Parasites, Hosts and Diseases

"Yukifumi Nawa"

Mini Reviews

Sparganosis in the Indian Sub-continent and the Middle East: Yukifumi Nawa, Mio Tanaka, Masahide Yoshikawa; Parasites Hosts Dis 2024;62(3):263-269.
Published online August 26, 2024; DOI: https://doi.org/10.3347/PHD.23126

Abstract
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Sparganosis is one of the common zoonotic diseases caused by infection with the larval plerocercoids (spargana) of the cestode genus Spirometra. While this parasite distributes globally in canine and feline hosts, human infection is predominantly reported in East Asia, especially China, Korea, Japan, and Thailand. Maybe related to the behavior and food culture, this zoonotic disease is rather rare in South Asia to the Middle East. In these areas, sporadic case reports have been appeared mostly in the local medical journals. To draw a solid picture of sparganosis in these non-endemic areas of Asia, we made an extensive literature survey to gather sparganosis cases in the Indian subcontinent and the Middle East.

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Case report: Sparganosis in Minervarya pierrei (Dubois, 1975) (Amphibia: Anura: Dicroglossidae), a new host from India
Neelanjana Saha, Sudheer Kumar Jena, Oindrila Paul, Suman Das, Upasana Bhattacharya, Anjum N. Rizvi, Pratyush P. Mohapatra
Journal of Parasitic Diseases.2025;[Epub] CrossRef
Deciphering the global genetic structure of Spirometra mansoni and S. erinaceieuropaei based on 28S ribosomal RNA: Insights into taxonomical revaluation and population dynamics
Anil Kumar Nehra, Rasmita Panda, Prem Sagar Maurya, Ansu Kumari, Aman Dev Moudgil
Parasitology Research.2025;[Epub] CrossRef

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Dipylidiasis cases in Japan–an update by literature survey: Yukifumi Nawa, Akinori Furusawa, Mio Tanaka, Masahide Yoshikawa; Parasites Hosts Dis 2024;62(2):163-168.
Published online May 27, 2024; DOI: https://doi.org/10.3347/PHD.23118

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Dipylidium caninum is a cosmopolitan parasite of companion animals such as dogs and cats. Accidental infection in humans occur mostly in children. Although considerable number of cases were reported from Europe and the Americas, case reports of this zoonotic disease are rather scarce from Asian countries. The aim of this study is to report the results of literature survey on dipylidiasis cases in humans in Japan. Conclusively, we have found a total of 17 cases since the first case report in from Aichi Prefecture in 1925.

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Case Report

Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report: Teera Kusolsuk, Orawan Phuphisut, Wanna Maipanich, Somchit Pubampen, Surapol Sa-nguankiat, Akkarin Poodeepiyasawat, Nirundorn Homsuwan, Srisuchart Mongkolmoo, Tippayarat Yoonuan, Poom Adisakwattana, Udomsak Silachamroon, Yukifumi Nawa; Korean J Parasitol 2020;58(1):57-60.
Published online February 29, 2020; DOI: https://doi.org/10.3347/kjp.2020.58.1.57

During the mobile clinic activities in Tak Province, Thailand, Paragonimus sp. eggs were found in a fecal sample of a 72-year-old Karen resident. Paragonimus DNA was amplified from the stool sample and identified to P. heterotremus. The patient did not have any symptoms. Apparent pulmonary lesion was not found on the chest X-ray. The patient admitted habitual consumption of semi-cooked or roasted waterfall crabs for several years. The waterfall crabs collected from stream near the village were found negative for Paragonimus metacercariae. In northern Thailand, paragonimiasis remains as one of the public health concerns and should be ruled out for asymptomatic pulmonary patients.

