Parasites, Hosts and Diseases

"praziquantel"

Case Reports

A Human Case of Lumbosacral Canal Sparganosis in China: Jian-Feng Fan, Sheng Huang, Jing Li, Ren-Jun Peng, He Huang, Xi-Ping Ding, Li-Ping Jiang, Jian Xi; Korean J Parasitol 2021;59(6):635-638.
Published online December 22, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.6.635

Abstract
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In this study, we intended to describe a human case of lumbosacral canal sparganosis in People’s Republic of China (China). A 56-year-old man was admitted to Xiangya Hospital Central South University in Changsha, Hunan province, China after having an experience of perianal pain for a week. An enhancing mass, a tumor clinically suggested, was showed at the S1-S2 level of the lumbosacral spine by the examination of magnetic resonance imaging (MRI) with gadolinium contrast. The patient was received the laminectomy from S1 to S2, and an ivory-white living worm was detected in inferior margin of L5. In ELISA-test with cerebrospinal fluid (CSF) and serum samples, anti-sparganum antibodies were detected. He had a ingesting history of undercooked frog meat in his youth. By the present study, a human case of spinal sparganosis invaded in lumbosacral canal at the S1-S2 level was diagnosed in China. Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study.

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Infectious Myelopathies
Anita M. Fletcher, Shamik Bhattacharyya
Continuum.2024; 30(1): 133. CrossRef
The serum IgG antibody level as a biomarker for clinical outcome in patients with cerebral sparganosis after treatment
Haijie Xiang, Jie Wang, Dandan Tan, Ying Xiong, Pengcheng Huang, Yu Shen, Yun Xu, Zhihong Gong, Fei Hu, Chunhua Xu, Jie Wu, Wei Liu, Junpu Liu, Hui Wan, Daojun Hong, Huiqun Xie
Frontiers in Immunology.2023;[Epub] CrossRef
Multiple sparganosis spinal infections mainly in the thoracic region: A case report
Gan-Jun Wen, Jian Chen, Shi-Fei Zhang, Zhi-Sen Zhou, Gen-Long Jiao
World Journal of Clinical Cases.2023; 11(36): 8507. CrossRef

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First Clinical Cases of Spirometrosis in Two Cats in Korea: Joohyung Kim, Younsung Ock, Kihwan Yang, Seongjun Choe, Kyung-Mee Park, Wan-Kyu Lee, Kyung-Chul Choi, Soochong Kim, Dongmi Kwak, Seung-Hun Lee; Korean J Parasitol 2021;59(2):153-157.
Published online April 22, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.2.153

This study reports the first two clinical cases of spirometrosis caused by Spirometra sp. in cats in Korea. In these two cases, the cats vomited, and long proglottids of tapeworm were recovered. The sick cats presented with anorexia and lethargy. However, they unexpectedly showed no diarrhea, which is the main symptom of spirometrosis. Based on a fecal floatation test as well as morphological and molecular analyses, the parasite was diagnosed as Spirometra sp. The 2 cases were treated with praziquantel. This study suggests regular monitoring of health and deworming in companion animals, even when animals are well cared for, with regular preventive medication. Additionally, spirometrosis should be considered in the differential diagnosis in cases of gastrointestinal symptoms in Spirometra endemic areas.

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First morphological and molecular characterisation of Spirometra mansoni (Cestoda, Diphyllobothriidae) in a domestic cat from Veracruz, Mexico
Enrique Salazar-Grosskelwing, Roger I. Rodriguez-Vivas, Manuel E. Bolio-González, Dora Romero-Salas, Rodolfo Ramos-Beltrán, Alberto Solano-Barquero, Alicia Rojas
Veterinary Parasitology: Regional Studies and Reports.2025; 57: 101189. CrossRef
Description of Spirometra asiana sp. nov. (Cestoda: Diphyllobothriidae) found in wild boars and hound dogs in Japan
Hiroshi Yamasaki, Hiromu Sugiyama, Yasuyuki Morishima, Hirotaka Kobayashi
Parasitology International.2024; 98: 102798. CrossRef
Molecular identification of Spirometra infections in companion animals and wildlife in Japan
Hiroshi YAMASAKI, Hiromu SUGIYAMA, Yasuyuki MORISHIMA, Yasuhito SAKO
Journal of Veterinary Medical Science.2024; 86(4): 409. CrossRef
WITHDRAWN: First morphological and molecular characterisation of Spirometra mansoni (Cestoda, Diphyllobothriidae) in a domestic cat from Veracruz, Mexico
Enrique Salazar-Grosskelwing, Roger I. Rodriguez-Vivas, Manuel E. Bolio-González, Dora Romero-Salas, Rodolfo Ramos-Beltrán, Alberto Solano-Barquero, Alicia Rojas
Veterinary Parasitology: Regional Studies and Reports.2024; 56: 101127. CrossRef

