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"paragonimiasis"

Case Reports

Cerebral Paragonimiasis Presenting with Dementia
Seok Woo Moon, Taeho Kim
Korean J Parasitol 2022;60(5):353-355.
Published online October 21, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.5.353
We report a case of an 80-year-old Korean man with chronic cerebral paragonimiasis who presented with progressive memory impairment. He suffered from pulmonary paragonimiasis 60 years ago and has been experiencing epilepsy since the age of 45. He began experiencing memory and cognitive deterioration 3 years ago. He visited the neuropsychiatric department of our hospital to check his symptoms and health from a year ago. Contrast-enhanced brain magnetic resonance imaging study revealed calcifications and cystic lesions encompassing the right temporo-occipital region. Encephalomalatic changes were also observed in the right occipital and temporal areas. The anti-Paragonimus specific IgG antibodies in his serum showed a strong positive response. The neuropsychological test results showed a Global Deterioration Scale of 4 and a Clinical Dementia Rating Scale of 1. The chronic cerebral paragonimiasis lesions in the patient’s right temporo-occipital region might induce the dementic change.

Citations

Citations to this article as recorded by  Crossref logo
  • A comprehensive review on the neurological impact of parasitic infections
    Firooz Shahrivar, Ata Moghimi, Ramin Hosseinzadeh, Mohammad Hasan Kohansal, Ali Mortazavi, Tahereh Mikaeili Galeh, Ehsan Ahmadpour
    Microbial Pathogenesis.2025; 206: 107762.     CrossRef
  • Answer to April 2024 Photo Quiz
    Alfredo Maldonado-Barrueco, Sol María San José-Villar, Julio García-Rodríguez, Marina Alguacil-Guillén, Álvaro López-Janeiro, Elena Trigo-Esteban, Marta Díaz-Menéndez, Guillermo Ruiz-Carrascoso, Bobbi S. Pritt
    Journal of Clinical Microbiology.2024;[Epub]     CrossRef
  • 3,432 View
  • 120 Download
  • 2 Web of Science
  • Crossref
Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report
Teera Kusolsuk, Orawan Phuphisut, Wanna Maipanich, Somchit Pubampen, Surapol Sa-nguankiat, Akkarin Poodeepiyasawat, Nirundorn Homsuwan, Srisuchart Mongkolmoo, Tippayarat Yoonuan, Poom Adisakwattana, Udomsak Silachamroon, Yukifumi Nawa
Korean J Parasitol 2020;58(1):57-60.
Published online February 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.1.57
During the mobile clinic activities in Tak Province, Thailand, Paragonimus sp. eggs were found in a fecal sample of a 72-year-old Karen resident. Paragonimus DNA was amplified from the stool sample and identified to P. heterotremus. The patient did not have any symptoms. Apparent pulmonary lesion was not found on the chest X-ray. The patient admitted habitual consumption of semi-cooked or roasted waterfall crabs for several years. The waterfall crabs collected from stream near the village were found negative for Paragonimus metacercariae. In northern Thailand, paragonimiasis remains as one of the public health concerns and should be ruled out for asymptomatic pulmonary patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Lung flukes of the genusParagonimus: ancient and re-emerging pathogens
    David Blair
    Parasitology.2022; 149(10): 1286.     CrossRef
  • 6,465 View
  • 132 Download
  • 1 Web of Science
  • Crossref
A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
Korean J Parasitol 2017;55(3):313-317.
Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.313
Paragonimiasis is a parasitic disease caused by Paragnonimus species. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with Paragonimus westermani, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Ectopic paragonimiasis raises diagnostic challenge since it is uncommon and may be confused with malignancy or other inflammatory diseases. Here, we report an ectopic paragonimiasis case initially presented with recurrent abdominal pain. The patient developed abdominal pain 3 times for the previous 3 years and the computed tomography (CT) of the abdomen revealed fluid collection with wall enhancement. Recurrent diverticulitis was initially suspected and part of the ascending colon was resected. However, the specimen showed intact colon wall without evidence of diverticulitis and multiple parasite eggs and granulomas were found instead. The size of about 70 μm, the presence of an operculum and relatively thick egg shell suggested eggs of Paragonimus species. With appropriate exposure history and a positive antibody test, the definitive diagnosis was made as peritoneal paragonimiasis.