Citations

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Lung flukes of the genusParagonimus: ancient and re-emerging pathogens
David Blair
Parasitology.2022; 149(10): 1286. CrossRef

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Mini Review

An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years? Unexpected Diseases Sometimes Far Away from the Origin: Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa; Korean J Parasitol 2018;56(3):215-227.
Published online June 30, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.3.215

Abstract
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Along with globalization of traveling and trading, fish-borne nematodiases seems to be increasing in number. However, apart from occasional and sporadic case reports or mini-reviews of particular diseases in particular countries, an overview of fish-borne nematodiasis among travelers have never been performed. In this review, we gathered fishborne nematodiasis among travelers for recent 25 years by an extensive global literature survey using appropriate keywords, e.g. travelers diseases, human infection, anisakiasis, gnathostomiasis, capillariasis, sushi, sashimi, ceviche, Gnathostoma, Pseudoterranova, Anisakis, Capillaria, etc., as well as various combinations of these key words. The Internet search engines PubMed, Medline, Google and Googler Scholar were used as much as possible, and the references of every paper were checked in order to identify useful and reliable publications. The results showed unexpectedly high incidence of gnathostomiasis and low incidence of anisakidosis. The different incidence values of the infection with several fish-borne zoonotic nematode species are discussed, as well as some epidemiological aspects of the infections. The difficulties of differential diagnosis in non-endemic countries are emphasized. It is concluded that travelers must avoid risky behaviors which can lead to infection and that physicians and health authorities must advice travelers on the risks of eating behaviors during travel.

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Brief Communication

A Recombinant Matrix Metalloproteinase Protein from Gnathostoma spinigerum for Serodiagnosis of Neurognathostomiasis: Penchom Janwan, Pewpan M. Intapan, Hiroshi Yamasaki, Porntip Laummaunwai, Kittisak Sawanyawisuth, Chaisiri Wongkham, Chatchai Tayapiwatana, Amnat Kitkhuandee, Viraphong Lulitanond, Yukifumi Nawa, Wanchai Maleewong; Korean J Parasitol 2013;51(6):751-754.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.751

Abstract
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Neurognathostomiasis is a severe form of human gnathostomiasis which can lead to disease and death. Diagnosis of neurognathostomiasis is made presumptively by using clinical manifestations. Immunoblotting, which recognizes antigenic components of molecular mass 21 kDa and 24 kDa in larval extracts of Gnathostoma spinigerum (Gs 21/24), has high sensitivity and specificity for diagnosis of neurognathostomiasis. However, only very small amounts of the Gs 21/24 antigens can be prepared from parasites harvested from natural or experimental animals. To overcome this problem, we recently produced a recombinant matrix metalloproteinase (rMMP) protein from G. spinigerum. In this study, we evaluated this rMMP alongside the Gs 21/24 antigens for serodiagnosis of human neurognathostomiasis. We studied sera from 40 patients from Srinagarind Hospital, Khon Kaen University, Thailand, with clinical criteria consistent with those of neurognathostomiasis, and sera from 30 healthy control adults from Thailand. All sera were tested for specific IgG antibodies against both G. spinigerum crude larval extract and rMMP protein using immunoblot analysis. The sensitivity and specificity for both antigenic preparations were all 100%. These results show that G. spinigerum rMMP protein can be used as an alternative diagnostic antigen, in place of larval extract, for serodiagnosis of neurognathostomiasis.

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Original Articles

Paragonimus paishuihoensis Metacercariae in Freshwater Crabs, Potamon lipkei, in Vientiane Province, Lao PDR: Shigehisa Habe, Pham Ngoc Doanh, Shinichiro Yahiro, Nanthasane Vannavong, Hubert Barennes, Peter Odermatt, Gilles Dreyfuss, Yoichiro Horii, Yukifumi Nawa; Korean J Parasitol 2013;51(6):683-687.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.683

Abstract
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Among Paragonimus species, P. paishuihoensis is one of the most mysterious and poorly understood species. Metacercariae are characterized by having a unique dendritically branched excretory bladder. However, the morphology of the adult worm remains unknown. To date, metacercariae of this species have been reported only in China and Thailand. In this study, we first found P. paishuihoensis metacercariae in freshwater crabs, Potamon lipkei, in Hinheub District, Vientiane, Lao PDR, with a prevalence of 77.7% and the average intensity of 10.3 (range 1-28) metacercariae per crab. The molecular data based on ITS2 and CO1 markers indicated that P. paishuihoensis from Laos and Thailand were almost completely identical and were close to members of the Paragonimus bangkokensis/Paragonimus harinasutai complex. Attempts to infect experimental animals (cats, dogs, and rats) with P. paishuihoensis were unsuccessful, suggesting that these animals might be unsuitable definitive hosts for the species. Further studies are necessary to elucidate the taxonomic status and life cycle of P. paishuihoensis.

