Parasites, Hosts and Diseases

"Suk Kim"

Original Articles

Anticoccidial activities of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina: Binh T. Nguyen, Rochelle A. Flores, Paula Leona T. Cammayo-Fletcher, Suk Kim, Woo H. Kim, Wongi Min; Parasites Hosts Dis 2025;63(2):135-146.
Published online May 26, 2025; DOI: https://doi.org/10.3347/PHD.24045

Poultry coccidiosis, caused by 7 Eimeria species, has a significant economic impact on the poultry industry and is managed mainly by chemotherapeutic drugs. However, alternative control measures are needed due to the emergence of drug-resistant strains. This study aimed to evaluate the anticoccidial effects of a multicomplex mineral-based diet in broilers infected with Eimeria acervulina. Broilers were fed a multicomplex mineral-based diet and infected with E. acervulina. Fecal oocyst shedding was 39.0% lower in the E. acervulina-infected broilers treated with the multicomplex mineral compared to that in untreated-infected broilers (365.7×10⁶±45.7 versus 599.8×10⁶±8.7, P<0.05). On day 6 post-infection, body weight gain was significantly higher in treated-infected chickens than untreated chickens (103.2±1.5% versus 94.1±1.7%, P<0.001). The lesion scores were similar between the 2 groups. Histopathological observations revealed that the width of the villi in the treated-infected chickens (286±9.5 μm) was significantly increased by 19.1% (240±10.8 μm, P<0.05) and 34.9% (212±7.3 μm, P<0.001) compared to those in the untreated-uninfected and untreated-infected groups, respectively. However, the villous height and crypt depth were similar between the untreated- and treated-infected groups. The positive effects of the dietary multicomplex mineral, including reduced fecal oocyst shedding, increased weight gain, and increased villi width, suggest its potential application in mitigating the adverse effects of Eimeria infection in both conventional and organic chicken industries.

Citations

Citations to this article as recorded by

Urban environmental drivers of eukaryotic microbiota and parasite prevalence in domestic pigeon faeces: a metabarcoding-based public health risk assessment in Seoul, South Korea
Singeun Oh, Jun Ho Choi, Xavier Chavarria, Myungjun Kim, Dongjun Kang, Myung-hee Yi, Yoon Hee Cho, In-Yong Lee, Tai-Soon Yong, Seongjun Choe, Ju Yeong Kim
Journal of The Royal Society Interface.2025;[Epub] CrossRef

2,002 View
57 Download
1 Web of Science
Crossref

Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis: Sang-Su Kim, Kyu-Shik Kim, Ik-Hwan Han, Yeseul Kim, Seong Sik Bang, Jung-Hyun Kim, Yong-Suk Kim, Soo-Yeon Choi, Jae-Sook Ryu; Korean J Parasitol 2021;59(6):547-556.
Published online December 22, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.6.547

Abstract
PDF

Our
objective
was to investigate whether inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation of prostate cancer (PCa) cells in vitro and in vivo mouse experiments. The production of CXCL1 and CCL2 increased when cells of the mouse PCa cells (TRAMP-C2 cell line) were infected with live T. vaginalis. T. vaginalis-conditioned medium (TCM) prepared from co-culture of PCa cells and T. vaginalis increased PCa cells migration, proliferation and invasion. The cytokine receptors (CXCR2, CCR2, gp130) were expressed higher on the PCa cells treated with TCM. Pretreatment of PCa cells with antibodies to these cytokine receptors significantly reduced the proliferation, mobility and invasiveness of PCa cells, indicating that TCM has its effect through cytokine-cytokine receptor signaling. In C57BL/6 mice, the prostates injected with T. vaginalis mixed PCa cells were larger than those injected with PCa cells alone after 4 weeks. Expression of epithelial-mesenchymal transition markers and cyclin D1 in the prostate tissue injected with T. vaginalis mixed PCa cells increased than those of PCa cells alone. Collectively, it was suggested that inflammatory reactions by T. vaginalis-stimulated PCa cells increase the proliferation and invasion of PCa cells through cytokine-cytokine receptor signaling pathways.

Citations

Citations to this article as recorded by

The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management
Amin Ullah, Wang Jiao, Bairong Shen
Cellular & Molecular Biology Letters.2024;[Epub] CrossRef
Trichomonas vaginalis excretory secretory proteins reduce semen quality and male fertility
Zhenchao Zhang, Fakun Li, Yangyang Deng, Yuhua Li, Wanxin Sheng, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lihua Guo, Lixia Hao, Xuefang Mei
Acta Tropica.2023; 238: 106794. CrossRef
Point-of-Care Diagnostic for Trichomonas vaginalis, the Most Prevalent, Non-Viral Sexually Transmitted Infection
John F. Alderete, Hermes Chan
Pathogens.2023; 12(1): 77. CrossRef
Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu
The Korean Journal of Parasitology.2021; 59(6): 557. CrossRef

5,121 View
143 Download
6 Web of Science
Crossref

Brief Communication

Anticoccidial Activity of Berberine against Eimeria-Infected Chickens: Binh Thanh Nguyen, Rochelle Alipio Flores, Paula Leona Taymen Cammayo, Suk Kim, Woo Hyun Kim, Wongi Min; Korean J Parasitol 2021;59(4):403-408.
Published online August 18, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.4.403

