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Brief Communication

Problems in Japanese archaeoparasitology: Analysis of paleo-parasitic eggs from Hachinohe Castle
Hisashi Fujita, Masako Funaba, Shiori O. Fujisawa
Parasites Hosts Dis 2025;63(3):278-283.
Published online August 20, 2025
DOI: https://doi.org/10.3347/PHD.25031
During the Edo period, Hachinohe Castle served as the residence of the Nanbu clan, the lords of the Hachinohe domain, and simultaneously functioned as the local government office. Although an analytical company reported on the soil samples from toilet remains within the castle, this study conducted a new analysis. Not only were Trichuris trichiura eggs found in Layer 21, but Metagonimus yokogawai and Dibothriocephalus nihonkaienesis eggs were also present. In Layer 20, which was initially thought to be free of parasitic organisms, T. trichiura, Ascaris lumbricoides, and M. yokogawai eggs were discovered. This paper discusses the differing results from previous studies, which demonstrate that the analytical methodology of Japanese archaeoparasitology is not yet well established, and suggests ways to improve it.
  • 1,310 View
  • 25 Download

Case Report

Fasciola hepatica infection in Korean water deer (Hydropotes inermis argyropus)
Na-Hyeon Kim, Min-Gyeong Seo, Bumseok Kim, Yu Jeong Jeon, In Jung Jung, Il-Hwa Hong
Parasites Hosts Dis 2025;63(3):243-247.
Published online August 20, 2025
DOI: https://doi.org/10.3347/PHD.25021
Fasciola hepatica is a species of zoonotic liver flukes with a broad range of definitive hosts worldwide. However, this liver fluke has not been detected in Korean water deer (Hydropotes inermis argyropus). This study provides the first evidence for Korean water deer being a definitive host of F. hepatica.
  • 1,521 View
  • 49 Download

Brief Communication

Organ-specific Toxocara canis larvae migration and host immune response in experimentally infected mice
Min Seok Kim, Yan Jin, Se Joon Woo
Parasites Hosts Dis 2024;62(2):243-250.
Published online May 27, 2024
DOI: https://doi.org/10.3347/PHD.23125
We investigated organ specific Toxocara canis larval migration in mice infected with T. canis larvae. We observed the worm burden and systemic immune responses. Three groups of BALB/c mice (n=5 each) were orally administered 1,000 T. canis 2nd stage larvae to induce larva migrans. Mice were sacrificed at 1, 3, and 5 weeks post-infection. Liver, lung, brain, and eye tissues were collected. Tissue from 2 mice per group was digested for larval count, while the remaining 3 mice underwent histological analysis. Blood hematology and serology were evaluated and compared to that in a control uninfected group (n=5) to assess the immune response. Cytokine levels in bronchoalveolar lavage (BAL) fluid were also analyzed. We found that, 1 week post-infection, the mean parasite load in the liver (72±7.1), brain (31±4.2), lungs (20±5.7), and eyes (2±0) peaked and stayed constant until the 3 weeks. By 5-week post-infection, the worm burden in the liver and lungs significantly decreased to 10±4.2 and 9±5.7, respectively, while they remained relatively stable in the brain and eyes (18±4.2 and 1±0, respectively). Interestingly, ocular larvae resided in all retinal layers, without notable inflammation in outer retina. Mice infected with T. canis exhibited elevated levels of neutrophils, monocytes, eosinophils, and immunoglobulin E. At 5 weeks post-infection, interleukin (IL)-5 and IL-13 levels were elevated in BAL fluid. Whereas IL-4, IL-10, IL-17, and interferon-γ levels in BAL fluid were similar to that in controls. Our findings demonstrate that a small portion of T. canis larvae migrate to the eyes and brain within the first week of infection. Minimal tissue inflammation was observed, probably due to increase of anti-inflammatory cytokines. This study contributes to our understanding of the histological and immunological responses to T. canis infection in mice, which may have implications to further understand human toxocariasis.

Citations

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  • Toxocara canis infections in mice: from subtle to severe consequences in 100 weeks
    Nicol Bernardová, Jan Novák, Chia-Kwung Fan, Libuše Kolářová, Marta Chanová
    Journal of Helminthology.2025;[Epub]     CrossRef
  • The association of seropositivity to Toxocara canis and Ascaris lumbricoides with blood group antigens
    Kravchun Pavlo Grigorovich, Leontyeva Frida Solomonivna, Povelichenko Olena Dmytrivna, Kadykova Olga Igorivna, Valentyna Dielievska
    Reviews and Research in Medical Microbiology.2025;[Epub]     CrossRef
  • Characteristics of Toxocara canis induced lung inflammation in C57BL/6 mice
    Janina Lekki-Jóźwiak, Justyna Karabowicz, Magdalena Paschall, Karolina Gregorczyk-Zboroch, Małgorzata Sobczak-Filipiak, Piotr Bąska, Irma Schabussova, Ewa Długosz
    Frontiers in Immunology.2025;[Epub]     CrossRef
  • Immunomodulatory and anti-fibrotic effects of Toxocara canis infection in a murine model of thioacetamide-induced chronic hepatic fibrosis
    Iman F. Abou-El-Naga, Eman Dorry Elkerdany, Rania G. Aly, Enas Mohamed Mostafa Zaytoun
    Acta Tropica.2025; 272: 107913.     CrossRef
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  • 87 Download
  • 4 Web of Science
  • Crossref

Mini Review

Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea
Woon-Mok Sohn
Parasites Hosts Dis 2024;62(1):1-29.
Published online February 23, 2024
DOI: https://doi.org/10.3347/PHD.23096
This article analyzed the infection characteristics of metacercariae of Metagonimus spp. (MsMc) in fish from 9 major water systems in Korea. A total of 19,568 fish in 87 species were examined over a period of 10 years (2011–2020). MsMc were detected in fish from all 44 survey areas in 9 water systems. Most of the surveyed sites showed very low and low infection levels (66.7%), while 33.3% of the areas, such as Tamjin-gang and Seomjin-gang, revealed moderate and high infection levels. High endemicity depends on the abundance of susceptible fish species, especially sweet smelt (Plecoglosus altivelis). The susceptibility index (SI) with MsMc in index fish, Zacco spp., was very low and low levels in 62.0%, moderate in 28.0%, and high in 10.0% regions. The SI was highest in the following order: Yeongam-cheon (283.8), Hoeng-cheon (192.3), Togyo-jeosuji (131.2), Deokcheon-gang (119.1), and Joyang-gang (106.3). The recent infection status of MsMc in P. altivelis was analyzed by the survey localities. In addition, except for P. altivelis, 9 fish species were highly infected with MsMc in some survey areas, including Zacco platypus, Z. koreanus, Z. temminckii, Opsariichthys uncirostris, Rhynchocypris oxycephalus, Carassius auratus, Acheilognathus rhombeus, Onchorhynchus masou, and Tribolodon hakonensis. In Korea, 74 fish species (15 families) are collectively listed as second intermediate hosts of Metagonimus spp. This review provides several novel characteristics of MsMc infection and clarifies the fish species of second intermediate host of Metagonimus spp. in this country.

Citations

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  • Detection of intestinal parasites in leopard cat fecal samples using shotgun metagenomics
    Jun Ho Choi, Singeun Oh, Myung-hee Yi, Dongjun Kang, Du-Yeol Choi, Xavier Chavarria, Arwa Shatta, Yoon Hee Cho, Seongjun Choe, Seung-Hun Lee, Ju Yeong Kim
    Parasites, Hosts and Diseases.2025; 63(4): 349.     CrossRef
  • 4,236 View
  • 106 Download
  • Crossref

Case Report

A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
Parasites Hosts Dis 2023;61(3):298-303.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.23065
This study aimed to describe a rare case of gnathostomiasis in the vocal cord. A 54-year-old Chinese woman living in Korea visited with a chief complaint of voice change at the outpatient department of otorhinolaryngology in Hallym Sacred Heart Hospital, Hallym University on August 2, 2021. She had eaten raw conger a few weeks before the voice change developed, but her medical history and physical examinations demonstrated neither gastrointestinal symptoms nor other health problems. A round and red cystic lesion, recognized in the anterior part of the right vocal cord, was removed using forceps and scissors through laryngeal microsurgery. The histopathological specimen of the cyst revealed 3 cross-sections of a nematode larva in the lumen of the cyst wall composed of inflammatory cells and fibrotic tissues. They differ in diameter, from 190 μm to 235 μm. They showed characteristic cuticular layers with tegumental spines, somatic muscle layers, and gastrointestinal tracts such as the esophagus and intestine. Notably, intestinal sections consisted of 27-28 lining cells containing 0-4 nuclei per cell. We tentatively identified the nematode larva recovered from the vocal cord cystic lesion as the third-stage larva of Gnathostoma, probably G. nipponicum or G. hispidum, based on the sectional morphologies.

Citations

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  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Zoonotic Agents in Farmed Fish: A Systematic Review from the Interdisciplinary Perspective of the One Health Concept
    Juliana Rosa Carrijo Mauad, Marcelo Corrêa da Silva, Carolina Marques Costa Araújo, Rosilda Mara Mussury Franco Silva, Silvia Morales de Queiroz Caleman, Márcia Regina Russo
    Veterinary Sciences.2025; 12(5): 437.     CrossRef
  • 5,337 View
  • 96 Download
  • 2 Web of Science
  • Crossref

Brief Communication

Eight cases of canine thelaziosis found in two localities in Korea
Seongjun Choe, Sunmin Kim, Tilak Chandra Nath, Jeong-Ho Kim
Parasites Hosts Dis 2023;61(3):325-331.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.23031
Thelazia callipaeda, a parasitic nematode that causes thelaziosis in various mammals, including humans, is known to be endemic in Korea. However, life cycle-related information on the parasite, primarily from human infection and a few dog cases, is limited. This study reports additional cases of T. callipaeda infections in dogs from both rural and urban areas in Korea, indicating the potential for transmission to humans and other animals. We collected 61 worms from 8 infected dogs from Paju and Cheongju Cities and observed their morphological characteristics under a light microscope. The findings indicate that T. callipaeda infections in animals in Korea may be underestimated and are distributed close to human environments. Our results contribute to the growing knowledge of the reservoir hosts of T. callipaeda in Korea and highlight the importance of continued surveillance and research to prevent and control this emerging zoonotic disease.

Citations

Citations to this article as recorded by  Crossref logo
  • Follicular conjunctivitis in a Border Collie dog caused by Thelazia callipaeda
    Georgi Terziev, Nikola Nizamov, Zvezdelina Kirkova
    Veterinary Record Case Reports.2025;[Epub]     CrossRef
  • Thelazia callipaeda (Nematoda: Spirurida) infections in 2 wildlife species, Prionailurus bengalensis and Nyctereutes procyonoides, in Korea
    Jinho Jang, Young-Seok Park, YoungMin Yun, Keeseon S. Eom, Seongjun Choe
    Parasites, Hosts and Diseases.2025; 63(1): 95.     CrossRef
  • Characteristics of canine thelaziasis in the Republic of Korea: a retrospective study (2022–2024)
    Eunjik Kim, Ye-In Oh, Youngwoo Park
    Journal of Veterinary Science.2025;[Epub]     CrossRef
  • Thelaziasis in humans: A systematic review of reported cases
    D. Katterine Bonilla-Aldana, Jorge Luis Bonilla-Aldana, Jaime David Acosta-España, Ranjit Sah, Alfonso J. Rodriguez-Morales
    New Microbes and New Infections.2025; 65: 101599.     CrossRef
  • Nematicidal Effects and Cytotoxicity of Levamisole on Thelazia callipaeda
    Zhengxuan Han, Yipeng Zhong, Ni Chen, Zichen Liu, Zhankui Yuan, Yipeng Jin
    Animals.2025; 15(11): 1551.     CrossRef
  • 9,738 View
  • 120 Download
  • 5 Web of Science
  • Crossref

Mini Reviews

Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica
Young Ah Lee, Seobo Sim, Kyeong Ah Kim, Myeong Heon Shin
Korean J Parasitol 2022;60(3):155-161.
Published online June 30, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.3.155
All living organisms are destined to die. Cells, the core of those living creatures, move toward the irresistible direction of death. The question of how to die is critical and is very interesting. There are various types of death in life, including natural death, accidental death, questionable death, suicide, and homicide. The mechanisms and molecules involved in cell death also differ depending on the type of death. The dysenteric amoeba, E. histolytica, designated by the German zoologist Fritz Schaudinn in 1903, has the meaning of tissue lysis; i.e., tissue destroying, in its name. It was initially thought that the amoebae lyse tissue very quickly leading to cell death called necrosis. However, advances in measuring cell death have allowed us to more clearly investigate the various forms of cell death induced by amoeba. Increasing evidence has shown that E. histolytica can cause host cell death through induction of various intracellular signaling pathways. Understanding of the mechanisms and signaling molecules involved in host cell death induced by amoeba can provide new insights on the tissue pathology and parasitism in human amoebiasis. In this review, we emphasized on the signaling role of NADPH oxidases in reactive oxygen species (ROS)-dependent cell death by pathogenic E. histolytica.

Citations

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  • Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica
    Young Ah Lee, Myeong Heon Shin
    Parasites, Hosts and Diseases.2023; 61(4): 388.     CrossRef
  • 4,643 View
  • 181 Download
  • 1 Web of Science
  • Crossref
Infection Characteristics of Clonorchis sinensis Metacercariae in Fish from Republic of Korea
Woon-Mok Sohn
Korean J Parasitol 2022;60(2):79-96.
Published online April 20, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.2.79
The infection nature of Clonorchis sinensis metacercariae (CsMc) in freshwater fish hosts is closely related to the transmission of human clonorchiasis. This article reviewed the infection characteristics of CsMc in freshwater fish in the Republic of Korea (Korea). The status of CsMc infection was examined in a total of 17,792 cyprinid fish of 49 species in 9 water systems, which included Hantan-/Imjin-gang, Han-gang, Geum-gang, Mangyeong-gang, Yeongsan-gang, Tamjin-gang, Seomjin-gang, Nakdong-gang, and streams in the east coastal areas from 2010 to 2020. The infection status of CsMc was examined according to cyprinid fish species and water systems, after which analyzed by endemicity and susceptibility index. The high endemicity was shown in the cyprinid fish from 3 regions (6.1%) in the upper reaches of Nakdong-gang, such as Banbyeon-cheon (stream), Yongjeon-cheon, and Wi-cheon. The moderate levels were observed in fishes from 8 regions (16.3%), and low endemicity was shown in fishes from 20 regions (40.8%). No CsMc were detected in fish from 18 regions (36.7%). The susceptibility of CsMc in index fish, Puntungia herzi, was found to be a reliable index without examination of other fish species. CsMc infection rates were closely related to subfamily groups in the cyprinid fish hosts in a highly endemic area. In Korea, a total of 58 fish species in 10 families has been listed as the second intermediate hosts for C. sinensis. This review provides several novel features of CsMc infection and clarifies the species of second intermediate freshwater fish host in Korea.

Citations

Citations to this article as recorded by  Crossref logo
  • Clonorchis sinensis and Cholangiocarcinoma
    Eun-Min Kim, Sung-Tae Hong
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Multiparasitism in Spain in a Korean Visiting Friends and Relatives: Case Report and Review of Imported Cases of Clonorchis sinensis in Europe
    Paola Cociancic, Jacklyn Comas, J. Guillermo Esteban
    Clinical Case Reports.2025;[Epub]     CrossRef
  • Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control
    Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou, Graeme N. Forrest
    Clinical Microbiology Reviews.2024;[Epub]     CrossRef
  • Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea
    Woon-Mok Sohn
    Parasites, Hosts and Diseases.2024; 62(1): 1.     CrossRef
  • Current status of Clonorchis sinensis and clonorchiasis in Korea: epidemiological perspectives integrating the data from human and intermediate hosts
    Won Gi Yoo, Woon-Mok Sohn, Byoung-Kuk Na
    Parasitology.2022; 149(10): 1296.     CrossRef
  • 10,061 View
  • 237 Download
  • 5 Web of Science
  • Crossref

Brief Communications

Cryptocotyle lata (Trematoda: Heterophyidae) Adult from a Korean Raccoon Dog, Nyctereutes procyonoides koreensis
Heon Woo Lee, Eui Ju Hong, Hyeon Cheol Kim, Si Yun Ryu, Bae Keun Park
Korean J Parasitol 2021;59(6):645-649.
Published online December 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.6.645
Total 513 heterophyid flukes were collected from a carcass of wild Korean raccoon dog, Nyctereutes procyonoides koreensis, in Korea. With morphological and molecular characteristics, the flukes were identified to Cryptocotyle lata. The adult C. lata were minute, transparent, pentagonal, 522 µm long by 425 µm wide. Ceca extended into post-testicular region. Ventrogenital sac elliptical, 79 µm by 87 µm with genital pore and ventral sucker. Two testes semielliptical and slightly lobed, located in the posterior region, right testis 173 µm by 155 µm, left testis 130 µm by 134 µm. In a phylogenetic tree, the fluke specimen of this study was grouped with C. lata divergent from Cryptocotyle lingua. We report here N. procyonoides koreensis first as a natural definitive host of C. lata.
  • 4,170 View
  • 122 Download
Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation
Young Ah Lee, Kyeong Ah Kim, Myeong Heon Shin
Korean J Parasitol 2021;59(5):501-505.
Published online October 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.5.501
The pathogenic free-living amoeba Naegleria fowleri causes primary amoebic meningoencephalitis, a fatal infection, by penetrating the nasal mucosa and migrating to the brain via the olfactory nerves. N. fowleri can induce host cell death via lytic necrosis. Similar to phosphorylation, O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is involved in various cell-signaling processes, including apoptosis and proliferation, with O-GlcNAc addition and removal regulated by O-GlcNAc transferase and O-GlcNAcase (OGA), respectively. However, the detailed mechanism of host cell death induced by N. fowleri is unknown. In this study, we investigated whether N. fowleri can induce the modulation of O-GlcNAcylated proteins during cell death in Jurkat T cells. Co-incubation with live N. fowleri trophozoites increased DNA fragmentation. In addition, incubation with N. fowleri induced a dramatic reduction in O-GlcNAcylated protein levels in 30 min. Moreover, pretreatment of Jurkat T cells with the OGA inhibitor PUGNAc prevented N. fowleri–induced O-deGlcNAcylation and DNA fragmentation. These results suggest that O-deGlcNAcylation is an important signaling process that occurs during Jurkat T cell death induced by N. fowleri.