Citations

Citations to this article as recorded by

Lung flukes of the genusParagonimus: ancient and re-emerging pathogens
David Blair
Parasitology.2022; 149(10): 1286. CrossRef
Paragonimus and paragonimiasis in Asia: An update
Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
Acta Tropica.2019; 199: 105074. CrossRef
Morphological and molecular identification of a lung fluke, Paragonimus macrorchis (Trematoda, Paragonimidae), found in central Lao PDR and its molecular phylogenetic status in the genus Paragonimus
Oranuch Sanpool, Pewpan Maleewong Intapan, Tongjit Thanchomnang, Penchom Janwan, Sakhone Laymanivong, Hiromu Sugiyama, Wanchai Maleewong
Parasitology International.2015; 64(6): 513. CrossRef

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Molecular Variation in the Paragonimus heterotremus Complex in Thailand and Myanmar: Oranuch Sanpool, Pewpan M. Intapan, Tongjit Thanchomnang, Penchom Janwan, Yukifumi Nawa, David Blair, Wanchai Maleewong; Korean J Parasitol 2013;51(6):677-681.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.677

Abstract
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Paragonimiasis is an important food-borne parasitic zoonosis caused by infection with lung flukes of the genus Paragonimus. Of the 7 members of the genus known in Thailand until recently, only P. heterotremus has been confirmed as causing human disease. An 8th species, P. pseudoheterotremus, has recently been proposed from Thailand, and has been found in humans. Molecular data place this species as a sister species to P. heterotremus, and it is likely that P. pseudoheterotremus is not specifically distinct from P. heterotremus. In this study, we collected metacercariae of both nominal species (identification based on metacercarial morphology) from freshwater crabs from Phetchabun Province in northern Thailand, Saraburi Province in central Thailand, and Surat Thani Province in southern Thailand. In addition, we purchased freshwater crabs imported from Myanmar at Myawaddy Province, western Thailand, close to the Myanmar-Thailand border. The DNAs extracted from excysted metacercariae were PCR-amplified and sequenced for ITS2 and cox1 genes. The ITS2 sequences were nearly identical among all samples (99-100%). Phylogenies inferred from all available partial cox1 sequences contained several clusters. Sequences from Indian P. heterotremus formed a sister group to sequences from P. pseudoheterotremus-type metacercariae. Sequences of P. heterotremus from Thailand, Vietnam, and China formed a separate distinct clade. One metacercaria from Phitsanulok Province was distinct from all others. There is clearly considerable genetic variation in the P. heterotremus complex in Thailand and the form referred to as P. pseudoheterotremus is widely distributed in Thailand and the Thai-Myanmar border region.

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Alongkorn Nonthapa, Rutchanee Rodpai, Tongjit Thanchomnang, Patcharaporn Boonroumkaew, Lakkhana Sadaow, David Blair, Pewpan M. Intapan, Wanchai Maleewong, Virasack Banouvong, Sakhone Laymanivong, Oranuch Sanpool
Infection, Genetics and Evolution.2025; 128: 105718. CrossRef
Nuclear ribosomal transcription units in Asian Paragonimus species (Paragonimidae: Platyhelminthes): genetic characteristics, polymorphism, and implications for intersuperfamilial phylogeny
Khue Thi Nguyen, Huong Thi Thanh Doan, Linh Thi Khanh Pham, Do Thi Roan, Takeshi Agatsuma, Pham Ngoc Doanh, Thanh Hoa Le
Parasitology Research.2024;[Epub] CrossRef
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Qiu-Hong Shu, Shu-De Li, Ming Tian, Yong Meng, Shu-Mei-Qi He, Min Zhu, Miao-Miao Wang, Wen-Lin Wang
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Abigail Hui En Chan, Naowarat Saralamba, Sompob Saralamba, Jiraporn Ruangsittichai, Urusa Thaenkham
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General overview of the current status of human foodborne trematodiasis
Jong-Yil Chai, Bong-Kwang Jung
Parasitology.2022; 149(10): 1262. CrossRef
Genetic differentiation of Southeast Asian Paragonimus Braun, 1899 (Digenea: Paragonimidae) and genetic variation in the Paragonimus heterotremus complex examined by nuclear DNA sequences
Chairat Tantrawatpan, Sumonta Tapdara, Takeshi Agatsuma, Oranuch Sanpool, Pewpan M. Intapan, Wanchai Maleewong, Weerachai Saijuntha
Infection, Genetics and Evolution.2021; 90: 104761. CrossRef
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Yoshifumi Nakagawa, Yuki Ikematsu, Takayuki Nakanishi, Yuji Ogawa, Ryuichi Taen, Yasunori Nakashima, Hironao Okabe, Ayako Yoshida, Haruhiko Maruyama
Parasitology International.2021; 81: 102279. CrossRef
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Lakkhana Sadaow, Oranuch Sanpool, Hiroshi Yamasaki, Wanchai Maleewong, Pewpan M. Intapan
Acta Tropica.2020; 203: 105325. CrossRef
Paragonimus and paragonimiasis in Asia: An update
Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
Acta Tropica.2019; 199: 105074. CrossRef
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Carolina Lenis, Alicia Galiano, Imelda Vélez, Iván Darío Vélez, Carlos Muskus, Antonio Marcilla
Acta Tropica.2018; 183: 95. CrossRef
Gene diversity and genetic variation in lung flukes (genusParagonimus)
David Blair, Yukifumi Nawa, Makedonka Mitreva, Pham Ngoc Doanh
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Helminthologia.2015; 52(3): 167. CrossRef

