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"echinococcosis"

Case Report

Imaging Manifestations and Misdiagnosis Analysis of Six Cases of Bone Hydatid Disease
Yanqiu Sun, Chunlong Yan, Dengfeng Tian, Chenhong Zhang, Qiang Zhang
Korean J Parasitol 2022;60(6):413-417.
Published online December 22, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.6.413
We retrospectively evaluated the clinical and imaging features of 6 patients with bone hydatid disease confirmed by surgery and pathological examination. Among the 6 patients, 2 were infected with Echinococcosis granulosus metacestode and 4 were infected with E. multilocularis metacestode. The 2 cases with cystic echinococcosis were diagnosed by computed tomographic (CT) examination, and other 4 cases were diagnosed by magnetic resonance (MR) imaging. On the initial evaluation, 1 case each was misdiagnosed as a giant cell tumor or neurogenic tumor, and 2 were misdiagnosed as tuberculosis. The imaging manifestations of bone hydatid disease are complex, but most common findings include expansive osteolytic bone destruction, which may be associated with sclerosing edges or dead bone formation, localized soft tissue masses, and vertebral lesions with wedge-shaped changes and spinal stenosis. Combining imaging findings with the patient’s epidemiological history and immunological examinations is of great help in improving the diagnosis and differential diagnosis of bone hydatid disease.

Citations

Citations to this article as recorded by  Crossref logo
  • Spinal Echinococcosis in a Japanese Woman Living in Tokyo: Diagnostic Challenges in Non-endemic Areas and Public Health Implications
    Takashi Katsuno, Yuriko Sugiura, Momoko Morishita, Shuhei Osaki, Manabu Suzuki, Jin Takasaki, Motoyasu Iikura, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama
    Internal Medicine.2025; 64(6): 971.     CrossRef
  • Dynamic evaluation of vertebral alveolar echinococcosis using MR T2 mapping
    Jinhuan Han, Yushan Chang, Hui Guo
    Journal of Orthopaedic Surgery.2025;[Epub]     CrossRef
  • Echinococcosis of the humerus with soft tissue and muscle involvement: A case report
    Weikai Chen, Yanan Zhang, Yin Wang, Gaosheng Yang
    Asian Journal of Surgery.2025; 48(6): 3870.     CrossRef
  • Pathological Fracture of the Tibia Due to Lytic Bone Lesion Caused by Hydatidosis with Absence of Systemic Involvement: A Case Report and Review of Literature
    Nashwah Samir AlHariry, Enas A. El Saftawy, Wesam Gamal Abousenna, Mansour A. Alghamdi, Basma Emad Aboulhoda
    Acta Parasitologica.2025;[Epub]     CrossRef
  • Current Perspectives on Cystic Echinococcosis: A Systematic Review
    Hawkar A. Nasralla, Berun A. Abdalla, Hiwa O. Abdullah, Sasan M. Ahmed, Fahmi H. Kakamad, Shvan H. Mohammed, Rawezh Q. Salih, Dahat A. Hussein, Tomas M. Mikael, Marwan N. Hassan, Hunar A. Hassan, Suhaib H. Kakamad, Kayhan A. Najar, Karukh K.
    Judi Clinical Journal.2025; 1(1): 12.     CrossRef
  • Mechanistic role of the IL-1β/c-Fos/NFATc1 signaling axis in echinococcal infection-promoted osteoclast differentiation and activation in pathological osteolysis: a prospective controlled trial
    Yelinaer Ayiheng, Wuluhan Mahan, Zengru Xie
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Complicated Hydatid Cyst Presentation: A Case Study on the Intersection of Cystobiliary Fistula, Bile Duct Obstruction, and Cholangitis: A Case Report
    Nasrin Razavianzadeh, Reza Dabiri, Aref Arminfar, Hessamedin Babaei, Faeze Gholipour, Farbod Noorbini, Soheil Shahramirad
    Clinical Case Reports.2025;[Epub]     CrossRef
  • Surgical Management of Cystic Pelvic Hydatid Bone Disease Using Additively Manufactured Customized Implants for Salvage Reconstruction: A Report of Two Cases
    Rodica Marinescu, Carmen Michaela Cretu, Stefan Ciumeica, Laptoiu Dan Constantin
    Cureus.2024;[Epub]     CrossRef
  • Hydatid cyst of the humerus presenting as a suspicious lesion: A rare case report and review of literature
    Chaymae Faraj, Khadija Laasri, Sara Essetti, Yahya El Harras, Nazik Allali, Siham El Haddad, Latifa Chat, Loubna Aqqaoui, Sarah Hosni, Fouad Ettayebi
    Radiology Case Reports.2024; 19(10): 4526.     CrossRef
  • Diagnostic Approach and Differences between Spinal Infections and Tumors
    Domenico Compagnone, Riccardo Cecchinato, Andrea Pezzi, Francesco Langella, Marco Damilano, Andrea Redaelli, Daniele Vanni, Claudio Lamartina, Pedro Berjano, Stefano Boriani
    Diagnostics.2023; 13(17): 2737.     CrossRef
  • Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation
    Haohao Sun, Sibo Wang, Wenbo Tan, Ye Li, Qian Ren, Yaqing Liu, Yiping Huang, Chenhui Shi, Jing Li
    Acta Tropica.2023; 248: 107027.     CrossRef
  • 3,372 View
  • 110 Download
  • 8 Web of Science
  • Crossref

