Parasites, Hosts and Diseases

"SCI"

Case Reports

An Autochthonous Human Case of Fasciolopsiasis in Nepal: Ranjit Sah, Michele Calatri, Rafael Toledo; Korean J Parasitol 2019;57(3):295-298.
Published online June 30, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.3.295

Abstract
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Fasciolopsiasis is rarely known as the parasitic disease in Nepal. Herein, we report a case of fasciolopsiasis in a 22-year-old man who was admitted in the hospital with abdominal pain, distension and loss of appetite for a month. He had previously diagnosed with acute viral hepatitis but, his abdominal pain was not resolving despite improvement in his liver function and general condition. During endoscopy an adult digenean worm was seen in the first part of the duodenum. After isolation, the worm was identified morphologically as Fasciolopsis buski. Microscogic examination of the patient’s stool revealed eggs with a morphology consistent with F. buski. Eggs were yellow-brown, ellipsoidal, unembmbryonated, operculated, filled with yolk cells, with thin shell and ranging 118-130 ?m in length and 60-69 ?m in width. The abdominal pain of the patient was resolved after treatment with praziquantel. By the present study, it was confirmed for the first time that fasciolopsiasis is indigenously transmitted in Nepal. Accordingly, the epidemiological studies in humans and reservoir host animals should be performed intensively in near future.

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Endoscopic retrograde cholangiopancreatography for the diagnosis and treatment of biliary Fasciolopsis buski: A rare case report and literature review
Qiao Zhou, Yu Cao, Youcai Lv, Qiuling Zhao, Yating Wei, Yunlan Gu, Juanjuan Yang, Luxi Yang, Hongping Li
Medicine.2025; 104(25): e42829. CrossRef
Fascioliasis and fasciolopsiasis: Current knowledge and future trends
Mar Siles-Lucas, David Becerro-Recio, Judit Serrat, Javier González-Miguel
Research in Veterinary Science.2021; 134: 27. CrossRef
A review of Fasciolopsis buski distribution and control in Indonesia
Muhammad Rasyid Ridha, Liestiana Indriyati, Dicky Andiarsa, April Hari Wardhana
Veterinary World.2021; : 2757. CrossRef
An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae
Blaine A. Mathison, Sarah G. H. Sapp
ZooKeys.2021; 1069: 1. CrossRef
Digestive tract trematodiases (invasions caused by intestinal flukes)
S. B. Chuyelov, A. L. Rossina
CHILDREN INFECTIONS.2020; 19(4): 38. CrossRef

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A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea: Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong; Korean J Parasitol 2018;56(4):375-378.
Published online August 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.4.375

Abstract
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A total of 44 adult or juvenile nutrias were necropsied for disease survey. A large nodule was found in the liver of a nutria. The histopathological specimen of the hepatic nodule was microscopically examined, and sectional worms were found in the bile duct. The worms showed a tegument with spines, highly branches of vitelline glands and intestine. Finally, we histopathologically confirmed fascioliasis in a wild nutria. In the present study, a case of fascioliasis in a wild nutria is first confirmed in Korea.

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The use of Glutathione-S-transferase levels as marker of hepatic damage in chronic fasciolosis in cattle
Al-Hassan Mohammed Mostafa, Gehan Mohammed Sayed, Ali Ali Hassan Al-Ezzi, Alaa Eldin Kamal
Veterinary Parasitology.2025; 339: 110577. CrossRef
Fasciola hepatica infection in Korean water deer (Hydropotes inermis argyropus)
Na-Hyeon Kim, Min-Gyeong Seo, Bumseok Kim, Yu Jeong Jeon, In Jung Jung, Il-Hwa Hong
Parasites, Hosts and Diseases.2025; 63(3): 243. CrossRef
Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
Regulatory Mechanisms in Biosystems.2025; 16(3): e25117. CrossRef
Prevalence and hepatic histopathological findings of fascioliasis in sheep slaughtered in Jeddah, Saudi Arabia
Safinaz J. Ashoor, Majed H. Wakid
Scientific Reports.2023;[Epub] CrossRef
Climate change induced habitat expansion of nutria (Myocastor coypus) in South Korea
Pradeep Adhikari, Baek-Jun Kim, Sun-Hee Hong, Do-Hun Lee
Scientific Reports.2022;[Epub] CrossRef
Genetic diversity and relationships of the liver fluke Fasciola hepatica (Trematoda) with native and introduced definitive and intermediate hosts
Antonio A. Vázquez, Emeline Sabourin, Pilar Alda, Clémentine Leroy, Carole Leray, Eric Carron, Stephen Mulero, Céline Caty, Sarah Hasfia, Michel Boisseau, Lucas Saugné, Olivier Pineau, Thomas Blanchon, Annia Alba, Dominique Faugère, Marion Vittecoq, Sylvi
Transboundary and Emerging Diseases.2021; 68(4): 2274. CrossRef
Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
Journal of Veterinary Science.2020;[Epub] CrossRef
Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
Journal of Veterinary Science.2019;[Epub] CrossRef

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Original Article

Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients: Xiaoying Wu, Jianwei Ren, Zulu Gao, Yun Xu, Huiqun Xie, Tingfang Li, Yanhua Cheng, Fei Hu, Hongyun Liu, Zhihong Gong, Jinyi Liang, Jia Shen, Zhen Liu, Feng Wu, Xi Sun, Zhongzheng Niu, An Ning; Korean J Parasitol 2017;55(2):167-174.
Published online April 30, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.2.167

Abstract
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China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients’ ascites were confined in the kidney area with median area of 20 mm². The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer (0.71±2.44 μg/L vs 0.48±2.12 μg /L, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs 44.50 μg/L). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as 0.81 μg/L. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.680.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.

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Machine learning algorithms to predict the 1 year unfavourable prognosis for advanced schistosomiasis
Honglin Jiang, Weicheng Deng, Jie Zhou, Guanghui Ren, Xinting Cai, Shengming Li, Benjiao Hu, Chunlin Li, Ying Shi, Na Zhang, Yingyan Zheng, Yue Chen, Qingwu Jiang, Yibiao Zhou
International Journal for Parasitology.2021; 51(11): 959. CrossRef
Derivation and external validation of a model to predict 2-year mortality risk of patients with advanced schistosomiasis after discharge
Guo Li, Shanshan Huang, Lifei Lian, Xiaoyan Song, Wenzhe Sun, Jinfeng Miao, Bohan Li, Yong Yuan, Shengfan Wu, Xiaoyan Liu, Zhou Zhu
EBioMedicine.2019; 47: 309. CrossRef

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Case Report

Ectopic Human Fasciola hepatica Infection by an Adult Worm in the Mesocolon: Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park; Korean J Parasitol 2015;53(6):725-730.
Published online December 31, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.6.725

Abstract
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We report here an ectopic case of Fasciola hepatica infection confirmed by recovery of an adult worm in the mesocolon. A 56-year-old female was admitted to our hospital with discomfort and pain in the left lower quadrant of the abdomen. Abdominal CT showed 3 abscesses in the left upper quadrant, mesentery, and pelvic cavity. On surgical exploration, abscess pockets were found in the mesocolon of the sigmoid colon and transverse colon. A leaf-like worm found in the abscess pocket of the mesocolon of the left colon was diagnosed as an adult fluke of F. hepatica. Histologically, numerous eggs of F. hepatica were noted with acute and chronic granulomatous inflammations in the subserosa and pericolic adipose tissues. Conclusively, a rare case of ectopic fascioliasis has been confirmed in this study by the adult worm recovery of F. hepatica in the mesocolon.