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Mini Reviews

Paragonimus and Paragonimiasis in Vietnam: an Update: Pham Ngoc Doanh, Yoichiro Horii, Yukifumi Nawa; Korean J Parasitol 2013;51(6):621-627.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.621

Abstract
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Paragonimiasis is a food-borne parasitic zoonosis caused by infection with lung flukes of the genus Paragonimus. In Vietnam, research on Paragonimus and paragonimiasis has been conducted in northern and central regions of the country. Using a combination of morphological and molecular methods, 7 Paragonimus species, namely P. heterotremus, P. westermani, P. skrjabini, P. vietnamensis, P. proliferus, P. bangkokenis and P. harinasutai, have been identified in Vietnam. Of these, the first 3, P. heterotremus, P. westermani and P. skrjabini, are known to infect humans in other countries. However, in Vietnam, only P. heterotremus, found in some northern provinces, has been shown to infect humans. Even nowadays, local people in some northern provinces, such as Lai Chau and Yen Bai, are still suffering from P. heterotremus infection. In some provinces of central Vietnam, the prevalence and infection intensity of P. westermani metacercariae in freshwater crabs (the second intermediate hosts) are extremely high, but human cases have not been reported. Likewise, although P. skrjabini was found in Thanh Hoa Province, its pathogenicity to humans in Vietnam still remains uncertain. The results of molecular phylogenetic analyses of Vietnamese Paragonimus species provides new insights on the phylogeny and taxonomy of the genus Paragonimus. Comprehensive molecular epidemiological and geobiological studies on the genus in Vietnam and adjacent countries are needed to clarify the biodiversity and public health significance of the lung flukes.

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Lung flukes of the genusParagonimus: ancient and re-emerging pathogens
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Parasitology.2022; 149(10): 1286. CrossRef
General overview of the current status of human foodborne trematodiasis
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Comprehensive Review of Ocular Angiostrongyliasis with Special Reference to Optic Neuritis: Ying Feng, Yukifumi Nawa, Kittisak Sawanyavisuth, Zhiyue Lv, Zhong-Dao Wu; Korean J Parasitol 2013;51(6):613-619.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.613

Abstract
PDF

Angiostrongyliasis, caused by Angiostrongylus cantonensis infection, is a food-borne parasitic disease. Its larvae evoke eosinophilic inflammation in the central nervous system, but can also cause pathological changes in the eyes. Among ocular angiostrongyliasis cases, the incidence of optic neuritis is low and only few sporadic reports exist. Some patients with optic neuritis developed obvious hypopsia or even vision loss, which would seriously influence the quality of life of patients. Prompt treatment of optic neuritis caused by A. cantonensis is the key factor for minimizing the incidence of serious complications of this disease. In this review, we first provide a comprehensive overview of ocular angiostrongyliasis, and then focus on the clinical features of optic neuritis caused by A. cantonensis.