Citations

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  • Primary amebic meningoencephalitis in children: A case report and literature review
    Binbin Song, Junwen Zheng, Dongchi Zhao
    IDCases.2024; 37: e02028.     CrossRef
  • 4,434 View
  • 116 Download
  • 1 Web of Science
  • Crossref

Original Article

Evaluation of Rapid IgG4 Test for Diagnosis of Gnathostomiasis
Yue Wang, An Ma, Xiao-Long Liu, Praphathip Eamsobhana, Xiao-Xian Gan
Korean J Parasitol 2021;59(3):257-263.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.257
Human gnathostomiasis is a parasitic disease caused by Gnathostoma nematode infection. A rapid, reliable, and practical immunoassay, named dot immuno-gold filtration assay (DIGFA), was developed to supporting clinical diagnosis of gnathostomiasis. The practical tool detected anti-Gnathostoma-specific IgG4 in human serum using crude extract of third-stage larvae as antigen. The result of the test was shown by anti-human IgG4 monoclonal antibody conjugated colloidal gold. The sensitivity and specificity of the test were both 100% for detection in human sera from patients with gnathostomiasis (13/13) and from healthy negative controls (50/50), respectively. Cross-reactivity with heterogonous serum samples from patients with other helminthiases ranged from 0 (trichinosis, paragonimiasis, clonorchiasis, schistosomiasis, and cysticercosis) to 25.0% (sparganosis), with an average of 6.3% (7/112). Moreover, specific IgG4 antibodies diminished at 6 months after treatment. This study showed that DIGFA for the detection of specific IgG4 in human sera could be a promising tool for the diagnosis of gnathostomiasis and useful for evaluating therapeutic effects.

Citations

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  • Health Impact of Gnathostomiasis and its Integral Approach to Parasitic Infection: A Systematic Review
    Gisnella María Cedeño Cajas, José Andrés Zaporta Ramos, Andrea Stefannia Flores Villacrés, Cesar Guevara
    Salud, Ciencia y Tecnología.2024; 4: 1096.     CrossRef
  • 5,693 View
  • 118 Download
  • Crossref

Brief Communication

High Endemicity with Clonorchis sinensis Metacercariae in Fish from Yongjeon-cheon (Stream) in Cheongsong-gun, Gyeongsangbuk-do, Korea
Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Myoung-Ro Lee, Jung-Won Ju, Gou Ok Kim
Korean J Parasitol 2021;59(1):97-101.
Published online February 19, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.1.97
The infection status with Clonorchis sinensis metacercariae (CsMc) was examined in freshwater fishes from Yongjeon-cheon (a branch of Nakdong-gang) located in Cheongsong-gun, Gyeongsangbuk-do, the Republic of Korea (Korea). A total of 750 fishes in 19 species were examined by the artificial digestion method for 2 years (2019 and 2020). CsMc were detected in 378 (51.4%) out of 735 fishes in 14 species (73.7%), and the infection intensity was 666 per fish infected. In 2019, CsMc were found in 172 (68.0%) out of 253 fishes in 10 species, and the infection intensity was 565 per fish infected. In 2020, CsMc were detected in 206 (62.2%) out of 331 fishes in 10 species, and the infection intensity was 751 per fish infected. The other zoonotic trematode, ie. Metagonimus spp., Centrocestus armatus, Echinostoma spp. and Clinostomum complanatum, metacercariae were also detected in fishes from the survey streams, but their endemicities were relatively low. Conclusively, it was first confirmed that CsMc are highly endemic in fishes from Yongjeon-cheon in Cheongsong-gun, Gyeongsangbuk-do, Korea.

Citations

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  • Factors Contributing to the High Malignancy Level of Cholangiocarcinoma and Its Epidemiology: Literature Review and Data
    Xuan Li, Renchu Guan, Shuangquan Zhang
    Biology.2025; 14(4): 351.     CrossRef
  • Infection Characteristics of Clonorchis sinensis Metacercariae in Fish from Republic of Korea
    Woon-Mok Sohn
    The Korean Journal of Parasitology.2022; 60(2): 79.     CrossRef
  • Current status of Clonorchis sinensis and clonorchiasis in Korea: epidemiological perspectives integrating the data from human and intermediate hosts
    Won Gi Yoo, Woon-Mok Sohn, Byoung-Kuk Na
    Parasitology.2022; 149(10): 1296.     CrossRef
  • Comparison of Pest Occurrence and Viral Disease Incidence Rate with Reduced the Application of Pesticides in Red Pepper Field
    Tae-young Kim, Cheol Jang, Hyun-woo Kang, Jae-hyuk Choi, Ho-wook Lee, Jong-won Lee, Dae-hong Lee, Seung-kyu Yang, Seon-yeong Lee6, Cheol-gi Min, DongWoon Lee
    The Korean Journal of Pesticide Science.2021; 25(1): 1.     CrossRef
  • Electron beam irradiation to control biohazards in seafood
    Raj Kamal Gautam, Vazhiyil Venugopal
    Food Control.2021; 130: 108320.     CrossRef
  • Prevalence and Infection Intensity of Zoonotic Trematode Metacercariae in Fish from Soyang-cheon (Stream), in Wanju-gun, Jeollabuk-do, Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Cheon-Hyeon Kim, Min-Ah Hwang, Kyeong-Woo No, Jong-Ho Park
    The Korean Journal of Parasitology.2021; 59(3): 265.     CrossRef
  • Survey of Zoonotic Trematode Metacercariae in Fish from Irrigation Canal of Togyo-jeosuji (Reservoir) in Cheorwon-gun, Gangwon-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Eun-Joo Lim, Sung Yong Son, Eunmi Ko, Jaeseok Choi
    The Korean Journal of Parasitology.2021; 59(4): 427.     CrossRef
  • Cholangiocarcinoma
    Paul J. Brindley, Melinda Bachini, Sumera I. Ilyas, Shahid A. Khan, Alex Loukas, Alphonse E. Sirica, Bin Tean Teh, Sopit Wongkham, Gregory J. Gores
    Nature Reviews Disease Primers.2021;[Epub]     CrossRef
  • Endemicity of Zoonotic Trematode Metacercariae in Fish from Deokcheon-gang (River) in Sancheong-gun, Gyeongsangnam-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Jeong-Gil Park, Jihee Ahn
    The Korean Journal of Parasitology.2021; 59(5): 523.     CrossRef
  • 5,210 View
  • 94 Download
  • 8 Web of Science
  • Crossref

Original Articles

Relative Abundance of a Vector of Scrub Typhus, Leptotrombidium sialkotense, in Southern Yunnan Province, China
Yan Lv, Xian-Guo Guo, Dao-Chao Jin, Wen-Yu Song, Rong Fan, Cheng-Fu Zhao, Zhi-Wei Zhang, Ke-Yu Mao, Yun-Ji Zou, Zhi-Hua Yang
Korean J Parasitol 2020;58(2):153-159.
Published online April 30, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.2.153
The chigger mite Leptotrombidium sialkotense is one of the 6 main vectors of scrub typhus in China. Before present study, L. sialkotense was found in some parts of Hunan province, China with a narrow geographical distribution. During field investigation 2016-2017, we found L. sialkotense in Jingha, southern Yunnan, China. Of 15 small mammal host species, L. sialkotense were collected from 6 species of the hosts. Rattus brunneusculus was a dominant host of L. sialkotense, from which 98.3% of the mites were collected. The chigger mite showed a relatively high infestation prevalence (PM=11.7%) and mean abundance (MA=0.5) in comparison with the rest 5 host species. These results reveal a certain host specificity of L. sialkotense to a rat R. brunneusculus. The mite L. sialkotense showed an aggregated distribution on the host (P<0.05). A positive correlation observed between L. sialkotense and the body length of hosts. There was a positive interspecific association between L. sialkotense and 2 other dominant vectors, L. deliense and L. scutellare.

Citations

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  • Abundance and Infestation of Mites on Bower’s White-Toothed Rat (Berylmys bowersi) in Southwest China
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Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components
Jhang Ho Pak, Ji-Yun Lee, Bo Young Jeon, Fuhong Dai, Won Gi Yoo, Sung-Jong Hong
Korean J Parasitol 2019;57(4):379-387.
Published online August 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.4.379
Clonorchis sinensis is a carcinogenic human liver fluke that promotes hepatic inflammatory environments via direct contact or through their excretory-secretory products (ESPs), subsequently leading to cholangitis, periductal fibrosis, liver cirrhosis, and even cholangiocarcinoma (CCA). This study was conducted to examine the host inflammatory responses to C. sinensis ESPs and their putative protein components selected from C. sinensis expressed sequenced tag (EST) pool databases, including TGF-β receptor interacting protein 1(CsTRIP1), legumain (CsLeg), and growth factor binding protein 2 (CsGrb2). Treatment of CCA cells (HuCCT1) with the ESPs or bacterial recombinant C. sinensis proteins differentially promoted the secretion of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) as well as anti-inflammatory cytokines (IL-10, TGF-β1, and TGF-β2) in a time-dependent manner. In particular, recombinant C. sinensis protein treatment resulted in increase (at maximum) of ~7-fold in TGF-β1, ~30-fold in TGF-β2, and ~3-fold in TNF-α compared with the increase produced by ESPs, indicating that CsTrip1, CsLeg, and CsGrb2 function as strong inducers for secretion of these cytokines in host cells. These results suggest that C. sinensis ESPs contribute to the immunopathological response in host cells, leading to clonorchiasis-associated hepatobiliary abnormalities of greater severity.

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  • The crosstalk between cholangiocytes and hepatic stellate cells promotes the progression of epithelial-mesenchymal transition and periductal fibrosis during Clonorchis sinensis infection
    Junyeong Yi, Ji Hoon Jeong, Jihee Won, Seok Chung, Jhang Ho Pak
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    Qiannan Liu, Nian Wang, Hengchang Sun, Huimin Dong, Xuerong Li, Xinbing Yu, Yan Huang
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Infection Status with Clonorchis sinensis Metacercariae in Fish from Yangcheon (Stream) in Sancheong-gun, Gyeongsangnam-do, Korea
Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju
Korean J Parasitol 2019;57(2):145-152.
Published online April 30, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.2.145
The infection status with Clonorchis sinensis metacercariae (CsMc) was examined in freshwater fishes from Yangcheon (a branch of Gyeongho-gang), which is located in Sancheong-gun, Gyeongsangnam-do, the Republic of Korea. Total 2,201 fishes in 26 species were examined by the artificial digestion method through 7 years. CsMc were detected in 1,171 (53.2%) fishes in 21 spp. (80.8%) and their density was 85 per fish infected. Total 532 (99.6%) out of 534 Pungtungia herzi (index fish) examined were infected with 147 CsMc per fish infected. Metacercarial densities in this fish were highest in 2015 (179 CsMc), followed by 2012 (168), 2013 (152), 2016 (145), 2014 (114), and 2017 (89) respectively. In the gobioninid fish group, i.e., P. herzi, Sarcocheilichthys spp., Squalidus spp., Pseudogobio esocinus, Hemibarbus longirostris, and Hemibarbus labeo, 841 (92.7%) fishes were infected with 117 CsMc per fish infected. Total 250 (54.7%) acheilognathinid fish (bitterlings), Acheilognathus spp. and Acanthorhodeus spp. were infected with 5.8 CsMc. In the rasborinid fish (chubs) group, i.e., Zacco platypus, Zacco temminckii, and Zacco koreanus, 77 (13.7%) out of 563 fish examined were infected with 2.4 CsMc in average. The susceptibility indices of CsMc were 49.09 in the overall positive fish group, 104.15 in the gobioninid group, 3.17 in the acheilognathinid group and 0.35 in the rasborinid fish group respectively. Only 1 CsMc was detected in 3 fish species, Coreoperca herzi, Channa argus, and Lepomis macrochirus, respectively. Conclusively, it was confirmed that CsMc are moderately prevalent in fishes from Yangcheon in Sancheon-gun, Gyeongsangnam-do, Korea.

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  • The spatial-temporal risk profiling of Clonorchis sinensis infection over 50 years implies the effectiveness of control programs in South Korea: a geostatistical modeling study
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    Won Gi Yoo, Woon-Mok Sohn, Byoung-Kuk Na
    Parasitology.2022; 149(10): 1296.     CrossRef
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    The Korean Journal of Parasitology.2021; 59(1): 23.     CrossRef
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    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Myoung-Ro Lee, Jung-Won Ju, Gou Ok Kim
    The Korean Journal of Parasitology.2021; 59(1): 97.     CrossRef
  • Prevalence and Infection Intensity of Zoonotic Trematode Metacercariae in Fish from Soyang-cheon (Stream), in Wanju-gun, Jeollabuk-do, Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Cheon-Hyeon Kim, Min-Ah Hwang, Kyeong-Woo No, Jong-Ho Park
    The Korean Journal of Parasitology.2021; 59(3): 265.     CrossRef
  • Survey of Zoonotic Trematode Metacercariae in Fish from Irrigation Canal of Togyo-jeosuji (Reservoir) in Cheorwon-gun, Gangwon-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Eun-Joo Lim, Sung Yong Son, Eunmi Ko, Jaeseok Choi
    The Korean Journal of Parasitology.2021; 59(4): 427.     CrossRef
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    Xin-He Zhang, Die Huang, Yi-Ling Li, Bing Chang
    World Journal of Clinical Cases.2021; 9(23): 6639.     CrossRef
  • Endemicity of Zoonotic Trematode Metacercariae in Fish from Deokcheon-gang (River) in Sancheong-gun, Gyeongsangnam-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Jeong-Gil Park, Jihee Ahn
    The Korean Journal of Parasitology.2021; 59(5): 523.     CrossRef
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Hypolobocera guayaquilensis (Decapoda: Pseudothelphusidae): A New Crab Intermediate Host of Paragonimus mexicanus in Manab? Province, Ecuador
Manuel Calvopina, Daniel Romero-Alvarez, Melina Rendon, Hidekazu Takagi, Hiromu Sugiyama
Korean J Parasitol 2018;56(2):189-194.
Published online April 30, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.2.189
To determine that Paragonimus sp. is actively transmitted in a tropical area of the Pacific region of Ecuador where human cases of pulmonary paragonimiasis have recently been documented, a total of 75 freshwater crabs were collected from 2 different streams in the Pedernales area of Manab? Province, Ecuador. All collected crabs were identified as Hypolobocera guayaquilensis based on morphological characteristics of the male gonopods. The hepatopancreas of each crab was examined by compressing it between 2 glass plates followed by observation under a stereomicroscope. Excysted Paragonimus metacercariae were detected in 39 (52.0%) crabs and their densities varied from 1 to 32 per infected crab. There was a positive relationship between crab size and metacercarial density. Sequences of the second internal transcribed spacer region of the ribosomal RNA gene of the Paragonimus metacercariae obtained in this study were identical to those of Paragonimus mexicanus deposited in the DDBJ/EMBL/GenBank database. Thus, the present study is the first to confirm that the crab species H. guayaquilensis is the second intermediate host of P. mexicanus in Manab? Province, Ecuador. Because this crab might be the possible source of human infections in this area, residents should pay attention to improper crab-eating habits related with a neglected parasitic disease, i.e., paragonimiasis.

