Parasites, Hosts and Diseases

"Joon-Yong Chung"

Original Articles

Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4: Joon-Yong Chung, Young-An Bae, Doo-Hee Yun, Hyun-Jong Yang, Yoon Kong; Korean J Parasitol 2012;50(4):301-308.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.301

Abstract
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19⁺ B cells was observed as early as week 1 post-infection while CD4⁺/CD8⁺ T cells were down-regulated. Accumulation of Mac1⁺ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.

Citations

Citations to this article as recorded by

Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
María Teresa Ruiz-Campillo, Isabel Lourdes Pacheco, Nieves Abril, María José Bautista, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Leandro Buffoni, José Pérez, Verónica Molina-Hernández, Rafael Zafra
Veterinary Research.2024;[Epub] CrossRef
Fascioliasis: Image Findings, Diagnosis, and Treatment
Jae Seung Lee
Clinical Ultrasound.2024; 9(1): 18. CrossRef
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Luis Miguel Flores-Velázquez, María Teresa Ruiz-Campillo, Guillem Herrera-Torres, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Rafael Zafra, Leandro Buffoni, Pablo José Rufino-Moya, Verónica Molina-Hernández, José Pérez
Frontiers in Veterinary Science.2023;[Epub] CrossRef
The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation
Lumin Wang, Yanping Li, Dawei Yang, Jiazhao Fu, Bin Zhao, Yaguang Li, Yanrong Ye, Zhongquan Qi
Clinical and Translational Discovery.2023;[Epub] CrossRef
Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge
Yongqian Bu, Caiwen Jia, Xiaowei Tian, Kalibixiati Aimulajiang, Muhammad Ali Memon, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
Pathogens.2020; 9(1): 46. CrossRef
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez
Veterinary Research.2020;[Epub] CrossRef
Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola
Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis
Experimental Results.2020;[Epub] CrossRef
Fasciola and fasciolosis in ruminants in Europe: Identifying research needs
N. J. Beesley, C. Caminade, J. Charlier, R. J. Flynn, J. E. Hodgkinson, A. Martinez-Moreno, M. Martinez-Valladares, J. Perez, L. Rinaldi, D. J. L. Williams
Transboundary and Emerging Diseases.2018; 65: 199. CrossRef
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez
Veterinary Research.2018;[Epub] CrossRef
Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review
Claudia Machicado, Jorge D. Machicado, Vicente Maco, Angelica Terashima, Luis A. Marcos, Hector H Garcia
PLOS Neglected Tropical Diseases.2016; 10(9): e0004962. CrossRef

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A seroepidemiological survey of Taenia solium cysticercosis in Nabo, Guangxi Zhuang Autonomous Region, China: Joon-Yong Chung, Keeseon S. Eom, Yichao Yang, Xenming Li, Zheng Feng, Han-Jong Rim, Seung-Yull Cho, Yoon Kong; Korean J Parasitol 2005;43(4):135-139.
Published online December 20, 2005; DOI: https://doi.org/10.3347/kjp.2005.43.4.135

Abstract
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We have observed the seropositive rate of Taenia solium cysticercosis in residents at Nabo Village, Tiandong County, Guangxi Zhuang Autonomous Region, China by enzyme linked immunosorbent assay. The village had been found to be a relatively high endemic area of porcine cysticercosis among roaming pigs. Of 202 persons examined four males aged 15, 25, 35 and 41 year-old exhibited absorbance (abs) at 0.18, 0.20, 0.35 and 0.55, respectively. In addition, two females whose ages were 35 and 39 years revealed specific antibody levels of abs 0.26 and 0.41 in their sera. Overall positive rate among the people was 2.97%. All of these persons agreed that they had ingested the pork infected with T. solium metacestode (TsM), while history of proglottid discharge was not noticed from all of them. Three males and one female complained of intermittent headache. Our findings reinforced not only that the prevalence of cysticercosis might be related with roaming pigs infected with TsM but also that behavioral and environmental practices in local community constituted risk factors for transmission of the infection.