Original Article

Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis
Jeong-Geun Kim, Xiumin Han, Yoon Kong
Korean J Parasitol 2022;60(1):25-34.
Published online February 23, 2022
DOI: https://doi.org/10.3347/kjp.2022.60.1.25
Alveolar echinococcosis (AE) caused by infection with E. multilocularis metacestode, represents one of the most fatal helminthic diseases. AE is principally manifested with infiltrative, proliferating hepatic mass, resembling primary hepatocellular carcinoma. Sometimes metastatic lesions are found in nearby or remote tissue. AE diagnosis largely depends on imaging studies, but atypical findings of imaging features frequently require differential diagnosis from other hepatic lesions. Serological tests may provide further evidence, while obtaining reliable AE materials is not easy. In this study, alternative antigens, specific to AE were identified by analyzing E. granulosus protoscolex proteins. An immunoblot analysis of E. granulosus protoscolex showed that a group of low-molecular-weight proteins in the range from 14 kDa to 16 kDa exhibited a sensitive and specific immune response to AE patient sera. Partial purification and proteomic analysis indicated that this protein group contained myosin, tubulin polymerization promoting protein, fatty-acid binding protein, uncharacterized DM9, heat shock protein 90 cochaperone tebp P-23, and antigen S. When the serological applicability of recombinant forms of these proteins was assessed using enzyme-linked immunosorbent assay, DM9 protein (rEgDM9) showed 90.1% sensitivity (73/81 sera tested) and 94.5% specificity (172/181 sera tested), respectively. rEgDM9 showed weak cross-reactions with patient sera from the transitional and chronic stages of cystic echinococcosis (3 to 5 stages). rEgDM9 would serve as a useful alternative antigen for serodiagnosis of both early- and advanced-stage AE cases.
  • 4,627 View
  • 185 Download

Case Reports

A Case of Human Hepatic Alveolar Echinococcosis Accompanied by Lung and Brain Metastases
Chuanchuan Liu, Haining Fan, Ri-li Ge
Korean J Parasitol 2021;59(3):291-296.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.291
Alveolar echinococcosis (AE) is considered as a fatal zoonosis caused by the larvae of Echinococcus multilocularis. The lungs and brain are the most common metastatic organs. We report a human case of hepatic alveolar echinococcosis accompanied by lung and brain metastasis. In particular, the patient had a history of tuberculosis and the lung lesions were easily misdiagnosed as lung abscesses. The lesions of liver and lung underwent radical resection and confirmed as alveolar echinococcosis by pathological examination. The patient had no surgical complications after operation and was discharged after symptomatic treatment. Unfortunately, the patient later developed multiple intracerebral AE metastases. We required the patient to take albendazole orally for life and follow up.