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Molecular identification of Fasciola and Dicrocoelium species isolates in ruminants livestock from Kashan and Arak in center of Iran
Mohsen Arbabi, Hossein Hooshyar, Mahdi Delavari
Journal of Parasitic Diseases.2025; 49(2): 453. CrossRef
Hepatic and Extrahepatic Fascioliasis Mimicking Colon Cancer with Hepatic Metastasis
Youe Ree Kim, Young Hwan Lee, Kwon-Ha Yoon
Korean Journal of Abdominal Radiology.2022; 6(1): 51. CrossRef
Phylogenetic Characteristics of Fasciola hepatica Isolated from a Korean Patient
Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
The Korean Journal of Parasitology.2022; 60(5): 367. CrossRef
Prevalence of Schistosoma japonicum infection in water buffaloes in selected areas in Davao del Norte and Davao de Oro, the Philippines
Rohani C. Navarro, Aleyla E. de Cadiz, Jordan M. Fronda, Lynnell Alexie D. Ong, Vicente Y. Belizario Jr.
International Journal of One Health.2021; 7(1): 12. CrossRef
Ascariasis Presenting as Hematoma in the Sigmoid Mesocolon: A Case Report
Ji-Eun Kim, Kyung Eun Bae, Hyun-Jung Kim, Byung-Noe Bae, Ji Hae Lee, Mi-Jin Kang, Ji-Young Kim, Jae Hyung Kim
Journal of the Korean Society of Radiology.2020; 81(4): 1013. CrossRef
Parasitological monitoring of European bison (Bison bonasus) from three forests of north-eastern Poland between 2014 and 2016
Michał K. Krzysiak, Aleksander W. Demiaszkiewicz, Magdalena Larska, Jarosław Tomana, Krzysztof Anusz
Journal of Veterinary Research.2020; 64(1): 103. CrossRef
NumerousFasciolaplasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis
J. González-Miguel, M. A. Valero, M. Reguera-Gomez, C. Mas-Bargues, M. D. Bargues, F. Simón, S. Mas-Coma
Parasitology.2019; 146(3): 284. CrossRef
Highlights of human ectopic fascioliasis: a systematic review
Ali Taghipour, Leila Zaki, Ali Rostami, Masoud Foroutan, Fatemeh Ghaffarifar, Atefeh Fathi, Amir Abdoli
Infectious Diseases.2019; 51(11-12): 785. CrossRef
A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
The Korean Journal of Parasitology.2017; 55(3): 313. CrossRef

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Brief Communication

Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis: In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee; Korean J Parasitol 2015;53(5):641-645.
Published online October 29, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.5.641

Abstract
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Fascioliasis, a food-borne trematode zoonosis, is a disease primarily in cattle and sheep and occasionally in humans. Water dropwort (Oenanthe javanica), an aquatic perennial herb, is a common second intermediate host of Fasciola, and the fresh stems and leaves are widely used as a seasoning in the Korean diet. However, no information regarding Fasciola species contamination in water dropwort is available. Here, we collected 500 samples of water dropwort in 3 areas in Korea during February and March 2015, and the water dropwort contamination of Fasciola species was monitored by DNA sequencing analysis of the Fasciola hepatica and Fasciola gigantica specific mitochondrial cytochrome c oxidase subunit 1 (cox1) and nuclear ribosomal internal transcribed spacer 2 (ITS-2). Among the 500 samples assessed, the presence of F. hepatica cox1 and 1TS-2 markers were detected in 2 samples, and F. hepatica contamination was confirmed by sequencing analysis. The nucleotide sequences of cox1 PCR products from the 2 F. hepatica-contaminated samples were 96.5% identical to the F. hepatica cox1 sequences in GenBank, whereas F. gigantica cox1 sequences were 46.8% similar with the sequence detected from the cox1 positive samples. However, F. gigantica cox1 and ITS-2 markers were not detected by PCR in the 500 samples of water dropwort. Collectively, in this survey of the water dropwort contamination with Fasciola species, very low prevalence of F. hepatica contamination was detected in the samples.

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Isolation and molecular identification of liver fluke cercariae in freshwater snails of Chaharmahal and Bakhtiari province, Iran
Bijan Hosseinpour Aghaei, Nadia Taiefi Nasrabadi, Yaser Pirali Kheirabadi, Seyed Shapoor Reza Shojaei
Molluscan Research.2024; 44(1): 84. CrossRef
Morphological and molecular identification of lymnaeid snail and trematodes cercariae in different water bodies in Perak, Malaysia
Nazir Ahmad Tookhy, Nur Mahiza Md Isa, Rozaihan Mansor, Yasmin Abd Rahaman, Nur Indah Ahmad, Dung Thi Bui, Lokman Hakim Idris, Noor Hazfalinda Hamzah, Norhadila Zulkifli
Parasitology Research.2023; 122(7): 1475. CrossRef
Green vegetable juice as a potential source of human fascioliasis in Korea
Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
One Health.2022; 15: 100441. CrossRef
Phylogenetic Characteristics of Fasciola hepatica Isolated from a Korean Patient
Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
The Korean Journal of Parasitology.2022; 60(5): 367. CrossRef
A Descriptive Study of Human Fascioliasis in Qaemshahr, Mazandaran Province, Iran: Its Prevalence and Risk Factors
Lotfollah Davoodi, Azadeh Mizani, Roya Najafi-Vosough, Saeed Hosseini Teshnizi, afsane amouei, Mousa Motavallihaghi, Hamideh Izadyar, Fateme Amuei, Sara Pourhaghighi, Seyed Reza Mirbadie, Eissa Soleymani
Archives of Clinical Infectious Diseases.2022;[Epub] CrossRef
A Review ofOenanthe javanica(Blume) DC. as Traditional Medicinal Plant and Its Therapeutic Potential
Chuan-li Lu, Xiu-fen Li
Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1. CrossRef
Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures
S. Mas-Coma, M. D. Bargues, M. A. Valero
Parasitology.2018; 145(13): 1665. CrossRef

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Original Articles

Experimental Life History and Biological Characteristics of Fasciola gigantica (Digenea: Fasciolidae): Anawat Phalee, Chalobol Wongsawad, Amnat Rojanapaibul, Jong-Yil Chai; Korean J Parasitol 2015;53(1):59-64.
Published online February 27, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.1.59

Abstract
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This study was conducted to investigate the life history, morphology, and maturation of larval stages and adult worms of Fasciola gigantica in experimental mice. Lymnaea auricularia rubiginosa was used as the intermediate host, and Oryza sativa was used for encystment of the metacercariae, while Mus musculus was used as the definitive host for maturation study. Fresh eggs from the gall bladder of water buffaloes fully developed into embryonated ones and hatched out at days 11-12 after incubation at about 29ºC. Free-swimming miracidia rapidly penetrated into the snail host, and gradually developed into the next larval stages; sporocyst, redia, and daughter redia with cercariae. Fully-developed cercariae were separated from the redia and shed from the snails on day 39 post-infection (PI). Free-swimming cercariae were immediately allowed to adhere to rice plants, and capsules were constructed to protect metacercariae on rice plants. Juvenile worms were detected in intestines of mice at days 3 and 6 PI, but they were found in the bile duct from day 9 PI. Juvenile and adult flukes were recovered from 16 mice experimentally infected with metacercariae, with the average recovery rate of 35.8%. Sexually mature adult flukes were recovered from day 42 PI. It could be confirmed that experimentally encysted metacercariae could infect and develop to maturity in the experimental host. The present study reports for the first time the complete life history of F. gigantica by an experimental study in Thailand. The obtained information can be used as a guide for prevention, elimination, and treatment of F. gigantica at environment and in other hosts.