Citations

Citations to this article as recorded by

A Marked Decline in Taenia solium Taeniasis and Cysticercosis Infections in China: Possible Reasons from the Ecological Determinants Perspective
Junqiang Li, Feifei Xu, Yuancai Chen, Md Robiul Karim, Yilin Wang, Kaihui Zhang, Xiaoying Li, Pitambar Dhakal, Rongjun Wang, Longxian Zhang
Zoonoses.2023;[Epub] CrossRef
The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique
Irene Langa, Fernando Padama, Noémia Nhancupe, Alberto Pondja, Delfina Hlashwayo, Lidia Gouveia, Dominik Stelzle, Clarissa Prazeres da Costa, Veronika Schmidt, Andrea S. Winkler, Emília Virgínia Noormahomed, Eduardo Torres
PLOS Neglected Tropical Diseases.2022; 16(7): e0010606. CrossRef
Taeniasis and cysticercosis in Asia: A review with emphasis on molecular approaches and local lifestyles
Akira Ito, Tiaoying Li, Toni Wandra, Paron Dekumyoy, Tetsuya Yanagida, Munehiro Okamoto, Christine M Budke
Acta Tropica.2019; 198: 105075. CrossRef
Infections of Soil-Transmitted Helminth in Refugees from North Korea
Young-Il Lee, Min Seo, Suk-Bae Kim
The Korean Journal of Parasitology.2018; 56(3): 291. CrossRef
Zoonoses in South-East Asia: a regional burden, a global threat
Marion Bordier, François Roger
Animal Health Research Reviews.2013; 14(1): 40. CrossRef
Prevalence and Risk Factors Associated with Human Taenia Solium Infections in Mbozi District, Mbeya Region, Tanzania
Gloria Mwanjali, Charles Kihamia, Deodatus Vitalis Conatus Kakoko, Faustin Lekule, Helena Ngowi, Maria Vang Johansen, Stig Milan Thamsborg, Arve Lee Willingham, Malcolm K. Jones
PLoS Neglected Tropical Diseases.2013; 7(3): e2102. CrossRef
Serodiagnostic reliability of single-step enriched low-molecular weight proteins of Taenia solium metacestode of American and Asian isolates
E.-G. Lee, Y.-A. Bae, S.-H. Kim, S.P. Díaz-Camacho, Y. Nawa, Y. Kong
Transactions of the Royal Society of Tropical Medicine and Hygiene.2010; 104(10): 676. CrossRef
Seroprevalence of Taenia solium antibodies in Vellore district, south India
V. Prabhakaran, M. Venkata Raghava, V. Rajshekhar, J. Muliyil, A. Oommen
Transactions of the Royal Society of Tropical Medicine and Hygiene.2008; 102(3): 246. CrossRef
What triggers seizures in neurocysticercosis? A MRI-based study in pig farming community from a district of North India
Amit Prasad, Rakesh K. Gupta, Sunil Pradhan, Mukesh Tripathi, Chandra M. Pandey, Kashi N. Prasad
Parasitology International.2008; 57(2): 166. CrossRef
Tissue parasitic helminthiases are prevalent at Cheongjin, North Korea
Chenghua Shen, Shunyu Li, Shanzi Zheng, Min-Ho Choi, Young Mee Bae, Sung-Tae Hong
The Korean Journal of Parasitology.2007; 45(2): 139. CrossRef

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Brief Communication

Cloning of a pore-forming subunit of ATP-sensitive potassium channel from Clonorchis sinensis: Seung-Young Hwang, Hye-Jin Han, So-Hee Kim, Sae-Gwang Park, Dae-Hyun Seog, Nari Kim, Jin Han, Joon-Yong Chung, Weon-Gyu Kho; Korean J Parasitol 2003;41(2):129-133.
Published online June 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.2.129

Abstract
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A complete cDNA sequence encoding a pore-forming subunit (Kir6.2) of ATP-senstive potassium channel in the adult worm, Clonorchis sinensis, termed CsKir6.2, was isolated from an adult cDNA library. The cDNA contained a single open-reading frame of 333 amino acids, which has a structural motif (a GFG-motif) of the putative pore-forming loop of the Kir6.2. Peculiarly, the CsKir6.2 shows a lack-sequence structure, which deleted 57 amino acids were deleted from its N-terminus. The predicted amino acid sequence revealed a highly conserved sequence as other known other Kir6.2 subunits. The mRNA was weekly expressed in the adult worm.