Citations

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  • A case report of Paragonimus infection diagnosed by medicine thoracoscopy
    Xia Wu, Zhengfu Li, Dan Yang, Zhangli Peng, Nana Li, Yuanbo Lan, Ling Chen
    Infection, Genetics and Evolution.2025; 134: 105791.     CrossRef
  • Intra-abdominal paragonimiasis presenting as abscesses: A case report
    Haidong Zhang, Mingchun Mu, Xin He, Yuan Yin
    Asian Journal of Surgery.2023; 46(2): 1004.     CrossRef
  • Crustaceans (shrimp, crab, and lobster): A comprehensive review of their potential health hazards and detection methods to assure their biosafety
    Mohamed A. Farag, Somaia T. Mansour, Roua A. Nouh, Amira R. Khattab
    Journal of Food Safety.2023;[Epub]     CrossRef
  • Intra-abdominal paragonimiasis abscess: A note on rare recurrent acute abdomen disease
    Pathum Sookaromdee, Viroj Wiwanitkit
    Formosan Journal of Surgery.2023; 56(6): 200.     CrossRef
  • A case of paragonimiasis inducing bilateral pneumothorax with lung and liver involvement
    Ji Sung Ha, Jang Young Lee, Won Young Sung, Sang Won Seo, Won Suk Lee
    Asian Cardiovascular and Thoracic Annals.2022; 30(3): 339.     CrossRef
  • Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis: A care report
    Jung Woo Choi, Chang Min Lee, Seong Je Kim, Se In Hah, Ji Yoon Kwak, Hyun Chin Cho, Chang Yoon Ha, Woon Tae Jung, Ok Jae Lee
    World Journal of Clinical Cases.2022; 10(16): 5359.     CrossRef
  • General overview of the current status of human foodborne trematodiasis
    Jong-Yil Chai, Bong-Kwang Jung
    Parasitology.2022; 149(10): 1262.     CrossRef
  • One delayed diagnosis of paragonimiasis case and literature review
    Luxia Kong, Lijuan Hua, Qian Liu, Chen Bao, Jiannan Hu, Shuyun Xu
    Respirology Case Reports.2021;[Epub]     CrossRef
  • Laparoscopic excision for ectopic peritoneal paragonimiasis mimicking a gastric duplication cyst: A case report
    Chul Kyu Roh, Min Jung Jung
    Annals of Medicine and Surgery.2021; 69: 102754.     CrossRef
  • A case of group infections with Paraginimus species in Henan, Central China
    Wei-qi Chen, Yan Deng, Ya-lan Zhang, Lin Ai, Jia-xu Chen, Xi-meng Lin, Xiao-bo Du, Peng Li, Rui-min Zhou, Cheng-yun Yang, Ying Liu, Hong-wei Zhang, Bian-li Xu, Yu-ling Zhao
    Acta Tropica.2020; 202: 105111.     CrossRef
  • Paragonimus westermani infection manifesting as a pulmonary cavity and adrenal gland mass: A case report
    Yong Shik Kwon, Hye Won Lee, Hyun Jung Kim
    Journal of Infection and Chemotherapy.2019; 25(3): 200.     CrossRef
  • A Paragonimiasis Mimicking Gastric Submucosal Tumor
    Hyeri Seok, Tae Sung Sohn, Kyong Ran Peck
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Simultaneous Paragonimus infection involving the breast and lung: A case report
    Moon Young Oh, Ajung Chu, Jeong Hwan Park, Jong Yoon Lee, Eun Youn Roh, Young Jun Chai, Ki-Tae Hwang
    World Journal of Clinical Cases.2019; 7(24): 4292.     CrossRef
  • 10,304 View
  • 208 Download
  • 13 Web of Science
  • Crossref

Brief Communications

To determine the cause of death of prisoners of war during the Korean War (1950-1953), death certificates or medical records were analyzed. Out of 7,614 deaths, 5,013 (65.8%) were due to infectious diseases. Although dysentery and tuberculosis were the most common infectious diseases, parasitic diseases had caused 14 deaths: paragonimiasis in 5, malaria in 3, amoebiasis in 2, intestinal parasitosis in 2, ascariasis in 1, and schistosomiasis in 1. These results showed that paragonimiasis, malaria, and amoebiasis were the most fatal parasitic diseases during the early 1950s in the Korean Peninsula. Since schistosomiasis is not endemic to Korea, it is likely that the infected private soldier moved from China or Japan to Korea.

Citations

Citations to this article as recorded by  Crossref logo
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Strongyloides stercoralis infection in the UK: A systematic review and meta-analysis of published cases
    Ali M. Alam, Cansu Ozdemir, Nada Reza
    Clinical Medicine.2024; 24(4): 100227.     CrossRef
  • Schistosomiasis in the Military—A Narrative Review
    Diana Isabela Costescu Strachinaru, Jemima Nyaboke Nyandwaro, Anke Stoefs, Eric Dooms, Peter Vanbrabant, Pierre-Michel François, Mihai Strachinaru, Marjan Van Esbroeck, Emmanuel Bottieau, Patrick Soentjens
    Tropical Medicine and Infectious Disease.2024; 9(9): 221.     CrossRef
  • Case Report of Urinary Schistosomiasis in a Returned Traveler in Korea
    Yangkyu Lee, Hyun Beom Song, Bong-Kwang Jung, Gheeyoung Choe, Min-Ho Choi
    The Korean Journal of Parasitology.2020; 58(1): 51.     CrossRef
  • 8,323 View
  • 97 Download
  • 4 Web of Science
  • Crossref
Evaluation of IgG4 Subclass Antibody Detection by Peptide-Based ELISA for the Diagnosis of Human Paragonimiasis Heterotrema
Pewpan M. Intapan, Oranuch Sanpool, Penchom Janwan, Porntip Laummaunwai, Nimit Morakote, Yoon Kong, Wanchai Maleewong
Korean J Parasitol 2013;51(6):763-766.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.763

A synthetic peptide was prepared based on the antigenic region of Paragonimus westermani pre-procathepsin L, and its applicability for immunodiagnosis for human paragonimiasis (due to Paragonimus heterotremus) was tested using an ELISA to detect IgG4 antibodies in the sera of patients. Sera from other helminthiases, tuberculosis, and healthy volunteers were used as the references. This peptide-based assay system gave sensitivity, specificity, accuracy, and positive and negative predictive values of 100%, 94.6%, 96.2%, 100%, and 88.9%, respectively. Cross reactivity was frequently seen against the sera of fascioliasis (75%) and hookworm infections (50%). Since differential diagnosis between paragonimiasis and fascioliasis can be easily done by clinical presentation and fascioliasis serology, this cross reaction is not a serious problem. Sera from patients with other parasitoses (0-25%) rarely responded to this synthetic antigen. This synthetic peptide antigen seems to be useful for development of a standardized diagnostic system for paragonimiasis.

