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A single dose (2.0, 5.0, 10.0 mg/kg) of pyrantel embonate given to three groups consisting 301 children with Ascaris lumbricoides infection achieved a cure rate of 91.3%, 94.4% and 98.9% respectively. Whereas in the other two groups of 71 and 75 patients who received 75 mg/kg body weight with piperazine adipate 2 or 3 consecutive days, the cure rates were 62.0% and 74.7% respectively. Administration of a single recommended dose of santonin-kainic acid complex given to 77 patients achived a cure rate of 80.5% with 91.0% of egg reduction rate. The cure rate resulting from a single lowest dose 2.5 mg/kg pyrantel embonate was significantly higher than those of piperazine adipate and santonin-kainic acid complex in the mass treatment for ascariasis. in addition to the group of 2.5 mg/kg pyrantel embonate treatment, the side effect was lesser than those of the other groups. Considering the efficacy and safety of pyrantel embonate against Ascaris lumbricoides, it would be one of the useful agents for the mass treatment of Ascaris control.
Citations
Citations to this article as recorded by
What was the main factor in successful control of ascariasis in Korea? Seung-Yull Cho, Sung-Tae Hong Parasites, Hosts and Diseases.2023; 61(2): 103. CrossRef
The major bioactive components of seaweeds and their mosquitocidal potential Ke-Xin Yu, Ibrahim Jantan, Rohani Ahmad, Ching-Lee Wong Parasitology Research.2014; 113(9): 3121. CrossRef
Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control Jürg Utzinger, Jennifer Keiser Expert Opinion on Pharmacotherapy.2004; 5(2): 263. CrossRef
Combination therapy in the treatment of helminth diseases Vijai K. Agrawal, Satyavan Sharma Medicinal Research Reviews.1985; 5(3): 333. CrossRef
Anthelmintic effects of single doses of fenbendazole and oxantel-pyrantel pamoate to the intestinal nematodes Han Jong Rim, Joon Sang Lee, Kyung Hwan Joo, Yung Shik Kim The Korean Journal of Parasitology.1981; 19(2): 95. CrossRef
A clinical trial of oxantel and pyrantel against intestinal nematodes infections Won Young Choi, Ok Ran Lee, Won Koo Lee, Wun Kyu Kim, Chang Seng Chung, Byong Ok Ough The Korean Journal of Parasitology.1979; 17(1): 60. CrossRef
Seasonal fluctuation of Ascaris reinfection incidences in a rural Korean population Byong Seol Seo, Seung Yull Cho, Jong Yil Chai The Korean Journal of Parasitology.1979; 17(1): 11. CrossRef
Pyrantel embonate and bephenium hydroxynaphthoate in the treatment of hookworm infection Jung Kyoo Lim The Korean Journal of Parasitology.1975; 13(1): 19. CrossRef