Citations

Citations to this article as recorded by

Pipeline for the identification and classification of ion channels in parasitic flatworms
Bahiyah Nor, Neil D. Young, Pasi K. Korhonen, Ross S. Hall, Patrick Tan, Andrew Lonie, Robin B. Gasser
Parasites & Vectors.2016;[Epub] CrossRef
Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects
Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Bronwyn E. Campbell, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser
Biotechnology Advances.2010; 28(6): 859. CrossRef
Functional Genes and Proteins of Clonorchis sinensis
Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong
The Korean Journal of Parasitology.2009; 47(Suppl): S59. CrossRef
Clonorchiasis: an update
H.-J. Rim
Journal of Helminthology.2005; 79(3): 269. CrossRef

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Original Articles

Analysis of polymorphic region of GAM-1 gene in Plasmodium vivax Korean isolates: Weon-Gyu Kho, Joon-Yong Chung, Ui-Wook Hwang, Jin-Ho Chun, Yeong-Hong Park, Woo-Chul Chung; Korean J Parasitol 2001;39(4):313-318.
Published online December 31, 2001; DOI: https://doi.org/10.3347/kjp.2001.39.4.313

Abstract
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The identification, characterization and quantification of Plasmodium sp. genetic polymorphism are becoming increasingly important in the vaccine development. We investigated polymorphism of Plasmodium vivax GAM-1 (PvGAM-1) gene in 30 Korean isolates. The polymorphic region of the PvGAM-1 gene, corresponding to nt 3792-4029, was amplified using polymerase chain reaction (PCR) followed by sequencing. All of the P. vivax Korean isolates were one type of GAM-1 gene, which were identical to that of the Belem strain. It is suggested that PvGAM-1 could not be used as a genetic marker for identifying or classifying P. vivax Korean isolates. It revealed that the polymorphic pattern was acquired basically by duplication and modification or deletion event of a 33 bp-motif fragment ended by poly guanine (G) and that there were at least three complete and one partial 33 bp-motif sequences within the polymorphic region in the longest cases such as those of South Korean and Belem isolates. In addition, we clustered P. vivax isolates with parsimonious criteria on the basis of PvGAM-1 polymorphic patterns (insertion/deletion patterns).

Citations

Citations to this article as recorded by

Complete mitochondrial genome of a malaria vector mosquito Anopheles sinensis from South Korea
Ashraf Akintayo Akintola, Bia Park, Eun Hwa Choi, Ui Wook Hwang
Mitochondrial DNA Part B.2022; 7(5): 881. CrossRef
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea
Young Yil Bahk, Jeonga Kim, Seong Kyu Ahn, Byoung-Kuk Na, Jong-Yil Chai, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(6): 545. CrossRef
Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax
Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho
The Korean Journal of Parasitology.2009; 47(Suppl): S51. CrossRef
Plasmodium vivax in India
Hema Joshi, Surendra K. Prajapati, Anju Verma, Simon Kang’a, Jane M. Carlton
Trends in Parasitology.2008; 24(5): 228. CrossRef
Allelic dimorphism of Plasmodium vivax gam-1 in the Indian subcontinent
Surendra K Prajapati, Anju Verma, Tridibes Adak, Rajpal S Yadav, Ashwini Kumar, Alex Eapen, Manoj K Das, Neeru Singh, Surya K Sharma, Moshahid A Rizvi, Aditya P Dash, Hema Joshi
Malaria Journal.2006;[Epub] CrossRef