Citations

Citations to this article as recorded by  Crossref logo
  • An immunochromatographic test using whole blood for rapid diagnosis of human paragonimiasis and its diagnostic usefulness
    Patcharaporn Boonroumkaew, Lakkhana Sadaow, Penchom Janwan, Rutchanee Rodpai, Oranuch Sanpool, Tongjit Thanchomnang, Hiroshi Yamasaki, Pewpan M. Intapan, Wanchai Maleewong
    Food and Waterborne Parasitology.2024; 37: e00246.     CrossRef
  • Development of point-of-care testing tool using immunochromatography for rapid diagnosis of human paragonimiasis
    Lakkhana Sadaow, Oranuch Sanpool, Hiroshi Yamasaki, Wanchai Maleewong, Pewpan M. Intapan
    Acta Tropica.2020; 203: 105325.     CrossRef
  • Paragonimus and paragonimiasis in Asia: An update
    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
  • A Case of Pulmonary Paragonimiasis with Chronic Abdominal Pain and Erythematous Rash in a 6-year-old Girl
    Ju Young Kim, Min Kyu Park, Yong Ju Lee, Sun Huh, Ky Young Cho
    Pediatric Infection and Vaccine.2018; 25(1): 54.     CrossRef
  • A tool for mass-screening of paragonimiasis: an enzyme-linked immunosorbent assay with urine samples
    Xu Guang Qiu, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Makoto Itoh
    Tropical Medicine and Health.2016;[Epub]     CrossRef
  • Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani
    Chun-Seob Ahn, Byoung-Kuk Na, Dong-ll Chung, Jeong-Geun Kim, Jin-Taek Kim, Yoon Kong
    Parasitology International.2015; 64(1): 37.     CrossRef
  • North American paragonimiasis: epidemiology and diagnostic strategies
    Peter U Fischer, Gary J Weil
    Expert Review of Anti-infective Therapy.2015; 13(6): 779.     CrossRef
  • 8,812 View
  • 109 Download
  • Crossref

Mini Review

Paragonimus and Paragonimiasis in Vietnam: an Update
Pham Ngoc Doanh, Yoichiro Horii, Yukifumi Nawa
Korean J Parasitol 2013;51(6):621-627.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.621

Paragonimiasis is a food-borne parasitic zoonosis caused by infection with lung flukes of the genus Paragonimus. In Vietnam, research on Paragonimus and paragonimiasis has been conducted in northern and central regions of the country. Using a combination of morphological and molecular methods, 7 Paragonimus species, namely P. heterotremus, P. westermani, P. skrjabini, P. vietnamensis, P. proliferus, P. bangkokenis and P. harinasutai, have been identified in Vietnam. Of these, the first 3, P. heterotremus, P. westermani and P. skrjabini, are known to infect humans in other countries. However, in Vietnam, only P. heterotremus, found in some northern provinces, has been shown to infect humans. Even nowadays, local people in some northern provinces, such as Lai Chau and Yen Bai, are still suffering from P. heterotremus infection. In some provinces of central Vietnam, the prevalence and infection intensity of P. westermani metacercariae in freshwater crabs (the second intermediate hosts) are extremely high, but human cases have not been reported. Likewise, although P. skrjabini was found in Thanh Hoa Province, its pathogenicity to humans in Vietnam still remains uncertain. The results of molecular phylogenetic analyses of Vietnamese Paragonimus species provides new insights on the phylogeny and taxonomy of the genus Paragonimus. Comprehensive molecular epidemiological and geobiological studies on the genus in Vietnam and adjacent countries are needed to clarify the biodiversity and public health significance of the lung flukes.