Avian coccidiosis has a major economic impact on the poultry industry, it is caused by 7 species of Eimeria, and has been primarily controlled using chemotherapeutic agents. Due to the emergence of drug-resistant strains, alternative control strategies are needed. We assessed anticoccidial effects of berberine-based diets in broiler chickens following oral infection with 5 Eimeria species (E. acervulina, E. maxima, E. tenella, E. mitis, and E. praecox). When 0.2% berberine, a concentration that does not affect weight gain, was added to the diet, the 4 groups infected with E. acervulina, E. tenella, E. mitis, or E. praecox showed significant reductions in fecal oocyst shedding (P<0.05) compared to their respective infected and untreated controls. In chickens treated 0.5% berberine instead of 0.2% and infected with E. maxima, fecal oocyst production was significantly reduced, but body weight deceased, indicating that berberine treatment was not useful for E. maxima infection. Taken together, these results illustrate the applicability of berberine for prophylactic use to control most Eimeria infections except E. maxima. Further studies on the mechanisms underlying the differences in anticoccidial susceptibility to berberine, particularly E. maxima, are remained.

Citations

Citations to this article as recorded by

Evaluation of the Effectiveness of a Phytogenic Supplement (Alkaloids and Flavonoids) in the Control of Eimeria spp. in Experimentally Challenged Broiler Chickens
Anne-Sophie Hascoët, Paulina Torres-Celpa, Roberto Riquelme-Neira, Héctor Hidalgo-Olate
Animals.2025; 15(6): 847. CrossRef
Improving The Sporulation of Eimeria tenella Oocysts Purified From Chicken Faeces
Nurfazila Latif, Aravind Marcus, Paul Bura Thlama, Suhaili Mustafa, Muhamad Hakim Mohd Ali Hanafiah, Lirong Yu Abit, Sharifah Salmah Syed Hussain, Nor Azlina Abdul Aziz, Shu-San Loo, Kiew Lian Wan, Sarah A Altwaim, Juriah Kamaludeen
Malaysian Applied Biology.2025; 54(1): 38. CrossRef
Berberine Reveals Anticoccidial Activity by Influencing Immune Responses in Eimeria acervulina-Infected Chickens
Binh T. Nguyen, Bujinlkham Altanzul, Rochelle A. Flores, Honghee Chang, Woo H. Kim, Suk Kim, Wongi Min
Biomolecules.2025; 15(7): 985. CrossRef
Vaccinations and Functional Feed Supplements as Alternatives to Coccidiostats for the Control of Coccidiosis in Raising Broiler Chickens
Maciej Rosłoń, Edward Majewski, Monika Gębska, Anna Grontkowska, Michał Motrenko, Artur Żbikowski, Monika Michalczuk, Jakub Urban
Animals.2025; 15(17): 2548. CrossRef
Management and control of coccidiosis in poultry — A review
Rafiq Ahmad, Yu-Hsiang Yu, Kuo-Feng Hua, Wei-Jung Chen, Daniel Zaborski, Andrzej Dybus, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
Animal Bioscience.2024; 37(1): 1. CrossRef
Large-Scale Field Trials of an Eimeria Vaccine Induce Positive Effects on the Production Index of Broilers
Binh T. Nguyen, Dongjean Yim, Rochelle A. Flores, Seung Yun Lee, Woo H. Kim, Seung-Hwan Jung, Sangkyu Kim, Wongi Min
Vaccines.2024; 12(7): 800. CrossRef
An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives
Navid Ghavipanje, Mohammad Hasan Fathi Nasri, Einar Vargas‐Bello‐Pérez
Journal of Animal Physiology and Animal Nutrition.2023; 107(3): 808. CrossRef
Botanicals: A promising approach for controlling cecal coccidiosis in poultry
Zohaib Saeed, Khalid A. Alkheraije
Frontiers in Veterinary Science.2023;[Epub] CrossRef
Pathological Role of Oxidative Stress in Aflatoxin-Induced Toxicity in Different Experimental Models and Protective Effect of Phytochemicals: A Review
Martha Cebile Jobe, Doctor M. N. Mthiyane, Phiwayinkosi V. Dludla, Sithandiwe E. Mazibuko-Mbeje, Damian C. Onwudiwe, Mulunda Mwanza
Molecules.2023; 28(14): 5369. CrossRef
The Immunoprotective Effect of ROP27 Protein of Eimeria tenella
Menggang Li, Xiaoling Lv, Mingxue Zheng, Yingyi Wei
Animals.2023; 13(22): 3500. CrossRef
Oral administration of Lactobacillus brevis 23017 combined with ellagic acid attenuates intestinal inflammatory injury caused by Eimeria infection by activating the Nrf2/HO-1 antioxidant pathway
Xuelian Yang, Xinghui Pan, Zhipeng Jia, Bingrong Bai, Wenjing Zhi, Hang Chen, Chunli Ma, Dexing Ma
Veterinary Research.2022;[Epub] CrossRef
Epidemiological investigation and drug resistance of Eimeria species in Korean chicken farms
Rochelle A. Flores, Binh T. Nguyen, Paula Leona T. Cammayo, Tuấn Cường Võ, Haung Naw, Suk Kim, Woo H. Kim, Byoung-Kuk Na, Wongi Min
BMC Veterinary Research.2022;[Epub] CrossRef

6,500 View
116 Download
13 Web of Science
Crossref

Case Report

Sparganosis of the Unilateral Breast: A Case Report: Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung You, Yong Hwa Eom, Tae Kyung Yoo, Ahwon Lee, Byung Joo Song, Byung Joo Chae; Korean J Parasitol 2017;55(4):421-424.
Published online August 31, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.4.421

Abstract
PDF

Sparganosis is a parasitic infection caused by the sparganum, the plercercoid of the genus Spirometra. The preoperative diagnosis of breast sparganosis is difficult in most cases because it is a rare parasitic infection less than 2% of all cases. We report a 62-year-old woman case of breast sparganosis that were confirmed by surgical removal of worms from the right breast. The radiologic images of the patient also revealed characteristic features of breast sparganosis. The patient described the migrating palpable breast mass, which strongly suggested the possibility of breast sparganosis. The treatment of choice and confirmative diagnosis for sparganosis are complete surgical extraction of the sparganum irrespective of infected site. Inspection of the mass site with detailed medical history and radiological examinations are important for preoperative diagnosis of sparganosis patients.