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Original Article

Impact of Single Dose Praziquantel Treatment on Schistosoma haematobium Infection among School Children in an Endemic Nigerian Community: Babatunde Adewale, Margaret A. Mafe, Medinat A. Sulyman, Emmanuel T. Idowu, Morakinyo B. Ajayi, David O. Akande, James H. Mckerrow, Emmanuel O. Balogun; Korean J Parasitol 2018;56(6):577-581.
Published online December 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.6.577

Abstract
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Schistosomiasis is prevalent in Nigeria, and the foremost pathogen is Schistosoma haematobium, which affects about 29 million people. Single dose of the drug praziquantel is often recommended for treatment but the efficacy has not been documented in certain regions. Therefore, this study was designed to assess the impact of single dose praziquantel treatment on S. haematobium infection among school children in an endemic community of South-Western Nigeria. Urine samples were collected from 434 school children and 10 ml was filtered through Nucleopore filter paper before examination for egg outputs by microscopy. The prevalence was 24.9% at pre-treatment. There was no statistically significant difference for the prevalence of infection between males (14.7%) and females (10.2%), although the mean egg count for the females (9.87) was significantly more (P < 0.05) than the males (6.06). At 6 and 12 months post-treatment there was 74.4% and 86.4% reduction in the mean egg count, respectively. Interestingly, an increased prevalence of infection from 2.1% at 6 months to 7.7% at 12 months post-treatment was observed, nonetheless the mean egg count was reduced to 0.27 at 12th month from 1.98 at 6 months post-treatment. Resurgence in the prevalence rate between 6 and 12 months post-treatment with praziquantel is herein reported and the need for a follow-up treatment in endemic areas for adequate impact on schistosomiasis control is discussed.

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School-Based Epidemiology of Schistosoma haematobium Infection in Kharif District of Amran Governorate, North of Yemen: Need for Chemopreventive Strategy Revisiting
Dawla Alansi, Mohammed Mahdy, Rashad Abdul-Ghani, Ahmed Azazy
Infection and Drug Resistance.2025; Volume 18: 161. CrossRef
Effects of paediatric schistosomiasis control programmes in sub-Saharan Africa: A systematic review
Maryline Vere, Wilma ten Ham-Baloyi, Paula Ezinne Melariri, Raquel Inocencio da Luz
PLOS ONE.2024; 19(5): e0301464. CrossRef
Promoting Sustainable Development in Combating Schistosomiasis through Community-Centric Approaches: The Role of Social Empowerment and Education in Ondo State
D. O. Balogun, O. C. Nwinyi, P. O. Isibor, B. Adewale, S. A. Oyegbade, E. O Mameh, V. O Aririguzoh
IOP Conference Series: Earth and Environmental Science.2024; 1342(1): 012017. CrossRef
The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review
Nathan Chanhanga, Tafadzwa Mindu, John Mogaka, Moses Chimbari
Infection and Drug Resistance.2023; Volume 16: 2453. CrossRef
Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines
Umar Saidu, Mohammed Auwal Ibrahim, Harry P. de Koning, James H. McKerrow, Conor R. Caffrey, Emmanuel Oluwadare Balogun
Parasitology Research.2023; 122(12): 2751. CrossRef
Prevalence of urinary schistosomiasis in women: a systematic review and meta-analysis of recently published literature (2016–2020)
Morteza Shams, Sasan Khazaei, Ezatollah Ghasemi, Naser Nazari, Erfan Javanmardi, Hamidreza Majidiani, Saeed Bahadory, Davood Anvari, Mohammad Fatollahzadeh, Taher Nemati, Ali Asghari
Tropical Medicine and Health.2022;[Epub] CrossRef
Prevalence and Associated Risk Factors of Urinary Schistosomiasis among Primary School Pupils in the Jidawa and Zobiya Communities of Jigawa State, Nigeria
J. B. Balogun, B. Adewale, S. U. Balogun, A. Lawan, I. S. Haladu, M. M. Dogara, A. U. Aminu, C. R. Caffrey, H. P. De Koning, Y. Watanabe, E. O. Balogun
Annals of Global Health.2022;[Epub] CrossRef
Epidemiological dynamics and associated risk factors ofS. haematobiumin humans and its snail vectors in Nigeria: a meta-analysis (1983–2018)
Paul Olalekan Odeniran, Kehinde Foluke Omolabi, Isaiah Oluwafemi Ademola
Pathogens and Global Health.2020; 114(2): 76. CrossRef
Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis
Danielle M. Cribb, Naomi E. Clarke, Suhail A. R. Doi, Susana Vaz Nery, Amadou Garba
PLOS Neglected Tropical Diseases.2019; 13(10): e0007808. CrossRef