Citations

Citations to this article as recorded by  Crossref logo
  • Paragonimiasis in Southeast Asia: A 60-Year Bibliometric Analysis (1963–2023)
    Harley M. Rodriguez, Jose Ma. M. Angeles
    Acta Parasitologica.2025;[Epub]     CrossRef
  • An overview of human helminthioses in Vietnam: Their prevention, control and lessons learnt
    Hung Manh Nguyen, Dung Trung Do, Stephen E. Greiman, Ha Van Nguyen, Hien Van Hoang, Toan Quoc Phan, Phuc Pham-Duc, Henry Madsen
    Acta Tropica.2023; 238: 106753.     CrossRef
  • Lung flukes of the genusParagonimus: ancient and re-emerging pathogens
    David Blair
    Parasitology.2022; 149(10): 1286.     CrossRef
  • General overview of the current status of human foodborne trematodiasis
    Jong-Yil Chai, Bong-Kwang Jung
    Parasitology.2022; 149(10): 1262.     CrossRef
  • Spectrum of pleuropulmonary paragonimiasis: An analysis of 685 cases diagnosed over 22 years
    Chun-Seob Ahn, Jong Wook Shin, Jeong-Geun Kim, Weon-Young Lee, Insug Kang, Jung-Gi Im, Yoon Kong
    Journal of Infection.2021; 82(1): 150.     CrossRef
  • Pleural lump after paragonimiasis treated by thoracoscopy: A case report
    Yue Xie, Ya-Rui Luo, Meng Chen, Yi-Min Xie, Chen-Yu Sun, Qiang Chen
    World Journal of Clinical Cases.2021; 9(3): 666.     CrossRef
  • Paragonimus and its hosts in China: An update
    Xiao-Juan Zhou, Qian Yang, Qi-Hong Tan, Li-Yanyang Zhang, Lin-Bo Shi, Jie-Xin Zou
    Acta Tropica.2021; 223: 106094.     CrossRef
  • Paragonimiasis (invasion by pulmonary flukes)
    S. B. Chuelov, A. L. Rossina
    CHILDREN INFECTIONS.2021; 20(3): 48.     CrossRef
  • Molecular identification of morphologically similar microcercous cercariae of two trematode families, Paragonimidae and Troglotrematidae, concurrently found in the same snail species of the subfamily Triculinae
    Pham Ngoc Doanh, Hoang Van Hien, Bui Thi Dung
    Folia Parasitologica.2020;[Epub]     CrossRef
  • Paragonimiasis: A missed diagnosis from Nepal
    Shreya Shrivastav, Anamika Jha
    Respiratory Medicine Case Reports.2020; 31: 101298.     CrossRef
  • Paragonimus and paragonimiasis in Asia: An update
    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
  • Simultaneous Paragonimus infection involving the breast and lung: A case report
    Moon Young Oh, Ajung Chu, Jeong Hwan Park, Jong Yoon Lee, Eun Youn Roh, Young Jun Chai, Ki-Tae Hwang
    World Journal of Clinical Cases.2019; 7(24): 4292.     CrossRef
  • Morphological and molecular characterization of Paragonimus caliensis Little, 1968 (Trematoda: Paragonimidae) from Medellin and Pichinde, Colombia
    Carolina Lenis, Alicia Galiano, Imelda Vélez, Iván Darío Vélez, Carlos Muskus, Antonio Marcilla
    Acta Tropica.2018; 183: 95.     CrossRef
  • First intermediate hosts of Paragonimus spp. in Vietnam and identification of intramolluscan stages of different Paragonimus species
    Pham Ngoc Doanh, Luu Anh Tu, Hoang Van Hien, Nguyen Van Duc, Yoichiro Horii, David Blair, Yukifumi Nawa
    Parasites & Vectors.2018;[Epub]     CrossRef
  • A Case of Pulmonary Paragonimiasis with Chronic Abdominal Pain and Erythematous Rash in a 6-year-old Girl
    Ju Young Kim, Min Kyu Park, Yong Ju Lee, Sun Huh, Ky Young Cho
    Pediatric Infection and Vaccine.2018; 25(1): 54.     CrossRef
  • Development of an immunodiagnosis method using recombinant PsCP for detection of Paragonimus skrjabini infection in human
    Shasha Yu, Xilin Zhang, Wenbi Chen, Hong Zheng, Guoping Ai, Nan Ye, Ying Wang
    Parasitology Research.2017; 116(1): 377.     CrossRef
  • Molecular identification of the trematode Paragonimus in faecal samples from the wild cat Prionailurus bengalensis in the Da Krong Nature Reserve, Vietnam
    P.N. Doanh, H.V. Hien, L.A. Tu, N. Nonaka, Y. Horii, Y. Nawa
    Journal of Helminthology.2016; 90(6): 658.     CrossRef
  • Molecular and morphological variation of Paragonimus westermani in Vietnam with records of new second intermediate crab hosts and a new locality in a northern province
    N. PHAM DOANH, A. LUU TU, T. DUNG BUI, T. HO LOAN, NARIAKI NONAKA, YOICHIRO HORII, DAVID BLAIR, YUKIFUMI NAWA
    Parasitology.2016; 143(12): 1639.     CrossRef
  • A tool for mass-screening of paragonimiasis: an enzyme-linked immunosorbent assay with urine samples
    Xu Guang Qiu, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Makoto Itoh
    Tropical Medicine and Health.2016;[Epub]     CrossRef
  • 15,900 View
  • 219 Download
  • Crossref

Case Reports

Paragonimiasis in the Abdominal Cavity and Subcutaneous Tissue: Report of 3 Cases
Chang Ho Lee, Jong Hun Kim, Woo Sung Moon, Min Ro Lee
Korean J Parasitol 2012;50(4):345-347.
Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.345

Paragonimiasis is a parasitic disease caused by the lung fluke, Paragonimus spp. Lung flukes may be found in various organs, such as the brain, peritoneum, subcutaneous tissues, and retroperitoneum, other than the lungs. Abdominal paragonimiasis raises a considerable diagnostic challenge to clinicians, because it is uncommon and may be confused with other abdominopelvic inflammatory diseases, particularly peritoneal tuberculosis, and peritoneal carcinomatosis. Also, subcutaneous paragonimiasis does not easily bring up clinical suspicion, due to its rarity. We herein report 2 cases of abdominal paragonimiasis and 1 case of subcutaneous paragonimiasis in Korea.