Citations

Citations to this article as recorded by  Crossref logo
  • Alveolar Echinococcosis in 11-Month-Old Dog—Clinical Case
    Zuzana Šufliarska, Štefan Tóth, Michaela Gentil, Filip Humeník
    Pathogens.2025; 14(5): 450.     CrossRef
  • Surgical Approach in the Pulmonary Alveolar Echinococcus
    Yener Aydin, Ali Bilal Ulas, Nurhak Aksungur, Atilla Eroglu
    Archivos de Bronconeumología.2024; 60(6): 385.     CrossRef
  • Epididymal alveolar echinococcosis and tuberculosis co-infection: A case report
    Chuanchuan Liu, Hainin Fan
    IDCases.2024; 36: e01966.     CrossRef
  • Study on the mechanism of miRNAs on liver injury in the condition of Protoscocephalus alveolarus transhepatic portal vein infection
    Yazhou Zhu, Ming Li, Zihua Li, Jiahui Song, Wei Zhao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • Echinococcosis: An Uncommon Cause of Thoracic Pain
    Beatriz Sampaio, Felisbela Gomes, Mafalda Leal, Rita Bernardino
    Cureus.2024;[Epub]     CrossRef
  • Diagnosis and comparative analysis of surgical treatment of patients with liver alveococcosis
    V. S. Panteleev, M. A. Nartaylakov, I. Z. Salimgareev, A. S. Petrov
    Acta Biomedica Scientifica.2023; 8(2): 214.     CrossRef
  • A Surgically Resected Case of Multiple Pulmonary Metastases of Echinococcosis Presented with Bloody Phlegm
    Ryota NAGASHIMA, Yasushi CHO, Kenji WAKAYAMA, Shusaku TAKAHASHI, Hiroyuki ISHIZU, Shin ICHIHARA
    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(9): 1442.     CrossRef
  • The Role of the Intestinal Epithelium in the “Weep and Sweep” Response during Gastro—Intestinal Helminth Infections
    Piotr Bąska, Luke James Norbury
    Animals.2022; 12(2): 175.     CrossRef
  • 4,891 View
  • 85 Download
  • 8 Web of Science
  • Crossref
A Case of Alveolar Echinococcosis Occurring in the Hilar Bile Duct
Jinyu Yang, Zhanxue Zhao, Shuai Li, Hekai Chen
Korean J Parasitol 2019;57(5):517-520.
Published online October 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.5.517
Echinococcosis is a disease caused by the Echinococcus species that parasitizes in humans. Alveolar echinococcosis (AE) which is caused by Echinococcus multilocularis is harmful to humans. AE mainly occurs in the liver and can be transferred to retroperitoneal lymph nodes, lung, brain, bone, spleen and other organs through lymphatic and blood vessels. Cholangiocarcinoma can occur in the intrahepatic and extrahepatic bile ducts and is more common in the hilar. We reported a case of hilar bile duct alveolar echinococcosis which was originally misdiagnosed an cholangiocarcinoma.

Citations

Citations to this article as recorded by  Crossref logo
  • An innovative mathematical approach to the evaluation of susceptibility in liver disorder based on fuzzy parameterized complex fuzzy hypersoft set
    Atiqe Ur Rahman, Muhammad Saeed, Mazin Abed Mohammed, Karrar Hameed Abdulkareem, Jan Nedoma, Radek Martinek
    Biomedical Signal Processing and Control.2023; 86: 105204.     CrossRef
  • In vivo and in vitro efficacy of crocin against Echinococcus multilocularis
    Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma
    Parasites & Vectors.2021;[Epub]     CrossRef
  • 6,861 View
  • 91 Download
  • 3 Web of Science
  • Crossref

Original Article

Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus
Wen Wang, Xiaojing Zhou, Fang Cui, Chunli Shi, Yulan Wang, Yanfei Men, Wei Zhao, Jiaqing Zhao
Korean J Parasitol 2019;57(5):489-497.
Published online October 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.5.489
Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction or even death. The interaction between E. granulosus and human body is incompletely understood. Exosomes are nanosized particles ubiquitously present in human body fluids. Exosomes carry biomolecules that facilitate communication between cells. To the best of our knowledge, the role of exosomes in patients with CE is not reported. Here, we isolated exosomes from the sera of patients with CE (CE-exo) and healthy donors and subjected them to liquid chromatography-tandem mass spectrometry analysis. Proteomic analysis identified 49 proteins specifically expressed in CE-exo, including 4 proteins of parasitic origin. The most valuable parasitic proteins included tubulin alpha-1C chain and histone H4. And 8 proteins were differentially regulated in CE-exo (fold change>1.5), as analyzed with bioinformatic methods such as annotation and functional enrichment analyses. These findings may improve our understanding about the interaction between E. granulosus and human body, and may contribute to the diagnosis and prevention of CE.

