Abstract
In order to compare the intraspecific variation in host-parasite relationship of Clonorchis sinensis, six strains of inbred mice, ICR, DDY, GPC, BALB/c, nude and DS, were infected orally with 20 metacercariae of C. sinensis.
The biologic incubation period of C. sinensis was the shortest in DDY mice, 21.2 days in average, followed by GPC 21.4, BALB/c and DS 23.2, ICR and nude 23.4 days, respectively. The fertile period of the fluke was also the longest in the DDY strain, 164 days on average, followed by GPC 132, BALB/c 97, nude 37, DS 32 and ICR 28 days. The egg-laying capacity of the fluke in DDY and GPC was relatively high and stable compared with the other four strains of mice. It was found that there are intraspecific variations in biologic incubation period, fertile period, and fecundity of C. sinensis. The DDY mouse is likely to be the most suitable experimental animal among the six strains of the mice tested.
Citations
Citations to this article as recorded by
- Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis
Min-Ji Park, Woon-Mok Sohn, Young-An Bae
Parasites, Hosts and Diseases.2024; 62(1): 98. CrossRef - Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis
Seon-Hee Kim, Dongki Yang, Young-An Bae, Krystyna Cwiklinski
PLOS Neglected Tropical Diseases.2021; 15(9): e0009811. CrossRef - Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice
Md. Hafiz Uddin, Shunyu Li, Young Mee Bae, Min-Ho Choi, Sung-Tae Hong
Parasitology International.2012; 61(1): 118. CrossRef - Response to re-infection with Brachylaima cribbi in immunocompetent and immunodeficient mice
Andrew R. Butcher, Helen M. Palethorpe, David I. Grove
Parasitology International.2003; 52(3): 219. CrossRef