Citations

Citations to this article as recorded by  Crossref logo
  • Survival and infectivity of Paragonimus westermani Metacercariae in soy sauce–marinated crayfish
    Eun-Min Kim, Yan Jin, Sung-Tae Hong
    Food and Waterborne Parasitology.2025; 40: e00277.     CrossRef
  • Pulmonary, liver and cerebral paragonimiasis: An unusual clinical case in Colombia
    Angel O. Donato-R., Jhon C. Donato-R.
    Travel Medicine and Infectious Disease.2022; 46: 102253.     CrossRef
  • Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis: A care report
    Jung Woo Choi, Chang Min Lee, Seong Je Kim, Se In Hah, Ji Yoon Kwak, Hyun Chin Cho, Chang Yoon Ha, Woon Tae Jung, Ok Jae Lee
    World Journal of Clinical Cases.2022; 10(16): 5359.     CrossRef
  • Intraspinal Paragonimiasis in Children: MRI Findings and Suggestions for Pathogenesis
    Y. Qin, J. Cai, W. Ji, X. Chen, L. Tian, S. Jun, L. Wang, X. He
    American Journal of Neuroradiology.2019;[Epub]     CrossRef
  • Simultaneous Paragonimus infection involving the breast and lung: A case report
    Moon Young Oh, Ajung Chu, Jeong Hwan Park, Jong Yoon Lee, Eun Youn Roh, Young Jun Chai, Ki-Tae Hwang
    World Journal of Clinical Cases.2019; 7(24): 4292.     CrossRef
  • Inactivation of Paragonimus westermani metacercariae in soy sauce-marinated and frozen freshwater crabs
    Tae Im Kim, Se-Ra Oh, Fuhong Dai, Hyun-Jong Yang, Sang-Do Ha, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 1003.     CrossRef
  • Paragonimiasis in Children in Southwest China
    Zongrong Gong, Ruixue Miao, Min Shu, Yu Zhu, Yang Wen, Qin Guo, Qiong Liao, Chaomin Wan
    Medicine.2017; 96(25): e7265.     CrossRef
  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
  • A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
    Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
    The Korean Journal of Parasitology.2017; 55(3): 313.     CrossRef
  • Hepatic paragonimiasis in a 15-month-old girl: a case report
    Zongrong Gong, Zhicheng Xu, Chuanfen Lei, Chaomin Wan
    BMC Pediatrics.2017;[Epub]     CrossRef
  • Distinct MDCT imaging features to differential diagnosis of hepatic paragonimiasis and small hepatocellular carcinoma
    Sheng Zhang, Si-Ming Xie, Yong-Hua Chen, Xu-Bao Liu, Gang Mai
    Oncotarget.2017; 8(23): 37291.     CrossRef
  • A Case of Intra-abdominal Paragonimiasis Mimicking Metastasis of Lung Cancer Diagnosed by Endoscopic Ultrasound-guided Fine Needle Aspiration
    Cho Rong Oh, Mi-Jin Kim, Kwang Hyuck Lee
    The Korean Journal of Gastroenterology.2015; 66(1): 41.     CrossRef
  • Pancreatic paragonimiasis mimics pancreatic cystic-solid tumor – A case report
    Xiaodong Yang, Mingqing Xu, Yang Wu, Bo Xiang
    Pancreatology.2015; 15(5): 576.     CrossRef
  • Cutaneous paragonimiasis due to triploid Paragonimus westermani presenting as a non-migratory subcutaneous nodule: a case report
    Makoto Kodama, Mayumi Akaki, Hiroyuki Tanaka, Haruhiko Maruyama, Eiji Nagayasu, Tetsuhiro Yokouchi, Yasuji Arimura, Hiroaki Kataoka
    Journal of Medical Case Reports.2014;[Epub]     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
  • Paragonimiasis: A Pictorial Essay
    Kyung Nyeo Jeon, Mi Jung Park, Kyungsoo Bae, Hae Young Choi, Ho Cheol Choi, Jae Boem Na, Dae Seob Choi, Ho Cheol Kim, In Seok Jang, Dong Chul Kim
    Journal of the Korean Society of Radiology.2013; 69(5): 365.     CrossRef
  • 8,770 View
  • 109 Download
  • Crossref
A Case of Pulmonary Paragonimiasis with Involvement of the Abdominal Muscle in a 9-Year-Old Girl
Ah-Rum Cho, Hae-Ran Lee, Kwan-Sub Lee, Sang-Eun Lee, So-Yeon Lee
Korean J Parasitol 2011;49(4):409-412.
Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.409

In Korea, many people enjoy eating raw or underkooked freshwater crayfish and crabs which unfortunately may cause paragonimiasis. Here, we describe a case of pulmonary and abdominal paragonimiasis in a 9-year-old girl, who presented with a 1-month history of abdominal pain, especially in the right flank and the right inguinal area, with anorexia. A chest radiograph revealed pleural effusion in both lungs, and her abdominal sonography indicated an inflammatory lesion in the right psoas muscle. Peripheral blood analysis of the patient showed hypereosinophilia (66.0%) and an elevated total serum IgE level (>2,500 IU/ml). The pleural effusion tested by ELISA were also positive for antibodies against paragonimiasis. Her dietary history stated that she had ingested raw freshwater crab, 4 months previously. The diagnosis was pulmonary paragonimiasis accompanied by abdominal muscle involvement. She was improved after 5 cycles of praziquantel treatment and 2 times of pleural effusion drainage. In conclusion, herein, we report a case of pulmonary and abdominal paragonimiasis in a girl who presented with abdominal pain and tenderness in the inguinal area.

Citations

Citations to this article as recorded by  Crossref logo
  • Pulmonary, liver and cerebral paragonimiasis: An unusual clinical case in Colombia
    Angel O. Donato-R., Jhon C. Donato-R.
    Travel Medicine and Infectious Disease.2022; 46: 102253.     CrossRef
  • A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children’s hospital from 2011 to 2019
    Manning Qian, Fei Li, Yuhan Zhang, Zhongwei Qiao, Yingyan Shi, Jun Shen
    Scientific Reports.2021;[Epub]     CrossRef
  • Inactivation of Paragonimus westermani metacercariae in soy sauce-marinated and frozen freshwater crabs
    Tae Im Kim, Se-Ra Oh, Fuhong Dai, Hyun-Jong Yang, Sang-Do Ha, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 1003.     CrossRef
  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
  • Rare case of paragonimiasis with involvement of the parotid gland alone in a 5-year-old boy
    Yiping Pu, Chuangqi Yu, Chi Yang
    British Journal of Oral and Maxillofacial Surgery.2013; 51(8): e299.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
  • Paragonimiasis in the Abdominal Cavity and Subcutaneous Tissue: Report of 3 Cases
    Chang Ho Lee, Jong Hun Kim, Woo Sung Moon, Min Ro Lee
    The Korean Journal of Parasitology.2012; 50(4): 345.     CrossRef
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A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel
Sun Young Kyung, Yong Kyun Cho, Yu Jin Kim, Jeong-Woong Park, Sung Hwan Jeong, Jae-Ik Lee, Yon Mi Sung, Sang Pyo Lee
Korean J Parasitol 2011;49(1):73-77.
Published online March 18, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.1.73

Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.