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Case Reports

Diphyllobothrium nihonkaiense Infections in a Family: Young Bin Go, Eun Hye Lee, Jaeeun Cho, Seoyun Choi, Jong-Yil Chai; Korean J Parasitol 2015;53(1):109-112.
Published online February 27, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.1.109

Abstract
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Diphyllobothrium latum and Diphyllobothrium nihonkaiense are morphologically similar to each other, and only genetic method can differentiate clearly between the 2 species. A strobila of diphyllobothriid tapeworm discharged from a 7-year-old boy was analyzed to identify the species by mitochondrial cytochrome c oxidase subunit 1 (cox1) gene sequencing. He and his family (total 4 persons) ate slices of 3 kinds of raw fish 16 days before visiting our outpatient clinic. All family members complained of abdominal pain and watery diarrhea. They all expelled tapeworm strobilae in their stools. They were treated with a single oral dose of praziquantel and then complained of no more symptoms. The cox1 gene sequencing of the strobila from the boy revealed 99.9% (687/688 bp) similarity with D. nihonkaiense and only 93.2% (641/688 bp) similarity with D. latum. Thus, we assigned this tapeworm as D. nihonkaiense. This is the first report of D. nihonkaiense infection in a family in Korea, and this report includes the 8th pediatric case in Korea. The current report is meaningful because D. nihonkaiense infection within a family is rare.

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Dietary footprints of a global parasite: diagnosing Dibothriocephalus nihonkaiensis in non-endemic regions
Wilson G.W. Goh, Jean-Marc Chavatte, Gabriel Z.R. Yan, Yuan Yi Constance Chen, Mark Dhinesh Muthiah, Lionel H.W. Lum
Gut Pathogens.2025;[Epub] CrossRef
Tapeworm Infection Diagnosed after Campylobacter jejuni-induced Enteritis
Sotaro Ozaka, Ryusuke Soma, Haruhiko Takahashi, Yuta Shimomori, Masahide Fukuda, Koshiro Tsutsumi, Yuka Hirashita, Kensuke Fukuda, Ryo Ogawa, Kazuhiro Mizukami, Yomei Kagoshima, Nozomi Sachi, Naganori Kamiyama, Hideo Hasegawa, Takashi Kobayashi, Masaaki K
Internal Medicine.2024; 63(21): 2939. CrossRef
Epidemiology ofDiphyllobothrium nihonkaienseDiphyllobothriasis, Japan, 2001–2016
Hiroshi Ikuno, Shinkichi Akao, Hiroshi Yamasaki
Emerging Infectious Diseases.2018;[Epub] CrossRef
RETROSPECTIVE ANALYSIS OF THE EPIDEMIOLOGIC LITERATURE, 1990–2015, ON WILDLIFE-ASSOCIATED DISEASES FROM THE REPUBLIC OF KOREA
Jusun Hwang, Kyunglee Lee, Young-Jun Kim, Jonathan M. Sleeman, Hang Lee
Journal of Wildlife Diseases.2017; 53(1): 5. CrossRef

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Two Human Cases of Diphyllobothrium nihonkaiense Infection in Korea: Su-Min Song, Hye-Won Yang, Min Kyu Jung, Jun Heo, Chang Min Cho, Youn-Kyoung Goo, Yeonchul Hong, Dong-Il Chung; Korean J Parasitol 2014;52(2):197-199.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.197

Abstract
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Diphyllobothrium latum and Diphyllobothrium nihonkaiense are the 2 reported main causes of human diphyllobothriasis in the Republic of Korea. However, the differentiation of these 2 species based on morphologic features alone is difficult. The authors used nucleotide sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene to diagnose Diphyllobothrium spp. Two patients visited the emergency room at Kyungpook National University Hospital on 3 April and 12 April 2013, respectively, with fragments of parasites found while defecating. The parasites were identified as Diphyllobothrium spp. based on morphologic characteristics, and subsequent cox1 gene sequencing showed 99.9% similarity (1,478/1,480 bp) with D. nihonkaiense. Our findings support the hypothesis that D. nihonkaiense is a dominant species in Korea.

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Diphyllobothrium nihonkaiense: wide egg size variation in 32 molecularly confirmed adult specimens from Korea
Seoyun Choi, Jaeeun Cho, Bong-Kwang Jung, Deok-Gyu Kim, Sarah Jiyoun Jeon, Hyeong-Kyu Jeon, Keeseon S. Eom, Jong-Yil Chai
Parasitology Research.2015; 114(6): 2129. CrossRef
Three Cases of Diphyllobothrium nihonkaiense Infection in Korea
Hong-Ja Kim, Keeseon S. Eom, Min Seo
The Korean Journal of Parasitology.2014; 52(6): 673. CrossRef
Extracorporeal Worm Extraction of Diphyllobothrium nihonkaiense with Amidotrizoic Acid in a Child
Hye Kyung Shin, Joo-Hyung Roh, Jae-Won Oh, Jae-Sook Ryu, Youn-Kyoung Goo, Dong-Il Chung, Yong Joo Kim
The Korean Journal of Parasitology.2014; 52(6): 677. CrossRef