Citations

Citations to this article as recorded by  Crossref logo
  • Progresses and challenges in Strongyloides spp. proteomics
    Natalia Tiberti, Marcello Manfredi, Chiara Piubelli, Dora Buonfrate
    Philosophical Transactions of the Royal Society B: Biological Sciences.2024;[Epub]     CrossRef
  • A pilot study of microRNAs expression profile in plasma of patients with hydatid disease: potential immunomodulation of hydatid disease
    Jing Xiao, Jian-Wen Wu, Yun-Zhuo Xin, Dong Song, Xiao-ping Gao, Mei Yin, Wei Zhao, Fu-lin Liu, Hao Wang, Jie Wang, Jia-Qing Zhao
    Parasitology Research.2024;[Epub]     CrossRef
  • Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response
    María Celeste Nicolao, Christian Rodriguez Rodrigues, Magalí B. Coccimiglio, Camila Ledo, Guillermo H. Docena, Andrea C. Cumino
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice With Echinococcus granulosus at Different Infection Stages and Their Immunomodulatory Functions
    Chunli Shi, Xiaojing Zhou, Wenjuan Yang, Jianwen Wu, Min Bai, Ying Zhang, Wei Zhao, Hui Yang, Atsushi Nagai, Mei Yin, Xiaoping Gao, Shuqin Ding, Jiaqing Zhao
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Expression profiling of exosomal miRNAs derived from different stages of infection in mice infected with Echinococcus granulosus protoscoleces using high-throughput sequencing
    Jing Xiao, Yazhou Zhu, Jianwen Wu, Min Bai, Yunzhuo Xin, Qiang Wang, Jiaqing Zhao
    Parasitology Research.2022; 121(7): 1993.     CrossRef
  • Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts
    Andrea Maglioco, Facundo A. Agüero, María Pía Valacco, Alejandra Juárez Valdez, Margot Paulino, Alicia G. Fuchs
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Proteomic profiling of serum extracellular vesicles identifies diagnostic markers for echinococcosis
    Xiaola Guo, Shuai Wang, Junmei Zhang, Rui Li, Yong’e Zhang, Zhengrong Wang, Qingming Kong, William C. Cho, Xianghong Ju, Yujuan Shen, Lingqiang Zhang, Haining Fan, Jianping Cao, Yadong Zheng, Alvaro Diaz
    PLOS Neglected Tropical Diseases.2022; 16(10): e0010814.     CrossRef
  • Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition
    Hynek Mazanec, Peter Koník, Zdenko Gardian, Roman Kuchta
    International Journal for Parasitology.2021; 51(5): 327.     CrossRef
  • Identification of Different Extracellular Vesicles in the Hydatid Fluid of Echinococcus granulosus and Immunomodulatory Effects of 110 K EVs on Sheep PBMCs
    Jing Yang, Jin'en Wu, Yong Fu, Lujun Yan, Yating Li, Xiaola Guo, Yong'e Zhang, Xiaoqiang Wang, Yujuan Shen, William C. Cho, Yadong Zheng
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Extensive mitochondrial proteome disturbance occurs during the early stages of acute myocardial ischemia
    Jie Wang, Jun He, Yucheng Fan, Fangjing Xu, Qian Liu, Ruhua He, Ru Yan
    Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
  • Characterization of exosome-like vesicles derived from Taenia pisiformis cysticercus and their immunoregulatory role on macrophages
    Li-Qun Wang, Ting-Li Liu, Pan-Hong Liang, Shao-Hua Zhang, Tao-Shan Li, Yan-Ping Li, Guang-Xue Liu, Li Mao, Xue-Nong Luo
    Parasites & Vectors.2020;[Epub]     CrossRef
  • 8,361 View
  • 173 Download
  • 12 Web of Science
  • Crossref

Case Report

An Imported Case of Disseminated Echinococcosis in Korea
Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
Korean J Parasitol 2019;57(4):429-434.
Published online August 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.4.429
A complicated case of echinococcosis with multiple organ involvement is reported in a 53-year-old businessman who frequently traveled overseas, including China, Russia, and Kazakhstan from 2001 to 2007. The patient was first diagnosed with a large liver cyst during a screening abdomen ultrasonography in 2011, but he did not follow up on the lesion afterwards. Six years later, dizziness, dysarthria, and cough developed, and cystic lesions were found in the brain, liver and lungs. The clinical course was complicated when the patient went through multiple surgeries and inadequate treatment with a short duration of albendazole without a definite diagnosis. The patient visited our hospital for the first time in August 2018 due to worsening symptoms; he was finally diagnosed with echinococcosis using imaging and serologic criteria. He is now on prolonged albendazole treatment (400 mg twice a day) with gradual clinical and radiological improvement. A high index of suspicion is warranted to early diagnose echinococcosis in a patient with a travel history to endemic areas of echinococcosis.