Citations

Citations to this article as recorded by

A Painful Breast Mass
Samkeliso Blundell, Manjiri Deshmukh, Alastair McGregor
Clinical Infectious Diseases.2022; 75(12): 2275. CrossRef

11,626 View
189 Download
1 Web of Science
Crossref

Original Article

Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice: Bayissa Chala, Min-Ho Choi, Kyung Chul Moon, Hyung Suk Kim, Cheol Kwak, Sung-Tae Hong; Korean J Parasitol 2017;55(1):21-29.
Published online February 28, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.1.21

Abstract
PDF

Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the S. haematobium eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of Ki-67 in urothelial epithelial cells of the S. haematobium eggs+BBN group at week 20. The qRT-PCR showed high expression of p53 gene in S. haematobium eggs group at week 4 and S. haematobium eggs+BBN group at week 20. E-cadherin and vimentin showed contrasting expression in S. haematobium eggs+BBN group. Such inverse expression of E-cadherin and vimentin may indicate epithelial mesenchymal transition in the UB tissue. In conclusion, S. haematobium eggs and nitrosamines may transform UB cells into squamous metaplasia and dysplasia in correlation with increased expression of Ki-67. Marked decrease in E-cadherin and increase in p53 and vimentin expressions may support the transformation. The present study introduces a promising modified animal model for UB cancer study using S. haematobium eggs.

Citations

Citations to this article as recorded by

Reinventing type 2 immunity in cancer
Marek Wagner, Hiroyoshi Nishikawa, Shigeo Koyasu
Nature.2025; 637(8045): 296. CrossRef
Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review
Anna M. Mertelsmann, Sheridan F. Bowers, Drew Wright, Jane K. Maganga, Humphrey D. Mazigo, Lishomwa C. Ndhlovu, John M. Changalucha, Jennifer A. Downs, Hamed Kalani
PLOS Neglected Tropical Diseases.2024; 18(9): e0012456. CrossRef
Development of an automated artificial intelligence-based system for urogenital schistosomiasis diagnosis using digital image analysis techniques and a robotized microscope
Carles Rubio Maturana, Allisson Dantas de Oliveira, Francesc Zarzuela, Edurne Ruiz, Elena Sulleiro, Alejandro Mediavilla, Patricia Martínez-Vallejo, Sergi Nadal, Tomàs Pumarola, Daniel López-Codina, Alberto Abelló, Elisa Sayrol, Joan Joseph-Munné, David J
PLOS Neglected Tropical Diseases.2024; 18(11): e0012614. CrossRef
Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis
Ana Gabriela Leija-Montoya, Javier González-Ramírez, Gustavo Martínez-Coronilla, María Esther Mejía-León, Mario Isiordia-Espinoza, Fausto Sánchez-Muñoz, Elda Georgina Chávez-Cortez, Viviana Pitones-Rubio, Nicolas Serafín-Higuera
International Journal of Molecular Sciences.2022; 23(15): 8173. CrossRef
The role of helminths in the development of non-communicable diseases
Yifan Wu, Megan Duffey, Saira Elizabeth Alex, Charlie Suarez-Reyes, Eva H. Clark, Jill E. Weatherhead
Frontiers in Immunology.2022;[Epub] CrossRef
Pathogens and Carcinogenesis: A Review
Muhammad Nur Adam Hatta, Ezanee Azlina Mohamad Hanif, Siok-Fong Chin, Hui-min Neoh
Biology.2021; 10(6): 533. CrossRef
E-cadherin and N-cadherin Immunohistochemical Expression in Proliferating Urothelial Lesions: Potential Novel Cancer Predictive EMT Profiles
Lobna S. Shash, Riham A. Ibrahim, Shimaa A. Elgohary
Applied Immunohistochemistry & Molecular Morphology.2021; 29(9): 657. CrossRef
Parasite–bacteria interrelationship
Dalia S. Ashour, Ahmad A. Othman
Parasitology Research.2020; 119(10): 3145. CrossRef
Urinary schistosomiasis and the associated bladder cancer: update
Mohamed S. Zaghloul, Tarek M. Zaghloul, Mai K. Bishr, Brian C. Baumann
Journal of the Egyptian National Cancer Institute.2020;[Epub] CrossRef
Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni
Rafael Nacif-Pimenta, Alessandra da Silva Orfanó, Ilana A. Mosley, Shannon E. Karinshak, Kenji Ishida, Victoria H. Mann, Paulo Marcos Zech Coelho, José M. Correia da Costa, Michael H. Hsieh, Paul J. Brindley, Gabriel Rinaldi
Scientific Reports.2019;[Epub] CrossRef
Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer
Patience B. Tetteh-Quarcoo, Benjamin K. Akuetteh, Irene A. Owusu, Solomon E. Quayson, Simon K. Attah, Robert Armah, Emmanuel Afutu, Ama Afrah, Kantanka Addo-Osafo, Cecilia Smith, Richard K. Gyasi, Patrick F. Ayeh-Kumi
Canadian Journal of Infectious Diseases and Medical Microbiology.2019; 2019: 1. CrossRef
Neglected Agent Eminent Disease: Linking Human Helminthic Infection, Inflammation, and Malignancy
Naina Arora, Rimanpreet Kaur, Farhan Anjum, Shweta Tripathi, Amit Mishra, Rajiv Kumar, Amit Prasad
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
Understanding Urogenital Schistosomiasis-Related Bladder Cancer: An Update
Kenji Ishida, Michael H. Hsieh
Frontiers in Medicine.2018;[Epub] CrossRef
Helminth infection–induced malignancy
Paul J. Brindley, Alex Loukas, Laura J Knoll
PLOS Pathogens.2017; 13(7): e1006393. CrossRef