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Intestinal Paragonimiasis with Colonic Ulcer and Hematochezia in An Elderly Taiwanese Woman: Chung-Te Liu, Yen-Cheng Chen, Tso-Hsiao Chen, Ursula Barghouth, Chia-Kwung Fan; Korean J Parasitol 2012;50(4):349-352.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.349

Abstract
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A 94-year-old female with end-stage renal disease presents with fever, fatigue, and hematochezia. She had previously resided in Hunan Province, China, and Myanmar, and she immigrated to Taiwan 30 years ago. Colonoscopy revealed a colonic ulcer. Biopsy of the colonic ulcer showed ulceration of the colonic mucosa, and many Paragonimus westermani-like eggs were noted. Serum IgG antibody levels showed strong reactivity with P. westermani excretory-secretory antigens by ELISA. Intestinal paragonimiasis was thus diagnosed according to the morphology of the eggs and serologic finding. After treatment with praziquantel, hematochezia resolved. The present case illustrates the extreme manifestations encountered in severe intestinal paragonimiasis.

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Incidental diagnosis of paragonimiasis after histopathological examination of cholecystectomy specimen in Nepal: A case report
Pearlbiga Karki, Pinky Jha, Gaurab Mainali, Manoj Khadka, Prabesh Karki, Jung Bahadur Thapa, Gayatri Karki
Annals of Medicine and Surgery.2021; 63: 102170. CrossRef
A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
The Korean Journal of Parasitology.2017; 55(3): 313. CrossRef
Current status of Paragonimus and paragonimiasis in Ecuador
Manuel Calvopiña, Daniel Romero, Byron Castañeda, Yoshihisa Hashiguchi, Hiromu Sugiyama
Memórias do Instituto Oswaldo Cruz.2014; 109(7): 849. CrossRef

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Four Human Cases of Diphyllobothrium latum Infection: Hee-Jung Choi, Junghye Lee, Hyun-Jong Yang; Korean J Parasitol 2012;50(2):143-146.
Published online May 24, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.2.143

Abstract
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Diphyllobothrium latum infections in 4 young Korean men detected from 2008 to 2012 are presented. Three were diagnosed based on spontaneously discharged strobila of the adult worm in their feces, and 1 case was diagnosed by finding the worm at colonoscopy examination in a local clinic. The morphologic characteristics of the gravid proglottid and eggs were consistent with D. latum. All patients were treated with praziquantel 15 mg/kg, and follow-up stool examinations were done at 2 months after the medication. The main clinical complaints were intermittent gastrointestinal troubles such as indigestion, abdominal distension, and spontaneous discharge of tapeworm's segments in their feces. The most probable source of infection was the flesh of salmon or trout according to a patient's past history. These are the 45th to 48th recorded cases diagnosed by the adult worm in the Republic of Korea since 1971.

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Epidemiological studies of Isoparorchis hypselobagri (Digenea: Trematoda) infecting freshwater catfish Wallago attu in the Aligarh region of Uttar Pradesh
Anam Sahreen, Mohammad Khalid Saifullah
Journal of Parasitic Diseases.2024; 48(3): 642. CrossRef
Presentación inusual de Diphyllobothrium pacificum: un caso de ileítis simulando linfoma
Siomara Aransuzú Chávez-Sánchez, David Rafael Guevara-Lazo, Álvaro Bellido-Caparó, José Luis Pinto-Valdivia
Revista de Gastroenterología del Perú.2024; 44(3): 288. CrossRef
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Jeffrey M. Perera, Claire Gurtler, Amber N. Barnes
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Hui-Yuan Yeh, Xiaoya Zhan, Wuyun Qi
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I. Hamad, D. Raoult, F. Bittar
Parasite Immunology.2016; 38(1): 12. CrossRef
Fish-borne, zoonotic cestodes (Diphyllobothrium and relatives) in cold climates: A never-ending story of neglected and (re)-emergent parasites
Tom?? Scholz, Roman Kuchta
Food and Waterborne Parasitology.2016;[Epub] CrossRef
Diphyllobothrium latuminfection in a child with recurrent abdominal pain
Seung Hyun Lee, Hyun Park, Seung Taek Yu
Korean Journal of Pediatrics.2015; 58(11): 451. CrossRef
Two Human Cases of Diphyllobothrium nihonkaiense Infection in Korea
Su-Min Song, Hye-Won Yang, Min Kyu Jung, Jun Heo, Chang Min Cho, Youn-Kyoung Goo, Yeonchul Hong, Dong-Il Chung
The Korean Journal of Parasitology.2014; 52(2): 197. CrossRef
Three Cases of Diphyllobothrium nihonkaiense Infection in Korea
Hong-Ja Kim, Keeseon S. Eom, Min Seo
The Korean Journal of Parasitology.2014; 52(6): 673. CrossRef
A Case of Diphyllobothrium nihonkaiense Infection as Confirmed by Mitochondrial COX1 Gene Sequence Analysis
Sang Hyun Park, Keeseon S. Eom, Min Sun Park, Oh Kyoung Kwon, Hyo Sun Kim, Jai Hoon Yoon
The Korean Journal of Parasitology.2013; 51(4): 471. CrossRef
Clinical Update on Parasitic Diseases
Min Seo
Korean Journal of Medicine.2013; 85(5): 469. CrossRef
An Unexpected Finding of Diphyllobothrium nihonkaiense in a Patient with Inflammatory Bowel Disease
Mawuli Attipoe, William Putnam, Charles Sturgis
Laboratory Medicine.2013; 44(4): e124. CrossRef