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Prevalence and Intensity of Clonorchis sinensis Metacercariae in Freshwater Fish from Wicheon Stream in Gunwi-gun, Gyeongsangbuk-do, Korea
Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Dong-Chul Son
Korean J Parasitol 2018;56(1):41-48.
Published online February 28, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.1.41
The infection status of Clonorchis sinensis metacercariae (CsMc) was examined in freshwater fish from a highly prevalent site, Wicheon (a branch of Nakdong-gang), which is located in Gunwi-gun, Gyeongsangbuk-do, the Republic of Korea. Total 1,162 fish in 32 species were examined by the artificial digestion method through 6 years. CsMc were detected in 720 (67.5%) out of 1,067 fish (26 spp.) and their density was 610 per fish infected. In the susceptible gobioninid fish group, i.e., Pungtungia herzi, Squalidus gracilis majimae, Squalidus japonicus coreanus, Sarcocheilichthys variegatus wakiyae and Pseudorasbora parva, all of 323 fish were infected with an average of 1,310 CsMc. Total 23 (95.8%) gobioninid fish, i.e., Pseudogobio esocinus, Abbottina springeri, Hemibarbus longirostris, Microphysogobio koreensis, and Microphysogobio jeoni, were infected with 127 CsMc in average. In the acheilognathinid fish (bitterlings) group, the prevalence was 77.0%, and the density was 50 CsMc per fish infected. In the rasborinid fish (chubs) group, i.e., Zacco platypus, Zacco temminckii, Zacco koreanus, and Opsariichthys uncirostris amurensis, 147 (36.5%) out of 403 fish examined were infected with 15 CsMc in average. The susceptibility indices of CsMc were 412 in the overall positive fish group, 1,310 in the gobioninid group-1, 122 in the gobioninid group-2, 38.5 in the acheilognathinid group, and 5.5 in the rasborinid fish group. Conclusively, it was confirmed that CsMc are highly prevalent in fish from Wicheon, and their infection tendency varied according to the subfamily groups in Cyprinidae fish hosts.

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    Parasitology.2022; 149(10): 1296.     CrossRef
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    Shuran Yang, Xiaoyan Pei, Shuoyan Yin, Xiaojie Yu, Lingling Mei, Wei Zhao, Hui Liang, Qizhi Wang, Dajin Yang
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  • Infection Status with Clonorchis sinensis Metacercariae in Fish from Tamjin-gang (River) in Jeollanam-do, Republic of Korea
    Ki-Bok Yoon, Hyun-Cheol Lim, Doo Young Jeon, Sook Park, Shin-Hyeong Cho, Jung-Won Ju, Sung-Shik Shin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2018; 56(2): 183.     CrossRef
  • Infections with Digenean Trematode Metacercariae in Two Invasive Alien Fish, Micropterus salmoides and Lepomis macrochirus, in Two Rivers in Chungcheongbuk-do, Republic of Korea
    Seongjun Choe, Hansol Park, Dongmin Lee, Yeseul Kang, Hyeong-Kyu Jeon, Keeseon S. Eom
    The Korean Journal of Parasitology.2018; 56(5): 509.     CrossRef
  • 8,545 View
  • 178 Download
  • 16 Web of Science
  • Crossref

Brief Communications

Indoor Occurrence of the Ghost Ant Tapinoma melanocephalum (Hymenoptera: Formicidae) in Urban Homes in Korea
In Yong Lee, Seong Joon Park, Jang Hoon Seo, Seobo Sim, Jin-Hwan Kim, Young Gon Gwon, Tai-Soon Yong
Korean J Parasitol 2017;55(2):225-228.
Published online April 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.2.225
The ghost ant Tapinoma melanocephalum is a common household pest worldwide. The present study examined the occurrence of the species in urban homes in Korea. During the period of September 2014 to January 2016, T. melanocephalum workers were collected from 58 homes at 29 different localities using bait traps with 10% sugar solution. The species was widely distributed throughout urban homes at 29 different localities, and the indoor occurrence of T. melanocephalum was highest in Seoul (32.7%) and metropolitan areas of Gyeonggi-do (Province) (29.3%). The indoor incidence rate of T. melanocephalum peaked in September (22.8%), remained moderate from October through April, and peaked again in May (15.7%). In contrast, a low incidence was observed from June to August (7.0%). The present study provides evidence that native ants, such as T. melanocephalum, are potential indoor pests of homes in Korea throughout the year.

Citations

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  • Ant invasion in China: An in-depth analysis of the country's ongoing battle with exotic ants
    Junaid Ali Siddiqui, Bamisope Steve Bamisile, Ruidong Fan, Muhammad Hafeez, Waqar Islam, Wenjia Yang, Minyi Wei, Hao Ran, Yijuan Xu, Xiaoyulong Chen
    Ecological Indicators.2024; 160: 111811.     CrossRef
  • Exotic Ants of the Asia-Pacific: Invasion, National Response, and Ongoing Needs
    Yijuan Xu, Edward L. Vargo, Kazuki Tsuji, Ross Wylie
    Annual Review of Entomology.2022; 67(1): 27.     CrossRef
  • 9,181 View
  • 132 Download
  • 2 Web of Science
  • Crossref
Mass Death of Predatory Carp, Chanodichthys erythropterus, Induced by Plerocercoid Larvae of Ligula intestinalis (Cestoda: Diphyllobothriidae)
Woon-Mok Sohn, Byoung-Kuk Na, Soo Gun Jung, Koo Hwan Kim
Korean J Parasitol 2016;54(3):363-368.
Published online June 30, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.3.363
We describe here the mass death of predatory carp, Chanodichthys erythropterus, in Korea induced by plerocercoid larvae of Ligula intestinalis as a result of host manipulation. The carcasses of fish with ligulid larvae were first found in the river-edge areas of Chilgok-bo in Nakdong-gang (River), Korea at early February 2016. This ecological phenomena also occurred in the adjacent areas of 3 dams of Nakdong-gang, i.e., Gangjeong-bo, Dalseong-bo, and Hapcheon-Changnyeong-bo. Total 1,173 fish carcasses were collected from the 4 regions. To examine the cause of death, we captured 10 wondering carp in the river-edge areas of Hapcheon-Changnyeong-bo with a landing net. They were 24.0-28.5 cm in length and 147-257 g in weight, and had 2-11 plerocercoid larvae in the abdominal cavity. Their digestive organs were slender and empty, and reproductive organs were not observed at all. The plerocercoid larvae occupied almost all spaces of the abdominal cavity under the air bladders. The proportion of larvae per fish was 14.6-32.1% of body weight. The larvae were ivory-white, 21.5-63.0 cm long, and 6.0-13.8 g in weight. We suggest that the preference for the river-edge in infected fish during winter is a modified behavioral response by host manipulation of the tapeworm larvae. The life cycle of this tapeworm seems to be successfully continued as the infected fish can be easily eaten by avian definitive hosts.

Citations

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  • De Novo transcriptome assembly of Ligula intestinalis (Linnaeus, 1758) Gmelin, 1790 (Cestoda: Diphyllobothriidae) plerocercoids and their host, the common bream Abramis Brama L. (Cypriniformes: Leuciscidae): model for studying host-parasite interactions
    Albina Tsekova, Polina Drozdova, Irina Sukhovskaya, Daria Lebedeva, Liudmila Lysenko, Nadezhda Kantserova
    Molecular Biology Reports.2025;[Epub]     CrossRef
  • Effect of parasitic infection on microplastic ingestion in a native leuciscid hybrid species (Alburnus derjugini x Squalius orientalis) from Kürtün Dam Lake, Türkiye
    Mert Minaz, Zeynep Zehra Ipek, Esra Bayçelebi, Munevver Oral, Tanju Mutlu, Baris Karsli, Sevki Kayis
    Chemosphere.2024; 363: 142978.     CrossRef
  • Destabilization Processes in the Hemopoietic Organs of Goldfish as a Consequence of the Survival Strategy of Cestode Ligula (Digramma) interrupta (Cestoda: Pseudophyllidea)
    O. E. Mazur, I. A. Kutyrev, Zh. N. Dugarov
    Inland Water Biology.2022; 15(4): 476.     CrossRef
  • Impact of Endocrine Disruption on Host-Parasite Interaction: A Digest from a Cosmopolitan Cestode Model Ligula intestinalis
    Roshmi Biswas, Anirban Ash
    Proceedings of the Zoological Society.2021; 74(4): 523.     CrossRef
  • Comparative mitogenomics supports synonymy of the genera Ligula and Digramma (Cestoda: Diphyllobothriidae)
    Wen X. Li, Pei P. Fu, Dong Zhang, Kellyanne Boyce, Bing W. Xi, Hong Zou, Ming Li, Shan G. Wu, Gui T. Wang
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Molecular Identification of Cestoda Isolated from Erythroculter erythropterus
    Aram HEO, Nam-Sil LEE, KwangIl KIM, Na Young KIM, Sung-Hee JUNG, Myoung Sug KIM
    JOURNAL OF FISHRIES AND MARINE SCIENCES EDUCATION.2018; 30(6): 1978.     CrossRef
  • Infection status with plerocercoid of ligulid tapeworm in cyprinid fish from three lakes in Republic of Korea
    H. B. Song, G. M. Park
    Helminthologia.2018; 55(3): 251.     CrossRef
  • 10,913 View
  • 122 Download
  • 4 Web of Science
  • Crossref

Original Articles

Larval Gnathostoma spinigerum Detected in Asian Swamp Eels, Monopterus albus, Purchased from a Local Market in Yangon, Myanmar
Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Jong-Bok Park, Hoo-Gn Jeoung, Eui-Hyug Hoang, Thi Thi Htoon, Htay Htay Tin
Korean J Parasitol 2015;53(5):619-625.
Published online October 29, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.5.619
The present study was performed to determine the infection status of swamp eels with Gnathostoma sp. larvae in Myanmar. We purchased total 37 Asian swamp eels, Monopterus albus, from a local market in Yangon in June and December 2013 and 2014. All collected eels were transferred with ice to our laboratory and each of them was examined by the artificial digestion technique. A total of 401 larval gnathostomes (1-96 larvae/eel) were detected in 33 (89.2%) swamp eels. Most of the larvae (n=383; 95.5%) were found in the muscle. The remaining 18 larvae were detected in the viscera. The advanced third-stage larvae (AdL3) were 2.3-4.4 mm long and 0.25-0.425 mm wide. The characteristic head bulb (0.093 × 0.221 mm in average size) with 4 rows of hooklets, muscular long esophagus (1.025 mm), and 2 pairs of cervical sacs (0.574 mm) were observed by light microscopy. The average number of hooklets in the 1st, 2nd, 3rd, and 4th rows was 41, 45, 48, and 51, respectively. As scanning electron microscopic findings, the characteristic 4-5 rows of hooklets on the head bulb, a cervical papilla, tegumental spines regularly arranged in the transverse striations, and an anus were well observed. Based on these morphological characters, they were identified as the AdL3 of Gnathostoma spinigerum. By the present study, it has been confirmed for the first time that Asian swamp eels, M. albus, from Yangon, Myanmar are heavily infected with G. spinigerum larvae.

Citations

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  • Regulation of immune response against third-stage Gnathostoma spinigerum larvae by human genes
    Pattarasuda Puasri, Wilanee Dechkhajorn, Paron Dekumyoy, Tippayarat Yoonuan, Sumate Ampawong, Onrapak Reamtong, Usa Boonyuen, Surachet Benjathummarak, Yaowapa Maneerat
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Human gnathostomiasis: A review on the biology of the parasite with special reference on the current therapeutic management
    Kathyleen Nogrado, Poom Adisakwattana, Onrapak Reamtong
    Food and Waterborne Parasitology.2023; 33: e00207.     CrossRef
  • A comparative transcriptome analysis focusing on immune responses of Asian swamp eel following infection with Aeromonas hydrophila
    Dingda Xu, Panpan Han, Lihai Xia, Jinping Gan, Qiaoqing Xu
    Aquaculture.2021; 539: 736655.     CrossRef
  • Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia
    Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 519.     CrossRef
  • Human gnathostomiasis: a neglected food-borne zoonosis
    Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Effects of Gnathostoma spinigerum infective stage larva excretory-secretory products on NK cells in peripheral blood mononuclear cell culture: focused on expressions of IFN-γ and killer cell lectin-like receptors
    Thanyathon Khetsuphan, Urai Chaisri, Wilanee Dechkhajorn, Surachet Benjathummarak, Paron Dekumyoy, Sumate Ampawong, Parnpen Viriyavejakul, Yaowapa Maneerat
    Parasitology Research.2020; 119(3): 1011.     CrossRef
  • Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection
    Jong-Yil Chai, Bong-Kwang Jung, Jin-Youp Ryu, Hyun-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(4): 467.     CrossRef
  • Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar
    Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(6): 701.     CrossRef
  • Infection Status of Gnathostoma spinigerum Larvae in Asian Swamp Eels, Monopterus albus, Purchased from Local Markets in Cambodia
    Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Sung-Jong Hong, Virak Khieu, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(6): 695.     CrossRef
  • Isolation, identification, and classification of a novel rhabdovirus from diseased Chinese rice-field eels (Monopterus albus)
    Wenzhi Liu, Yuding Fan, Zhong Li, Jianqing Zhao, Yong Zhou, Nan Jiang, Jia Zeng, Kenneth Cain, Lingbing Zeng
    Archives of Virology.2019; 164(1): 105.     CrossRef
  • Molecular identification and genetic diversity of Gnathostoma spinigerum larvae in freshwater fishes in southern Lao PDR, Cambodia, and Myanmar
    Patcharaporn Boonroumkaew, Oranuch Sanpool, Rutchanee Rodpai, Lakkhana Sadaow, Chalermchai Somboonpatarakun, Sakhone Laymanivong, Win Pa Pa Aung, Mesa Un, Porntip Laummaunwai, Pewpan M. Intapan, Wanchai Maleewong
    Parasitology Research.2019; 118(5): 1465.     CrossRef
  • Transcriptome and excretory–secretory proteome of infective-stage larvae of the nematode Gnathostoma spinigerum reveal potential immunodiagnostic targets for development
    Supaporn Nuamtanong, Onrapak Reamtong, Orawan Phuphisut, Palang Chotsiri, Preeyarat Malaithong, Paron Dekumyoy, Poom Adisakwattana
    Parasite.2019; 26: 34.     CrossRef
  • Aeromonas veronii caused disease and pathological changes in Asian swamp eel Monopterus albus
    Lihai Xia, Panpan Han, Xiaoli Cheng, Youshen Li, Chuwen Zheng, Hanwen Yuan, Wenbing Zhang, Qiaoqing Xu
    Aquaculture Research.2019; 50(10): 2978.     CrossRef
  • Gnathostomatidae nematode parasite of Colomesus psittacus (Osteichthyes, Tetraodontiformes) in the Ilha de Marajó, Brazilian Amazon
    Raul Henrique da Silva Pinheiro, Ricardo Luís Sousa Santana, Francisco Tiago Vasconcelos Melo, Jeannie Nascimento dos Santos, Elane Guerreiro Giese
    Revista Brasileira de Parasitologia Veterinária.2017; 26(3): 340.     CrossRef
  • 13,610 View
  • 141 Download
  • 15 Web of Science
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Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
Young Ah Lee, Kyeong Ah Kim, Arim Min, Myeong Heon Shin
Korean J Parasitol 2014;52(4):355-365.
Published online August 29, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.4.355

The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce caspase-3-dependent or -independent host cell death. Phosphorylinositol 3-kinase (PI3K) and protein kinase C (PKC) in E. histolytica play an important function in the adhesion, killing, or phagocytosis of target cells. In this study, we examined the role of amoebic PI3K and PKC in amoeba-induced apoptotic cell death in Jurkat T cells. When Jurkat T cells were incubated with E. histolytica trophozoites, phosphatidylserine (PS) externalization and DNA fragmentation in Jurkat cells were markedly increased compared to those of cells incubated with medium alone. However, when amoebae were pretreated with a PI3K inhibitor, wortmannin before being incubated with E. histolytica, E. histolytica-induced PS externalization and DNA fragmentation in Jurkat cells were significantly reduced compared to results for amoebae pretreated with DMSO. In addition, pretreatment of amoebae with a PKC inhibitor, staurosporine strongly inhibited Jurkat T cell death. However, E. histolytica-induced cleavage of caspase-3, -6, and -7 were not inhibited by pretreatment of amoebae with wortmannin or staurosporin. In addition, we found that amoebic PI3K and PKC have an important role on amoeba adhesion to host compartment. These results suggest that amebic PI3K and PKC activation may play an important role in caspase-independent cell death in Entamoeba-induced apoptosis.