17,011 View
239 Download
16 Web of Science
Crossref

Brief Communications

Prevalence of Trichomoniasis by PCR in Women Attending Health Screening in Korea: Seung-Ryong Kim, Jung-Hyun Kim, Na-Yeong Gu, Yong-Suk Kim, Yeon-Chul Hong, Jae-Sook Ryu; Korean J Parasitol 2016;54(2):187-190.
Published online April 30, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.2.187

Abstract
PDF

Trichomoniasis is the most common curable sexually-transmitted infection (STI) worldwide. There are few reports on the prevalence of Trichomonas vaginalis in Korea. The purpose of this study was to examine the prevalence of trichomoniasis by PCR in Guri city, Korea. All adult women who visited Hanyang University Guri Hospital for health screening within the National Health Care Service were invited to participate in the study, and 424 women were enrolled between March and June 2011. PCR was used to detect Trichomonas vaginalis using primers based on a repetitive sequence cloned from T. vaginalis (TV-E650). Fourteen women (3.3%) were found to have T. vaginalis. All were over 50, and they were significantly older on average than the 410 Trichomonas-negative women (mean ages 63.4 vs 55.3 years). It seems that T. vaginalis infection is not rare in women receiving health screening, especially among those over 50.

Citations

Citations to this article as recorded by

Molecular diagnosis of Trichomonas vaginalis in liquid-based Papanicolaou samples in Shiraz, southern Iran
Mohammad Saleh Bahreini, Samaneh Sedghi, Yalda Badalzadeh, Mohammad Hossein Motazedian, Manouchehr Shirani, Sareh Sami Jahromi, Aref Teimouri, Mahmoud Agholi, Qasem Asgari
BMC Women's Health.2023;[Epub] CrossRef
Construction a novel detection method for Trichomonas vaginalis based on recombinant enzyme polymerase amplification targeting the Actin gene
Fakun Li, Yangyang Deng, Wanxin Sheng, Xihui Gao, Weijuan Wang, Zhili Chu, Xuefang Mei, Zhenke Yang, Xiaowei Tian, Shuai Wang, Zhenchao Zhang
Journal of Eukaryotic Microbiology.2023;[Epub] CrossRef
Molecular characterization of Trichomonas infections in women of Ilam City, southwestern Iran
Maryam Alikhani, Mohammad Akhoundi, Denis Sereno, Jahangir Abdi, Razi Naserifar, Mohammad Reza Mahmoudi, Asad Mirzaei
Parasitology Research.2022; 121(6): 1631. CrossRef
Status of common parasitic diseases in Korea in 2019
Sun Huh
Journal of the Korean Medical Association.2019; 62(8): 437. CrossRef

8,721 View
105 Download
5 Web of Science
Crossref

Molecular Detection of Giardia intestinalis from Stray Dogs in Animal Shelters of Gyeongsangbuk-do (Province) and Daejeon, Korea: Jin-Cheol Shin, Alisha Wehdnesday Bernardo Reyes, Sang-Hun Kim, Suk Kim, Hyung-Jin Park, Kyoung-Won Seo, Kun-Ho Song; Korean J Parasitol 2015;53(4):477-481.
Published online August 25, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.4.477

Abstract
PDF

Giardia is a major public health concern and considered as reemerging in industrialized countries. The present study investigated the prevalence of giardiosis in 202 sheltered dogs using PCR. The infection rate was 33.2% (67/202); Gyeongsangbuk-do and Daejeon showed 25.7% (39/152, P<0.0001) and 56% (28/50), respectively. The prevalence of infected female dogs (46.7%, P<0.001) was higher than in male dogs (21.8%). A higher prevalence (43.5%, P<0.0001) was observed in mixed breed dogs than purebred (14.1%). Although most of the fecal samples collected were from dogs of ≥1 year of age which showed only 27.4% positive rate, 61.8% (P<0.001) of the total samples collected from young animals (<1 year of age) were positive for G. intestinalis. A significantly higher prevalence in symptomatic dogs (60.8%, P<0.0001) was observed than in asymptomatic dogs (23.8%). Furthermore, the analysis of nucleotide sequences of the samples revealed that G. intestinalis Assemblages A and C were found in the feces of dogs from Gyeongsangbuk-do and Daejeon. Since G. intestinalis Assemblage A has been known to infect humans, our results suggest that dogs can act as an important reservoir of giardiosis in Korea. Hence, hygienic management should be given to prevent possible transmission to humans.