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Knowledge and Awareness of Bovine Fasciolosis Among Dairy Farm Personnel in the Eastern Cape Province, South Africa
Zuko Mpisana, Mandla Yawa, Mhlangabezi Slayi, Nkululeko Nyangiwe, James Oguttu, Ishmael Festus Jaja
Parasitologia.2025; 5(3): 33. CrossRef
Prevalence and risk factors of fasciolosis in a bovine population from farms in Taiping, Malaysia
Naim Che-Kamaruddin, Nur Fazila Saulol Hamid, Lokman Hakim Idris, Ferdaus Mohamat Yusuff, Zulfa Hanan Ashaari, Hasmawati Yahaya, Norhidayu Sahimin, Nur Mahiza Md Isa
Veterinary Parasitology: Regional Studies and Reports.2024; 49: 100998. CrossRef
Coproprevalence, seroprevalence, and geographic distribution of Fasciola spp. infection in beef and dairy cattle in Pak Chong highland, Nakhon-Ratchasima Province, Northeast Thailand
Pongsakorn Martviset, Amornrat Geadkaew-Krenc, Pantip Piyatadsananon, Ruttiroj Jirojwong, Pathanin Chantree, Wansika Phadungsil, Chompunoot Wangboon, Mantana Jamklang, Sirilak Chumkiew, Rawipreeya Poomkhokrak, Aree Taylor, Nanthawat Kosa, Rudi Grams
Parasitology International.2024; 98: 102809. CrossRef
Investigation of Fasciola gigantica in freshwater snail Radix ( Lymnaea ) spp. In the highly parasite-prevalent area of Nakhon Ratchasima Province, Thailand
Pongsakorn Martviset, Pathanin Chantree, Amornrat Geadkaew-Krenc, Pantip Piyatadsananon, Ruttiroj Jirojwong, Chompunoot Wangboon, Mantana Jamklang, Sirilak Chumkiew, Rawipreeya Poomkhokrak, Nanthawat Kosa, Salisa Chaimon, Bumpenporn Sanannam, Rudi Grams,
International Journal of Veterinary Science and Medicine.2024; 12(1): 125. CrossRef
Towards the comprehension of fasciolosis (re-)emergence: an integrative overview
Annia Alba, Antonio A. Vazquez, Sylvie Hurtrez-Boussès
Parasitology.2021; 148(4): 385. CrossRef
Differential expression of microRNAs and tRNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts
Rui-Si Hu, Xiao-Xuan Zhang, Qiao-Ni Ma, Hany M. Elsheikha, Muhammad Ehsan, Quan Zhao, Bastian Fromm, Xing-Quan Zhu
International Journal for Parasitology.2021; 51(5): 405. CrossRef
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Zhengjiao Wu, Jinhui Wang, Zhen Meng, Weikun Jin, Kangxin He, Weiyu Zhang, Wenda Di
Veterinary Parasitology.2021; 300: 109585. CrossRef
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M.P. Malatji, S. Mukaratirwa
Journal of Helminthology.2020;[Epub] CrossRef
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Young-Jun Choi, Santiago Fontenla, Peter U Fischer, Thanh Hoa Le, Alicia Costábile, David Blair, Paul J Brindley, Jose F Tort, Miguel M Cabada, Makedonka Mitreva, Keith Crandall
Molecular Biology and Evolution.2020; 37(1): 84. CrossRef
Lymnaeidae from Santander and bordering departments of Colombia: Morphological characterization, molecular identification and natural infection with Fasciola hepatica
Andrés Esteban Pereira, Nelson Uribe, Jean-Pierre Pointier
Veterinary Parasitology: Regional Studies and Reports.2020; 20: 100408. CrossRef
Prevalence, risk factors, and spatial distribution of Fasciola in carabao and intermediate host in Baybay, Leyte, Philippines
Harvie P. Portugaliza, Ivy Mae C. Balaso, June Clyde B. Descallar, Eugene B. Lañada
Veterinary Parasitology: Regional Studies and Reports.2019; 15: 100261. CrossRef
Les helminthoses à tropisme hépatique
Brice Autier, Hélène Guegan, Kévin Ory, Sorya Belaz, Sarah Dion, Brigitte Degeilh, Florence Robert-Gangneux, Jean-Pierre Gangneux
Revue Francophone des Laboratoires.2019; 2019(512): 73. CrossRef
Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts
Xiao-Xuan Zhang, Krystyna Cwiklinski, Rui-Si Hu, Wen-Bin Zheng, Zhao-An Sheng, Fu-Kai Zhang, Hany M. Elsheikha, John P. Dalton, Xing-Quan Zhu
BMC Genomics.2019;[Epub] CrossRef
Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
Fu-Kai Zhang, Jun-Ling Hou, Ai-Jiang Guo, Ai-Ling Tian, Zhao-An Sheng, Wen-Bin Zheng, Wei-Yi Huang, Hany M. Elsheikha, Xing-Quan Zhu
Molecular Immunology.2018; 94: 18. CrossRef
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Fu-Kai Zhang, Xiao-Xuan Zhang, Hany M. Elsheikha, Jun-Jun He, Zhao-An Sheng, Wen-Bin Zheng, Jian-Gang Ma, Wei-Yi Huang, Ai-Jiang Guo, Xing-Quan Zhu
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High prevalence of cattle fascioliasis in coastal areas of Thua Thien Hue province, Vietnam
Nga Thi NGUYEN, Thinh Cong LE, Minh Duc Co VO, Hoang VAN CAO, Ly Thi NGUYEN, Khanh Thi HO, Quyet Ngoc NGUYEN, Vui Quang TRAN, Yasunobu MATSUMOTO
Journal of Veterinary Medical Science.2017; 79(6): 1035. CrossRef
Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica
Fu-Kai Zhang, Ai-Jiang Guo, Jun-Ling Hou, Miao-Miao Sun, Zhao-An Sheng, Xiao-Xuan Zhang, Wei-Yi Huang, Hany M. Elsheikha, Xing-Quan Zhu
Veterinary Parasitology.2017; 244: 97. CrossRef

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Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR: Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee; Korean J Parasitol 2014;52(6):645-652.
Published online December 23, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.6.645

Abstract
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Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

