in goats
Michał Czopowicz, Olga Szaluś-Jordanow, Marcin Mickiewicz, Agata Moroz, Lucjan Witkowski, Iwona Markowska-Daniel, Daria Reczyńska, Emilia Bagnicka, Jarosław Kaba
Acta Veterinaria Scandinavica.2017;[Epub] CrossRef
Effect of Ketoprofen on acute phase protein concentrations in goats undergoing castration
Umit Karademir, Ibrahim Akin, Hasan Erdogan, Kerem Ural, Gamze Sevri Ekren Asici
BMC Veterinary Research.2016;[Epub] CrossRef
Dynamic Patterns of Systemic Innate Immunity and Inflammatory Associated Factors in Experimental Caprine Coccidiosis
Shabnam Tadayon, Seyed Mostafa Razavi, Saeed Nazifi
The Korean Journal of Parasitology.2016; 54(6): 719. CrossRef
Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves
Leena Seppä-Lassila, Toomas Orro, Brian Lassen, Riikka Lasonen, Tiina Autio, Sinikka Pelkonen, Timo Soveri
Comparative Immunology, Microbiology and Infectious Diseases.2015; 41: 10. CrossRef
Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii
Brian Lassen, Berit Bangoura, Triin Lepik, Toomas Orro
Veterinary Parasitology.2015; 212(3-4): 140. CrossRef
Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review
C. Tothova, O. Nagy, G. Kovac
Veterinární medicína.2014; 59(4): 163. CrossRef

10,228 View
94 Download
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Hematological and Serum Biochemical Analyses in Experimental Caprine Besnoitiosis: Saeed Nazifi, Ahmad Oryan, Fatemeh Namazi; Korean J Parasitol 2011;49(2):133-138.
Published online June 14, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.2.133

Abstract
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This study was undertaken to investigate the hematological and biochemical changes in experimentally infected goats with Besnoitia caprae from the time of infection till 360 days post-infection (PI). Six male goats were inoculated subcutaneously with 13×10⁷ bradyzoites of B. caprae, and blood samples were collected from the jugular vein. The total erythrocyte and total leukocyte counts, hematocrit value, and differential leukocyte counts were determined. Serum biochemical analysis, including the total protein, albumin, total globulin, cholesterol, triglyceride, chloride, testosterone, calcium (Ca²⁺), inorganic phosphorus, sodium (Na⁺), potassium (K⁺), iron (Fe²⁺), glucose, serum amyloid A (SAA), haptoglobin (Hp), fibrinogen, ceruloplasmin, aspartate aminotransferase, alanine aminotransferase, creatine kinase, lactate dehydrogenase, and alkaline phosphatase, was undertaken. Skin biopsy from the limbs were collected at weekly intervals and histologically examined for Besnoitia cysts. Cysts were present in the skin biopsies of the leg of the infected goats from day 28 PI. There were variations in hematological analyses, but no significant difference was seen. From day 30 to 360 PI, results showed that SAA, Hp, fibrinogen, and ceruloplasmin concentrations increased, whereas testosterone concentrations decreased. Infected goats exhibited decrease of albumin and increase of serum total protein and globulin concentrations. By contrast, there were no significant differences in the remained analyses concentrations.

Citations

Citations to this article as recorded by

Effect of Ketoprofen on acute phase protein concentrations in goats undergoing castration
Umit Karademir, Ibrahim Akin, Hasan Erdogan, Kerem Ural, Gamze Sevri Ekren Asici
BMC Veterinary Research.2016;[Epub] CrossRef
Natural Besnoitia besnoiti infections in cattle: hematological alterations and changes in serum chemistry and enzyme activities
Martin C Langenmayer, Julia C Scharr, Carola Sauter-Louis, Gereon Schares, Nicole S Gollnick
BMC Veterinary Research.2015; 11(1): 32. CrossRef