Citations

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  • PI3K/AKT signaling in parasites and parasite diseases: Role and therapeutic potential
    Lujun Yan, Yating Li, Xing Yang, Rui Li, Chunyin Zhu, Xuedong He, Xiaoliang Jin, Guanghui Zheng, Naunain Mehmood, William C. Cho, Shijun Bao, Houhui Song, Yadong Zheng
    Virulence.2025;[Epub]     CrossRef
  • Formation and culture of cell spheroids by using magnetic nanostructures resembling a crown of thorns
    Shijiao Li, Jingjiang Qiu, Zhongwei Guo, Qiulei Gao, Chen-Yu Huang, Yilin Hao, Yifan Hu, Tianshui Liang, Ming Zhai, Yudong Zhang, Bangbang Nie, Wei-Jen Chang, Wen Wang, Rui Xi, Ronghan Wei
    Biofabrication.2024; 16(4): 045018.     CrossRef
  • AGC family kinase of Entamoeba histolytica: Decoding the members biochemically
    Azhar Ahmad, Vikas Kumar, Tushar Kushwaha, Akash Kumar, Deepak Sehgal, Krishna K. Inampudi, Somlata, Katherine S. Ralston
    PLOS Pathogens.2024; 20(11): e1012729.     CrossRef
  • Pathogenicity and virulence of Entamoeba histolytica , the agent of amoebiasis
    Nancy Guillén
    Virulence.2023;[Epub]     CrossRef
  • Apoptotic mimicry as a strategy for the establishment of parasitic infections: parasite- and host-derived phosphatidylserine as key molecule
    João Luiz Mendes Wanderley, Renato Augusto DaMatta, Marcello André Barcinski
    Cell Communication and Signaling.2020;[Epub]     CrossRef
  • Entamoeba histolytica Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells
    Itzel López-Rosas, César López-Camarillo, Yarely M. Salinas-Vera, Olga N. Hernández-de la Cruz, Carlos Palma-Flores, Bibiana Chávez-Munguía, Osbaldo Resendis-Antonio, Nancy Guillen, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Esther Ramírez-Mo
    Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
  • Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
    Kumiko Nakada-Tsukui, Natsuki Watanabe, Tomohiko Maehama, Tomoyoshi Nozaki
    Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
  • AGC family kinase 1 participates in trogocytosis but not in phagocytosis in Entamoeba histolytica
    Somlata, Kumiko Nakada-Tsukui, Tomoyoshi Nozaki
    Nature Communications.2017;[Epub]     CrossRef
  • 10,210 View
  • 87 Download
  • 9 Web of Science
  • Crossref

Brief Communications

Detection of Gnathostoma spinigerum Antibodies in Sera of Non-Traumatic Subarachnoid Hemorrhage Patients in Thailand
Amnat Kitkhuandee, Waranon Munkong, Kittisak Sawanyawisuth, Penchom Janwan, Wanchai Maleewong, Pewpan M. Intapan
Korean J Parasitol 2013;51(6):755-757.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.755

Gnathostoma spinigerum can cause subarachnoid hemorrhage (SAH). The detection of specific antibodies in serum against G. spinigerum antigen is helpful for diagnosis of neurognathostomiasis. There is limited data on the frequency of G. spinigerum infection in non-traumatic SAH. A series of patients diagnosed as non-traumatic SAH at the Srinagarind Hospital, Khon Kaen University, Thailand between January 2011 and January 2013 were studied. CT or MR imaging of the brain was used for diagnosis of SAH. Patients were categorized as aneurysmal subarachnoid hemorrhage (A-SAH) or non-aneurysmal subarachnoid hemorrhage (NA-SAH) according to the results of cerebral angiograms. The presence of specific antibodies in serum against 21- or 24-kDa G. spinigerum antigen was determined using the immunoblot technique. The detection rate of antibodies was compared between the 2 groups. Of the 118 non-traumatic SAH patients for whom cerebral angiogram and immunoblot data were available, 80 (67.8%) patients had A-SAH, whereas 38 (32.2%) had NA-SAH. Overall, 23.7% were positive for specific antibodies against 21- and/or 24-kDa G. spinigerum antigen. No significant differences were found in the positive rate of specific antibodies against G. spinigerum in both groups (P-value=0.350).

  • 9,563 View
  • 76 Download
A Recombinant Matrix Metalloproteinase Protein from Gnathostoma spinigerum for Serodiagnosis of Neurognathostomiasis
Penchom Janwan, Pewpan M. Intapan, Hiroshi Yamasaki, Porntip Laummaunwai, Kittisak Sawanyawisuth, Chaisiri Wongkham, Chatchai Tayapiwatana, Amnat Kitkhuandee, Viraphong Lulitanond, Yukifumi Nawa, Wanchai Maleewong
Korean J Parasitol 2013;51(6):751-754.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.751

Neurognathostomiasis is a severe form of human gnathostomiasis which can lead to disease and death. Diagnosis of neurognathostomiasis is made presumptively by using clinical manifestations. Immunoblotting, which recognizes antigenic components of molecular mass 21 kDa and 24 kDa in larval extracts of Gnathostoma spinigerum (Gs 21/24), has high sensitivity and specificity for diagnosis of neurognathostomiasis. However, only very small amounts of the Gs 21/24 antigens can be prepared from parasites harvested from natural or experimental animals. To overcome this problem, we recently produced a recombinant matrix metalloproteinase (rMMP) protein from G. spinigerum. In this study, we evaluated this rMMP alongside the Gs 21/24 antigens for serodiagnosis of human neurognathostomiasis. We studied sera from 40 patients from Srinagarind Hospital, Khon Kaen University, Thailand, with clinical criteria consistent with those of neurognathostomiasis, and sera from 30 healthy control adults from Thailand. All sera were tested for specific IgG antibodies against both G. spinigerum crude larval extract and rMMP protein using immunoblot analysis. The sensitivity and specificity for both antigenic preparations were all 100%. These results show that G. spinigerum rMMP protein can be used as an alternative diagnostic antigen, in place of larval extract, for serodiagnosis of neurognathostomiasis.

Citations

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  • Protein and antigen profiles of third-stage larvae of Gnathostoma spinigerum assessed with next-generation sequencing transcriptomic information
    Kathyleen Nogrado, Tipparat Thiangtrongjit, Poom Adisakwattana, Paron Dekumyoy, Sant Muangnoicharoen, Charin Thawornkuno, Onrapak Reamtong
    Scientific Reports.2022;[Epub]     CrossRef
  • Development of Immunochromatographic Test Kit for Rapid Detection of Specific IgG4 Antibody in Whole-Blood Samples for Diagnosis of Human Gnathostomiasis
    Penchom Janwan, Pewpan M. Intapan, Lakkhana Sadaow, Rutchanee Rodpai, Hiroshi Yamasaki, Patcharaporn Boonroumkaew, Oranuch Sanpool, Tongjit Thanchomnang, Phuangphaka Sadee, Wanchai Maleewong
    Diagnostics.2021; 11(5): 862.     CrossRef
  • Proteomics of Gnathostomiasis: A Way Forward for Diagnosis and Treatment Development
    Tipparat Thiangtrongjit, Kathyleen Nogrado, Thawatchai Ketboonlue, Preeyarat Malaitong, Poom Adisakwattana, Onrapak Reamtong
    Pathogens.2021; 10(9): 1080.     CrossRef
  • Combining lexical and context features for automatic ontology extension
    Sara Althubaiti, Şenay Kafkas, Marwa Abdelhakim, Robert Hoehndorf
    Journal of Biomedical Semantics.2020;[Epub]     CrossRef
  • Human gnathostomiasis: a neglected food-borne zoonosis
    Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Surveillance and diagnosis of zoonotic foodborne parasites
    Reza Zolfaghari Emameh, Sami Purmonen, Antti Sukura, Seppo Parkkila
    Food Science & Nutrition.2018; 6(1): 3.     CrossRef
  • 8,881 View
  • 101 Download
  • Crossref

Original Article

Modulation of Antibody Responses against Gnathostoma spinigerum in Mice Immunized with Crude Antigen Formulated in CpG Oligonucleotide and Montanide ISA720
Pewpan M. Intapan, Chakrit Hirunpetcharat, Churairat Kularbkaew, Wiboonchai Yutanawiboonchai, Penchom Janwan, Wanchai Maleewong
Korean J Parasitol 2013;51(6):637-644.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.637

This study aimed to investigate the antibody responses in mice immunized with Gnathostoma spinigerum crude antigen (GsAg) incorporated with the combined adjuvant, a synthetic oligonucleotide containing unmethylated CpG motif (CpG ODN 1826) and a stable water in oil emulsion (Montanide ISA720). Mice immunized with GsAg and combined adjuvant produced all antibody classes and subclasses to GsAg except IgA. IgG2a/2b/3 but not IgG1 subclasses were enhanced by immunization with CpG ODN 1826 when compared with the control groups immunized with non-CpG ODN and Montanide ISA or only with Montanide ISA, suggesting a biased induction of a Th1-type response by CpG ODN. After challenge infection with live G. spinigerum larvae, the levels of IgG2a/2b/3 antibody subclasses decreased immediately and continuously, while the IgG1 subclass remained at high levels. This also corresponded to a continuous decrease of the IgG2a/IgG1 ratio after infection. Only IgM and IgG1 antibodies, but not IgG2a/2b/3, were significantly produced in adjuvant control groups after infection. These findings suggest that G. spinigerum infection potently induces a Th2-type biased response.

Citations

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  • Evaluation of immunodiagnostic tests for human gnathostomiasis using different antigen preparations of Gnathostoma spinigerum larvae against IgE, IgM, IgG, IgG1‐4 and IgG1 patterns of post‐treated patients
    Issariya Ieamsuwan, Dorn Watthanakulpanich, Urai Chaisri, Poom Adisakwattana, Paron Dekumyoy
    Tropical Medicine & International Health.2021; 26(12): 1634.     CrossRef
  • 8,758 View
  • 86 Download
  • Crossref

Case Report

Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
Jing Cui, Ye Wang, Zhong Quan Wang
Korean J Parasitol 2013;51(4):467-470.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.467

The present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in China. A 52-year-old woman from Henan Province, central China, presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 months. Blood examination showed eosinophila (21.2%), and anti-sparganum antibodies were positive. Skin biopsy of the lesion and histopathological examinations revealed dermal infiltrates of eosinophils but did not show any parasites. Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. On further inquiring, she recalled having eaten undercooked eels and specific antibodies to the larvae of Gnathostoma spinigerum were detected. The patient was definitely diagnosed as cutaneous gnathostomiasis caused by Gnathostoma sp. and treated with albendazole (1,000 mg/day) for 15 days, and the subsequent papule and blister developed after the treatment. After 1 month, laboratory findings indicated a reduced eosinophil count (3.3%). At her final follow-up 18 months later, the patient had no further symptoms and anti-Gnathostoma antibodies became negative. Conclusively, the present study is the first report on a human case of cutaneous gnathostomiasis in Henan Province, China, based on the past history (eating undercooked eels), clinical manifestations (migratory subcutaneous nodule and persistent eosinophilia), and a serological finding (positive for specific anti-Gnathostoma antibodies).

Citations

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  • First reported case of intraocular gnathostomiasis in China
    Shuang Wang, Ling Zhang, Feng Miao, Jun Huang, Juan Guo
    Journal of Travel Medicine.2022;[Epub]     CrossRef
  • Current and future strategies against cutaneous parasites
    Ernest Man, Helen P. Price, Clare Hoskins
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    Nelson Iván Agudelo Higuita, Jackrapong Bruminhent
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  • Morphological and Phylogenetic Analysis of Eustrongylides sp. and Gnathostoma spinigerum Parasitizing the Asian Swamp Eel Monopterusalbus in China
    Sixin Zhang, Guangping Huang, Liang Li, Xianyong Liu, Xiaoli Tang, Xun Suo
    Pathogens.2021; 10(6): 711.     CrossRef
  • Human gnathostomiasis: a neglected food-borne zoonosis
    Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Imported gnathostomiasis manifesting as cutaneous larva migrans and Löffler’s syndrome
    William L. Hamilton, Daniel Agranoff
    BMJ Case Reports.2018; 2018: bcr-2017-223132.     CrossRef
  • 12,912 View
  • 175 Download
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Original Article

Balantidium honghuensis n. sp. (Ciliophora: Trichostomatidae) from the Rectum of Rana nigromaculata and R. limnocharis from Honghu Lake, China
Ming Li, Weidong Li, Lei Zhang, Chong Wang
Korean J Parasitol 2013;51(4):427-431.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.427

A new trichostome ciliate, Balantidium honghuensis n. sp., was isolated from the recta of Rana nigromaculata and R. limnocharis during parasite surveys in Honghu Lake, Hubei Province, central China in summer of 2010 and 2011. Its detailed morphometric characters based on LM and SEM studies were described herein. The organism is oval in shape and thickly ciliated. The vestibulum is "V" shaped and occupies about 1/3 to 2/5 of the body length. The vestibular and nearby regions possess strong peripheral fibers which form a marked axial fiber about the cytopharynx. More than 10 contractile vacuoles are distributed along the periphery of the latter body. Comparisions were made between this new species and B. sinensis Nie, 1935. They were discriminated from each other in terms of general body forms, body size, and vestibulum shapes. Besides, special attention was paid to its high-speed daughter swarmers which we believed to be the infective stage of B. honghuensis. Possible infection routes of anura amphibian balantidia were discussed.

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    Emmanuel Hernández-Valdivia, Efraín Islas-Ojeda, Rafael Casillas-Peñuelas, Arturo Valdivia-Flores, Alberto García-Munguía
    Revista Brasileira de Parasitologia Veterinária.2023;[Epub]     CrossRef
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    Xia-lian Bu, Wei-shan Zhao, Zhong-yang Li, Hong-wei Ma, Yu-shun Chen, Wen-xiang Li, Hong Zou, Ming Li, Gui-tang Wang
    BMC Genomics.2023;[Epub]     CrossRef
  • Balantidium grimi n. sp. (Ciliophora, Litostomatea), a new species inhabiting the rectum of the frog Quasipaa spinosa from Lishui, China
    Weishan Zhao, Can Li, Dong Zhang, Runqiu Wang, Yingzhen Zheng, Hong Zou, Wenxiang Li, Shangong Wu, Guitang Wang, Ming Li
    Parasite.2018; 25: 29.     CrossRef
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    Zongyi Sun, Chuanqi Jiang, Jinmei Feng, Wentao Yang, Ming Li, Wei Miao
    Parasite.2017; 24: 43.     CrossRef
  • Reisolation and redescription of Balantidium duodeni Stein, 1867 (Litostomatea, Trichostomatia)
    Lyudmila V. Chistyakova, Alexei Yu. Kostygov, Olga A. Kornilova, Vyacheslav Yurchenko
    Parasitology Research.2014; 113(11): 4207.     CrossRef
  • New insights into the molecular phylogeny of Balantidium (Ciliophora, Vetibuliferida) based on the analysis of new sequences of species from fish hosts
    Ming Li, Francisco Ponce-Gordo, J. Norman Grim, Chong Wang, Frank Nilsen
    Parasitology Research.2014; 113(12): 4327.     CrossRef
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Case Report

Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
Korean J Parasitol 2013;51(3):343-347.
Published online June 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.3.343

Autochthonous human gnathostomiasis had never been reported in the Republic of Korea. We report here a case of Gnathostoma spinigerum infection in a 32-year-old Korean woman, presumed to have been infected via an indigenous route. The patient had experienced a painful migratory swelling near the left nasolabial fold area of the face for a year, with movement of the swelling to the mucosal area of the upper lip 2 weeks before surgical removal of the lesion. Histopathological examinations of the extracted tissue revealed inflammation with heavy eosinophilic infiltrations and sections of a nematode suggestive of a Gnathostoma sp. larva. The larva characteristically revealed about 25 intestinal cells with multiple (3-6) nuclei in each intestinal cell consistent with the 3rd-stage larva of G. spinigerum. The patient did not have any special history of travel abroad except a recent trip, 4 months before surgery, to China where she ate only cooked food. The patient is the first recorded autochthonous case of G. spinigerum infection in Korea.