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Distribution and Fasciola infection rates of Lymnaea snails and cattle in high-salinity areas of Mekong Delta, Vietnam
Dang Thi LOAN, Lam Thanh NGUYEN, Tran Ngoc BICH, Nguyen Thuy Y VI, Yasunobu MATSUMOTO
Journal of Veterinary Medical Science.2025; 87(3): 291. CrossRef
Susceptibility of lymnaeid snails to Fasciola hepatica and Fasciola gigantica (Digenea: Fasciolidae): a systematic review and meta-analysis
Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
PeerJ.2025; 13: e18976. CrossRef
Green vegetable juice as a potential source of human fascioliasis in Korea
Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
One Health.2022; 15: 100441. CrossRef
Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
Infectious Diseases of Poverty.2018;[Epub] CrossRef
Morphological Characterization of Emerging Cercariae among Lymnaeid Snails from Barangay Cawongan, Padre Garcia, Batangas, Philippines
Gregorio L. Martin I, Esperanza C. Cabrera
Journal of Parasitology Research.2018; 2018: 1. CrossRef
A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
The Korean Journal of Parasitology.2018; 56(4): 375. CrossRef
Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
The Korean Journal of Parasitology.2015; 53(5): 641. CrossRef
Ectopic Human <i>Fasciola hepatica</i> Infection by an Adult Worm in the Mesocolon
Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park
The Korean Journal of Parasitology.2015; 53(6): 725. CrossRef

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Brief Communication

Development of Loop-Mediated Isothermal Amplification Targeting 18S Ribosomal DNA for Rapid Detection of Azumiobodo hoyamushi (Kinetoplastea): Su-Min Song, Dinzouna-Boutamba Sylvatrie-Danne, So-Young Joo, Yun Kyung Shin, Hak Sun Yu, Yong-Seok Lee, Ji-Eon Jung, Noboru Inoue, Won Kee Lee, Youn-Kyoung Goo, Dong-Il Chung, Yeonchul Hong; Korean J Parasitol 2014;52(3):305-310.
Published online June 26, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.3.305

Abstract
PDF

Ascidian soft tunic syndrome (AsSTS) caused by Azumiobodo hoyamushi (A. hoyamushi) is a serious aquaculture problem that results in mass mortality of ascidians. Accordingly, the early and accurate detection of A. hoyamushi would contribute substantially to disease management and prevention of transmission. Recently, the loop-mediated isothermal amplification (LAMP) method was adopted for clinical diagnosis of a range of infectious diseases. Here, the authors describe a rapid and efficient LAMP-based method targeting the 18S rDNA gene for detection of A. hoyamushi using ascidian DNA for the diagnosis of AsSTS. A. hoyamushi LAMP assay amplified the DNA of 0.01 parasites per reaction and detected A. hoyamushi in 10 ng of ascidian DNA. To validate A. hoyamushi 18S rDNA LAMP assays, AsSTS-suspected and non-diseased ascidians were examined by microscopy, PCR, and by using the LAMP assay. When PCR was used as a gold standard, the LAMP assay showed good agreement in terms of sensitivity, positive predictive value (PPV), and negative predictive value (NPV). In the present study, a LAMP assay based on directly heat-treated samples was found to be as efficient as DNA extraction using a commercial kit for detecting A. hoyamushi. Taken together, this study shows the devised A. hoyamushi LAMP assay could be used to diagnose AsSTS in a straightforward, sensitive, and specific manner, that it could be used for forecasting, surveillance, and quarantine of AsSTS.

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Measurement of Tunic Hardness in an Edible Ascidian, Halocynthia roretzi, with Remarks on Soft Tunic Syndrome
Euichi Hirose, Kei Nakayama, Tetsuya Yanagida, Akatsuki Nawata, Shin-Ichi Kitamura
Zoological Science.2018; 35(6): 548. CrossRef

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2 Web of Science
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Case Report

A Case of Fasciola hepatica Infection Mimicking Cholangiocarcinoma and ITS-1 Sequencing of the Worm: Bong Kyun Kang, Bong-Kwang Jung, Yoon Suk Lee, In Kyeom Hwang, Hyemi Lim, Jaeeun Cho, Jin-Hyeok Hwang, Jong-Yil Chai; Korean J Parasitol 2014;52(2):193-196.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.193

Abstract
PDF

Fascioliasis is a zoonotic infection caused by Fasciola hepatica or Fasciola gigantica. We report an 87-year-old Korean male patient with postprandial abdominal pain and discomfort due to F. hepatica infection who was diagnosed and managed by endoscopic retrograde cholangiopancreatography (ERCP) with extraction of 2 worms. At his first visit to the hospital, a gallbladder stone was suspected. CT and magnetic retrograde cholangiopancreatography (MRCP) showed an intraductal mass in the common bile duct (CBD) without proximal duct dilatation. Based on radiological findings, the presumed diagnosis was intraductal cholangiocarcinoma. However, in ERCP which was performed for biliary decompression and tissue diagnosis, movable materials were detected in the CBD. Using a basket, 2 living leaf-like parasites were removed. The worms were morphologically compatible with F. hepatica. To rule out the possibility of the worms to be another morphologically close species, in particular F. gigantica, 1 specimen was processed for genetic analysis of its ITS-1 region. The results showed that the present worms were genetically identical (100%) with F. hepatica but different from F. gigantica.

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Heung Up Kim
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Yue Hu, Rong-Jian Zhan, Shi-Lin Lu, Yi-Yang Zhang, Min-Yu Zhou, Hui Huang, Ding-Ding Wang, Tao Zhang, Zi-Xin Huang, Yun-Fei Zhou, Zhi-Yue Lv
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Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
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Hyun Joon Park, Gil-Soon Choi, Minjung Jung, Sang Uk Lee
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Nuno Vale, Maria João Gouveia, Fátima Gärtner, Paul J Brindley
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Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
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Hüseyin KAÇMAZ, Elif Tuğba TUNCEL, Berat EBİK, Feyzullah UÇMAK, Muhsin KAYA, Kendal YALÇIN
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Alexander M. Bronshteyn, N. A Malyshev, L. V Fedianina, I. V Davydova
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In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
The Korean Journal of Parasitology.2015; 53(5): 641. CrossRef
Endoscopic Extraction of Biliary Fascioliasis Diagnosed Using Intraductal Ultrasonography in a Patient with Acute Cholangitis
Ji Su Ha, Hyun Jong Choi, Jong Ho Moon, Yun Nah Lee, Jae Woong Tae, Moon Han Choi, Tae Hoon Lee, Sang-Woo Cha
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Prevalence of Fasciola spp. from cattle in slaughterhouse by macroscopic examination
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Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR
Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee
The Korean Journal of Parasitology.2014; 52(6): 645. CrossRef

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Original Articles

Morphological and Molecular Characterization of Lymnaeid Snails and Their Potential Role in Transmission of Fasciola spp. in Vietnam: Bui Thi Dung, Pham Ngoc Doanh, Dang Tat The, Ho Thi Loan, Bertrand Losson, Yannick Caron; Korean J Parasitol 2013;51(6):657-662.
Published online December 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.6.657