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Hypersensitive Reaction to Praziquantel in a Clonorchiasis Patient: Jung-Min Lee, Hyun-Sul Lim, Sung-Tae Hong; Korean J Parasitol 2011;49(3):273-275.
Published online September 30, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.3.273

Abstract
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Praziquantel is the drug of choice for clonorchiasis. Since clonorchiasis is endemic in most river basins, praziquantel has been widely used for 30 years in Korea. A 54-year-old Korean woman suffered from hypersensitive reactions, such as nausea, dyspnea, rash, and urticaria after taking the first dose of praziquantel to treat clonorchiasis. She ingested one dose again and the same symptoms appeared, and she was treated at a clinic with anti-histamines. She tried one more dose with anti-histamines but found the same symptoms. Later, she was found to pass eggs of Clonorchis sinensis and medicated with flubendazole. The hypersensitive reaction to praziquantel is rare but occurs. This is the 5th case report in the world.

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Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
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Clonorchiasis
Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou
The Lancet.2016; 387(10020): 800. CrossRef
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A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel: Sun Young Kyung, Yong Kyun Cho, Yu Jin Kim, Jeong-Woong Park, Sung Hwan Jeong, Jae-Ik Lee, Yon Mi Sung, Sang Pyo Lee; Korean J Parasitol 2011;49(1):73-77.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.73

Abstract
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Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.

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Original Articles

Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism: Chung Hyeon Kim, Jeong-Keun Lee, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong; Korean J Parasitol 2011;49(1):45-49.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.45

Abstract
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Chemotherapy of clonorchiasis with praziquantel (PZQ) is effective but about 15% of treated cases have been reported uncured. The present study investigated correlation of single nucleotide polymorphisms (SNPs) of the cytochrome P450 gene, CYP3A5 and cure of clonorchiasis. A total of 346 egg passing residents were subjected and treated by 3 doses of 25 mg/kg PZQ. Reexamination recognized 33 (9.5%) uncured and 313 cured. Numbers of eggs per gram of feces (EPGs) before treatment were significantly lower in the cured group than in the uncured group (2,011.2±3,600.0 vs 4,998.5±7,012.0, P<0.001). DNAs of the subjects were screened for SNPs at 7 locations of CYP3A5 using PCR. In the uncured group, the SNP frequencies at g.-20555G>A and g.27526C>T of CYP3A5 were 15.2% and 9.1% while those were 3.8% and 1.0%, respectively, in the cured group. The cure rate was significantly lower in the cases with SNP at g.27526C>T and EPGs≥1,000. In conclusion, EPGs and SNPs of CYP3A5 are factors which influence cure of clonorchiasis by PZQ therapy. It is strongly suggested to recommend 2-day medication for individuals with high EPGs≥1,000.

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Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
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Men-Bao Qian, Peiling Yap, Yi-Chao Yang, Hai Liang, Zhi-Hua Jiang, Wei Li, Yu-Guang Tan, Hui Zhou, Jürg Utzinger, Xiao-Nong Zhou, Jennifer Keiser
Clinical Infectious Diseases.2013; 56(7): e76. CrossRef
Efficacy of Praziquantel against Schistosoma mekongi and Opisthorchis viverrini: A Randomized, Single-Blinded Dose-Comparison Trial
Leonore Lovis, Tippi K. Mak, Khampheng Phongluxa, Phonepasong Ayé Soukhathammavong, Youthanavanh Vonghachack, Jennifer Keiser, Penelope Vounatsou, Marcel Tanner, Christoph Hatz, Jürg Utzinger, Peter Odermatt, Kongsap Akkhavong, Banchob Sripa
PLoS Neglected Tropical Diseases.2012; 6(7): e1726. CrossRef