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Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates: Weon-Gyu Kho, Joon-Yong Chung, Eun-Jeong Sim, Dong-Wook Kim, Woo-Chul Chung; Korean J Parasitol 2001;39(2):143-150.
Published online June 30, 2001; DOI: https://doi.org/10.3347/kjp.2001.39.2.143

Abstract
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The present study was designed to investigate polymorphism in Duffy binding protein (DBP) gene of Plasmodium vivax isolates of Korea. Thirty samples were obtained from P. vivax patients in Yonchon-gun, Kyonggi-do in 1998. The PCR products of the samples were subjected to sequencing and hybridization analyses of the regions II and IV of P. vivax DBP gene. Two genotypes, SK-1 and SK-2, were identified on the basis of amino acid substitution and deletion. The genotype of 10 isolates was SK-1 and that of 20 isolates was SK-2. Most of the predicted amino acids in the region II of DBP gene were conserved between the Korean isolates and Belem strain except for 4-5 amino acid substitutions. In the region IV of DBP, a 6-bp insert that was shown in the Sal-1 allele type was found in SK-1, and a 27-bp insert that was shown in the Papua New Guinea allele type was found in SK-2. In conclusion, the present findings suggest that two genotypes of P. vivax coexist in the endemic area of Korea.

Citations

Citations to this article as recorded by

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial
Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Vira
npj Vaccines.2024;[Epub] CrossRef
Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador
Andrés Núñez, Francis B. Ntumngia, Yasel Guerra, John H. Adams, Fabián E. Sáenz
Malaria Journal.2023;[Epub] CrossRef
Plasmodium vivax Duffy Binding Protein-Based Vaccine: a Distant Dream
Sonalika Kar, Abhinav Sinha
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Global distribution of single amino acid polymorphisms in Plasmodium vivax Duffy-binding-like domain and implications for vaccine development efforts
Payal Mittal, Siddhartha Mishra, Sonalika Kar, Veena Pande, Abhinav Sinha, Amit Sharma
Open Biology.2020;[Epub] CrossRef
Paleopathological Considerations on Malaria Infection in Korea before the 20th Century
Dong Hoon Shin, Min Seo, Jong Ha Hong, Eunju Lee
BioMed Research International.2018; 2018: 1. CrossRef
Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion
Camille Roesch, Jean Popovici, Sophalai Bin, Vorleak Run, Saorin Kim, Stéphanie Ramboarina, Emma Rakotomalala, Rado Lalaina Rakotoarison, Tsikiniaina Rasoloharimanana, Zo Andriamanantena, Anuj Kumar, Micheline Guillotte-Blisnick, Christèle Huon, David Ser
PLOS Neglected Tropical Diseases.2018; 12(10): e0006555. CrossRef
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea
Young Yil Bahk, Jeonga Kim, Seong Kyu Ahn, Byoung-Kuk Na, Jong-Yil Chai, Tong-Soo Kim
The Korean Journal of Parasitology.2018; 56(6): 545. CrossRef
Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014)
Chao Xu, Qing-Kuan Wei, Jin Li, Ting Xiao, Kun Yin, Chang-Lei Zhao, Yong-Bin Wang, Xiang-Li Kong, Gui-Hua Zhao, Hui Sun, Xin Liu, Bing-Cheng Huang
The Korean Journal of Parasitology.2016; 54(4): 407. CrossRef
Strain-Transcending Inhibitory Antibodies against Homologous and Heterologous Strains of Duffy Binding Protein region II
Sudarat Wongkidakarn, Amy M. McHenry, Jetsumon Sattabongkot, John H Adams, Patchanee Chootong, Laurent Rénia
PLOS ONE.2016; 11(5): e0154577. CrossRef
Diversity and evolutionary genetics of the three major Plasmodium vivax merozoite genes participating in reticulocyte invasion in southern Mexico
Lilia González-Cerón, Rene Cerritos, Jordán Corzo-Mancilla, Frida Santillán
Parasites & Vectors.2015;[Epub] CrossRef