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    The American Journal of Tropical Medicine and Hygiene.2019; 100(3): 700.     CrossRef
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    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
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  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
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    Trupti A. Patel, Robin L. Bailey, Joanna Lukawska, Jennifer Rowe
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    Jong-Yil Chai
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    Jung-Min Lee, Hyun-Sul Lim, Sung-Tae Hong
    The Korean Journal of Parasitology.2011; 49(3): 273.     CrossRef
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A Pulmonary Paragonimiasis Case Mimicking Metastatic Pulmonary Tumor
Ki Uk Kim, Kwangha Lee, Hye-Kyung Park, Yeon Joo Jeong, Hak Sun Yu, Min Ki Lee
Korean J Parasitol 2011;49(1):69-72.
Published online March 18, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.1.69

Pulmonary paragonimiasis is a relatively rare cause of lung disease revealing a wide variety of radiologic findings, such as air-space consolidation, nodules, and cysts. We describe here a case of pulmonary paragonimiasis in a 27-year-old woman who presented with a 2-month history of cough and sputum. Based on chest computed tomography (CT) scans and fluorodeoxyglucose positron emission tomography (FDG-PET) findings, the patient was suspected to have a metastatic lung tumor. However, she was diagnosed as having Paragonimus westermani infection by an immunoserological examination using ELISA. Follow-up chest X-ray and CT scans after chemotherapy with praziquantel showed an obvious improvement. There have been several reported cases of pulmonary paragonimiasis mimicking lung tumors on FDG-PET. However, all of them were suspected as primary lung tumors. To our knowledge, this patient represents the first case of paragonimiasis mimicking metastatic lung disease on FDG-PET CT imaging.

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    Journal of Medical Case Reports.2025;[Epub]     CrossRef
  • Dynamic Computed Tomography for detecting pulmonary cysts in canine Paragonimiasis: a case report
    Shinya MIZUTANI, Yuko MIZUTANI, Yoshimichi GODA, Hiroyuki SATOH, Taketoshi ASANUMA, Ayako YOSHIDA, Shidow TORISU
    Journal of Veterinary Medical Science.2025; 87(9): 986.     CrossRef
  • A clinical mimicry of malignancies in patients diagnosed with paragonimiasis
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  • Pulmonary, liver and cerebral paragonimiasis: An unusual clinical case in Colombia
    Angel O. Donato-R., Jhon C. Donato-R.
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    Tomography.2022; 8(3): 1493.     CrossRef
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    Luxia Kong, Lijuan Hua, Qian Liu, Chen Bao, Jiannan Hu, Shuyun Xu
    Respirology Case Reports.2021;[Epub]     CrossRef
  • Pulmonary larval paragonimiasis mimicking lung cancer
    V. V. Ermilov, A. V. Smirnov, G. L. Snigur, R. S. Dudin, S. S. Popov
    Arkhiv patologii.2018; 80(2): 60.     CrossRef
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    Mihir S. Parikh, Eric Seeley, Ganesh Krishna
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  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
  • A 15-Year Old Burmese Girl With Hemoptysis: A Case Report
    Charlie McLeod, Daniel Yeoh, Cameron Truarn, Christopher C Blyth, Asha C Bowen, Tom L Snelling, Ushma Wadia, Briony Hazelton, Michelle Porter
    Open Forum Infectious Diseases.2017;[Epub]     CrossRef
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    Su Eun Park, Bokyung Song, Jae-Yeon Hwang
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  • Imaging findings of Paragonimus westermani
    Shambhu Kumar Sah, Silin Du, Yi Liu, Ping Yin, Oormila Ganganah, Manu Chiniah, Pranesh Kumar Yadav, You You Guo, Yongmei Li
    Radiology of Infectious Diseases.2016; 3(2): 66.     CrossRef
  • A Case of Intra-abdominal Paragonimiasis Mimicking Metastasis of Lung Cancer Diagnosed by Endoscopic Ultrasound-guided Fine Needle Aspiration
    Cho Rong Oh, Mi-Jin Kim, Kwang Hyuck Lee
    The Korean Journal of Gastroenterology.2015; 66(1): 41.     CrossRef
  • A Case of Delayed Diagnosis of Pulmonary Paragonimiasis due to Improvement after Anti-tuberculosis Therapy
    Suhyeon Lee, Yeonsil Yu, Jinyoung An, Jeongmin Lee, Jin-Sung Son, Young Kyung Lee, Sookhee Song, Hyeok Kim, Suhyun Kim
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    Charuwan Tantipalakorn, Surapan Khunamornpong, Theera Tongsong
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  • A Case of Pulmonary Paragonimiasis Mimicking Lung Cancer Diagnosed by EBUS-TBNA
    Jae June Lee, Chang Min Choi, Hwuk Hee Kwon, Min Soo Kim, Joon-Seok Kim, So Young Park, Hee Sang Hwang
    Korean Journal of Medicine.2013; 84(3): 423.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
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    Travis S. Henry, Michael A. Lane, Gary J. Weil, Thomas C. Bailey, Sanjeev Bhalla
    American Journal of Roentgenology.2012; 198(5): 1076.     CrossRef
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Three Cases of Paragonimiasis in a Family
Byeong Seok Sohn, Yun-Jeong Bae, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
Korean J Parasitol 2009;47(3):281-285.
Published online August 28, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.3.281