Citations

Citations to this article as recorded by

Global prevalence of Giardia infection in nonhuman mammalian hosts: A systematic review and meta-analysis of five million animals
Kareem Hatam-Nahavandi, Ehsan Ahmadpour, Milad Badri, Aida Vafae Eslahi, Davood Anvari, David Carmena, Lihua Xiao, Aysegul Taylan Ozkan
PLOS Neglected Tropical Diseases.2025; 19(4): e0013021. CrossRef
An Epidemiology Study on Distribution of Giardia lamblia in Incheon City
Su Jin Park, Ju Hee Kim, Hyeon-Jeong Go, Nam Yee Kim, Sung Suck Oh, Young Woo Gong, MunJu Kwon, Jeong-An Gim, Soo-Son Lim
Biomedical Science Letters.2025; 31(2): 218. CrossRef
Prevalence and genotype analysis of Cryptosporidium and Giardia duodenalis from shelter dogs in South Korea
Chi Sun Yun, Bo-Youn Moon, Kichan Lee, Seok Ha Hwang, Bok-Kyung Ku, Mi-Hye Hwang
Veterinary Parasitology: Regional Studies and Reports.2024; 55: 101103. CrossRef
Current status of intestinal parasite infections in fecal samples of dogs in Korea
You-Jeong Lee, Beoul Kim, Dongmi Kwak, Min-Goo Seo
Parasites, Hosts and Diseases.2024; 62(4): 438. CrossRef
Cryptosporidium and Giardia in cats and dogs: What is the real zoonotic risk?
Amanda D. Barbosa, Siobhon Egan, Yaoyu Feng, Lihua Xiao, Una Ryan
Current Research in Parasitology & Vector-Borne Diseases.2023; 4: 100158. CrossRef
Prevalence, diversity and public health implications of Helicobacter species in pet and stray dogs
Joseph Opeolu Ashaolu, Yu-Jen Tsai, Chia-Chen Liu, Dar-Der Ji
One Health.2022; 15: 100430. CrossRef
Genotypes of Giardia duodenalis in Household Dogs and Cats from Poland
Agnieszka Piekara-Stępińska, Jolanta Piekarska, Michał Gorczykowski, Jacek Bania
Acta Parasitologica.2021; 66(2): 428. CrossRef
DNA-based detection of Leptospira wolffii, Giardia intestinalis and Toxoplasma gondii in environmental feces of wild animals in Korea
Priyanka KUMARI, Kyung Yeon EO, Woo-Shin LEE, Junpei KIMURA, Naomichi YAMAMOTO
Journal of Veterinary Medical Science.2021; 83(5): 850. CrossRef
Zoonotic giardiasis: an update
Weilong Cai, Una Ryan, Lihua Xiao, Yaoyu Feng
Parasitology Research.2021; 120(12): 4199. CrossRef
Molecular prevalence and genotyping of Giardia duodenalis in cattle in Central Anatolia Region of Turkey
Zuhal Onder, Emrah Simsek, Onder Duzlu, Gamze Yetismis, Arif Ciloglu, Mubeccel Okur, Nesrin Delibası Kokcu, Abdullah Inci, Alparslan Yildirim
Parasitology Research.2020; 119(9): 2927. CrossRef
Multilocus genotyping of Giardia duodenalis from pigs in Korea
Haeseung Lee, ByeongYeal Jung, Jun-Sik Lim, Min-Goo Seo, Seung-Hun Lee, Kwang-Ho Choi, Mi-Hye Hwang, Tae-Hwan Kim, Oh-Deog Kwon, Dongmi Kwak
Parasitology International.2020; 78: 102154. CrossRef
Multilocus genotyping and risk factor analysis of Giardia duodenalis in dogs in Korea
Ha-Young Kim, Haeseung Lee, Seung-Hun Lee, Min-Goo Seo, Seonju Yi, Jong Wan Kim, Chung Hyun Kim, Yu-Ran Lee, ByungJae So, Oh-Deog Kwon, Dongmi Kwak
Acta Tropica.2019; 199: 105113. CrossRef
Practical Guidance for Clinical Microbiology Laboratories: Laboratory Diagnosis of Parasites from the Gastrointestinal Tract
Lynne S. Garcia, Michael Arrowood, Evelyne Kokoskin, Graeme P. Paltridge, Dylan R. Pillai, Gary W. Procop, Norbert Ryan, Robyn Y. Shimizu, Govinda Visvesvara
Clinical Microbiology Reviews.2018;[Epub] CrossRef
Prevalence and risk factors of Giardia duodenalis in domestic rabbbits (Oryctolagus cuniculus) in Jilin and Liaoning province, northeastern China
Jing Jiang, Jian-Gang Ma, Nian-Zhang Zhang, Peng Xu, Guangyu Hou, Quan Zhao, Xiao-Xuan Zhang
Journal of Infection and Public Health.2018; 11(5): 723. CrossRef
The presence of Giardia intestinalis in donkeys, Equus asinus, in China
Xiao-Xuan Zhang, Fu-Kai Zhang, Fa-Cai Li, Jun-Ling Hou, Wen-Bin Zheng, Shuai-Zhi Du, Quan Zhao, Xing-Quan Zhu
Parasites & Vectors.2017;[Epub] CrossRef
Zoonotic Parasites of Sheltered and Stray Dogs in the Era of the Global Economic and Political Crisis
Domenico Otranto, Filipe Dantas-Torres, Andrei D. Mihalca, Rebecca J. Traub, Michael Lappin, Gad Baneth
Trends in Parasitology.2017; 33(10): 813. CrossRef
Detection of small number of Giardia in biological materials prepared from stray dogs
Leila Esmailikia, Elahe Ebrahimzade, Parviz Shayan, Narges Amininia
Acta Parasitologica.2017;[Epub] CrossRef
Molecular typing of canine Giardia duodenalis isolates from Minas Gerais, Brazil
Natália M.N. Fava, Rodrigo M. Soares, Luana A.M. Scalia, Maria Júlia Rodrigues da Cunha, Elaine S.M. Faria, Márcia Cristina Cury
Experimental Parasitology.2016; 161: 1. CrossRef
Occurrence and multilocus genotyping of Giardia intestinalis assemblage C and D in farmed raccoon dogs, Nyctereutes procyonoides, in China
Xiao-Xuan Zhang, Wen-Bin Zheng, Jian-Gang Ma, Qiu-Xia Yao, Yang Zou, Cai-Jia Bubu, Quan Zhao, Xing-Quan Zhu
Parasites & Vectors.2016;[Epub] CrossRef