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    Jong-Yil Chai
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    Heung Up Kim
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    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
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  • Morphological and Phylogenetic Analysis of Eustrongylides sp. and Gnathostoma spinigerum Parasitizing the Asian Swamp Eel Monopterusalbus in China
    Sixin Zhang, Guangping Huang, Liang Li, Xianyong Liu, Xiaoli Tang, Xun Suo
    Pathogens.2021; 10(6): 711.     CrossRef
  • Human gnathostomiasis: a neglected food-borne zoonosis
    Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
    Parasites & Vectors.2020;[Epub]     CrossRef
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    Francisco Bravo, Bernardo Gontijo
    Anais Brasileiros de Dermatologia.2018; 93(2): 172.     CrossRef
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    William L. Hamilton, Daniel Agranoff
    BMJ Case Reports.2018; 2018: bcr-2017-223132.     CrossRef
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    James H. Diaz
    Journal of Travel Medicine.2015; 22(5): 318.     CrossRef
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Original Articles

Echinostoma revolutum: Freshwater Snails as the Second Intermediate Hosts in Chiang Mai, Thailand
Kittichai Chantima, Jong-Yil Chai, Chalobol Wongsawad
Korean J Parasitol 2013;51(2):183-189.
Published online April 25, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.2.183

The occurrence of 37-collar spined echinostome metacercariae in freshwater snails was investigated in 6 districts of Chiang Mai Province, Thailand, from October 2011 to April 2012. A total of 2,914 snails that belong to 12 species were examined, and 7 snail species (Clea helena, Eyriesia eyriesi, Bithynia funiculata, Bithynia siamensis siamensis, Filopaludina doliaris, Filopaludina sumatrensis polygramma, and Filopaludina martensi martensi) were found infected with echinostome metacercariae. The prevalence of metacercariae was the highest in Filopaludina spp. (38.5-58.7%) followed by B. funiculata (44.0%), E. eyriesi (12.5%), B. siamensis siamensis (8.2%), and C. helena (5.1%). Metacercariae were experimentally fed to hamsters and domestic chicks, and adult flukes were recovered from both hosts at days 15 and 20 post-infection. The adult flukes were identified based on morphological features, morphometrics, host-parasite relationships, and geographical distribution. They were compatible to Echinostoma revolutum or Echinostoma jurini, with only minor differences. As the adults were recovered from both hamsters and chicks, our specimens were more compatible to E. revolutum rather than E. jurini (reported only from mammals). This is the first report for metacercariae of E. revolutum in the snail host, C. helena, and also confirmed that Filopaludina spp., E. eryresi, and Bithynia spp. act as the second intermediate hosts of E. revolutum under natural conditions, which are indigenously distributed in Chiang Mai province.

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  • Development and utilization of a visual loop-mediated isothermal amplification coupled with a lateral flow dipstick (LAMP-LFD) assay for rapid detection of Echinostomatidae metacercaria in edible snail samples
    Wasin Panich, Phonkawin Jaruboonyakorn, Awika Raksaman, Thanawan Tejangkura, Thapana Chontananarth
    International Journal of Food Microbiology.2024; 418: 110732.     CrossRef
  • Genetic diversity and population structure of the helminths intermediate host Anentome helena (von dem Busch, 1847) in northern Thailand
    Nithinan Chomchoei, Chalobol Wongsawad, Preeyaporn Butboonchoo, Nattawadee Nantarat
    Asian Pacific Journal of Tropical Medicine.2024; 17(12): 536.     CrossRef
  • Morphological and DNA analyses reveal cryptic diversity in Anentome wykoffi (Brandt, 1974) (Gastropoda: Nassariidae), with descriptions of two new species from Thailand
    Nithinan Chomchoei, Thierry Backeljau, Piyatida Pimvichai, Ting Hui Ng, Nattawadee Nantarat, Gonzalo Giribet
    Invertebrate Systematics.2023; 37(11): 755.     CrossRef
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    Pichit Wiroonpan, Thapana Chontananarth, Jong-Yil Chai, Watchariya Purivirojkul
    Parasitology.2022; 149(7): 913.     CrossRef
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    The European Zoological Journal.2022; 89(1): 601.     CrossRef
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    Journal of Helminthology.2022;[Epub]     CrossRef
  • Genetic variation of a freshwater snail Hydrobioides nassa (Gastropoda: Bithyniidae) in Thailand examined by mitochondrial DNA sequences
    Naruemon Bunchom, Weerachai Saijuntha, Warayutt Pilap, Warong Suksavate, Kotchaphon Vaisusuk, Narufumi Suganuma, Takeshi Agatsuma, Trevor N. Petney, Chairat Tantrawatpan
    Hydrobiologia.2021; 848(12-13): 2965.     CrossRef
  • Echinostoma mekongi: Discovery of Its Metacercarial Stage in Snails, Filopaludina martensi cambodjensis, in Pursat Province, Cambodia
    Jong-Yil Chai, Woon-Mok Sohn, Jaeeun Cho, Bong-Kwang Jung, Taehee Chang, Keon Hoon Lee, Virak Khieu, Rekol Huy
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    Jong-Yil Chai, Bong-Kwang Jung
    Acta Tropica.2020; 201: 105210.     CrossRef
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    Jong-Yil Chai, Jaeeun Cho, Taehee Chang, Bong-Kwang Jung, Woon-Mok Sohn
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    K. Chantima, C. Rika
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    Preeyaporn Butboonchoo, Chalobol Wongsawad, Pheravut Wongsawad, Jong-Yil Chai
    The Korean Journal of Parasitology.2020; 58(5): 499.     CrossRef
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  • The study of Cytochrome B (CYTB): species-specific detection and phylogenetic relationship of Echinostoma revolutum, (Froelich, 1802)
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    Journal of Parasitic Diseases.2019; 43(1): 66.     CrossRef
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  • Investigation of cryptic diversity and occurrence of echinostome metacercariae infection in Anentome helena (von dem Busch, 1847)
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Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
Kyeong Ah Kim, Ju Young Kim, Young Ah Lee, Arim Min, Young Yil Bahk, Myeong Heon Shin
Korean J Parasitol 2013;51(1):61-68.
Published online February 18, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.1.61

Entamoeba histolytica, which causes amoebic colitis and occasionally liver abscess in humans, is able to induce host cell death. However, signaling mechanisms of colon cell death induced by E. histolytica are not fully elucidated. In this study, we investigated the signaling role of NOX in cell death of HT29 colonic epithelial cells induced by E. histolytica. Incubation of HT29 cells with amoebic trophozoites resulted in DNA fragmentation that is a hallmark of apoptotic cell death. In addition, E. histolytica generate intracellular reactive oxygen species (ROS) in a contact-dependent manner. Inhibition of intracellular ROS level with treatment with DPI, an inhibitor of NADPH oxidases (NOXs), decreased Entamoeba-induced ROS generation and cell death in HT29 cells. However, pan-caspase inhibitor did not affect E. histolytica-induced HT29 cell death. In HT29 cells, catalytic subunit NOX1 and regulatory subunit Rac1 for NOX1 activation were highly expressed. We next investigated whether NADPH oxidase 1 (NOX1)-derived ROS is closely associated with HT29 cell death induced by E. histolytica. Suppression of Rac1 by siRNA significantly inhibited Entamoeba-induced cell death. Moreover, knockdown of NOX1 by siRNA, effectively inhibited E. histolytica-triggered DNA fragmentation in HT29 cells. These results suggest that NOX1-derived ROS is required for apoptotic cell death in HT29 colon epithelial cells induced by E. histolytica.

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    Young Ah Lee, Myeong Heon Shin
    Parasites, Hosts and Diseases.2023; 61(4): 388.     CrossRef
  • Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica
    Young Ah Lee, Seobo Sim, Kyeong Ah Kim, Myeong Heon Shin
    The Korean Journal of Parasitology.2022; 60(3): 155.     CrossRef
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    Nancy Guillén
    Cellular Microbiology.2019;[Epub]     CrossRef
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    Young Ah Lee, Kyeong Ah Kim, Arim Min, Myeong Heon Shin
    Parasite Immunology.2019;[Epub]     CrossRef
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    Young Ah Lee, Arim Min, Myeong Heon Shin
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    Ming‑Zhen Wang, Cheng‑Zhi Qiu, Wai‑Shi Yu, Yan‑Ta Guo, Chun‑Xiao Wang, Zhi‑Xiong Chen
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    Bruno M. Di Genova, Renata R. Tonelli
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    Chelsea Marie, Hans P. Verkerke, Dan Theodorescu, William A. Petri
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    Kyeong Ah Kim, Arim Min, Young Ah Lee, Myeong Heon Shin
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Positivity and Intensity of Gnathostoma spinigerum Infective Larvae in Farmed and Wild-Caught Swamp Eels in Thailand
Wilai Saksirisampant, Benjamas Wongsatayanon Thanomsub
Korean J Parasitol 2012;50(2):113-118.
Published online May 24, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.2.113

From July 2008 to June 2009, livers of the swamp eels (Monopterus alba) were investigated for advanced third-stage larvae (AL3) of Gnathostoma spinigerum. Results revealed that 10.2% (106/1,037) and 20.4% (78/383) of farmed eels from Aranyaprathet District, Sa Kaeo Province and those of wild-caught eels obtained from a market in Min Buri District of Bangkok, Thailand were infected, respectively. The prevalence was high during the rainy and winter seasons. The infection rate abruptly decreased in the beginning of summer. The highest infection rate (13.7%) was observed in September and absence of infection (0%) in March-April in the farmed eels. Whereas, in the wild-caught eels, the highest rate (30.7%) was observed in November, and the rate decreased to the lowest at 6.3% in March. The average no. (mean±SE) of AL3 per investigated liver in farmed eels (1.1±0.2) was significantly lower (P=0.040) than those in the caught eels (0.2±0.03). In addition, the intensity of AL3 recovered from each infected liver varied from 1 to 18 (2.3±0.3) in the farmed eels and from 1 to 47 (6.3±1.2) in the caught eels, respectively. The AL3 intensity showed significant difference (P=0.011) between these 2 different sources of eels. This is the first observation that farmed eels showed positive findings of G. spinigerum infective larvae. This may affect the standard farming of the culture farm and also present a risk of consuming undercooked eels from the wild-caught and farmed eels.

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    Molecular Biology.2016; 50(5): 671.     CrossRef
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    Qiaoqing Xu, Jin Wan, Tingshuang Pan, Jingwen Zhou, Kete Ai, Daiqin Yang
    Genes & Genomics.2015; 37(5): 429.     CrossRef
  • Larval Gnathostoma spinigerum Detected in Asian Swamp Eels, Monopterus albus, Purchased from a Local Market in Yangon, Myanmar
    Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Jong-Bok Park, Hoo-Gn Jeoung, Eui-Hyug Hoang, Thi Thi Htoon, Htay Htay Tin
    The Korean Journal of Parasitology.2015; 53(5): 619.     CrossRef
  • Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
    Jing Cui, Ye Wang, Zhong Quan Wang
    The Korean Journal of Parasitology.2013; 51(4): 467.     CrossRef
  • 10,811 View
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Case Report

Imported Intraocular Gnathostomiasis with Subretinal Tracks Confirmed by Western Blot Assay
Ji Ho Yang, Moosang Kim, Eung Suk Kim, Byoung-Kuk Na, Seung-Young Yu, Hyung-Woo Kwak
Korean J Parasitol 2012;50(1):73-78.
Published online March 6, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.1.73

We report a case of intraocular gnathostomiasis diagnosed by western blot assay in a patient with subretinal tracks. A 15-year-old male patient complained of blurred vision in the right eye, lasting for 2 weeks. Eight months earlier, he had traveled to Vietnam for 1 week and ate raw wild boar meat and lobster. His best-corrected visual acuity was 20/20 in both eyes and anterior chamber examination revealed no abnormalities. Fundus examination showed subretinal tracks in the right eye. Fluorescein angiography and indocyanine green angiography showed linear hyperfluorescence of the subretinal lesion observed on fundus in the right eye. Ultrasound examination revealed no abnormalities. Blood tests indicated mild eosinophilia (7.5%), and there was no abnormality found by systemic examinations. Two years later, the patient visited our department again for ophthalmologic evaluation. Visual acuity remained 20/20 in both eyes and the subretinal tracks in the right eye had not changed since the previous examination. Serologic examination was performed to provide a more accurate diagnosis, and the patient's serum reacted strongly to the Gnathostoma nipponicum antigen by western blot assay, which led to a diagnosis of intraocular gnathostomiasis. This is the first reported case of intraocular gnathostomiasis with subretinal tracks confirmed serologically using western blot in Korea.

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  • Ocular infections in international travelers
    Francesca F. Norman, Julio J. González-López, Diego Gayoso-Cantero, Marta Vicente-Antolin, Maria-Dolores Corbacho-Loarte, Rogelio López-Vélez, Marta González-Sanz
    Travel Medicine and Infectious Disease.2025; 63: 102789.     CrossRef
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    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Intracameral gnathostomiasis presenting as neuroretinitis
    Kimhour Lay, Leng Un, Kossama Chukmol, Piseth Kong
    BMJ Case Reports.2025; 18(3): e260393.     CrossRef
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    Chenghao Zhu, Shangtao Wang, Siyu Ma, Shurui Zhang, Yanjun Wang, Baoshan Li, Wei Zhang, Zhirong Sun
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  • Intracameral Gnathostomiasis: A Case Report and Literature Review
    Wijak Kongwattananon, Thanaporn Wiriyabanditkul, Waraluck Supwatjariyakul, Thanapong Somkijrungroj
    Ocular Immunology and Inflammation.2023; 31(5): 1092.     CrossRef
  • A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
    Parasites, Hosts and Diseases.2023; 61(3): 298.     CrossRef
  • Subretinal gnathostomiasis: A successful focal laser photocoagulation for a living parasite
    Supalert Prakhunhungsit, Somanus Thoongsuwan, Sutasinee Boonsopon, Thitiyaporn Panawattanawong, Pitchaya Amornvararak, Nuttawut Rodanant, Nopasak Phasukkijwatana
    American Journal of Ophthalmology Case Reports.2022; 26: 101413.     CrossRef
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    Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa
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    William L. Hamilton, Daniel Agranoff
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  • Ocular Gnathostomiasis—Update of Earlier Survey
    Kittisak Sawanyawisuth, Yukifumi Nawa, Sandra Fernández Figueiras, Sylvia Paz Diaz Camacho, Verajit Chotmongkol, Masahide Yoshikawa, Maria Benavides
    The American Journal of Tropical Medicine and Hygiene.2017; 97(4): 1232.     CrossRef
  • First reported case of intraocular Gnathostoma spinigerum in Cambodia
    S. Hem, A. Tarantola, R. Chheang, P. Nop, A. Kerléguer
    Bulletin de la Société de pathologie exotique.2015; 108(5): 312.     CrossRef
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    Aziz A. Khanifar, Michael J. Espiritu, Jane S. Myung, Grant D. Aaker, Audrey N. Schuetz, Donald J. D’Amico, R. V. Paul Chan
    Journal of Ophthalmic Inflammation and Infection.2015;[Epub]     CrossRef
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    Hee Kyung Yang, Se Joon Woo, Jeong-Min Hwang
    Optometry and Vision Science.2014; 91(11): e267.     CrossRef
  • Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
    Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(3): 343.     CrossRef
  • Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
    Jing Cui, Ye Wang, Zhong Quan Wang
    The Korean Journal of Parasitology.2013; 51(4): 467.     CrossRef
  • 9,138 View
  • 105 Download
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Brief Communications

Discovery of Larval Gnathostoma nipponicum in Frogs and Snakes from Jeju-do (Province), Republic of Korea
Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2011;49(4):445-448.
Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.445

A survey was performed to find out the intermediate hosts of Gnathostoma nipponicum in Jeju-do (Province), the Republic of Korea. In August 2009 and 2010, a total of 82 tadpoles, 23 black-spotted pond frogs (Rana nigromaculata), 7 tiger keelback snakes (Rhabdophis tigrinus tigrinus), 6 red-tongue viper snakes (Agkistrodon ussuriensis), and 2 cat snakes (Elaphe dione) were collected in Jeju-do and examined by the pepsin-HCl digestion method. Total 5 gnathostome larvae were detected in 3 (50%) of 6 A. ussuriensis, 70 larvae in 3 of 7 (42.9%) R. tigrinus tigrinus, and 2 larvae in 2 of 82 (8.7%) frogs. No gnathostome larvae were detected in tadpoles and cat snakes. The larvae detected were a single species, and 2.17×0.22 mm in average size. They had characteristic head bulbs, muscular esophagus, and 4 cervical sacs. Three rows of hooklets were arranged in the head bulbs, and the number of hooklets in each row was 29, 33, and 36 posteriorly. All these characters were consistent with the advanced third-stage larvae of G. nipponicum. It has been first confirmed in Jeju-do that R. nigromaculata, A. ussuriensis, and R. tigrinus tigrinus play a role for intermediate and/or paratenic hosts for G. nipponicum.

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    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
    Parasites, Hosts and Diseases.2023; 61(3): 298.     CrossRef
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    Seongjun Choe, Junsik Lim, Hyun Kim, Youngjun Kim, Heejong Kim, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Keeseon S. Eom
    The Korean Journal of Parasitology.2016; 54(2): 205.     CrossRef
  • Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
    Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(3): 343.     CrossRef
  • 8,984 View
  • 84 Download
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Ticks Collected from Selected Mammalian Hosts Surveyed in the Republic of Korea During 2008-2009
Heung Chul Kim, Sang Hoon Han, Sung Tae Chong, Terry A. Klein, Chang-Yong Choi, Hyun-Young Nam, Hee-Young Chae, Hang Lee, Sungjin Ko, Jun-Gu Kang, Joon-Seok Chae
Korean J Parasitol 2011;49(3):331-335.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.331

A tick survey was conducted to determine the relative abundance and distribution of ticks associated with selected mammals in the Republic of Korea (ROK) during 2008-2009. A total of 918 ticks were collected from 76 mammals (6 families, 9 species) captured at 6 provinces and 3 Metropolitan Cities in ROK. Haemaphysalis longicornis (54.4%) was the most frequently collected tick, followed by Haemaphysalis flava (28.5%), Ixodes nipponensis (7.6%), Ixodes pomerantzevi (4.8%), Ixodes persulcatus (4.6%), and Haemaphysalis japonica (0.1%). Adults (57.0%) and nymphs (28.7%) of Ixodes and Haemaphysalis spp. were collected most frequently from medium or large mammals in this survey, while few larvae (14.3%) were collected. Hydropotes inermis was the most frequently captured mammal (52.6%), with a 16.4 tick index and 5 of 6 species of ticks collected during this survey. H. longicornis (69.7%) was the predominant tick collected from H. inermis, followed by H. flava (22.2%), I. persulcatus (6.1%), I. nipponensis (1.8%), and H. japonica (0.2%).