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Original Article

Haplorchis taichui as a Possible Etiologic Agent of Irritable Bowel Syndrome-Like Symptoms: Dorn Watthanakulpanich, Jitra Waikagul, Wanna Maipanich, Supaporn Nuamtanong, Surapol Sanguankiat, Somchit Pubampen, Rangson Praevanit, Srisuchat Mongkhonmu, Yukifumi Nawa; Korean J Parasitol 2010;48(3):225-229.
Published online September 16, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.3.225

Abstract
PDF

The aim of this study is to clarify the clinical features of Haplorchis taichui infection in humans in Nan Province, Thailand, and to correlate the clinical features with irritable bowel syndrome (IBS)-like symptoms. In this study area, only H. taichui, but neither other minute intestinal flukes nor small liver flukes were endemic. The degree of infection was determined by fecal egg counts and also by collecting adult worms after deworming. The signs and symptoms of individual patients together with their hematological and biochemical laboratory data were gathered to evaluate the relationship between the clinical features and the severity of infection. Special emphasis was made to elucidate the possible similarities of the clinical features of H. taichui infection and IBS-like symptoms. The results showed useful clinical information and the significant (> 50%) proportion of haplorchiasis patients complained of abdominal pain, lassitude, and flatulence, which were the important diagnostic symptoms of IBS. This study has reported a possible link between H. taichui and IBS, and H. taichui might probably play a role in the etiology of these IBS-like symptoms.

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Case Report

A serologically diagnosed human case of cutaneous larva migrans caused by Ancylostoma caninum: In-Ho Kwon, Hyung-Su Kim, Jong-Hee Lee, Min-Ho Choi, Jong-Yil Chai, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Kwang-Hyun Cho; Korean J Parasitol 2003;41(4):233-237.
Published online December 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.4.233

Abstract
PDF

A 15-year-old boy, who had recently arrived back from a trip to Cambodia for a missionary camp, presented with several serpiginous thread-like skin lesions that began as small papules on the left upper extremities 2 weeks before his visit to Hospital. The skin lesions were pruritic and erythematous, and had migrated to the chest and abdomen. The histopathological findings showed only lymphocytic and eosinophilic infiltrations in the dermis of the biopsied skin lesion. The patient's serum reacted strongly to the Ancylostoma caninum antigen by an ELISA method. Therefore, he was diagnosed with cutaneous larva migrans by A. caninum. After the oral administration of albendazole and ivermectin, the skin lesions resolved without recurrence. This is the first reported case of a cutaneous larva migrans caused by Ancylostoma canimum diagnosed serologically using ELISA in Korea.

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Mini Review

Mucosal immunity against parasitic gastrointestinal nematodes: Denis Nnabuike Onah, Yukifumi Nawa; Korean J Parasitol 2000;38(4):209-236.
Published online December 31, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.4.209

Abstract
PDF

The last two decades witnessed significant advances in the efforts of immunoparasitologists to elucidate the nature and role of the host mucosal defence mechanisms against intestinal nematode parasites. Aided by recent advances in basic immunology and biotechnology with the concomitant development of well defined laboratory models of infection, immunoparasitologists have more precisely analyzed and defined the different immune effector mechanisms during the infection; resulting in great improvement in our current knowledge and understanding of protective immunity against gastrointestinal (GI) nematode parasites. Much of this current understanding comes from experimental studies in laboratory rodents, which have been used as models of livestock and human GI nematode infections. These rodent studies, which have concentrated on Heligmosomoides polygyrus, Nippostrongylus brasiliensis, Strongyloides ratti/S. venezuelensis, Trichinella spiralis and Trichuris muris infections in mice and rats, have helped in defining the types of T cell responses that regulate effector mechanisms and the effector mechanisms responsible for worm expulsion. In addition, these studies bear indications that traditionally accepted mechanisms of resistance such as eosinophilia and IgE responses may not play as important roles in protection as were previously conceived. In this review, we shall, from these rodent studies, attempt an overview of the mucosal and other effector responses against intestinal nematode parasites beginning with the indices of immune protection as a model of the protective immune responses that may occur in animals and man.