11,035 View
148 Download
20 Web of Science
Crossref

Seroprevalence of Encephalitozoon cuniculi in Pet Rabbits in Korea: Jin-Cheol Shin, Dae-Geun Kim, Sang-Hun Kim, Suk Kim, Kun-Ho Song; Korean J Parasitol 2014;52(3):321-323.
Published online June 26, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.3.321

Abstract
PDF

Encephalitozoon cuniculi is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis. The prevalence of encephalitozoonosis is not well documented, even when many clinics suspect pet rabbits as being highly infected. This study investigated the seropositivity of E. cuniculi using ELISA. The examination of 186 rabbits using ELISA showed that 22.6% (42/186) were seropositive against E. cuniculi. In analysis with healthy status, all 42 seropositive sera were collected from clinically normal rabbits. Moreover, the gender and age of pet rabbits did not have anysignificant effect on E. cuniculi infection. To the best of our knowledge, this is the first report to describe the seroprevalence of E. cuniculi in pet rabbits and suggests that pet rabbits could act as an important reservoir of encephalitozoonosis for both pet animals and humans in Korea.

Citations

Citations to this article as recorded by

Seroprevalence of Encephalitozoon cuniculi in companion rabbits in Mexico City
Ethel Cortés-Pérez, Angela Rodríguez-Hernández, María Grisel Anaya-Santillán, María Guadalupe Sánchez-González, Ricardo Itzcóatl Maldonado-Reséndiz
Veterinaria México OA.2025;[Epub] CrossRef
Comparative Evaluation of the Serological Methods and the Molecular Genetics Techniques for the Diagnosis of Encephalitozoon cuniculi in Rabbits (Oryctolagus cuniculus)
Anca-Alexandra Doboși, Anamaria Ioana Paștiu, Sanda Andrei, Dana Liana Pusta
Microorganisms.2025; 13(7): 1478. CrossRef
The Prevalence of Encephalitozoon cuniculi in Domestic Rabbits (Oryctolagus cuniculus) in the North-Western Region of Romania Using Serological Diagnosis: A Preliminary Study
Anca-Alexandra Doboși, Anamaria Ioana Paștiu, Lucia-Victoria Bel, Dana Liana Pusta
Microorganisms.2024; 12(7): 1440. CrossRef
Association of Encephalitozoon cuniculi with Clinical Signs and Abnormal Hematologic/Biochemical Changes in Pet Rabbits in Thailand
Taksaon Duangurai, Natruree Khamchomphu, Kanyanut Dusitkul, Chawaporn Tousee, Yosanun Sukmai, Teerapat Rungnirundorn, Ladawan Areevijittrakul, Siriluk Jala, Naris Thengchaisri
Animals.2024; 14(19): 2766. CrossRef
Encephalitozoon cuniculi Infection of Domestic Rabbits (Oryctolagus cuniculus) in Slovenia between 2017 and 2021
Maruša Škrbec, Alenka Dovč, Nina Mlakar Hrženjak, Brigita Slavec, Zoran Žlabravec, Nina Kočar, Olga Zorman Rojs, Jožko Račnik
Pathogens.2023; 12(4): 516. CrossRef
Seroprevalence of Encephalitozoon cuniculi and Toxoplasma gondii antibodies and risk-factor assessment for Encephalitozoon cuniculi seroprevalence in Finnish pet rabbits (Oryctolagus cuniculus)
Johanna Mäkitaipale, Emmi Järvenpää, Anne Bruce, Satu Sankari, Anna-Maija Virtala, Anu Näreaho
Acta Veterinaria Scandinavica.2022;[Epub] CrossRef
Serological survey for antibodies to Encephalitozoon cuniculi and Toxoplasma gondii in pet rabbits in eastern coastal areas of China
Yong WANG, Xuling QIN, Xiuguo DIAO, Yongxia LIU, Jianzhu LIU
Journal of Veterinary Medical Science.2022; 84(6): 777. CrossRef
A multidisciplinary review about Encephalitozoon cuniculi in a One Health perspective
Tomás Rodrigues Magalhães, Filipe Fontes Pinto, Felisbina Luisa Queiroga
Parasitology Research.2022; 121(9): 2463. CrossRef
A Review of Encephalitozoon cuniculi in Domestic Rabbits (Oryctolagus cuniculus)—Biology, Clinical Signs, Diagnostic Techniques, Treatment, and Prevention
Anca-Alexandra Doboși, Lucia-Victoria Bel, Anamaria Ioana Paștiu, Dana Liana Pusta
Pathogens.2022; 11(12): 1486. CrossRef
First molecular evidence of ocular transmission of Encephalitozoonosis during the intrauterine period in rabbits
Ozcan Ozkan, Alper Karagoz, Nadir Kocak
Parasitology International.2019; 71: 1. CrossRef
Seroprevalence of Toxoplasma gondii and Encephalitozoon cuniculi among domestic rabbits in central China
Shuai Wang, Zhijun Yao, Lingjuan Li, Yaoqian Pan, Pengju Li, Xiaoxu Nan, Qing Xie, Zhenchao Zhang
Parasite.2018; 25: 9. CrossRef
Prevalence and risk factors of Giardia duodenalis in domestic rabbbits (Oryctolagus cuniculus) in Jilin and Liaoning province, northeastern China
Jing Jiang, Jian-Gang Ma, Nian-Zhang Zhang, Peng Xu, Guangyu Hou, Quan Zhao, Xiao-Xuan Zhang
Journal of Infection and Public Health.2018; 11(5): 723. CrossRef
Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings
Giovanni Maestrini, Emanuele Ricci, Carlo Cantile, Riccardo Mannella, Francesca Mancianti, Gisella Paci, Carlo D’Ascenzi, Stefania Perrucci
Comparative Immunology, Microbiology and Infectious Diseases.2017; 50: 54. CrossRef
Histochemical study of Encephalitozoon cuniculi spores in the kidneys of naturally infected New Zealand rabbits
Luis E. Rodríguez-Tovar, Alejandra Villarreal-Marroquín, Alicia M. Nevárez-Garza, Uziel Castillo-Velázquez, Heidi G. Rodríguez-Ramírez, Magda C. Navarro-Soto, Juán J. Zárate-Ramos, Gustavo Hernández-Vidal, Armando Trejo-Chávez
Journal of Veterinary Diagnostic Investigation.2017; 29(3): 269. CrossRef
Encephalitozoon cuniculi: Grading the Histological Lesions in Brain, Kidney, and Liver during Primoinfection Outbreak in Rabbits
Luis E. Rodríguez-Tovar, Alicia M. Nevárez-Garza, Armando Trejo-Chávez, Carlos A. Hernández-Martínez, Gustavo Hernández-Vidal, Juan J. Zarate-Ramos, Uziel Castillo-Velázquez
Journal of Pathogens.2016; 2016: 1. CrossRef
Molecular Characterization of Enterocytozoon bieneusi in Domestic Rabbits (Oryctolagus cuniculus) in Northeastern China
Xiao-Xuan Zhang, Jing Jiang, Ya-Nan Cai, Chun-Feng Wang, Peng Xu, Gui-Lian Yang, Quan Zhao
The Korean Journal of Parasitology.2016; 54(1): 81. CrossRef
Seroprevalence of Encephalitozoon cuniculi and Toxoplasma gondii in domestic rabbits (Oryctolagus cuniculus) in China
Qing-Feng Meng, Wei-Lin Wang, Xiao-Ting Ni, Hai-Bin Li, Gui-Zhe Yao, Xiao-Lin Sun, Wei-Li Wang, Wei Cong
The Korean Journal of Parasitology.2015; 53(6): 759. CrossRef