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Changes in Sonographic Findings after Treatment of Patients with Clonorchiasis in a Heavy Endemic Area: Dongil Choi, Yong Hwan Jeon, Geun-Chan Lee, Min-Ho Choi, Sung-Tae Hong; Korean J Parasitol 2009;47(1):19-23.
Published online March 12, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.1.19

Abstract
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We measured changes in sonographic findings of patients with clonorchiasis after a treatment in a highly endemic area. A total of 347 residents showed positive stool results for Clonorchis sinensis eggs in a village in northeastern China, and were treated with praziquantel. Of them, 132 patients underwent abdominal sonography both before and 1 year after treatment, and the changes in sonographic findings of 83 cured subjects were compared. Diffuse dilatation of intrahepatic bile ducts (DDIHD) was found in 82 patients (98.2%) before and 80 (96.4%) after treatment, which was improved in 3, aggravated in 1, and unchanged in 79 patients. Increased periductal echogenicity (IPDE) was observed in 42 patients (50.6%) before and 45 (54.2%) after treatment, which was improved in 5, aggravated in 8, and unchanged in 70 patients. Floating echogenic foci in the gallbladder (FEFGB) was detected in 32 patients (38.6%) before and 17 (20.5%) after treatment, which was improved in 20, aggravated in 5, and unchanged in 58 patients. Improvement of FEFGB only was statistically significantly (P = 0.004). The present results confirm that DDIHD and IPDE persist but FEFGB decreases significantly at 1 year after treatment. In a heavy endemic area, the sonographic finding of FEFGB may suggest active clonorchiasis 1 year after treatment.

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Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
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Severe hepatobiliary morbidity is associated with Clonorchis sinensis infection: The evidence from a cross-sectional community study
Men-Bao Qian, Hong-Mei Li, Zhi-Hua Jiang, Yi-Chao Yang, Ming-Fei Lu, Kang Wei, Si-Liang Wei, Yu Chen, Chang-Hai Zhou, Ying-Dan Chen, Xiao-Nong Zhou, Maria Angeles Gómez-Morales
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Miriam López-Gómez, Belén García de Santiago, Pedro-David Delgado-López, Eduardo Malmierca, Jesús González-Olmedo, César Gómez-Raposo, Carmen Sandoval, Pilar Ruiz-Seco, Nora Escribano, Jorge Francisco Gómez-Cerezo, Enrique Casado
World Journal of Meta-Analysis.2021; 9(6): 505. CrossRef
Clonorchiasis
Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou
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Enrico Brunetti, Tom Heller, Joachim Richter, Daniel Kaminstein, Daniel Youkee, Maria Teresa Giordani, Samuel Goblirsch, Francesca Tamarozzi
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Ze-Li Tang, Yan Huang, Xin-Bing Yu
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Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings
Hermann Feldmeier, Miklos Hazay, Megumi Sato, Pongvongsa Tiengkham, Futoshi Nishimoto, Hongwei Jiang, Vatsana Sopraseuth, Kazuhiko Moji
Tropical Medicine and Health.2016;[Epub] CrossRef
Gallbladder infection by trematodes
Claudio Tana, Andrea Mezzetti, Cosima Schiavone
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Geunyoung Jung, Kwang-Min Park, Seung Soo Lee, Eunsil Yu, Seung-Mo Hong, Jihun Kim
Journal of Hepatology.2012; 57(4): 787. CrossRef
Clonorchis sinensis and clonorchiasis, an update
Sung-Tae Hong, Yueyi Fang
Parasitology International.2012; 61(1): 17. CrossRef
Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden andCYP3A5Gene Polymorphism
Chung Hyeon Kim, Jeong-Keun Lee, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong
The Korean Journal of Parasitology.2011; 49(1): 45. CrossRef
Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis
Jae-Hwan Kim, Min-Ho Choi, Young Mee Bae, Jin-Kyoung Oh, Min Kyung Lim, Sung-Tae Hong, Akira Ito
PLoS Neglected Tropical Diseases.2011; 5(10): e1339. CrossRef

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Case Report

A case of Diphyllobothrium latum infection with a brief review of diphyllobothriasis in the Republic of Korea: Eun Bin Lee, Jung Hoon Song, Nam Seon Park, Byung Kook Kang, Hyung Suk Lee, Yoon Ju Han, Hyo-Jin Kim, Eun-Hee Shin, Jong-Yil Chai; Korean J Parasitol 2007;45(3):219-223.
Published online September 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.3.219

Abstract
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A case of Diphyllobothrium latum infection in a 49-year old man is described, and diphyllobothriasis latum in the Republic of Korea is briefly reviewed. An incomplete strobila of a tapeworm, 95 cm in length, without scolex and neck, was spontaneously discharged in the feces of a patient. On the basis of morphologic characteristics of the worm and eggs, the worm was identified as D. latum. The patient was successfully treated with a single dose (15 mg/kg) of praziquantel. The most probable source of infection was salmon flesh according to the past history of the patient. The first case of D. latum infection was documented in 1971, and this is the 43rd recorded case in the Republic of Korea. The 43 cases were briefly reviewed. The patients' main complaints were gastrointestinal troubles, such as mild abdominal pain, indigestion, and diarrhea, and discharge of tapeworm segments in the feces. The suspected infection sources included raw or improperly cooked flesh of fresh or brackish water fish, including the perch, mullet, salmon, and trout.