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International Journal of Molecular Sciences.2024; 25(3): 1409. CrossRef
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Junfei Wei, Venkatesh L. Hegde, Ananta V. Yanamandra, Madison P. O’Hara, Brian Keegan, Kathryn M. Jones, Ulrich Strych, Maria Elena Bottazzi, Bin Zhan, K. Jagannadha Sastry, Peter J. Hotez
Frontiers in Immunology.2022;[Epub] CrossRef
Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection
Vanessa Dela Justina, Loyane Almeida Gama, Tatiane Schönholzer, Alecsander F. Bressan, Victor Vitorino Lima, Madileine F. Americo, Fernanda R. Giachini
Experimental Parasitology.2021; 222: 108078. CrossRef
The latest FAD – Faecal antibody detection in cattle. Protocol and results from three UK beef farms naturally infected with gastrointestinal nematodes
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Parasitology.2019; 146(1): 89. CrossRef
Globule Leukocytes and Other Mast Cells in the Mouse Intestine
Peter Vogel, Laura Janke, David M. Gravano, Meifen Lu, Deepali V. Sawant, Dorothy Bush, E Shuyu, Dario A. A. Vignali, Asha Pillai, Jerold E. Rehg
Veterinary Pathology.2018; 55(1): 76. CrossRef
Salmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes
Aina-Cathrine Øvergård, Lars Are Hamre, Sindre Grotmol, Frank Nilsen
Developmental & Comparative Immunology.2018; 86: 86. CrossRef
Inducible nitric oxide synthase controls experimental Strongyloides infection
Rosângela Maria Rodrigues, Ana Lúcia Ribeiro Gonçalves, Neide Maria Silva, Cristina Ribeiro de Barros Cardoso, Natália Rodrigues Araújo, Loyane Bertagnolli Coutinho, Ronaldo Alves, Marlene Tiduko Ueta, Julia Maria Costa‐Cruz
Parasite Immunology.2018;[Epub] CrossRef
The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice
Emilia Souza Araujo, Cintia Aparecida de Jesus Pereira, Ana Terezinha de Moura Pereira, João Marcelo Peixoto Moreira, Michelle Carvalho de Rezende, Jailza Lima Rodrigues, Mauro Martins Teixeira, Deborah Negrão-Corrêa
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IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
José L. Reyes, Maria R. Fernando, Fernando Lopes, Gabriella Leung, Nicole L. Mancini, Chelsea E. Matisz, Arthur Wang, Derek M. McKay, Debroski R. Herbert
PLOS Pathogens.2016; 12(4): e1005481. CrossRef
Strongyloides stercoralisInfection in Alcoholic Patients
Marcia C. A. Teixeira, Flavia T. F. Pacheco, Joelma N. Souza, Mônica L. S. Silva, Elizabete J. Inês, Neci M. Soares
BioMed Research International.2016; 2016: 1. CrossRef
Partially Protective Immunity Induced by a 20 kDa Protein Secreted by Trichinella spiralis Stichocytes
Kuo Bi, Jing Yang, Lei Wang, Yuan Gu, Bin Zhan, Xinping Zhu, Érika Martins Braga
PLOS ONE.2015; 10(8): e0136189. CrossRef
Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology
Vitor Luís Tenório Mati, Pedro Raso, Alan Lane de Melo
Parasites & Vectors.2014;[Epub] CrossRef
Strongyloides cebus(Nematoda: Strongyloididae) inLagothrix cana(Primates: Atelidae) from the Brazilian Amazon: Aspects of Clinical Presentation, Anatomopathology, Treatment, and Parasitic Biology
Vitor Luís Tenório Mati, Francisco Carlos Ferreira Junior, Hudson Alves Pinto, Alan Lane de Melo
Journal of Parasitology.2013; 99(6): 1009. CrossRef
Increased susceptibility to Strongyloides venezuelensis infection is related to the parasite load and absence of major histocompatibility complex (MHC) class II molecules
Rosângela Maria Rodrigues, Cristina Ribeiro Cardoso, Ana Lúcia Ribeiro Gonçalves, Neide Maria Silva, Virgínia Massa, Ronaldo Alves, Marlene Tiduko Ueta, João Santana Silva, Julia Maria Costa-Cruz
Experimental Parasitology.2013; 135(3): 580. CrossRef
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Y. SHINTOKU, T. KADOSAKA, E. KIMURA, H. TAKAGI, S. KONDO, M. ITOH
Parasitology.2013; 140(5): 626. CrossRef
Hymenolepis diminuta: Analysis of the expression of Toll-like receptor genes (TLR2 and TLR4) in the small and large intestines of rats