Abstract
PDF

Freshwater snails of the family Lymnaeidae play an important role in the transmission of fascioliasis worldwide. In Vietnam, 2 common lymnaeid species, Lymnaea swinhoei and Lymnaea viridis, can be recognized on the basis of morphology, and a third species, Lymnaea sp., is known to exist. Recent studies have raised controversy about their role in transmission of Fasciola spp. because of confusion in identification of the snail hosts. The aim of this study is, therefore, to clarify the identities of lymnaeid snails in Vietnam by a combination of morphological and molecular approaches. The molecular analyses using the second internal transcribed spacer (ITS2) of the nuclear ribosomal DNA clearly showed that lymnaeids in Vietnam include 3 species, Austropeplea viridis (morphologically identified as L. viridis), Radix auricularia (morphologically identified as L. swinhoei) and Radix rubiginosa (morphologically identified as Lymnaea sp.). R. rubiginosa is a new record for Vietnam. Among them, only A. viridis was found to be infected with Fasciola spp. These results provide a new insight into lymnaeid snails in Vietnam. Identification of lymnaeid snails in Vietnam and their role in the liver fluke transmission should be further investigated.

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The Korean Journal of Parasitology.2014; 52(6): 645. CrossRef

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Histopathological Changes in Tissues of Bithynia siamensis goniomphalos Incubated in Crude Extracts of Camellia Seed and Mangosteen Pericarp: Ratchadawan Aukkanimart, Thidarut Boonmars, Somchai Pinlaor, Smarn Tesana, Surasit Aunpromma, Chantana Booyarat, Pranee Sriraj, Porntip Laummaunwai, Wiyada Punjaruk; Korean J Parasitol 2013;51(5):537-544.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.537

Abstract
PDF

The present study was performed to observe histopathological changes in tissues of Bithynia siamensis goniomphalos (Gastropoda, Bithyniidae) incubated in crude extract solutions of camellia (Camellia oleifera) seed and mangosteen (Garcinia mangostana) pericarp, and furthermore to estimate the molluscicidal effects of 2 plant substances. Substantial numbers of bithyniid snails were incubated in various concentrations of 2 plant solution for 24 hr. As the positive control, snails incubated in various concentrations of niclosamide, a chemical molluscicide, were used. The histopathological findings were observed in sectioned snail specimens of each experimental and control groups. The results showed that both camellia and mangosteen extracts had molluscicidal effects at 24 hr with 50% lethal concentration (LC₅₀) at concentrations of 0.003 and 0.002 g/ml, respectively, while niclosamide had LC₅₀ at concentrations 0.599 ppm. B. siamensis goniomphalos snail tissues (foot, gill, and digestive system) showed disruption of columnar muscle fibers of the foot, reduction of the length and number of gill cilia, numerous mucous vacuoles, and irregularly shaped of epithelial cells. Irregular apical and calciferous cells, dilatation of the digestive gland tubule, and large hemolymphatic spaces, and irregular apical surfaces, detachment of cilia, and enlargement of lysosomal vacuoles of epidermis were also shown in all groups. By the present study, it is confirmed that 2 plants, camellia and mangosteen, are keeping some substance having molluscicidal effects, and histopathological findings obtained in this study will provide some clues in further studies on their action mechanisms to use them as natural molluscicides.

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Xingzhou Chen, Yuan He, Zhikai Wang, Anqi Niu, Yi Xue, Diao Zhou, Guoying Zhou, Junang Liu
Frontiers in Microbiology.2023;[Epub] CrossRef
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Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
Infectious Diseases of Poverty.2018;[Epub] CrossRef
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Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum
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Parasites & Vectors.2014;[Epub] CrossRef

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Dot-Blot Immunoassay of Fasciola gigantica Infection using 27 kDa and Adult Worm Regurge Antigens in Egyptian Patients: Hanan H. Kamel, Ghada A. Saad, Rania M. Sarhan; Korean J Parasitol 2013;51(2):177-182.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.177

Abstract
PDF

The purpose of the present study was to evaluate the potential role of the 27-Kilodalton (KDa) antigen versus Fasciola gigantica adult worm regurge antigens in a DOT-Blot assay and to assess this assay as a practical tool for diagnosis fascioliasis in Egyptian patients. Fasciola gigantica antigen of an approximate molecular mass 27-(KDa) was obtained from adult worms by a simple elution SDS-PAGE. A Dot-Blot was developed comparatively to adult worm regurge antigens for the detection of specific antibodies from patients infected with F. gigantica in Egypt. Control sera were obtained from patients with other parasitic infections and healthy volunteers to assess the test and compare between the antigens. The sensitivity, specificity, positive and negative predictive values of Dot-Blot using the adult worm regurge were 80%, 90%, 94.1%, and 69.2% respectively, while those using 27-KDa were 100% which confirms the diagnostic potential of this antigen. All patients infected with Fasciola were positive, with cross reactivity reported with Schistosoma mansoni serum samples. This 27-KDa Dot-Blot assay showed to be a promising test which can be used for serodiagnosis of fascioliasis in Egyptian patients especially, those presenting with hepatic disease. It is specific, sensitive and easy to perform method for the rapid diagnosis particularly when more complex laboratory tests are unavailable.

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Research Journal of Parasitology.2018; 13(2): 47. CrossRef
Immunolocalization and immunodetection of the excretory/secretory (ES) antigens of Fasciola gigantica
M. A. Hannan Khan, Rizwan Ullah, Abdur Rehman, Lubna Rehman, Ahammed Shareef P. A., S. M. A. Abidi, Travis Beddoe
PLOS ONE.2017; 12(10): e0185870. CrossRef
Detection of Fasciola hepatica and Fasciola gigantica common and uncommon antigens, using rabbit hyper immune serum raised against their excretory–secretory and somatic antigens
S. Abdolahi Khabisi, B. Sarkari
Journal of Parasitic Diseases.2016; 40(4): 1552. CrossRef
Diagnosis ofFasciolainfection by SDS–PAGE eluted excretory secretory (ES) protein fractions using dot-ELISA
M.A. Sabry, E.S. Taher, N. Farag Allah, A.M. Mahgoub
International Journal of Veterinary Science and Medicine.2014; 2(2): 130. CrossRef
Development of Two Antibody Detection Enzyme-Linked Immunosorbent Assays for Serodiagnosis of Human Chronic Fascioliasis
Kimberly Cabán-Hernández, José F. Gaudier, Caleb Ruiz-Jiménez, Ana M. Espino, M. J. Loeffelholz
Journal of Clinical Microbiology.2014; 52(3): 766. CrossRef

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Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4: Joon-Yong Chung, Young-An Bae, Doo-Hee Yun, Hyun-Jong Yang, Yoon Kong; Korean J Parasitol 2012;50(4):301-308.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.301

Abstract
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19⁺ B cells was observed as early as week 1 post-infection while CD4⁺/CD8⁺ T cells were down-regulated. Accumulation of Mac1⁺ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.