Population genetics and natural selection in the gene encoding the Duffy binding protein II in Iranian Plasmodium vivax wild isolates
Vahideh Valizadeh, Sedigheh Zakeri, Akram Abouie Mehrizi, Navid Dinparast Djadid
Infection, Genetics and Evolution.2014; 21: 424. CrossRef
Non-allele specific antibody responses to genetically distinct variant forms of Plasmodium vivax Duffy binding protein (PvDBP-II) in Iranians exposed to seasonal malaria transmission
Vahideh Valizadeh, Sedigheh Zakeri, Akram Abouei Mehrizi, Navid Dinparast Djadid
Acta Tropica.2014; 136: 89. CrossRef
Genetic diversity, haplotypes and allele groups of Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia
Mun-Yik Fong, Yee-Ling Lau, Phooi-Yee Chang, Claudia Anthony
Parasites & Vectors.2014; 7(1): 161. CrossRef
The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon
Taís Nóbrega de Sousa, Flora Satiko Kano, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho
Memórias do Instituto Oswaldo Cruz.2014; 109(5): 608. CrossRef
Genetic diversity and natural selection of Duffy binding protein of Plasmodium vivax Korean isolates
Hye-Lim Ju, Jung-Mi Kang, Sung-Ung Moon, Young-Yil Bahk, Pyo-Yun Cho, Woon-Mok Sohn, Yun-Kyu Park, Jae-Won Park, Tong-Soo Kim, Byoung-Kuk Na
Acta Tropica.2013; 125(1): 67. CrossRef
Microsatellite DNA Analysis Revealed a Drastic Genetic Change of Plasmodium vivax Population in the Republic of Korea During 2002 and 2003
Moritoshi Iwagami, Seung-Young Hwang, So-Hee Kim, So-Jung Park, Ga-Young Lee, Emilie Louise Akiko Matsumoto-Takahashi, Weon-Gyu Kho, Shigeyuki Kano, Shan Lv
PLoS Neglected Tropical Diseases.2013; 7(10): e2522. CrossRef
Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
Hye-Lim Ju, Jung-Mi Kang, Sung-Ung Moon, Jung-Yeon Kim, Hyeong-Woo Lee, Khin Lin, Woon-Mok Sohn, Jin-Soo Lee, Tong-Soo Kim, Byoung-Kuk Na
Malaria Journal.2012;[Epub] CrossRef
Population Structure and Transmission Dynamics of Plasmodium vivax in the Republic of Korea Based on Microsatellite DNA Analysis
Moritoshi Iwagami, Megumi Fukumoto, Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho, Shigeyuki Kano, Mehmet Ali Ozcel
PLoS Neglected Tropical Diseases.2012; 6(4): e1592. CrossRef
Characterization of Inhibitory Anti-Duffy Binding Protein II Immunity: Approach to Plasmodium vivax Vaccine Development in Thailand
Patchanee Chootong, Tasanee Panichakul, Chongrak Permmongkol, Samantha J. Barnes, Rachanee Udomsangpetch, John H. Adams, Georges Snounou
PLoS ONE.2012; 7(4): e35769. CrossRef
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Hajime Honma, Jung-Yeon Kim, Nirianne MQ Palacpac, Toshihiro Mita, Wonja Lee, Toshihiro Horii, Kazuyuki Tanabe
Malaria Journal.2011;[Epub] CrossRef
Worldwide Genetic Variability of the Duffy Binding Protein: Insights into Plasmodium vivax Vaccine Development
Taís Nóbrega de Sousa, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Mauricio Martins Rodrigues
PLoS ONE.2011; 6(8): e22944. CrossRef
Determination of the Molecular Basis for a Limited Dimorphism, N417K, in the Plasmodium vivax Duffy-Binding Protein
Amy M. McHenry, Samantha J. Barnes, Francis B. Ntumngia, Christopher L. King, John H. Adams, Ivo Mueller
PLoS ONE.2011; 6(5): e20192. CrossRef
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Cristiana Ferreira Alves de Brito, Marcelo Urbano Ferreira
Memórias do Instituto Oswaldo Cruz.2011; 106(suppl 1): 12. CrossRef
Antibody Responses and Avidity of Naturally Acquired Anti-Plasmodium vivax Duffy Binding Protein (PvDBP) Antibodies in Individuals from an Area with Unstable Malaria Transmission
Sedigheh Zakeri, Akram Abouie Mehrizi, Navid Dinparast Djadid, Laleh Babaeekhou, Maryam Abbasi
The American Journal of Tropical Medicine and Hygiene.2011; 84(6): 944. CrossRef
Mapping Epitopes of the Plasmodium vivax Duffy Binding Protein with Naturally Acquired Inhibitory Antibodies