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  • Molecular and phylogenetic analysis of equine piroplasms in the Republic of Korea
    Min-Goo Seo, Sun-Hee Yun, Seong-Kyoon Choi, Gil-Jae Cho, Yong-Soo Park, Kwang-Hyun Cho, Oh-Deog Kwon, Dongmi Kwak
    Research in Veterinary Science.2013; 94(3): 579.     CrossRef
  • Detection of Rickettsia monacensis from Ixodes nipponensis collected from rodents in Gyeonggi and Gangwon Provinces, Republic of Korea
    Sun-Hye Shin, Hyun-Ji Seo, Yeon-Joo Choi, Min-Kyung Choi, Heung-Chul Kim, Terry A. Klein, Sung-Tae Chong, Allen L. Richards, Kyung-Hee Park, Won-Jong Jang
    Experimental and Applied Acarology.2013; 61(3): 337.     CrossRef
  • Spotted fever group rickettsia closely related to Rickettsia monacensis isolated from ticks in South Jeolla province, Korea
    Kyung‐Min Lee, Yeon‐Joo Choi, Sun‐Hye Shin, Min‐Kyung Choi, Hyeon‐Je Song, Heung‐Chul Kim, Terry A. Klein, Allen L. Richards, Kyung‐Hee Park, Won‐Jong Jang
    Microbiology and Immunology.2013; 57(7): 487.     CrossRef
  • First report of Borrelia burgdorferi sensu lato in two threatened carnivores: the Marbled polecat, Vormela peregusna and the European mink, Mustela lutreola (Mammalia: Mustelidae)
    Călin M Gherman, Attila D Sándor, Zsuzsa Kalmár, Mihai Marinov, Andrei D Mihalca
    BMC Veterinary Research.2012;[Epub]     CrossRef
  • 14,300 View
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The Jeju Weasel, Mustela sibilica quelpartis, A New Definitive Host for Gnathostoma nipponicum Yamaguti, 1941
Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2011;49(3):317-321.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.317

Adult gnathostomes were discovered in the stomach of the Jeju weasel, Mustela sibilica quelpartis, road-killed in Jeju-do (Province). Their morphological characters were examined to identify the species. Total 50 gnathostome adults were collected from 6 out of 10 weasels examined. In infected weasels, 4-6 worms were grouped and embedded in each granulomatous gastric tumor, except 1 weasel. Male worms were 25.0×1.4 mm in average size, and had a tail with pedunculate papillae, a spicule, and minute tegumental spines. Females were 40.0×2.5 mm in average size, and had a tail without tegumental spines. Pointed and posteriorly curved hooklets were arranged in 8-10 rows on the head bulb. Tegumental spines were distributed from behind the head bulb to the middle portion of the body. The spines were different in size and shape by the distribution level of the body surface. Fertilized eggs were 65.5×38.9 ?m in average size, and had a mucoid plug at 1 pole. These gnathostomes from Jeju weasels were identified as Gnathostoma nipponicum Yamaguti, 1941. By the present study, it was confirmed for the first time that G. nipponicum is distributed in Jeju-do, the Republic of Korea, and the Jeju weasel, M. sibilica quelpartis, plays a crucial role for its definitive host.

Citations

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  • A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
    Parasites, Hosts and Diseases.2023; 61(3): 298.     CrossRef
  • Mustela sibirica (Carnivora: Mustelidae)
    Chris J Law
    Mammalian Species.2018; 50(966): 109.     CrossRef
  • Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
    Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(3): 343.     CrossRef
  • Discovery of LarvalGnathostoma nipponicumin Frogs and Snakes from Jeju-do (Province), Republic of Korea
    Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2011; 49(4): 445.     CrossRef
  • 11,439 View
  • 95 Download
  • Crossref
Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells
Yun Soo Jang, Kyoung-Ju Song, Ju Young Kim, Young Ah Lee, Kyeong Ah Kim, Sang Kyou Lee, Myeong Heon Shin
Korean J Parasitol 2011;49(2):177-180.
Published online June 14, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.2.177

Entamoeba histolytica is an enteric tissue-invading protozoan parasite that can cause amebic colitis and liver abscess in humans. E. histolytica has the capability to kill colon epithelial cells in vitro; however, information regarding the role of calpain in colon cell death induced by ameba is limited. In this study, we investigated whether calpains are involved in the E. histolytica-induced cell death of HT-29 colonic epithelial cells. When HT-29 cells were co-incubated with E. histolytica, the propidium iodide stained dead cells markedly increased compared to that in HT-29 cells incubated with medium alone. This pro-death effect induced by ameba was effectively blocked by pretreatment of HT-29 cells with the calpain inhibitor, calpeptin. Moreover, knockdown of m- and ?-calpain by siRNA significantly reduced E. histolytica-induced HT-29 cell death. These results suggest that m- and ?-calpain may be involved in colon epithelial cell death induced by E. histolytica.

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  • Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica
    Young Ah Lee, Myeong Heon Shin
    Parasites, Hosts and Diseases.2023; 61(4): 388.     CrossRef
  • Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica
    Young Ah Lee, Seobo Sim, Kyeong Ah Kim, Myeong Heon Shin
    The Korean Journal of Parasitology.2022; 60(3): 155.     CrossRef
  • Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses
    Bruno M. Di Genova, Renata R. Tonelli
    Frontiers in Microbiology.2016;[Epub]     CrossRef
  • Degradation of the Transcription Factors NF-κB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
    Kyeong Ah Kim, Arim Min, Young Ah Lee, Myeong Heon Shin
    The Korean Journal of Parasitology.2014; 52(5): 459.     CrossRef
  • Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
    Kyeong Ah Kim, Ju Young Kim, Young Ah Lee, Arim Min, Young Yil Bahk, Myeong Heon Shin
    The Korean Journal of Parasitology.2013; 51(1): 61.     CrossRef
  • Mechanisms of Adherence, Cytotoxicity and Phagocytosis Modulate the Pathogenesis of Entamoeba Histolytica
    Nathaniel CV Christy, William A Petri
    Future Microbiology.2011; 6(12): 1501.     CrossRef
  • 7,579 View
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Prevalence of the Intestinal Flukes Haplorchis taichui and H. yokogawai in a Mountainous Area of Phongsaly Province, Lao PDR
Jong-Yil Chai, Tai-Soon Yong, Keeseon S. Eom, Duk-Young Min, Eun-Hee Shin, Virasack Banouvong, Bounnaloth Insisiengmay, Sithat Insisiengmay, Bounlay Phommasack, Han-Jong Rim
Korean J Parasitol 2010;48(4):339-342.
Published online December 16, 2010
DOI: https://doi.org/10.3347/kjp.2010.48.4.339

Phongsaly Province, located in the northernmost area of Lao PDR, was previously suggested to be endemic for the liver fluke Opisthorchis viverrini infection. To confirm, or rule out, this suggestion, the Phonxay village in the Khoua District, Phongsaly Province, was selected for a survey. Ten volunteers (8 men and 2 women aged 31-57 years) who consumed raw freshwater fish and had gastrointestinal troubles were treated with a single dose of praziquantel (40 mg/kg) and pyrantel pamoate (10 mg/kg) and purged with magnesium sulfate to recover any worm parasites. Eight of the 10 volunteers expelled 1 or more species of trematodes, nematodes, or cestodes (worm positive rate; 80%). The worms were morphologically identified as H. taichui (861 worms from 8 people), H. yokogawai (59 from 6 people), Phaneropsolus bonnei (1 from 1 person), Trichostrongylus sp. (2 from 2 people), Ascaris lumbricoides (2 from 1 person), Enterobius vermicularis (11 from 3 people), and Taenia saginata (1 strobila with scolex from 1 person). The results indicate that the mountainous area of Phongsaly Province, Lao PDR, is not endemic for the liver fluke but endemic for intestinal flukes, in particular, Haplorchis taichui and H. yokogawai.

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    Transboundary and Emerging Diseases.2023; 2023: 1.     CrossRef
  • Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia
    Ting-Ting Zhao, Yi-Jing Feng, Pham Ngoc Doanh, Somphou Sayasone, Virak Khieu, Choosak Nithikathkul, Men-Bao Qian, Yuan-Tao Hao, Ying-Si Lai
    eLife.2021;[Epub]     CrossRef
  • Prevalence and Risk Factors of Intestinal Helminthiasis in Remote Mountainous Villages of Northern Lao PDR: A Cross-Sectional Study
    Hanna Jin, Kyungshick Ryu, Dajeong Lee, Youthanavanh Vonghachack, Min-Ho Choi, Sung-Tae Hong, Hyun Beom Song
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  • Intestinal Helminths Recovered from Humans in Xieng Khouang Province, Lao PDR with a Particular Note on <i>Haplorchis pumilio</i> Infection
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    The Korean Journal of Parasitology.2015; 53(4): 439.     CrossRef
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    Woon-Mok Sohn, Tai-Soon Yong, Keeseon S. Eom, Duk-Young Min, Dongmin Lee, Bong-Kwang Jung, Virasack Banouvong, Bounnaloth Insisiengmay, Bounlay Phommasack, Han-Jong Rim, Jong-Yil Chai
    Acta Tropica.2014; 136: 74.     CrossRef
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    Thapana Chontananarth, Chalobol Wongsawad, Siriwadee Chomdej, Duangduen Krailas, Jong Yil Chai
    Asian Pacific Journal of Tropical Medicine.2014; 7(6): 446.     CrossRef
  • Echinostoma macrorchis in Lao PDR: Metacercariae in Cipangopaludina Snails and Adults from Experimentally Infected Animals
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    The Korean Journal of Parasitology.2013; 51(2): 191.     CrossRef
  • High Prevalence of Haplorchiasis in Nan and Lampang Provinces, Thailand, Proven by Adult Worm Recovery from Suspected Opisthorchiasis Cases
    Adulsak Wijit, Nimit Morakote, Jaewwaew Klinchid
    The Korean Journal of Parasitology.2013; 51(6): 767.     CrossRef
  • Hyperendemicity of Haplorchis taichui Infection among Riparian People in Saravane and Champasak Province, Lao PDR
    Jong-Yil Chai, Tai-Soon Yong, Keeseon S. Eom, Duk-Young Min, Hyeong-Kyu Jeon, Tae-Yun Kim, Bong-Kwang Jung, Lay Sisabath, Bounnaloth Insisiengmay, Bounlay Phommasack, Han-Jong Rim
    The Korean Journal of Parasitology.2013; 51(3): 305.     CrossRef
  • Echinostome Flukes Receovered from Humans in Khammouane Province, Lao PDR
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    The Korean Journal of Parasitology.2012; 50(3): 269.     CrossRef
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    Acta Tropica.2012; 124(3): 215.     CrossRef
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    Tai-Soon Yong, Eun-Hee Shin, Jong-Yil Chai, Woon-Mok Sohn, Keeseon S. Eom, Dong-Min Lee, Keunhee Park, Hoo-Gn Jeoung, Eui-Hyug Hoang, Yoon-Hee Lee, Hyun-Ju Woo, Ji-Hwa Lee, Sin-Il Kang, Jae-Ku Cha, Keon-Hoon Lee, Cheong-Ha Yoon, Muth Sinuon, Duong Socheat
    The Korean Journal of Parasitology.2012; 50(2): 173.     CrossRef
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Suppression of CD4+ T-Cells in the Spleen of Mice Infected with Toxoplasma gondii KI-1 Tachyzoites
Won-Hee Kim, Eun-Hee Shin, Jae-Lip Kim, Seung-Young Yu, Bong-Kwang Jung, Jong-Yil Chai
Korean J Parasitol 2010;48(4):325-329.
Published online December 16, 2010
DOI: https://doi.org/10.3347/kjp.2010.48.4.325

Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune enhancement or suppression, we investigated proliferative responses and phenotypes of spleen cells. In addition, kinetics of IFN-γ, a Th1 cytokine, was examined in BALB/c mice up to day 6 post-infection (PI). Intraperitoneal injection of mice with 103 KI-1 tachyzoites induced significant decreases (P < 0.05) in proliferative responses of spleen cells. This occurred at days 2-6 PI even when concanavalin A (con A) was added and when stimulated with KI-1 antigen, suggesting suppression of the immunity. CD4+ T-cells decreased markedly at day 2 PI (P < 0.05), whereas CD8+ T-cells, NK cells, and macrophages did not show significant changes, except a slight, but significant, increase of CD8+ T-cells at day 6 PI. The capacity of splenocytes to produce IFN-γ by con A stimulation dropped significantly at days 2-6 PI. These results demonstrate that intraperitoneal injection of KI-1 tachyzoites can induce immunosuppression during the early stage of infection, as revealed by the decrease of CD4+ T-cells and IFN-γ.

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  • Exploring the potential of Toxoplasma gondii in drug development and as a delivery system
    Chanjin Yoon, Yu Seong Ham, Woo Jin Gil, Chul-Su Yang
    Experimental & Molecular Medicine.2024; 56(2): 289.     CrossRef
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    Chanjin Yoon, Hyo Keun Kim, Yu Seong Ham, Woo Jin Gil, Seok-Jun Mun, Euni Cho, Jae-Min Yuk, Chul-Su Yang
    Science Advances.2024;[Epub]     CrossRef
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    Jaroslav Flegr, Šárka Kaňková
    Early Human Development.2020; 141: 104874.     CrossRef
  • Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice
    Xiucai Xu, Tingting Liu, Aimei Zhang, Xingxing Huo, Qingli Luo, Zhaowu Chen, Li Yu, Qing Li, Lili Liu, Zhao-rong Lun, Jilong Shen, J. H. Adams
    Infection and Immunity.2012; 80(6): 2121.     CrossRef
  • 8,130 View
  • 63 Download
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Case Report

Gnathostoma hispidum Infection in a Korean Man Returning from China
Han-Seong Kim, Jin-Joo Lee, Mee Joo, Sun-Hee Chang, Je G. Chi, Jong-Yil Chai
Korean J Parasitol 2010;48(3):259-261.
Published online September 16, 2010
DOI: https://doi.org/10.3347/kjp.2010.48.3.259

Human Gnathostoma hispidum infection is extremely rare in the world literature and has never been reported in the Republic of Korea. A 74-year-old Korean man who returned from China complained of an erythematous papule on his back and admitted to our hospital. Surgical extraction of the lesion and histopathological examination revealed sections of a nematode larva in the deep dermis. The sectioned larva had 1 nucleus in each intestinal cell and was identified as G. hispidum. The patient recalled having eaten freshwater fish when he lived in China. We designated our patient as an imported G. hispidum case from China.

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  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
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    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
    Parasites, Hosts and Diseases.2023; 61(3): 298.     CrossRef
  • Morphology and phylogeny of the parasitic nematode Mooleptus rabuka (Machida, Ogawa & Okiyama, 1982) (Rhabditida, Spirurina: Mooleptinae nom. nov.), with notes on taxonomy of the family Gnathostomatidae
    S.G. Sokolov, I.I. Gordeev
    Journal of Helminthology.2021;[Epub]     CrossRef
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    Guo-Hua Liu, Miao-Miao Sun, Hany M. Elsheikha, Yi-Tian Fu, Hiromu Sugiyama, Katsuhiko Ando, Woon-Mok Sohn, Xing-Quan Zhu, Chaoqun Yao
    Parasites & Vectors.2020;[Epub]     CrossRef
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    Jorge Costa Eiras, Gilberto Cezar Pavanelli, Ricardo Massato Takemoto, Yukifumi Nawa
    The Korean Journal of Parasitology.2018; 56(3): 215.     CrossRef
  • Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China
    Jing Cui, Ye Wang, Zhong Quan Wang
    The Korean Journal of Parasitology.2013; 51(4): 467.     CrossRef
  • Gnathostoma spinigerum Infection in the Upper Lip of a Korean Woman: An Autochthonous Case in Korea
    Jae Hee Kim, Hyemi Lim, Young-Sang Hwang, Tae Yeon Kim, Eun Mee Han, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(3): 343.     CrossRef
  • Imported Intraocular Gnathostomiasis with Subretinal Tracks Confirmed by Western Blot Assay
    Ji Ho Yang, Moosang Kim, Eung Suk Kim, Byoung-Kuk Na, Seung-Young Yu, Hyung-Woo Kwak
    The Korean Journal of Parasitology.2012; 50(1): 73.     CrossRef
  • Discovery of LarvalGnathostoma nipponicumin Frogs and Snakes from Jeju-do (Province), Republic of Korea
    Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2011; 49(4): 445.     CrossRef
  • Imported Parasitic Diseases in Korea
    Myoung-Hee Ahn
    Infection and Chemotherapy.2010; 42(5): 271.     CrossRef
  • 10,764 View
  • 92 Download
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Mini Reviews

GRA Proteins of Toxoplasma gondii: Maintenance of Host-Parasite Interactions across the Parasitophorous Vacuolar Membrane
Ho-Woo Nam
Korean J Parasitol 2009;47(Suppl):S29.
Published online October 26, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.S.S29

The dense granule of Toxoplasma gondii is a secretory vesicular organelle of which the proteins participate in the modification of the parasitophorous vacuole (PV) and PV membrane for the maintenance of intracellular parasitism in almost all nucleated host cells. In this review, the archives on the research of GRA proteins are reviewed on the foci of finding GRA proteins, characterizing molecular aspects, usefulness in diagnostic antigen, and vaccine trials in addition to some functions in host-parasite interactions.