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Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
María Teresa Ruiz-Campillo, Isabel Lourdes Pacheco, Nieves Abril, María José Bautista, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Leandro Buffoni, José Pérez, Verónica Molina-Hernández, Rafael Zafra
Veterinary Research.2024;[Epub] CrossRef
Fascioliasis: Image Findings, Diagnosis, and Treatment
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Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Luis Miguel Flores-Velázquez, María Teresa Ruiz-Campillo, Guillem Herrera-Torres, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Rafael Zafra, Leandro Buffoni, Pablo José Rufino-Moya, Verónica Molina-Hernández, José Pérez
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The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation
Lumin Wang, Yanping Li, Dawei Yang, Jiazhao Fu, Bin Zhao, Yaguang Li, Yanrong Ye, Zhongquan Qi
Clinical and Translational Discovery.2023;[Epub] CrossRef
Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge
Yongqian Bu, Caiwen Jia, Xiaowei Tian, Kalibixiati Aimulajiang, Muhammad Ali Memon, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
Pathogens.2020; 9(1): 46. CrossRef
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez
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Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola
Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis
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Fasciola and fasciolosis in ruminants in Europe: Identifying research needs
N. J. Beesley, C. Caminade, J. Charlier, R. J. Flynn, J. E. Hodgkinson, A. Martinez-Moreno, M. Martinez-Valladares, J. Perez, L. Rinaldi, D. J. L. Williams
Transboundary and Emerging Diseases.2018; 65: 199. CrossRef
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez
Veterinary Research.2018;[Epub] CrossRef
Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review
Claudia Machicado, Jorge D. Machicado, Vicente Maco, Angelica Terashima, Luis A. Marcos, Hector H Garcia
PLOS Neglected Tropical Diseases.2016; 10(9): e0004962. CrossRef

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Protective Role of Purified Cysteine Proteinases against Fasciola gigantica Infection in Experimental Animals: Eman EL-Ahwany, Ibrahim Rabia, Faten Nagy, Mona Zoheiry, Tarek Diab, Suher Zada; Korean J Parasitol 2012;50(1):45-51.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.45

Abstract
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Fascioliasis is one of the public health problems in the world. Cysteine proteinases (CP) released by Fasciola gigantica play a key role in parasite feeding, migration through host tissues, and in immune evasion. There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infections. Cysteine proteinases were purified and tested in vaccine trials of sheep infected with the liver fluke. Multiple doses (2 mg of CP in Freund's adjuvant followed by 3 booster doses 1 mg each at 4 week intervals) were injected intramuscularly into sheep 1 week prior to infect orally with 300 F. gigantica metacercariae. All the sheep were humanely slaughtered 12 weeks after the first immunization. Changes in the worm burden, ova count, and humoral and cellular responses were evaluated. Significant reduction was observed in the worm burden (56.9%), bile egg count (70.7%), and fecel egg count (75.2%). Immunization with CP was also found to be associated with increases of total IgG, IgG₁, and IgG₂ (P<0.05). Data showed that the serum cytokine levels of pro-inflammatory cytokines, IL-12, IFN-γ, and TNF-α, revealed significant decreases (P<0.05). However, the anti-inflammatory cytokine levels, IL-10, TGF-β, and IL-6, showed significant increases (P<0.05). In conclusion, it has been found that CP released by F. gigantica are highly important candidates for a vaccine antigen because of their role in the fluke biology and host-parasite relationships.

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Serodiagnosis of Fasciola gigantica Infection in Buffaloes with Native Cathepsin-L Proteases and Recombinant Cathepsin L1-D
Andleeb Aftab, Rohit Lall, Savita Bisen, Arun Anandanarayanan, Ajayta Rialch, Jayanta K. Chamuah, Shobha Yadav, M. Silamparasan, O. K. Raina
Acta Parasitologica.2020; 65(2): 413. CrossRef
A Survey on the Adjuvant Role of Naloxone Alone or Combined with Alum in Vaccination Against Fasciolosis in BALB/c Mice
Hakim Azizi, Hadi Mirzaeei, Amin Bagheri, Ali Bazi, Ali Khamesipour, Hajar Yaghoobi, Aliyar Mirzapour, Mehrdad Khatami, Samira Elikaee
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Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp ( Ctenopharyngodon idellus ): Induces immune responses and has no damage on liver and intestine function
Zeli Tang, Hengchang Sun, TingJin Chen, Zhipeng Lin, Hongye Jiang, Xinyi Zhou, Cunbin Shi, Houjun Pan, Ouqin Chang, Pengli Ren, Jinyun Yu, Xuerong Li, Jin Xu, Yan Huang, Xinbing Yu
Fish & Shellfish Immunology.2017; 64: 287. CrossRef
Comparative analysis of immune effects in mice model: Clonorchis sinensis cysteine protease generated from recombinant Escherichia coli and Bacillus subtilis spores
Zhanshuai Wu, Zeli Tang, Mei Shang, Lu Zhao, Lina Zhou, Xiangzhan Kong, Zhipeng Lin, Hengchang Sun, Tingjin Chen, Jin Xu, Xuerong Li, Yan Huang, Xinbing Yu
Parasitology Research.2017; 116(7): 1811. CrossRef
The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease
Zeli Tang, Mei Shang, Tingjin Chen, Pengli Ren, Hengchang Sun, Hongling Qu, Zhipeng Lin, Lina Zhou, Jinyun Yu, Hongye Jiang, Xinyi Zhou, Xuerong Li, Yan Huang, Jin Xu, Xinbing Yu
Parasites & Vectors.2016;[Epub] CrossRef
Immunological features of LPS from Ochrobactrum intermedium on sheep experimentally infected with Fasciola hepatica
J.M. Martínez-Pérez, D. Robles-Pérez, F.A. Rojo-Vázquez, M. Martínez-Valladares
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Hayley Toet, David M. Piedrafita, Terry W. Spithill
International Journal for Parasitology.2014; 44(12): 915. CrossRef

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Fasciola gigantica Fatty Acid Binding Protein (FABP) as a Prophylactic Agent against Schistosoma mansoni Infection in CD1 Mice: Ibrahim Rabia Aly, M. Diab, A. M. El-Amir, M. Hendawy, S. Kadry; Korean J Parasitol 2012;50(1):37-43.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.37

Abstract
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Although schistosomicidal drugs and other control measures exist, the advent of an efficacious vaccine remains the most potentially powerful means for controlling this disease. In this study, native fatty acid binding protein (FABP) from Fasciola gigantica was purified from the adult worm's crude extract by saturation with ammonium sulphate followed by separation on DEAE-Sephadex A-50 anion exchange chromatography and gel filtration using Sephacryl HR-100, respectively. CD1 mice were immunized with the purified, native F. gigantica FABP in Freund's adjuvant and challenged subcutaneously with 120 Schistosoma mansoni cercariae. Immunization of CD1 mice with F. gigantica FABP has induced heterologous protection against S. mansoni, evidenced by the significant reduction in mean worm burden (72.3%), liver and intestinal egg counts (81.3% and 80.8%, respectively), and hepatic granuloma counts (42%). Also, it elicited mixed IgG₁/IgG_2b immune responses with predominant IgG1 isotype, suggesting that native F. gigantica FABP is mediated by a mixed Th1/Th2 response. However, it failed to induce any significant differences in the oogram pattern or in the mean granuloma diameter. This indicated that native F. gigantica FABP could be a promising vaccine candidate against S. mansoni infection.