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Experimental Parasitology.2012; 130(3): 261. CrossRef
Iron deficiency reduces serum and in vitro secretion of interleukin-4 in mice independent of altered spleen cell proliferation
Solo R. Kuvibidila, Maria Velez, Renée Gardner, Kavitha Penugonda, Lawrance C. Chandra, Lolie Yu
Nutrition Research.2012; 32(2): 107. CrossRef
Immunological mechanisms involved in the protection against intestinal taeniosis elicited by oral immunization with Taenia solium calreticulin
Sonia Leon-Cabrera, Mayra Cruz-Rivera, Fela Mendlovic, Mirza Romero-Valdovinos, Gilberto Vaughan, Ana María Salazar, Guillermina Avila, Ana Flisser
Experimental Parasitology.2012; 132(3): 334. CrossRef
Hookworm virulence factors: making the most of the host
Maria V. Periago, Jeffrey M. Bethony
Microbes and Infection.2012; 14(15): 1451. CrossRef
Intraepithelial lymphocytes, goblet cells and VIP‐IR submucosal neurons of jejunum rats infected with Toxoplasma gondii
Débora M. G. Sant’Ana, Marcelo B. Góis, Jacqueline N. Zanoni, Aristeu V. da Silva, Cleverton J. T. da Silva, Eduardo J. A. Araújo
International Journal of Experimental Pathology.2012; 93(4): 279. CrossRef
Helminth infections: therapeutic potential in autoimmune disorders
M. EL‐MALKY, N. NABIH, M. HEDER, N. SAUDY, M. EL‐MAHDY
Parasite Immunology.2011; 33(11): 589. CrossRef
Strongyloides ratti:transplantation of adults recovered from the small intestine at different days after infection into the colon of naive and infection-primed Wistar rats, and the effect of antioxidant treatment on large intestinal parasitism
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Taenia solium: Immune response against oral or systemic immunization with purified recombinant calreticulin in mice
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Experimental Parasitology.2011; 127(1): 313. CrossRef
Taenia solium: current understanding of laboratory animal models of taeniosis
A. FLISSER, G. ÁVILA, P. MARAVILLA, F. MENDLOVIC, S. LEÓN-CABRERA, M. CRUZ-RIVERA, A. GARZA, B. GÓMEZ, L. AGUILAR, N. TERÁN, S. VELASCO, M. BENÍTEZ, D. E. JIMENEZ-GONZALEZ
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Regulation of immune responses toStrongyloides venezuelensischallenge after primary infection with different larvae doses
H. C. SCHILTER, A. T. M. PEREIRA, P. D. ESCHENAZI, A. FERNANDES, D. SHIM, A. L. S. SOUSA, M. M. TEIXEIRA, D. NEGRÃO-CORRÊA
Parasite Immunology.2010; 32(3): 184. CrossRef
Major histocompatibility complex (MHC) class II but not MHC class I molecules are required for efficient control of Strongyloides venezuelensis infection in mice
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Immunology.2009;[Epub] CrossRef
Cd4+ T-cell-dependent Goblet Cell Proliferation and Expulsion of Gymnophalloides seoi from the Intestine of C57bl/6 Mice
Sang-Mee Guk, Jun-Haeng Lee, Hyo-Jin Kim, Won-Hee Kim, Eun-Hee Shin, Jong-Yil Chai
Journal of Parasitology.2009; 95(3): 581. CrossRef
The Immunological Effects of Electrolyzed Reduced Water on the Echinostoma hortense Infection in C57BL/6 Mice
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Biological and Pharmaceutical Bulletin.2009; 32(3): 456. CrossRef
INCREASED INTESTINAL ENDOTOXIN ABSORPTION DURING ENTERIC NEMATODE BUT NOT PROTOZOAL INFECTIONS THROUGH A MAST CELL-MEDIATED MECHANISM
Ayman Samir Farid, Fumiko Jimi, Kyoko Inagaki-Ohara, Yoichiro Horii
Shock.2008; 29(6): 709. CrossRef
Immunolocalization and pathological alterations following Strongyloides venezuelensis infection in the lungs and the intestine of MHC class I or II deficient mice
A.L.R. Gonçalves, R.M. Rodrigues, N.M. Silva, F.A. Gonçalves, C.R. Cardoso, M.E. Beletti, M.T. Ueta, J.S. Silva, J.M. Costa-Cruz
Veterinary Parasitology.2008; 158(4): 319. CrossRef
Evaluation of the immune response against Strongyloides venezuelensis in antigen‐immunized or previously infected mice
A. FERNANDES, A. T. M. PEREIRA, P. D. ESCHENAZI, H. C. SCHILTER, A. L. S. SOUSA, M. M. TEIXEIRA, D. NEGRÃO‐CORRÊA