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    Parasites & Vectors.2025;[Epub]     CrossRef
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    Xuewei Fan, Nan Zhang, Xichen Zhang, Shudong Li, Jiangming Fu, Min Sun, Xiaoxiao Ma, Muhammad Zahoor Khan, Xin Jiang
    Frontiers in Veterinary Science.2025;[Epub]     CrossRef
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    Gonzalo Sanchez-Arsuaga, Damer P. Blake, Fiona M. Tomley, Virginia Marugan-Hernandez
    Frontiers in Immunology.2025;[Epub]     CrossRef
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    Vaccines.2025; 13(8): 851.     CrossRef
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    Informatics in Medicine Unlocked.2024; 44: 101435.     CrossRef
  • Comparative GRA6 and GRA7 for their Utility as Genetic Markers in the Genotyping of Cerebral Toxoplasmosis in Cerebrospinal Fluid
    Nora Harminarti, Ika Puspa Sari, Wayan Tunas Artama, Darma Imran, Agnes Kurniawan
    Acta Parasitologica.2024; 69(3): 1555.     CrossRef
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Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection
Myeong Heon Shin, Young Ah Lee, Duk-Young Min
Korean J Parasitol 2009;47(Suppl):S125.
Published online October 26, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.S.S125

Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.

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Original Articles

High Prevalence of Haplorchis taichui, Phaneropsolus molenkampi, and Other Helminth Infections among People in Khammouane Province, Lao PDR
Jong-Yil Chai, Eun-Taek Han, Eun-Hee Shin, Woon-Mok Sohn, Tai-Soon Yong, Keeseon S. Eom, Duk-Young Min, Jin-Young Um, Min-Sung Park, Eui-Hyug Hoang, Bounlay Phommasack, Bounnaloth Insisiengmay, Soon-Hyung Lee, Han-Jong Rim
Korean J Parasitol 2009;47(3):243-247.
Published online August 28, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.3.243

The prevalence of liver and intestinal helminth infections, including Opisthorchis, Haplorchis, Phaneropsolus, hookworms, Enterobius, and Taenia, was surveyed in Khammouane province, Lao PDR. Fecal specimens were collected from 1,242 people (590 men and 652 women) in 3 Mekong riverside villages and were examined by the Kato-Katz thick smear technique. The overall helminth egg positive rate was 81.1%. The positive rate for small trematode eggs, including Opisthorchis viverrini, heterophyids, and lecithodendriids, was 81.1% and the positive rate for hookworms was 6.7%. To obtain adult worms, 35 people who were positive for small trematode eggs were treated with 20-30 mg/kg praziquantel and 10-15 mg/kg pyrantel pamoate, and then purged. Diarrheic stools were collected from 33 of these people and searched for helminth parasites using a stereomicroscope. Mixed infections with various helminths (Haplorchis taichui, Haplorchis yokogawai, Prosthodendrium molenkampi, Phaneropsolus bonnei, echinostomes, hookworms, Trichostrongylus spp., Trichuris trichiura, Enterobius vermicularis, and/or Taenia saginata) were found. The total number of helminth specimens collected was 20,907 (approximately 634 per person). The most common species was H. taichui, followed by P. molenkampi, O. viverrini, P. bonnei, E. vermicularis, hookworms, and Trichostrongylus spp. These results show that diverse species of intestinal nematodes, trematodes, and cestodes are infecting humans in Khammouane province, Lao PDR.

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    Jong-Yil Chai, Tai-Soon Yong, Keeseon S. Eom, Duk-Young Min, Eun-Hee Shin, Virasack Banouvong, Bounnaloth Insisiengmay, Sithat Insisiengmay, Bounlay Phommasack, Han-Jong Rim
    The Korean Journal of Parasitology.2010; 48(4): 339.     CrossRef
  • Double Strand Problems: Reverse DNA Sequences Deposited in the DNA Database
    Urusa Thaenkham, Yukifumi Nawa
    The Korean Journal of Parasitology.2010; 48(1): 89.     CrossRef
  • Haplorchis taichuias a Possible Etiologic Agent of Irritable Bowel Syndrome-Like Symptoms
    Dorn Watthanakulpanich, Jitra Waikagul, Wanna Maipanich, Supaporn Nuamtanong, Surapol Sanguankiat, Somchit Pubampen, Rangson Praevanit, Srisuchat Mongkhonmu, Yukifumi Nawa
    The Korean Journal of Parasitology.2010; 48(3): 225.     CrossRef
  • Foodborne Intestinal Flukes in Southeast Asia
    Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
    The Korean Journal of Parasitology.2009; 47(Suppl): S69.     CrossRef
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Indochinamon ou (Crustacea: Potamidae) as a New Second Intermediate Host for Paragonimus harinasutai in Luang Prabang Province, Lao PDR
Woon-Mok Sohn, Jae-Sook Ryu, Duk-Young Min, Hyun-Ouk Song, Han-Jong Rim, Youthanavanh Vonghachack, Daluny Bouakhasith, Virasack Banouvong
Korean J Parasitol 2009;47(1):25-29.
Published online March 12, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.1.25

Paragonimus harinasutai metacercariae were found in a species of freshwater crab, Indochinamon ou, collected in a small stream of Namback District, Luang Prabang Province, Lao PDR. Adult flukes were recovered after experimental infection of the metacercariae to dogs. Metacercariae were round or slightly elliptical, 0.666 × 0.626 mm in average size, and had a thin cyst wall of about 20 ?m in thickness, a black excretory bladder, convoluted ceca, and some pinkish materials in the body. Adults were somewhat elongated, 95.2 × 36.5 mm in average size, covered with single-tipped tegumental spines, had a smaller oral sucker than the ventral sucker, a moderately branched ovary, and 5-6 lobulated testes. Eggs were ovoid and bilaterally symmetrical in shape, 79 × 45 ?m in average size, and had a uniformly thickened shell. By the present study, it has been confirmed that I. ou is a new second intermediate host for P. harinasutai.

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  • Considerable genetic diversity within Paragonimus heterotremus in Luang Prabang, northern Lao People's Democratic Republic
    Alongkorn Nonthapa, Rutchanee Rodpai, Tongjit Thanchomnang, Patcharaporn Boonroumkaew, Lakkhana Sadaow, David Blair, Pewpan M. Intapan, Wanchai Maleewong, Virasack Banouvong, Sakhone Laymanivong, Oranuch Sanpool
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    Kethmany Ratsavong, Fabrice Quet, Fulgence Nzabintwali, Jeoffray Diendéré, Jacques Sebert, Michel Strobel, Yves Buisson
    Parasite Epidemiology and Control.2017; 2(1): 1.     CrossRef
  • Morphological and molecular identification of a lung fluke, Paragonimus macrorchis (Trematoda, Paragonimidae), found in central Lao PDR and its molecular phylogenetic status in the genus Paragonimus
    Oranuch Sanpool, Pewpan Maleewong Intapan, Tongjit Thanchomnang, Penchom Janwan, Sakhone Laymanivong, Hiromu Sugiyama, Wanchai Maleewong
    Parasitology International.2015; 64(6): 513.     CrossRef
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Brief Communications

Detection of Gnathostoma spinigerum Third-Stage Larvae in Snakeheads Purchased from a Central Part of Myanmar
Bong-Kwang Jung, Jin-Ju Lee, Kyoung-Ho Pyo, Hyeong-Jin Kim, Hoo-Gn Jeong, Cheong-Ha Yoon, Soon-Hyung Lee, Eun-Hee Shin, Jong-Yil Chai
Korean J Parasitol 2008;46(4):285-288.
Published online December 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.4.285

To examine the infection status of freshwater fish with Gnathostoma spp. larvae in Myanmar, we purchased 15 snakeheads, Channa striatus, from a local market in a suburban area of Naypyidaw, the new capital city. Two larval gnathostomes were collected using an artificial digestion technique, and observed by a light microscope and a scanning electron microscope. The size of an intact larva was 2.65 mm long and 0.32 mm wide. The characteristic morphology of the larvae included the presence of a long esophagus (0.80 mm long), 2 pairs of cervical sacs (0.43 mm long), and a characteristic head bulb with 4 rows of hooklets. The number of hooklets in the 1st, 2nd, 3rd, and 4th row was 45, 48, 50, and 52, respectively. Based on these morphological characters, the larvae were identified as the advanced 3rd-stage larvae of Gnathostoma spinigerum. This is the first report of detection of G. spinigerum 3rd-stage larvae in the central part of Myanmar. Our study suggests that intake of raw meat of snakehead fish in Myanmar may result in human gnathostomiasis.

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  • The occurrence and clinical importance of infectious stage of Echinocephalus (Nematoda: Gnathostomidae) larvae in selected Australian edible fish
    Shokoofeh Shamsi, Eleanor Steller, Xiaocheng Zhu
    Parasitology International.2021; 83: 102333.     CrossRef
  • Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia
    Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 519.     CrossRef
  • Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection
    Jong-Yil Chai, Bong-Kwang Jung, Jin-Youp Ryu, Hyun-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(4): 467.     CrossRef
  • Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar
    Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(6): 701.     CrossRef
  • Molecular identification and genetic diversity of Gnathostoma spinigerum larvae in freshwater fishes in southern Lao PDR, Cambodia, and Myanmar
    Patcharaporn Boonroumkaew, Oranuch Sanpool, Rutchanee Rodpai, Lakkhana Sadaow, Chalermchai Somboonpatarakun, Sakhone Laymanivong, Win Pa Pa Aung, Mesa Un, Porntip Laummaunwai, Pewpan M. Intapan, Wanchai Maleewong
    Parasitology Research.2019; 118(5): 1465.     CrossRef
  • Gnathostomatidae nematode parasite of Colomesus psittacus (Osteichthyes, Tetraodontiformes) in the Ilha de Marajó, Brazilian Amazon
    Raul Henrique da Silva Pinheiro, Ricardo Luís Sousa Santana, Francisco Tiago Vasconcelos Melo, Jeannie Nascimento dos Santos, Elane Guerreiro Giese
    Revista Brasileira de Parasitologia Veterinária.2017; 26(3): 340.     CrossRef
  • Larval Gnathostoma spinigerum Detected in Asian Swamp Eels, Monopterus albus, Purchased from a Local Market in Yangon, Myanmar
    Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Jong-Bok Park, Hoo-Gn Jeoung, Eui-Hyug Hoang, Thi Thi Htoon, Htay Htay Tin
    The Korean Journal of Parasitology.2015; 53(5): 619.     CrossRef
  • Zoonoses in South-East Asia: a regional burden, a global threat
    Marion Bordier, François Roger
    Animal Health Research Reviews.2013; 14(1): 40.     CrossRef
  • Gnathostoma spinigerum: Immunodepression in experimental infected mice
    Wilai Saksirisampant, Sunida Thaisom, Mai Ratanavararak, Benjamas Wongsatayanon Thanomsub
    Experimental Parasitology.2012; 132(3): 320.     CrossRef
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The Ruddy Turnstone, Arenaria interpres interpres, a New Definitive Host for Gynaecotyla squatarolae (Digenea: Microphallidae)
Min Seo, Sang-Mee Guk, Jong-Yil Chai
Korean J Parasitol 2008;46(1):41-43.
Published online March 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.1.41

The ruddy turnstone, Arenaria interpres interpres, a migratory Korean bird, was proved to be a natural definitive host for Gynaecotyla squatarolae (Digenea: Microphallidae). The ruddy turnstone was found dead at the seashore of Okgu-eup, Gunsan-si, Jeollabuk-do. The intestinal tract was examined, and 98 unknown flukes were recovered. The worms were 600 × 284 ?m in size, and had 2 ventral suckers. The seminal vesicle was large, the genital atrium was prominent, and the average egg size was 20 × 12.5 ?m. Based on these results, the worms were identified as G. squatarolae. This is the first report on the ruddy turnstone as a natural definitive host of G. squatarolae in the Republic of Korea.

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  • A preliminary study on some larval trematodes parasites of marine snail Cerithidea cingulata (Gmelin, 1791) in Al- faw Bay, South of Iraq

    International Journal of Biosciences (IJB).2020; : 464.     CrossRef
  • Infections with Digenetic Trematode Metacercariae in Freshwater Fishes from Two Visiting Sites of Migratory Birds in Gyeongsangnam-do, Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na
    The Korean Journal of Parasitology.2019; 57(3): 273.     CrossRef
  • New Record of Schistorophus cirripedesmi (Nematoda: Acuariidae) from a Bar-Tailed Godwit, Limosa lapponica baueri (Charadriformes: Scolopacidae) in Korea
    Seongjun Choe, Hyun Kim, Junsik Lim, Dongmin Lee, Hansol Park, Hyeong-Kyu Jeon, Heejong Kim, Youngjun Kim, Keeseon S. Eom
    The Korean Journal of Parasitology.2016; 54(3): 349.     CrossRef
  • Recovery of Oswaldotrema nacinovici from Whimbrels (Aves) in Korea
    Young-Il Lee, Ok-Sik Chung, Min Seo
    The Korean Journal of Parasitology.2016; 54(6): 809.     CrossRef
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    Ho-Jin Yoo, Ok-Sik Chung, Min Seo
    The Korean Journal of Parasitology.2012; 50(3): 273.     CrossRef
  • Discovery ofMaritrema obstipum(Digenea: Microphallidae) from Migratory Birds in Korea
    Ok-Sik Chung, Woon-Mok Sohn, Jong-Yil Chai, Min Seo, Hye-Jung Lee
    The Korean Journal of Parasitology.2011; 49(4): 457.     CrossRef
  • First report of human infection with Gynaecotyla squatarolae and first Korean record of Haplorchis pumilio in a patient
    Ok-Sik Chung, Hye-Jung Lee, Yoo-Me Kim, Woon-Mok Sohn, Sahng-June Kwak, Min Seo
    Parasitology International.2011; 60(2): 227.     CrossRef
  • Surveys of Gynaecotyla squatarolae and Microphallus koreana (Digenea: Microphallidae) Metacercariae in Two Species of Estuarine Crabs in Western Coastal Areas, Korea
    Hye Jung Lee, Jong-Yil Chai, Jin-Woo Lee, Ho Jin, Kwan-Hong Min, Yong-Jun Cho, Min Seo
    The Korean Journal of Parasitology.2010; 48(1): 81.     CrossRef
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    Wafa Y. Al-Kandari, Suzanne A. Al-Bustan
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  • Tegumental Ultrastructure of Adult Gynaecotyla squatarolae (Digenea: Microphallidae)
    Do-Seon Lim, Ki-Ju Choi, Sang-Mee Guk, Jong-Yil Chai, Il-Yong Park, Yun-Kyu Park, Min Seo
    The Korean Journal of Parasitology.2008; 46(2): 87.     CrossRef
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Original Article

Larval Gnathostoma hispidum detected in the red banded odd-tooth snake, Dinodon rufozonatum rufozonatum, from China
Shin-Hyeong Cho, Tong-Soo Kim, Yoon Kong, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2007;45(3):191-198.
Published online September 20, 2007
DOI: https://doi.org/10.3347/kjp.2007.45.3.191

A total of 205 larval gnathostomes were collected from 18 (22.5%) of 80 red banded odd-tooth snakes, Dinodon rufozonatum rufozonatum, which had been smuggled from China and confiscated at Customs in Busan, Republic of Korea. In order to identify the species, some of the larvae were observed by a light microscope and a scanning electron microscope (SEM). The larvae were 2.18 x 0.29 mm in average size, and had a pair of lips at the anterior end, a muscular esophagus, 2 pairs of cervical sacs, and brownish intestines. The head bulb was characteristically equipped with 4 rows of hooklets; the average number of hooklets in each respective row was 38.6, 40.5, 41.5, and 43.7. In SEM views, the mouth evidenced a pair of lateral lips of equal size in a half-moon shape. Each lip featured a couple of labial papillae and a small amphid located between the 2 papillae. The hooklets on the head bulb had single-pointed, posteriorly-curved tips. The cuticular spines were larger and more densely distributed on the anterior part of the body, and decreased gradually in size and number toward the posterior body. On the basis of these morphological characteristics, the larvae were identified as the third stage larvae of Gnathostoma hispidum.