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Parasitology Research.2015; 114(6): 2129. CrossRef
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Seung Hyun Lee, Hyun Park, Seung Taek Yu
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Su-Min Song, Hye-Won Yang, Min Kyu Jung, Jun Heo, Chang Min Cho, Youn-Kyoung Goo, Yeonchul Hong, Dong-Il Chung
The Korean Journal of Parasitology.2014; 52(2): 197. CrossRef
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Hye Kyung Shin, Joo-Hyung Roh, Jae-Won Oh, Jae-Sook Ryu, Youn-Kyoung Goo, Dong-Il Chung, Yong Joo Kim
The Korean Journal of Parasitology.2014; 52(6): 677. CrossRef
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Sung-Chul Choi, Soo-Young Lee, Hyun-Ouk Song, Jae-Sook Ryu, Myoung-Hee Ahn
The Korean Journal of Parasitology.2014; 52(2): 215. CrossRef
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Hong-Ja Kim, Keeseon S. Eom, Min Seo
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Sang Hyun Park, Keeseon S. Eom, Min Sun Park, Oh Kyoung Kwon, Hyo Sun Kim, Jai Hoon Yoon
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Korean Journal of Medicine.2013; 85(5): 469. CrossRef
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Ai-Jiang Guo, Kan Liu, Wei Gong, Xue-Nong Luo, Hong-Bin Yan, Song-Buo Zhao, Song-Nian Hu, Wan-Zhong Jia
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Hee-Jung Choi, Junghye Lee, Hyun-Jong Yang
The Korean Journal of Parasitology.2012; 50(2): 143. CrossRef
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KV Ramana, Sanjeev Rao, Moses Vinaykumar, M Krishnappa, Rajeshwar Reddy, Mohammed Sarfaraz, Vamshikrishna Kondle, MS Ratnamani, Ratna Rao
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Fish-borne Parasitic Diseases
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Myoung-Hee Ahn
Hanyang Medical Reviews.2010; 30(3): 149. CrossRef
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Hyeong-Kyu Jeon, Kyu-Heon Kim, Sun Huh, Jong-Yil Chai, Duk-Young Min, Han-Jong Rim, Keeseon S. Eom
The Korean Journal of Parasitology.2009; 47(4): 369. CrossRef
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M Detrait, L Poirier, D-C Roy, T Kiss, L Busque, S Cohen, S Lachance, G Sauvageau, J Roy
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Tomáš Scholz, Hector H. Garcia, Roman Kuchta, Barbara Wicht
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Trends in Parasitology.2008; 24(3): 143. CrossRef

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Brief Communication

Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment: Chenghua Shen, Jae-hwan Kim, Jeong-Keun Lee, Young Mee Bae, Min-Ho Choi, Jin-Kyoung Oh, Min Kyung Lim, Hai-Rim Shin, Sung-Tae Hong; Korean J Parasitol 2007;45(2):149-152.
Published online June 20, 2007; DOI: https://doi.org/10.3347/kjp.2007.45.2.149

Abstract
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A cohort was established for evaluation of cancer risk factors in Sancheong-gun, Gyeongsangnam-do, Korea. As one of the cohort studies, stools of 947 residents (403 males and 544 females, age range: 29-86 years) were screened for Clonorchis sinensis eggs using both Kato-Katz method and formalin-ether sedimentation technique. The overall egg positive rate of C. sinensis was 37.7% and individual EPG (eggs per gram of feces) counts ranged from 24 to 28,800. Eight egg positive residents voluntarily joined a process of collection of the passed worms after praziquantel treatment. A total of 158 worms were recovered from 5 of the 8 treated persons, ranged from 3 to 108 in each individual. The worms were 15-20 mm × 2-3 mm in size, and showed brown-pigmented, red, or white body colors. This is the first collection record of C. sinensis adult worms from humans through anthelmintic treatment and purgation. The adult worms of C. sinensis may be paralyzed by praziquantel and then discharged passively through bile flow in the bile duct and by peristaltic movement of the bowel.