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IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections
Reece G Marillier, Chesney Michels, Elizabeth M Smith, Lizette CE Fick, Mosiuoa Leeto, Benjamin Dewals, William GC Horsnell, Frank Brombacher
BMC Immunology.2008;[Epub] CrossRef
Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion
R. A. WEBB, T. HOQUE, S. DIMAS
Parasite Immunology.2007; 29(1): 11. CrossRef
Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti
Colin Bleay, Clare P. Wilkes, Steve Paterson, Mark E. Viney
International Journal for Parasitology.2007; 37(13): 1501. CrossRef
Expression of IL-4 receptor on non-bone marrow-derived cells is necessary for the timely elimination of Strongyloides venezuelensis in mice, but not for intestinal IL-4 production
Deborah Negrão-Corrêa, Vanessa Pinho, Danielle G. Souza, Ana Terezinha M. Pereira, Adriana Fernandes, Karina Scheuermann, Adriano L.S. Souza, Mauro M. Teixeira
International Journal for Parasitology.2006; 36(10-11): 1185. CrossRef
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Helene Kringel, Allan Roepstorff
Veterinary Parasitology.2006; 139(1-3): 132. CrossRef
Microcapsules formulated in the enteric coating copolymer Eudragit L100 as delivery systems for oral vaccination against infections by gastrointestinal nematode parasites
Maria A. Dea-Ayuela, Sara Rama-Iñiguez, S. Torrado-Santiago, F. Bolas-Fernandez
Journal of Drug Targeting.2006; 14(8): 567. CrossRef
Haemonchus contortus(Nematoda: Trichostrongylidae) infection in lambs elicits an unequivocal Th2 immune response
Caroline Lacroux, Thi Hai Chi Nguyen, Olivier Andreoletti, Françoise Prevot, Christelle Grisez, Jean-Paul Bergeaud, Lucas Gruner, Jean-Claude Brunel, Dominique Francois, Philippe Dorchies, Philippe Jacquiet
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Raja S Vadlamudi, David S Chi, Guha Krishnaswamy
Clinical and Molecular Allergy.2006;[Epub] CrossRef
Haemonchus contortus egg excretion and female length reduction in sheep previously infected with Oestrus ovis (Diptera: Oestridae) larvae
G. Terefe, H.T. Yacob, C. Grisez, F. Prevot, E. Dumas, J.P. Bergeaud, Ph. Dorchies, H. Hoste, P. Jacquiet
Veterinary Parasitology.2005; 128(3-4): 271. CrossRef
Interactions between intrinsic and extrinsic mechanisms in a cyclic species: testosterone increases parasite infection in red grouse
Linzi J Seivwright, Stephen M Redpath, François Mougeot, Fiona Leckie, Peter J Hudson
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Separating Behavioral and Physiological Mechanisms in Testosterone‐Mediated Trade‐Offs
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The American Naturalist.2005; 166(2): 158. CrossRef
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D.N Onah, I.W Onyenwe, J.I Ihedioha, O.S Onwumere
Veterinary Parasitology.2004; 119(2-3): 165. CrossRef
Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases
Sebnem Ustun
World Journal of Gastroenterology.2004; 10(24): 3643. CrossRef
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The Korean Journal of Parasitology.2003; 41(2): 81. CrossRef
Role of Intestinal Goblet Cells in the Expulsion of Gymnophalloides seoi From Mice
M. Seo, S-M. Guk, E-T. Han, J-Y. Chai
Journal of Parasitology.2003; 89(5): 1080. CrossRef
The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype
A. Ben-Smith, D.A. Lammas, J.M. Behnke
Journal of Helminthology.2003; 77(2): 133. CrossRef
Food-borne intestinal trematode infections in the Republic of Korea
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Parasitology International.2002; 51(2): 129. CrossRef
Intestinal histopathology and in situ postures of Gymnophalloides seoi in experimentally infected mice
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The Korean Journal of Parasitology.2001; 39(1): 31. CrossRef
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The Korean Journal of Parasitology.2001; 39(2): 85. CrossRef