Paragonimiasis typically results from the consumption of raw or improperly cooked crustacea, especially crabs and crayfish. Although previously endemic in Korea, the prevalence of this disease decreased in the early 1970s because of educational campaigns and fewer intermediate hosts as a result of ecological changes. Recently, we were presented with a family where all members were infected with Paragonimus after ingestion of Kejang (= drunken crab). The mother was hospitalized for general myalgia and weakness first, followed by the father, who was hospitalized for dyspnea 2 month later. After the parents were diagnosed with paragonimiasis, we recommended their daughter to visit our hospital for a checkup, because they all had eaten freshwater crabs soaked in soybean sauce. She complained of generalized myalgia, fever, and pleuritic pain, and was also diagnosed with paragonimiasis. Peripheral blood of the 3 patients revealed hypereosinophilia, and computed tomography (CT) scans of their chests showed pleural effusion. The results of antibody tests by ELISA were positive for paragonimiasis. We report here the case series of familial paragonimiasis in a modern urban city, rather than in a typical endemic area.

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  • A Cluster of Paragonimiasis with Delayed Diagnosis Due to Difficulty Distinguishing Symptoms from Post-COVID-19 Respiratory Symptoms: A Report of Five Cases
    Jun Sasaki, Masanobu Matsuoka, Takashi Kinoshita, Takayuki Horii, Shingo Tsuneyoshi, Daiki Murata, Reiko Takaki, Masaki Tominaga, Mio Tanaka, Haruhiko Maruyama, Tomotaka Kawayama, Tomoaki Hoshino
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    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
  • Inactivation of Paragonimus westermani metacercariae in soy sauce-marinated and frozen freshwater crabs
    Tae Im Kim, Se-Ra Oh, Fuhong Dai, Hyun-Jong Yang, Sang-Do Ha, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 1003.     CrossRef
  • Paragonimiasis in Children in Southwest China
    Zongrong Gong, Ruixue Miao, Min Shu, Yu Zhu, Yang Wen, Qin Guo, Qiong Liao, Chaomin Wan
    Medicine.2017; 96(25): e7265.     CrossRef
  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
  • A Case of Ectopic Paragonimiasis in a 17th Century Korean Mummy
    D. H. Shin, Y.-S. Kim, D. S. Yoo, M. J. Kim, C. S. Oh, J. H. Hong, E. Lee, J. Y. Chai, M. Seo
    Journal of Parasitology.2017; 103(4): 399.     CrossRef
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  • Ectopic paragonimiasis from 400-year-old female mummy of Korea
    Dong Hoon Shin, Chang Seok Oh, Sang Jun Lee, Eun-Joo Lee, Se Gwon Yim, Myeung Ju Kim, Yi-Suk Kim, Soong Deok Lee, Yong Seok Lee, Hye Jung Lee, Min Seo
    Journal of Archaeological Science.2012; 39(4): 1103.     CrossRef
  • Consecutive extrapulmonary paragonimiasis involving liver and colon
    Chang Wook PARK, Woo Jin CHUNG, Young Lan KWON, Yong Jin KIM, Eun Soo KIM, Byung Kuk JANG, Kyung Sik PARK, Kwang Bum CHO, Jae Seok HWANG, Jung Hyuk KWON
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  • Characterization of MicroRNAs in Paragonimus westermani by Solexa Deep Sequencing and Bioinformatics Analysis
    L. Ai, M.X. Chen, S.H. Chen, Y.N. Zhang, H. Li, Y.C. Cai, Y. Lu, L.G. Tian, X.N. Zhou, J.X. Chen
    Journal of Animal and Veterinary Advances.2012; 11(18): 3469.     CrossRef
  • Sensitive and rapid detection of Paragonimus westermani infection in humans and animals by loop-mediated isothermal amplification (LAMP)
    M. X. Chen, L. Ai, R. L. Zhang, J. J. Xia, K. Wang, S. H. Chen, Y. N. Zhang, M. J. Xu, X. Li, X. Q. Zhu, J. X. Chen
    Parasitology Research.2011; 108(5): 1193.     CrossRef
  • A Case of Pulmonary Paragonimiasis with Involvement of the Abdominal Muscle in a 9-Year-Old Girl
    Ah-Rum Cho, Hae-Ran Lee, Kwan-Sub Lee, Sang-Eun Lee, So-Yeon Lee
    The Korean Journal of Parasitology.2011; 49(4): 409.     CrossRef
  • Prevalence of Paragonimus and Angiostrongylus cantonensis Infections in Snails in Southeastern China
    Y.Z. Cheng, J. Hou, X.H. He, Z.K. Hong, L.S. Li, G.H. Lin, M.X. Chen, S.H. Chen
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Brief Communication

Skin Test for Paragonimiasis among Schoolchildren and Villagers in Namback District, Luangprabang Province, Lao PDR
Hyun-Ouk Song, Duk-Young Min, Han-Jong Rim, Vonghachack Youthanavanh, Bouakhasith Daluny, Vongsouvan Sengdara, Banouvong Virasack, Phommasak Bounlay
Korean J Parasitol 2008;46(3):179-182.
Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.179

As a part of a broader effort to determine the status of Paragonimus species infection in Lao PDR, an epidemiological survey was conducted on villagers and schoolchildren in Namback District between 2003 and 2005. Among 308 villagers and 633 primary and secondary schoolchildren, 156 villagers and 92 children evidenced a positive reaction on a Paragonimus skin test. Only 4 schoolchildren out of 128 skin test-positive cases had Paragonimus sp. eggs in their sputum, all of which was collected on 1 day. Several types of crabs, which were identified as the second intermediate host of the Paragonimus species, were collected from markets and streams in a paragonimiasis endemic area for the inspection of metacercariae. Among the examined crabs, only "rock crabs" (Indochinamon ou) harbored Paragonimus sp. metacercariae, and it is speculated that the life cycle of Paragonimus sp. was maintained via rock crabs in Namback District, Lao PDR.