9,492 View
102 Download
17 Web of Science
Crossref

Case Report

Imported Intraocular Gnathostomiasis with Subretinal Tracks Confirmed by Western Blot Assay: Ji Ho Yang, Moosang Kim, Eung Suk Kim, Byoung-Kuk Na, Seung-Young Yu, Hyung-Woo Kwak; Korean J Parasitol 2012;50(1):73-78.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.73

Abstract
PDF

We report a case of intraocular gnathostomiasis diagnosed by western blot assay in a patient with subretinal tracks. A 15-year-old male patient complained of blurred vision in the right eye, lasting for 2 weeks. Eight months earlier, he had traveled to Vietnam for 1 week and ate raw wild boar meat and lobster. His best-corrected visual acuity was 20/20 in both eyes and anterior chamber examination revealed no abnormalities. Fundus examination showed subretinal tracks in the right eye. Fluorescein angiography and indocyanine green angiography showed linear hyperfluorescence of the subretinal lesion observed on fundus in the right eye. Ultrasound examination revealed no abnormalities. Blood tests indicated mild eosinophilia (7.5%), and there was no abnormality found by systemic examinations. Two years later, the patient visited our department again for ophthalmologic evaluation. Visual acuity remained 20/20 in both eyes and the subretinal tracks in the right eye had not changed since the previous examination. Serologic examination was performed to provide a more accurate diagnosis, and the patient's serum reacted strongly to the Gnathostoma nipponicum antigen by western blot assay, which led to a diagnosis of intraocular gnathostomiasis. This is the first reported case of intraocular gnathostomiasis with subretinal tracks confirmed serologically using western blot in Korea.