Citations

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  • A case of vocal cord gnathostomiasis diagnosed with sectional morphologies in a histopathological specimen from a Chinese woman living in Korea
    Doo Sik Park, Eun Hyun Cho, Kyung Hoon Park, Soo Min Jo, Bumjung Park, Sun Huh
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  • The occurrence and clinical importance of infectious stage of Echinocephalus (Nematoda: Gnathostomidae) larvae in selected Australian edible fish
    Shokoofeh Shamsi, Eleanor Steller, Xiaocheng Zhu
    Parasitology International.2021; 83: 102333.     CrossRef
  • Detection of Pentastomida on Crab-Eating Frog (Fejervarya cancrivora) in Surabaya and Sidoarjo Areas
    Gilang Maulana Putra, Emmanuel Djoko Poetranto, Fedik Abdul Rantam
    Journal of Parasite Science.2020; 4(2): 75.     CrossRef
  • Tetrathyridia of Mesocestoides lineatus in Chinese Snakes and Their Adults Recovered from Experimental Animals
    Shin-Hyeong Cho, Tong-Soo Kim, Yoon Kong, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2013; 51(5): 531.     CrossRef
  • The Jeju Weasel,Mustela sibilica quelpartis, A New Definitive Host forGnathostoma nipponicumYamaguti, 1941
    Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2011; 49(3): 317.     CrossRef
  • Discovery of LarvalGnathostoma nipponicumin Frogs and Snakes from Jeju-do (Province), Republic of Korea
    Ho-Choon Woo, Hong-Shik Oh, Shin-Hyeong Cho, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2011; 49(4): 445.     CrossRef
  • Precocity of Gnathostoma turgidum in naturally infected four-eyed opossum Philander opossum pallidus from Temascal, Oaxaca, Mexico
    Roberto Javier Almeyda-Artigas, Miguel Ángel Mosqueda-Cabrera, Edmundo Sánchez-Núñez
    Parasitology Research.2010; 106(2): 439.     CrossRef
  • Detection of Gnathostoma spinigerum Third-Stage Larvae in Snakeheads Purchased from a Central Part of Myanmar
    Bong-Kwang Jung, Jin-Ju Lee, Kyoung-Ho Pyo, Hyeong-Jin Kim, Hoo-Gn Jeong, Cheong-Ha Yoon, Soon-Hyung Lee, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2008; 46(4): 285.     CrossRef
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Brief Communication

Differential diagnosis of Trichostrongylus and hookworm eggs via PCR using ITS-1 sequence
Tai-Soon Yong, Jong-Ho Lee, Seobo Sim, Jongweon Lee, Duk-Young Min, Jong-Yil Chai, Keeseon S. Eom, Woon-Mok Sohn, Soon-Hyung Lee, Han-Jong Rim
Korean J Parasitol 2007;45(1):69-74.
Published online March 20, 2007
DOI: https://doi.org/10.3347/kjp.2007.45.1.69

Trichostrongylus eggs observed in cellophane-thick smears are difficult, in practice, to distinguish from hookworm eggs. In order to overcome these limitations, a molecular approach was conducted. A Trichostrongylus colubriformis adult worm was obtained from a human in Laos, which was identified morphologically. ITS-1 sequence of this worm was determined, and found to be most similar with that of T. colubriformis among the Trichostrongylus spp. reported so far. Then, this sequence was compared with those of human hookworm species, Ancylostoma duodenale and Necator americanus, and species-specific oligonucleotide primers were designed. Polymerase chain reaction (PCR) using these primers evidenced specifically amplified PCR products of Trichostrongylus sp., A. duodenale and N. americanus from the eggs of each (520 bp, 690 bp, and 870 bp, respectively). A species-specific PCR technique can be developed in order to study the epidemiology of Trichostrongylus spp. and hookworms in endemic areas.

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Original Article

Interactions between secreted GRA proteins and host cell proteins across the parasitophorous vacuolar membrane in the parasitism of Toxoplasma gondii
Hye-Jin Ahn, Sehra Kim, Hee-Eun Kim, Ho-Woo Nam
Korean J Parasitol 2006;44(4):303-312.
Published online December 20, 2006
DOI: https://doi.org/10.3347/kjp.2006.44.4.303

Interactions between GRA proteins of dense granules in Toxoplasma gondii and host cell proteins were analyzed by yeast two-hybrid technique. The cMyc-GRA fusion proteins expressed from pGBKT7 plasmid in Y187 yeast were bound to host cell proteins from pGADT7-Rec-HeLa cDNA library transformed to AH109 yeast by mating method. By the selection procedures, a total of 939 colonies of the SD/-AHLT culture, 348 colonies of the X-α-gal positive and PCR, 157 colonies of the X-β-gal assay were chosen for sequencing the cDNA and finally 90 colonies containing ORF were selected to analyze the interactions. GRA proteins interacted with a variety of host cell proteins such as enzymes, structural and functional proteins of organellar proteins of broad spectrum. Several specific bindings of each GRA protein to host proteins were discussed presumptively the role of GRA proteins after secreting into the parasitophorous vacuoles (PV) and the PV membrane in the parasitism of this parasite.

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    Jingquan Dong, Nan Zhang, Panpan Zhao, Jianhua Li, Lili Cao, Xiaocen Wang, Xin Li, Ju Yang, Xichen Zhang, Pengtao Gong
    Frontiers in Veterinary Science.2021;[Epub]     CrossRef
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    Herbert J. Santos, Tomoyoshi Nozaki
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    K. L. D. Tharaka D. Liyanage, Anke Wiethoelter, Jasmin Hufschmid, Abdul Jabbar
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Brief Communications
Two species of goby, Boleophthalmus pectinirostris and Scartelaos sp., as the new second intermediate hosts of heterophyid fluke in Korea
Woon-Mok Sohn, Jung-A Kim, Hyun-Jae Song
Korean J Parasitol 2005;43(4):161-164.
Published online December 20, 2005
DOI: https://doi.org/10.3347/kjp.2005.43.4.161

A survey was performed in order to determine the infection status of the metacercariae of heterophyid fluke in two goby species, Boleophthalmus pectinirostris and Scartelaos sp., collected from Gangjin-gun, and Shinan-gun, Sooncheon-shi, Jeollanam-do, Republic of Korea. A total of three metacercariae of Heterophyopsis continua was found in only one B. pectinirostris (10.0%) from Gangjin-gun. Heterophyes nocens metacercariae were detected in 24 B. pectinirostris (96.0%) and 14 Scartelaos sp. (63.6%) from Shinan-gun. Heterophyopsis continua metacercariae were found in 11 B. pectinirostris (44.0%) and 21 Scartelaos sp. (95.5%) from Shinan-gun. Stictodora fuscata metacercariae were detected in 18 B. pectinirostris (72.0%) from Shinan-gun. No metacercariae were detected in 20 B. pectinirostris from Sooncheon-shi. From the above results, this study is the first to prove that B. pectinirostris and Scartelaos sp. serve as the second intermediate hosts of some heterophyid flukes in Korea.

Citations

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  • Infections with Zoonotic Trematode Metacercariae in Yellowfin Goby, Acanthogobius flavimanus, from Coastal Areas of Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Soon-Won Lee, Won-Seok Seok
    The Korean Journal of Parasitology.2018; 56(3): 259.     CrossRef
  • Fishborne zoonotic heterophyid infections: An update
    Jong-Yil Chai, Bong-Kwang Jung
    Food and Waterborne Parasitology.2017; 8-9: 33.     CrossRef
  • Pygidiopsis summa (Digenea: Heterophyidae): Status of Metacercarial Infection in Mullets from Coastal Areas in the Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Won-Ja Lee, Mi-Yeoun Park, Soon-Won Lee, Seung-Bong Choi, Beom-Nyung Huh, Won-Seok Seok
    The Korean Journal of Parasitology.2016; 54(4): 497.     CrossRef
  • A digenean parasite in a mudskipper: Opegaster ouemoensis sp. n. (Digenea: Opecoelidae) in Periophthalmus argentilineatus Valenciennes (Perciformes: Gobiidae) in the mangroves of New Caledonia
    Rodney A. Bray, Jean-Lou Justine
    Folia Parasitologica.2013; 60(1): 7.     CrossRef
  • Infection Status of Estuarine Fish and Oysters with Intestinal Fluke Metacercariae in Muan-gun, Jeollanam-do, Korea
    Shin-Hyeong Cho, In-Sang Kim, Eun-Jung Hwang, Tong-Soo Kim, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2012; 50(3): 215.     CrossRef
  • Fish-borne Zoonotic Trematode Metacercariae in the Republic of Korea
    Woon-Mok Sohn
    The Korean Journal of Parasitology.2009; 47(Suppl): S103.     CrossRef
  • Heterophyid metacercarial infections in brackish water fishes from Jinju-man (Bay), Kyongsangnam-do, Korea
    Do Gyun Kim, Tong-Soo Kim, Shin-Hyeong Cho, Hyeon-Je Song, Woon-Mok Sohn
    The Korean Journal of Parasitology.2006; 44(1): 7.     CrossRef
  • 8,480 View
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Identification of Acanthotrema felis (Digenea: Heterophyidae) metacercariae encysted in the brackish water fish Acanthogobius flavimanus
Woon-Mok Sohn, Eun-Taek Han, Min Seo, Jong-Yil Chai
Korean J Parasitol 2003;41(2):101-105.
Published online June 20, 2003
DOI: https://doi.org/10.3347/kjp.2003.41.2.101

The metacercariae of Acanthotrema felis Sohn et al., 2003 (Digenea: Heterophyidae) were discovered in a species of the brackish water fish, Acanthogobius flavimanus, in the Republic of Korea. They were experimentally fed to kittens, and adult flukes were harvested 7 days later. The adults were morphologically characterized by the presence of a bipartite seminal vesicle, the ventral sucker associated with a ventrogenital sac enclosing 3 sclerites (2 long and pointed, and 1 short and thumb-like), and an unarmed gonotyl. The adult flukes were identified as A. felis Sohn et al., 2003, and the brackish water fish A. flavimanus has been verified as one of its second intermediate hosts.

Citations

Citations to this article as recorded by  Crossref logo
  • Infections with Zoonotic Trematode Metacercariae in Yellowfin Goby, Acanthogobius flavimanus, from Coastal Areas of Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Soon-Won Lee, Won-Seok Seok
    The Korean Journal of Parasitology.2018; 56(3): 259.     CrossRef
  • Fishborne zoonotic heterophyid infections: An update
    Jong-Yil Chai, Bong-Kwang Jung
    Food and Waterborne Parasitology.2017; 8-9: 33.     CrossRef
  • Four Human Cases of Acanthotrema felis (Digenea: Heterophyidae) Infection in Korea
    Jong-Yil Chai, Jae-Lip Kim, Min Seo
    The Korean Journal of Parasitology.2014; 52(3): 291.     CrossRef
  • Infection Status of Estuarine Fish and Oysters with Intestinal Fluke Metacercariae in Muan-gun, Jeollanam-do, Korea
    Shin-Hyeong Cho, In-Sang Kim, Eun-Jung Hwang, Tong-Soo Kim, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2012; 50(3): 215.     CrossRef
  • Epidemiological Survey on the Infection of Intestinal Flukes in Residents of Muan-gun, Jeollanam-do, the Republic of Korea
    Shin-Hyeong Cho, Pyo-Yun Cho, Dong-Min Lee, Tong-Soo Kim, In-Sang Kim, Eun-Jung Hwang, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2010; 48(2): 133.     CrossRef
  • Fish-borne Zoonotic Trematode Metacercariae in the Republic of Korea
    Woon-Mok Sohn
    The Korean Journal of Parasitology.2009; 47(Suppl): S103.     CrossRef
  • Echinostoma hortense and Heterophyid Metacercariae Encysted in Yellowfin Goby, Acanthogobius flavimanus, from Shinan-gun and Muan-gun (Jeollanam-do), Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho
    The Korean Journal of Parasitology.2009; 47(3): 307.     CrossRef
  • Heterophyid metacercarial infections in brackish water fishes from Jinju-man (Bay), Kyongsangnam-do, Korea
    Do Gyun Kim, Tong-Soo Kim, Shin-Hyeong Cho, Hyeon-Je Song, Woon-Mok Sohn
    The Korean Journal of Parasitology.2006; 44(1): 7.     CrossRef
  • Two species of goby, Boleophthalmus pectinirostris and Scartelaos sp., as the new second intermediate hosts of heterophyid fluke in Korea
    Woon-Mok Sohn, Jung-A Kim, Hyun-Jae Song
    The Korean Journal of Parasitology.2005; 43(4): 161.     CrossRef
  • 8,236 View
  • 93 Download
  • Crossref
Enzooticity of the dogs, the reservoir host of Thelazia callipaeda, in Korea
Min Seo, Jae-Ran Yu, Hyun-Young Park, Sun Huh, Sang-Kun Kim, Sung-Tae Hong
Korean J Parasitol 2002;40(2):101-103.
Published online June 30, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.2.101

The reservoir hosts of Thelazia callipaeda were examined. The eyes of the 76 dogs raised at farm, 78 military dogs (shepherds), 96 cattle, and 105 pigs were investigated for the presence of eyeworm. Among them, six worms of T. callipaeda were collected from two dogs raised at farm (2.7%), and 188 worms from 26 shepherds (33.5%). No worms were recovered from the cattle or pigs. These results suggest that the dogs, especially the military dogs are serving as a reservoir host of T. callipaeda in Korea.

Citations

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  • Thelazia callipaeda (Nematoda: Spirurida) infections in 2 wildlife species, Prionailurus bengalensis and Nyctereutes procyonoides, in Korea
    Jinho Jang, Young-Seok Park, YoungMin Yun, Keeseon S. Eom, Seongjun Choe
    Parasites, Hosts and Diseases.2025; 63(1): 95.     CrossRef
  • Characteristics of canine thelaziasis in the Republic of Korea: a retrospective study (2022–2024)
    Eunjik Kim, Ye-In Oh, Youngwoo Park
    Journal of Veterinary Science.2025;[Epub]     CrossRef
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    Zichen Liu, Chang Yu, Xiaoli Tan, Ni Chen, Yipeng Jin
    Pathogens.2024; 13(2): 166.     CrossRef
  • Eight cases of canine thelaziosis found in two localities in Korea
    Seongjun Choe, Sunmin Kim, Tilak Chandra Nath, Jeong-Ho Kim
    Parasites, Hosts and Diseases.2023; 61(3): 325.     CrossRef
  • Thelazia Callipaeda Infestation with Tarsal Ectropion
    Yeo Jin Lee, Sung Eun Kim, Ji Hyun Kim, Ji-Sun Paik, Suk-Woo Yang
    Journal of the Korean Ophthalmological Society.2020; 61(3): 294.     CrossRef
  • A human corneal ulcer caused by Thelazia callipaeda in Southwest China: case report
    Xiaoxing Wei, Bo Liu, Yijian Li, Ke Wang, Lixia Gao, Yuli Yang
    Parasitology Research.2020; 119(10): 3531.     CrossRef
  • Mitochondrial Genome of the Eyeworm, Thelazia callipaeda (Nematoda: Spirurida), as the First Representative from the Family Thelaziidae
    Guo-Hua Liu, Robin B. Gasser, Domenico Otranto, Min-Jun Xu, Ji-Long Shen, Namitha Mohandas, Dong-Hui Zhou, Xing-Quan Zhu, Peter U. Fischer
    PLoS Neglected Tropical Diseases.2013; 7(1): e2029.     CrossRef
  • Zoonotic helminths affecting the human eye
    Domenico Otranto, Mark L Eberhard
    Parasites & Vectors.2011;[Epub]     CrossRef
  • Parasitic Diseases of Companion Animals
    Sung Shik Shin
    Hanyang Medical Reviews.2010; 30(3): 246.     CrossRef
  • Review of Zoonotic Parasites in Medical and Veterinary Fields in the Republic of Korea
    Heejeong Youn
    The Korean Journal of Parasitology.2009; 47(Suppl): S133.     CrossRef
  • Human Thelaziosis—A Neglected Parasitic Disease of the Eye
    Jilong Shen, Robin B. Gasser, Deyong Chu, Zengxian Wang, Xiaosong Yuan, Cinzia Cantacessi, Domenico Otranto
    Journal of Parasitology.2006; 92(4): 872.     CrossRef
  • First Thelazia callipaeda Infestation Report in a Dog in Taiwan
    Chih-Huan YANG, Kwong-Chung TUNG, Ming-Yuan WANG, Shih-Chieh CHANG, Wu-Chun TU, Kai-Sung WANG, Ching-Lin SHYU, Wei-Ming LEE
    Journal of Veterinary Medical Science.2006; 68(1): 103.     CrossRef
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