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Investigating the Taenia solium Fatty Acid Binding Protein Superfamily for Their Immunological Outlook and Prospect for Therapeutic Targets
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Bartholomew N. Ondigo, Rachael E. Hamilton, Edwin O. Magomere, Isaac O. Onkanga, Pauline N. Mwinzi, Maurice R. Odiere, Lisa Ganley-Leal
Frontiers in Immunology.2022;[Epub] CrossRef
Effect of regulatory T cells on the efficacy of the fatty acid-binding protein vaccine against Schistosoma japonicum
Chun-lian Tang, Rong-hui Zhang, Zhi-ming Liu, Huang Jin, Long He
Parasitology Research.2019; 118(2): 559. CrossRef
Protection against Schistosoma mansoni infection using a Fasciola hepatica-derived fatty acid binding protein from different delivery systems
Belén Vicente, Julio López-Abán, Jose Rojas-Caraballo, Esther del Olmo, Pedro Fernández-Soto, Antonio Muro
Parasites & Vectors.2016;[Epub] CrossRef
Schistosomiasis in Egypt: A never-ending story?
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Molecular characterization, functional expression, tissue localization and protective potential of a Taenia solium fatty acid-binding protein
Oscar Illescas, Julio C. Carrero, Raúl J. Bobes, Ana Flisser, Gabriela Rosas, Juan P. Laclette
Molecular and Biochemical Parasitology.2012; 186(2): 117. CrossRef

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Case Reports

A Case of Biliary Fascioliasis by Fasciola gigantica in Turkey: Vedat Goral, Senem Senturk, Omer Mete, Mutallib Cicek, Berat Ebik, Be?ir Kaya; Korean J Parasitol 2011;49(1):65-68.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.65

Abstract
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A case of Fasciola gigantica-induced biliary obstruction and cholestasis is reported in Turkey. The patient was a 37- year-old woman, and suffered from icterus, ascites, and pain in her right upper abdominal region. A total of 7 living adult flukes were recovered during endoscopic retrograde cholangiopancreatography (ERCP). A single dose of triclabendazole was administered to treat possible remaining worms. She was living in a village of southeast of Anatolia region and had sheeps and cows. She had the history of eating lettuce, mallow, dill, and parsley without washing. This is the first case of fascioliasis which was treated via endoscopic biliary extraction during ERCP in Turkey.

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Human and Animal Fascioliasis: Origins and Worldwide Evolving Scenario
Santiago Mas-Coma, M. Adela Valero, M. Dolores Bargues
Clinical Microbiology Reviews.2022;[Epub] CrossRef
Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains
Sarah Gabriël, Pierre Dorny, Ganna Saelens, Veronique Dermauw
Foods.2022; 12(1): 142. CrossRef
Triclabendazole in the treatment of human fascioliasis: a review
Preetam Gandhi, Esther K Schmitt, Chien-Wei Chen, Sanjay Samantray, Vinay Kumar Venishetty, David Hughes
Transactions of The Royal Society of Tropical Medicine and Hygiene.2019; 113(12): 797. CrossRef
Fasciola hepatica in the common bile duct: spyglass visualization and endoscopic extraction
Edson Guzmán Calderón, Augusto Vera Calderón, Ramiro Díaz Ríos, Ronald Arcana López, Edgar Alva Alva
Revista Española de Enfermedades Digestivas.2018;[Epub] CrossRef
Human fascioliasis by Fasciola hepatica: the first case report in Nepal
Ranjit Sah, Shusila Khadka, Mohan Khadka, Dipesh Gurubacharya, Jeevan Bahadur Sherchand, Keshab Parajuli, Niranjan Prasad Shah, Hari Prasad Kattel, Bharat Mani Pokharel, Basista Rijal
BMC Research Notes.2017;[Epub] CrossRef
Biliary Fasciola gigantica infestation in a nonendemic area — An intraoperative surprise
Prema Menon, Amit Kumar Sinha, Katragadda Lakshmi Narasimha Rao, Sumeeta Khurana, Sadhana Lal, Babu Ram Thapa
Journal of Pediatric Surgery.2015; 50(11): 1983. CrossRef
Molecular identification ofFasciolaspp. (Digenea: Platyhelminthes) in cattle from Vietnam
S. Nguyen, S. Amer, M. Ichikawa, T. Itagaki, Y. Fukuda, Y. Nakai
Parasite.2012; 19(1): 85. CrossRef

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A Case of Probable Mixed-Infection with Clonorchis sinensis and Fasciola sp.: CT and Parasitological Findings: Tae Yun Kim, Yun-Sik Lee, Ji Hye Yun, Jeong Ju Kim, Won Hyung Choi, In Hwan Oh, Hyun Ouk Song, Jong Phil Chu; Korean J Parasitol 2010;48(2):157-160.
Published online June 17, 2010; DOI: https://doi.org/10.3347/kjp.2010.48.2.157

Abstract
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We report here a human case probably mixed-infected with Clonorchis sinensis and Fasciola sp. who was diagnosed by computed tomography (CT) scan, serological findings, and/or fecal examination. The patient was a 43-year-old Korean female and was admitted to Kyung Hee University Hospital with the complaints of fever and abdominal pain. On admission, marked eosinophilia was noted in her peripheral blood. CT scan showed specific lesions for clonorchiasis and fascioliasis in the liver, along with lesions suggestive of amebic abscess. Micro-ELISA revealed positive results for the 2 helminthic infections. Eggs of C. sinensis and trophozoites of Entamoeba histolytica were observed in the stool. Treatment with praziquantel followed by metronidazole and tinidazole reduced abnormalities in the liver and eosinophilia. This is the first case report of a possible co-infection with 2 kinds of liver flukes in the Republic of Korea.

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Helminth/Protozoan Coinfections in Chronic Fascioliasis Cases in Human Hyperendemic Areas: High Risk of Multiparasitism Linked to Transmission Aspects and Immunological, Environmental and Social Factors
M. Adela Valero, M. Manuela Morales-Suarez-Varela, Davis J. Marquez-Guzman, Rene Angles, Jose R. Espinoza, Pedro Ortiz, Filippo Curtale, M. Dolores Bargues, Santiago Mas-Coma
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Seung Wan Kim, Byoung Kuk Jang
Journal of Korean Medical Science.2023;[Epub] CrossRef
Ultrasound and contrast-enhanced ultrasound (CEUS) in infective liver lesions
Nitin Chaubal, Thomas Thomsen, Adnan Kabaalioglu, David Srivastava, Stephanie Simone Rösch, Christoph F. Dietrich
Zeitschrift für Gastroenterologie.2021; 59(12): 1309. CrossRef
Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario
S. MAS-COMA, M. D. BARGUES, M. A. VALERO
Parasitology.2014; 141(14): 1918. CrossRef

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Original Article

Bibliometric Analysis of the Korean Journal of Parasitology: Measured from SCI, PubMed, Scopus, and Synapse Databases: Choon Shil Lee; Korean J Parasitol 2009;47(Suppl):S155.
Published online October 27, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.S.S155