Patchanee Chootong, Francis B. Ntumngia, Kelley M. VanBuskirk, Jia Xainli, Jennifer L. Cole-Tobian, Christopher O. Campbell, Tresa S. Fraser, Christopher L. King, John H. Adams
Infection and Immunity.2010; 78(3): 1089. CrossRef
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Taís N Sousa, Eduardo M Tarazona-Santos, Daniel J Wilson, Ana P Madureira, Paula RK Falcão, Cor JF Fontes, Luiz HS Gil, Marcelo U Ferreira, Luzia H Carvalho, Cristiana FA Brito
Malaria Journal.2010;[Epub] CrossRef
Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax
Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho
The Korean Journal of Parasitology.2009; 47(Suppl): S51. CrossRef
Naturally acquired inhibitory antibodies toPlasmodium vivaxDuffy binding protein are short-lived and allele-specific following a single malaria infection
I P Ceravolo, B A M Sanchez, T N Sousa, B M Guerra, I S Soares, E M Braga, A M McHenry, J H Adams, C F A Brito, L H Carvalho
Clinical and Experimental Immunology.2009; 156(3): 502. CrossRef
Plasmodium vivax PCR genotyping of the first malaria case imported from South Korea into Japan
Moritoshi Iwagami, Shigeyuki Kano, Ichiro Itoda, Seung-Young Hwang, Weon-Gyu Kho
Journal of Infection and Chemotherapy.2009; 15(1): 27. CrossRef
Molecular Genetic Characterization of the Merozoite Surface Protein 1 Gene of Plasmodium vivax from Reemerging Korean Isolates
So-Hee Kim, Seung-Young Hwang, Jeong Hwan Shin, Chi-Sook Moon, Dong-Wook Kim, Weon-Gyu Kho
Clinical and Vaccine Immunology.2009; 16(5): 733. CrossRef
Single-Chain Antibody Fragment Specific forPlasmodium vivaxDuffy Binding Protein
So-Hee Kim, Seung-Young Hwang, Yong-Seok Lee, In-Hak Choi, Sae-Gwang Park, Weon-Gyu Kho
Clinical and Vaccine Immunology.2007; 14(6): 726. CrossRef
The crystal structure of P. knowlesi DBPα DBL domain and its implications for immune evasion
Amy M. McHenry, John H. Adams
Trends in Biochemical Sciences.2006; 31(9): 487. CrossRef
Reemerging vivax malaria: changing patterns of annual incidence and control programs in the Republic of Korea
Eun-Taek Han, Duk-Hyoung Lee, Ki-Dong Park, Won-Seok Seok, Young-Soo Kim, Takafumi Tsuboi, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2006; 44(4): 285. CrossRef
The pattern of major polymorphisms in the Duffy binding protein ligand domain among Plasmodium vivax isolates from the Brazilian Amazon area
Taís N. Sousa, Isabela P. Cerávolo, Cor Jésus Fernandes Fontes, Álvaro Couto, Luzia H. Carvalho, Cristiana F.A. Brito
Molecular and Biochemical Parasitology.2006; 146(2): 251. CrossRef
Plasmodium vivax Duffy binding protein: a modular evolutionary proposal
P. MARTINEZ, C. F. SUAREZ, P. P. CARDENAS, M. A. PATARROYO
Parasitology.2004; 128(4): 353. CrossRef
Diversity and natural selection in Plasmodium vivax Duffy binding protein gene
Jennifer Cole-Tobian, Christopher L. King
Molecular and Biochemical Parasitology.2003; 127(2): 121. CrossRef
Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates
Joon-Yong Chung, Eui-Hyun Chun, Jin-Ho Chun, Weon-Gyu Kho
Parasitology Research.2003; 90(4): 325. CrossRef
Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea
Eun-Taek Han, Jae-Hwan Park, Eun-Hee Shin, Min-Ho Choi, Myoung-Don Oh, Jong-Yil Chai
The Korean Journal of Parasitology.2002; 40(3): 157. CrossRef
Age-Dependent Cellular Immune Responses toPlasmodium vivaxDuffy Binding Protein in Humans
Jia Xainli, Moses Baisor, Will Kastens, Moses Bockarie, John H. Adams, Christopher L. King
The Journal of Immunology.2002; 169(6): 3200. CrossRef
Analysis of polymorphic region of GAM-1 gene in Plasmodium vivax Korean isolates
Weon-Gyu Kho, Joon-Yong Chung, Ui-Wook Hwang, Jin-Ho Chun, Yeong-Hong Park, Woo-Chul Chung
The Korean Journal of Parasitology.2001; 39(4): 313. CrossRef