Citations

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  • Paragonimus and paragonimiasis in Asia: An update
    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
  • Usefulness and limits of Ziehl-Neelsen staining to detect paragonimiasis in highly endemic tuberculosis areas
    Kethmany Ratsavong, Fabrice Quet, Fulgence Nzabintwali, Jeoffray Diendéré, Jacques Sebert, Michel Strobel, Yves Buisson
    Parasite Epidemiology and Control.2017; 2(1): 1.     CrossRef
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Original Article

Persisting antibody reaction in paragonimiasis after praziquantel treatment is elicited mainly by egg antigens
Seung-Yull Cho, Yoon Kong, Doo-Hee Yun, Shin-Yong Kang, Lee-Soo Kim, Young-Bae Chung, Hyun-Jong Yang
Korean J Parasitol 2000;38(2):75-84.
Published online June 30, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.2.75

Antibody responses in serum and cerebrospinal fluid (CSF) samples from patients with active and chronic paragonimiasis and in sera from patients on whom follow-up studies were done after praziquantel treatment were analyzed using antigens of Paragonimus westermani prepared from eggs, metacercariae, juveniles of 4- and 7-week old, adult worms and recombinant protein of 28 kDa cruzipain-like cysteine protease (rPw28CCP). The patient sera/CSFs of active and chronic paragonimiasis revealed strong antibody reactions against the crude extracts of 4- and 7-week old juveniles as well as against those from egg and adult. rPw28CCP also showed specific reaction to the sera with active paragonimiasis. After the treatment, levels of specific antibodies in the sera gradually decreased to negative range in most patients. In some cases with persisting high antibody levels, however, the reactions at 27 kDa egg protein were sustained throughout the observation period of 34 months. The reactions at 35 and 32 kDa in adult extract and rPw28CCP disappeared rapidly after the treatment. Persistent antibody reactions even after successful treatment are provoked by continuous antigenic challenge from eggs which were not resolved by treatment.

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    Jeong-Geun Kim, Chun-Seob Ahn, Insug Kang, Jong-Wook Shin, Hae-Bong Jeong, Yukifumi Nawa, Yoon Kong, Chukwunonso Nzelu
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    Neha Paranjape, Victor Nunez, Demetrius Dicks
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    SEON-HEE KIM, YOUNG-AN BAE
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    Weng-Kin Wong, Phiaw-Chong Foo, Alfonso Olivos-Garcia, Rahmah Noordin, Zeehaida Mohamed, Nurulhasanah Othman, Ling-Ling Few, Boon-Huat Lim
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    Gary W. Procop, Annie Cowell, Sharon L. Reed, Deirdre E. Amaro, Marion J. Tuohy, Jacquelyn Morhaime
    The American Journal of Tropical Medicine and Hygiene.2016; 95(6): 1424.     CrossRef
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    Y.-A. BAE, S.-H. KIM, C.-S. AHN, J.-G. KIM, Y. KONG
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    Young-An Bae, Guo-Bin Cai, Seon-Hee Kim, Woon-Mok Sohn, Yoon Kong
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Brief Communication
Analysis of Parasitic Diseases Diagnosed by Tissue Biopsy Specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea
Choi, Won Hyung , Chu, Jong Phil , Jiang, Meihua , Lee, Yun Sik , Kim, Bum Shik , Kim, Deog Gon , Park, Yong Koo
Korean J Parasitol 2010;48(1):85-88.
DOI: https://doi.org/10.3347/kjp.2010.48.1.85
We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0.07%) out of the total 211,859 biopsy specimens submitted for histopathological examinations. They consisted of 62 cysticercosis, 23 sparganosis, 16 paragonimiasis, 15 amebiasis, 11 anisakiasis, 11 clonorchiasis, 3 ascariasis, 2 scabies, 2 enterobiasis, 2 trichuriasis, 1 leishmaniasis, 1 taeniasis, and 1 thelaziasis. Out of 62 cysticercosis cases, 55 were detected in subcutaneous tissues or the central nerve system. Eighteen out of 23 sparganosis cases were involved in muscular and subcutaneous tissues. In most anisakiasis cases, the involved organ was the stomach. The lung and the pleura were the most common site of paragonimiasis. The incidence of parasitic diseases during the first 5 years (1984-1988) was the highest of all observed periods. After 1989, similar incidences were shown throughout the period. Whereas cysticercosis was diagnosed in 34 cases during 1984-1988, no case has been diagnosed since 2000. In the case of sparganosis, the chronological incidence was almost uniform throughout the period 1984-2005. Paragonimiasis showed a similar tendency to cysticercosis. In gender and age distribution of parasitic diseases, men showed higher incidence rates than females, and the age groups of the 40s or older indicated higher infection frequencies than other age groups. Therefore, these results are a significant report to appear the tendency of human parasitic disease diagnosed by tissue biopsy in association with parasitosis at KMC in Seoul.

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