Abstract
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The Korean Journal of Parasitology (KJP) is the official journal of the Korean Society for Parasitology which is celebrating its 50th anniversary in 2009. To assess the contributions and achievements of the KJP, bibliometric analysis was conducted based on the citation data retrieved from 4 major databases; SCI, PubMed, Synapse, and Scopus. It was found that the KJP articles were constantly cited by the articles published in major international journals represented in these databases. More than 60% of 1,370 articles published in the KJP from 1963 to June 2009 were cited at least once by SCI articles. The overall average times cited by SCI articles are 2.6. The rate is almost 3 times higher for the articles published in the last 10 years compared to 1.0 for the articles of the 1960s. The SCI journal impact factor for 2008 is calculated as 0.871. It is increasing and it is expected to increase further with the introduction of the KJP in the database in 2008. The more realistic h-indixes were measured from the study data set covering all the citations to the KJP; 17 for SCI, 6 for PubMed, 19 for Synapse, and 17 for Scopus. Synapse extensively picked up the citations to the earlier papers not retrievable from the other 3 databases. It identified many papers published in the 1960s and in the 1980s which have been cited heavily, proving the central role of the KJP in the dissemination of the important research findings over the last 5 decades.

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Journal of the Korean Medical Association.2010; 53(8): 659. CrossRef

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Brief Communication

Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis: Kwangsig Kim, Hyun Jong Yang, Young-Bae Chung; Korean J Parasitol 2003;41(2):121-123.
Published online June 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.2.121

Abstract
PDF

This study was designed to detect and evaluate an antigenicity of low molecular weight proteins of Fasciola hepatica in fascioliasis. Low molecular weight protein of F. hepatica was purified by ammonium sulfate precipitation and Sephacryl S-100 HR gel filtration. The protein obtained was estimated to be 8 kDa on 7.5-15% gradient sodium dodecyl sulfate gel electrophoresis. Immunoblotting studies showed that the 8 kDa protein reacted with human fascioliasis sera, but not other trematodiasis sera. This result suggests that the 8 kDa protein of F. hepatica is one of diagnostic antigens in human fascioliasis without cross-reaction with other human trematodiasis.

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Paramphistomum cervi: Antigenic profile of adults as recognized by infected cattle sera
Panat Anuracpreeda, Chaitip Wanichanon, Prasert Sobhon
Experimental Parasitology.2008; 118(2): 203. CrossRef
Humoral immune responses during experimental infection with Fascioloides magna and Fasciola hepatica in goats and comparison of their excretory/secretory products
Adam Novobilský, Martin Kašný, Libor Mikeš, Kamil Kovařčík, Břetislav Koudela
Parasitology Research.2007; 101(2): 357. CrossRef
Preliminary antigenic characterisation of an adult worm vomit preparation of Fasciola hepatica by infected human sera
María Alejandra De Almeida, María Benardetti Ferreira, Sandra Planchart, Angélica Terashima, Vicente Maco, Luis Marcos, Eduardo Gotuzzo, Elizabeth Sánchez, César Náquira, José Vicente Scorza, Renzo Nino Incani
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Original Articles

Identification of newly isolated Babesia parasites from cattle in Korea by using the Bo-RBC-SCID mice: Shin-Hyeong Cho, Tong-Soo Kim, Hyeong-Woo Lee, Masayoshi Tsuji, Chiaki Ishihara, Jong-Taek Kim, Sung-Hwan Wee, Chung-Gil Lee; Korean J Parasitol 2002;40(1):33-40.
Published online March 31, 2002; DOI: https://doi.org/10.3347/kjp.2002.40.1.33

Abstract
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Attempts were made to isolate and identify Korean bovine Babesia parasite. Blood samples were collected from Holstein cows in Korea, and Babesia parasites were propagated in SCID mice with circulating bovine red blood cells for isolation. The isolate was then antigenically and genotypically compared with several Japanese isolates. The Korean parasite was found to be nearly identical to the Oshima strain isolated from Japanese cattle, which was recently designated as Babesia ovata oshimensis n. var. Haemaphysalis longicornis was the most probable tick species that transmited the parasite.

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Analysis of spatial and seasonal variations of Haemaphysalis longicornis population based on field survey collected under different habitats and years
Sunhee Yoon, Jae‐Min Jung, Sumin Oh, Jongmin Bae, Hye‐Min Byun, Subin Choi, Geunho Jang, Minjoon Kang, Eunji Kim, Jaekook Park, Keon Mook Seong, Wang‐Hee Lee, Sunghoon Jung
Entomological Research.2024;[Epub] CrossRef
Molecular investigation of tick-borne pathogens in ticks removed from tick-bitten humans in the southwestern region of the Republic of Korea
Mi Seon Bang, Choon-Mee Kim, Sang-Hyun Pyun, Dong-Min Kim, Na Ra Yun, Martin Chtolongo Simuunza
PLOS ONE.2021; 16(6): e0252992. CrossRef
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Jae Hyoung Im, JiHyeon Baek, Areum Durey, Hea Yoon Kwon, Moon-Hyun Chung, Jin-Soo Lee
Vector-Borne and Zoonotic Diseases.2019; 19(4): 225. CrossRef
Genetic Analysis of Babesia Isolates from Cattle with Clinical Babesiosis in Sri Lanka
Thillaiampalam Sivakumar, Bumduuren Tuvshintulga, Atambekova Zhyldyz, Hemal Kothalawala, Palitha Rohana Yapa, Ratnam Kanagaratnam, Singarayar Caniciyas Vimalakumar, Thuduwege Sanath Abeysekera, Amitha Sampath Weerasingha, Junya Yamagishi, Ikuo Igarashi, S
Journal of Clinical Microbiology.2018;[Epub] CrossRef
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Rodent model for long-term maintenance and development of the viable cysticerci of Taenia saginata asiatica: I.C. Wang, W.C. Chung, S.C. Lu, P.C. Fan; Korean J Parasitol 2000;38(4):237-244.
Published online December 31, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.4.237

Abstract
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Although oncospheres of Taenia saginata asiatica can develop into cysticerci in immunodeficiency, immunosuppressed, and normal mice, no detailed information on the development features of these cysticerci from SCID mice is available. In the present study, the tumor-like cyst was found in the subcutaneous tissues of each of 10 SCID mice after 38-244 days inoculation with 39,000 oncospheres of T. s. asiatica. These cysts weighed 2.0-9.6 gm and were 1.5-4.3 cm in diameter. The number of cysticerci were collected from these cysts ranged from 125 to 1,794 and the cysticercus recovery rate from 0.3% to 4.6%. All cysticerci were viable with a diameter of 1-6 mm and 9 abnormal ones each with 2 evaginated protoscoleces were also found. The mean length and width of scolex, protoscolex, and bladder were 477 × 558, 756 × 727, and 1,586 × 1,615 ?m, respectively. The diameters of suckers and rostellum were 220 ?m and 70 ?m, respectively. All cysticerci had two rows of rostellar hooks. These findings suggest that the SCID mouse model can be employed as a tool for long-term maintenance of the biological materials for advanced studies of immunodiagnosis, vaccine development, and evaluation of cestocidal drugs which would be most benefit for the good health of the livestocks.

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