Parasites, Hosts and Diseases

"uveitis"

Brief Communications

Elevated interleukin-10 levels in patients with ocular toxoplasmosis: Gee-Hyun Kim, Jae Hyuck Kwak, Young-Hoon Park; Parasites Hosts Dis 2023;61(3):310-316.
Published online August 21, 2023; DOI: https://doi.org/10.3347/PHD.22172

Abstract
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In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

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Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes
Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin
Parasites, Hosts and Diseases.2024; 62(1): 30. CrossRef
Factors related to central nervous system involvement of primary vitreoretinal lymphoma
Joo Young Kim, Jae Jung Kim, Rae Young Kim, Mirinae Kim, Young Gun Park, Young-Hoon Park
Graefe's Archive for Clinical and Experimental Ophthalmology.2024; 262(8): 2421. CrossRef

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Detection of Ocular Toxoplasma gondii Infection in Chronic Irregular Recurrent Uveitis by PCR: Sang-Eun Lee, Sung-Hee Hong, Seong-Ho Lee, Young-Il Jeong, Su Jin Lim, Oh Woong Kwon, Sun Hyun Kim, Young Sung You, Shin-Hyeong Cho, Won-Ja Lee; Korean J Parasitol 2012;50(3):229-231.
Published online August 13, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.3.229

Abstract
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Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.

Citations

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Molecular diagnosis of toxoplasmosis in immunocompromised patients
Florence Robert-Gangneux, Sorya Belaz
Current Opinion in Infectious Diseases.2016; 29(4): 330. CrossRef
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Naushaba Siddiqui, Fatima Shujatullah, Haris M. Khan, Tamkin Rabbani, Parvez A. Khan
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PCR-Based Detection of Toxoplasma gondii DNA in Blood and Ocular Samples for Diagnosis of Ocular Toxoplasmosis
C. Bourdin, A. Busse, E. Kouamou, F. Touafek, B. Bodaghi, P. Le Hoang, D. Mazier, L. Paris, A. Fekkar, M. J. Loeffelholz
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The Korean Journal of Parasitology.2013; 51(3): 363. CrossRef
Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2012; 50(4): 287. CrossRef

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62 Download
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Case Report

A toxoplasmic uveitis case of a 60-year-old male in Korea: Min-Ho Kim, Yeun-Kyoung Choi, Yun-Kyu Park, Ho-Woo Nam; Korean J Parasitol 2000;38(1):29-31.
Published online March 31, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.1.29

Abstract
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A toxoplasmic uveitis case was reported on the focus of impairment of pathological findings and serological antibody titers after chemotherapy. A chief complaint of a 60-year-old male was a decreased and blurred vision in his right eye for 2 weeks after experiencing tremendous stress and fatigue. A steroid therapy for 3 weeks was not effective and the retinal lesion became necrotic. Anti-Toxoplasma gondii antibody titer was checked to be a strong positive by both ELISA and indirect latex agglutination assay (ILA). He was treated with Fansidar F for 8 weeks. His vision improved as the necrotic lesion healed by scarring, but the antibody titers still remained very high without any signs of negative conversion. It is suggested to be a recurrent case of the past asymptomatic infection by presumed immune suppression caused by excessive stress.

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