Citations

Citations to this article as recorded by

Ocular infections in international travelers
Francesca F. Norman, Julio J. González-López, Diego Gayoso-Cantero, Marta Vicente-Antolin, Maria-Dolores Corbacho-Loarte, Rogelio López-Vélez, Marta González-Sanz
Travel Medicine and Infectious Disease.2025; 63: 102789. CrossRef
Imported parasitic diseases in the Republic of Korea: status and issues
Jong-Yil Chai
Journal of the Korean Medical Association.2025; 68(1): 52. CrossRef
Intracameral gnathostomiasis presenting as neuroretinitis
Kimhour Lay, Leng Un, Kossama Chukmol, Piseth Kong
BMJ Case Reports.2025; 18(3): e260393. CrossRef
Gastrodin reduces Aβ brain levels in an Alzheimer's disease mouse model by inhibiting P-glycoprotein ubiquitination
Chenghao Zhu, Shangtao Wang, Siyu Ma, Shurui Zhang, Yanjun Wang, Baoshan Li, Wei Zhang, Zhirong Sun
Phytomedicine.2024; 135: 156229. CrossRef
Intracameral Gnathostomiasis: A Case Report and Literature Review
Wijak Kongwattananon, Thanaporn Wiriyabanditkul, Waraluck Supwatjariyakul, Thanapong Somkijrungroj
Ocular Immunology and Inflammation.2023; 31(5): 1092. CrossRef
A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
Parasites, Hosts and Diseases.2023; 61(3): 298. CrossRef
Subretinal gnathostomiasis: A successful focal laser photocoagulation for a living parasite
Supalert Prakhunhungsit, Somanus Thoongsuwan, Sutasinee Boonsopon, Thitiyaporn Panawattanawong, Pitchaya Amornvararak, Nuttawut Rodanant, Nopasak Phasukkijwatana
American Journal of Ophthalmology Case Reports.2022; 26: 101413. CrossRef
An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years– Unexpected Diseases Sometimes Far Away from the Origin
Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa
The Korean Journal of Parasitology.2018; 56(3): 215. CrossRef
Imported gnathostomiasis manifesting as cutaneous larva migrans and Löffler’s syndrome
William L. Hamilton, Daniel Agranoff
BMJ Case Reports.2018; 2018: bcr-2017-223132. CrossRef
Ocular Gnathostomiasis—Update of Earlier Survey
Kittisak Sawanyawisuth, Yukifumi Nawa, Sandra Fernández Figueiras, Sylvia Paz Diaz Camacho, Verajit Chotmongkol, Masahide Yoshikawa, Maria Benavides
The American Journal of Tropical Medicine and Hygiene.2017; 97(4): 1232. CrossRef
First reported case of intraocular Gnathostoma spinigerum in Cambodia
S. Hem, A. Tarantola, R. Chheang, P. Nop, A. Kerléguer
Bulletin de la Société de pathologie exotique.2015; 108(5): 312. CrossRef
Three-dimensional spectral domain optical coherence tomography and light microscopy of an intravitreal parasite
Aziz A. Khanifar, Michael J. Espiritu, Jane S. Myung, Grant D. Aaker, Audrey N. Schuetz, Donald J. D’Amico, R. V. Paul Chan
Journal of Ophthalmic Inflammation and Infection.2015;[Epub] CrossRef
Toxocara Optic Neuropathy after Ingestion of Raw Meat Products
Hee Kyung Yang, Se Joon Woo, Jeong-Min Hwang
Optometry and Vision Science.2014; 91(11): e267. CrossRef
Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2013; 51(3): 343. CrossRef
Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
Jing Cui, Ye Wang, Zhong Quan Wang
The Korean Journal of Parasitology.2013; 51(4): 467. CrossRef

9,137 View
105 Download
Crossref

Brief Communication

Effects of Simple and Disposable Chicken Cages for Experimental Eimeria Infections: Jeongmi Yoo, Sung H. Kang, Jipseol Jeong, Woo H. Kim, Suk Kim, Hyun S. Lillehoj, Wongi Min; Korean J Parasitol 2011;49(3):299-302.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.299

Abstract
PDF

During experimental Eimeria infections in chickens, facilities are often contaminated by fecal oocysts known to be highly resistant to both chemical and enzymatic treatments. Thus, studies using experimental Eimeria infections have been limited due to the difficulty of complete elimination of residual oocysts from both cages and facilities. To overcome this limitation, simple, inexpensive, and disposable cages were constructed from cardboard boxes and tested during experimental Eimeria maxima infections. The cages were used in animal rooms with only a 1.7% evidence of coccidia contamination between adjacent cages. No significant differences in fecal oocyst output and body weight gain were noted between animals housed in disposable cages and animals housed in wire control cages. This cage design is a useful means for preventing oocyst contamination during experimental conditions, suggesting that this disposable cage design could be used for other avian infectious disease studies.

Citations

Citations to this article as recorded by

Different strategies for producing naturally soluble form of common cytokine receptor γ chain
Jipseol Jeong, Woo H. Kim, Cherry P. Fernandez, Suk Kim, Yong-Hwan Kim, Hyung-Kwan Jang, Hyun S. Lillehoj, Hee-Jong Woo, Wongi Min
Developmental & Comparative Immunology.2015; 48(1): 13. CrossRef
Chicken IL-17F: Identification and comparative expression analysis in Eimeria-infected chickens
Woo H. Kim, Jipseol Jeong, Ae R. Park, Dongjean Yim, Yong-Hwan Kim, Kwang D. Kim, Hong H. Chang, Hyun S. Lillehoj, Byung-Hyung Lee, Wongi Min
Developmental & Comparative Immunology.2012; 38(3): 401. CrossRef
Identification and Comparative Expression Analysis of Interleukin 2/15 Receptor β Chain in Chickens Infected with E. tenella
Jipseol Jeong, Woo H. Kim, Jeongmi Yoo, Changhwan Lee, Suk Kim, Jae-Hyeon Cho, Hyung-Kwan Jang, Dong W. Kim, Hyun S. Lillehoj, Wongi Min, Ivan Cruz Moura
PLoS ONE.2012; 7(5): e37704. CrossRef