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Jung-Min Lee, Hyun-Sul Lim, Sung-Tae Hong
The Korean Journal of Parasitology.2011; 49(3): 273. CrossRef
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Original Articles

Therapeutic evaluation of sustained-releasing praziquantel (SRP) for clonorchiasis: Phase 1 and 2 clinical studies: Min-Ho Choi, Byung-Chan Chang, Seung-Jin Lee, In-Jin Jang, Sang-Goo Shin, Weon-Gyu Kho, Jin-Ho Chun, Sung-Tae Hong; Korean J Parasitol 2006;44(4):361-366.
Published online December 20, 2006; DOI: https://doi.org/10.3347/kjp.2006.44.4.361

Abstract
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Sustained-releasing praziquantel (SRP) tablet was designed for single dose treatment regimen of clonorchiasis. A previous pre-clinical study confirmed its sustained-releasing characteristics and a better cure rate than conventional praziquantel (PZQ). In this clinical study, the pharmacokinetics of this SRP tablet were investigated in human volunteers (phase 1; 12 volunteers), and its curative efficacy was examined in clonorchiasis patients (phase 2; 20 volunteers). In the phase 1 clinical study, blood concentrations of both tablets showed wide individual variation. The AUC_last of SRP was 497.9 ± 519.0 ng · hr/ml (mean ± SD) and PZQ of 628.6 ± 695.5 ng · hr/ml, and the AUC_inf of SRP was 776.0 ± 538.5 ng · hr/ml and of PZQ 658.6 ± 709.9 ng · hr/ml. C_max values of SRP and PZQ were 90.7 ± 82.2 ng/ml and 214.9 ± 251.9 ng/ml, and T_max values were 3.42 ± 1.43 hr and 1.96 ± 1.23 hr, respectively. SRP tablets showed similar AUC values, but lower C_max and longer T_max values than PZQ. In the phase 2 study, SRP at 30 mg/kg (single dose) achieved a 60% cure rate and a 95.5% egg reduction rate. The cure rate of a single dose SRP was unsatisfactory compared with that of the conventional PZQ dose, but much better than that achieved by a single dose PZQ.

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Control of clonorchiasis by repeated treatments with praziquantel: Sung-Tae Hong, Han-Jong Rim, Duk-Young Min, Xueming Li, Jingxian Xu, Zheng Feng, Soon-Hyung Lee; Korean J Parasitol 2001;39(4):285-292.
Published online December 31, 2001; DOI: https://doi.org/10.3347/kjp.2001.39.4.285

Abstract
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The present study aimed to evaluate control efficacy of clonorchiasis by two schemes of repeated treatment with praziquantel at two endemic villages In China. Residents of one village at Guangxi Autonomous Region were treated and examined 6-monthly and of another at Liaoning Province 12-monthly. In residents that took 25 mg/kg x3 (total 75 mg/kg) of praziquantel every 6 months for one year the egg positive rate showed a significant drop from 69.0% to 17.1%. In contrast, a group of same praziquantel medication once showed a slight marginal decrease in the egg rate from 18.9% to 12.2% after one year. Of 39 subjects examined 3 times, 56.4% were cured, 7.7% persistently positive, one (2.6%) reinfected after cure or newly infected, but 25.6% were persistently negative. The present finding suggests that 6-monthly medication with 75 mg/kg of praziquantel should effectively lower the prevalence but incomplete for control of clonorchiasis in heavy endemic areas.

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Control of clonorchiasis by repeated praziquantel treatment and low diagnostic efficacy of sonography: Sung-Tae Hong, Kisung Yoon, Mejeong Lee, Min Seo, Min-Ho Choi, Jung Suk Sim, Byung Ihn Choi, Chong Ku Yun, Soon-Hyung Lee; Korean J Parasitol 1998;36(4):249-254.
Published online December 20, 1998; DOI: https://doi.org/10.3347/kjp.1998.36.4.249

Abstract
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In Korea, Clonorchis sinensis infection is still highly prevalent because case detection in the field is difficult and the detected cases used to be incompletely cured due to treatment failure. The present study tried to control clonorchiasis in an endemic village by repeated treatments with praziquantel every 6 months and to evaluate sonography as a diagnostic measure. By stool examinations, the egg positive rate in the endemic village was 22.7%, but it decreased to 19.6% at 6 months, 15.1% at 12 months. 12.2% at 18 months, 6.3% at 24 months, 11.4% at 30 months, and 6.3% at 42 months after the beginning of repeated praziquantel administration. The sonography showed 61 (49.6%) positive cases of 123 screened residents: among egg-positives the sonography positive rate was 52.2% and among egg-negatives it was still 49%. The rate among cured cases was 64.3% after 6 months, 50.0% after 12 months, 50.0% after 18 months, and 66.7% after 24 months. In a non-endemic village, 64 residents were found egg-negative by fecal examination, but 20 (31.3%) of them were positive by sonography. The present findings indicate that control of clonorchiasis in an endemic village by repeated praziquantel treatment for 42 months is still insufficient and sonography is of little value for diagnosis of clonorchiasis.

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