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Brief Communication

The 10 kDa protein of Taenia solium metacestodes shows genus specific antigenicity: Seung-Kyu Park, Doo-Hee Yun, Joon-Yong Chung, Yoon Kong, Seung-Yull Cho; Korean J Parasitol 2000;38(3):191-194.
Published online September 30, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.3.191

Abstract
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Genus specific antigenicity of the 10 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was demonstrated by comparative immunoblot analysis. When CFs from taeniid metacestodes of T. saginata, T. solium, T. taeniaeformis and T. crassiceps were probed with specific monoclonal antibody (mAb) raised against 150 kDa protein of T. solium metacestodes, specific antibody reactions were observed in 7 and 10 kDa proteins of T. solium and in 7/8 kDa of T. saginata, T. taeniaeformis and T. crassiceps. The mAb did not react with any protein in hydatid fluid of Echinococcus granulosus and E. multilocularis. This result revealed that the 10 kDa peptide of T. solium metacestodes and its equivalent proteins of different Taenia metacestodes are genus specific antigens that are shared among different Taenia species.

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Original Article

Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea: Weon-Gyu Kho, Yeong-Hong Park, Joon-Yong Chung, Jong-Pil Kim, Sung-Tae Hong, Won-Ja Lee, Tong-Soo Kim, Jong-Soo Lee; Korean J Parasitol 1999;37(4):265-270.
Published online December 31, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.4.265

Abstract
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The gene encoding Plasmodium vivax circumsporozoite protein (PvCSP) exhibits polymorphism in many geographical isolates. The present study was designed to investigate polymorphism in PvCSP gene of P. vivax isolates in Korea. Thirty isolates, obtained from indigenous cases in Yonchon-gun, Kyonggi-do in 1997, were subjected for sequencing and RFLP analysis of the repeat and post-repeat regions of PvCSP gene and two genotypes (SK-A and SK-B) were identified. The genotype of 19 isolates was SK-A and that of 11 isolates was SK-B. Although the number of 12-base repeats present in SK-A was three while two were found in a Chinese strain CH-5, the repeat sequence of SK-A was identical to that of CH-5 except for one base substitution. Compared with known data there was no identical isolates with SK-B, but the sequence of SK-B was similar to that of a North Korean (NK) isolate. These results indicate that two genotypes of PvCSP coexist in the present epidemic area of Korea and the present parasite may originate from East Asia. RFLP would be useful to classify genotypes of P. vivax population instead of gene sequencing.

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