Citations

Citations to this article as recorded by  Crossref logo
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Clinical Implications for the Comprehensive Interpretation of Radiologic and Immunodiagnostic Tests in Patients Suspected of Parasitic Hepatic Cyst, a Rare Case in Korea
    Jae-Sung Yoo, Min-Kyu Kang, Jung-Gil Park, Hyung-Joo Kim, Joon-Hyuk Choi
    Tropical Medicine and Infectious Disease.2023; 8(3): 155.     CrossRef
  • Renal Hydatid With Tuberculosis in a Child: A Rare Coexistence
    Sravanthi Vutukuru, Shailesh Solanki, Prema Menon, Nitin Peters, Ram Samujh, Radhika Srinivasan
    Advances in Pediatric Surgery.2022; 28(2): 76.     CrossRef
  • Hepatic Hydatid Cyst: A Case Report
    Wan Chul Kim, Jae Uk Shin, Su Sin Jin
    The Korean Journal of Gastroenterology.2021; 77(1): 35.     CrossRef
  • 7,111 View
  • 113 Download
  • 5 Web of Science
  • Crossref

Original Article

Prevalence and Molecular Characterization of Echinococcus granulosus Sensu Stricto in Northern Xinjiang, China
Baoping Guo, Zhuangzhi Zhang, Xueting Zheng, Yongzhong Guo, Gang Guo, Li Zhao, Ren Cai, Bingjie Wang, Mei Yang, Xi Shou, Wenbao Zhang, Bin Jia
Korean J Parasitol 2019;57(2):153-159.
Published online April 30, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.2.153
Echinococcus granulosus is an important zoonotic parasite globally causing cystic echinococcosis (CE) in humans and animals. In this study, prevalence of CE and variation of cox1 gene sequence were analyzed with isolates E. granulosus collected from different areas in northern Xinjiang, China. The survey showed that 3.5% of sheep and 4.1% of cattle were infected with CE. Fragment of cox1 was amplified from all the positive sheep and cattle samples by PCR. In addition, 26 positive samples across the 4 areas were included. The isolates were all E. granulosus sensu stricto (s.s.) containing 15 haplotypes (Hap1-15), and clustered into 2 genotypes, G1 (90.1%, 91/101) and G3 (9.9%, 10/101). Hap1 was the most common haplotype (48.5%, 49/101). Hap9 were found in humans samples, indicating that sheep and cattle reservoir human CE. It is indicate that E. granulosus may impact on control of CE in livestock and humans in the region.

Citations

Citations to this article as recorded by  Crossref logo
  • Whole-genomic comparison reveals complex population dynamics and parasitic adaptation of Echinococcus granulosus sensu stricto
    Yao-Dong Wu, Zirui Ren, Li Li, Wen-Hui Li, Nian-Zhang Zhang, Yan-Tao Wu, Guo-Dong Dai, Wei-Gang Chen, Wen-Jie Mu, Shuai Wang, Jiandong Li, Qin Yu, Xue-Peng Cai, Xin Jin, Bao-Quan Fu, Daxi Wang, Wan-Zhong Jia, Hong-Bin Yan, Julian Parkhill, James Cotton
    mBio.2025;[Epub]     CrossRef
  • First report of Echinococcus granulosus genotype 1 in a wild boar (Sus scrofa) from China
    Baoping Guo, Cairen, Li Zhao, Kalibixiati Aimulajiang, Wenqiang Tang, Chuanchuan Wu, Maiweilidan Yimingjiang, Jianyong Wu, Rongsheng Mi, Hao Wen
    Parasitology Research.2024;[Epub]     CrossRef
  • Phylogeny and population structure of Echinococcus granulosus (sensu stricto) based on full-length cytb-nad2-atp6 mitochondrial genes – First report from Sialkot District of Pakistan
    Mughees Aizaz Alvi, Rana Muhammad Athar Ali, Li Li, Muhammad Saqib, Warda Qamar, Ali Hassan, Muzafar Ghafoor, Siddiq Ur Rahman, Muhammad Umar Zafar Khan, Bao-Quan Fu, Youyu Liu, Hong Yin, Hong-Bin Yan, Wan-Zhong Jia
    Molecular and Biochemical Parasitology.2023; 253: 111542.     CrossRef
  • Survey and Molecular Characterization of Echinococcus granulosus sensu stricto from Livestock and Humans in the Altai Region of Xinjiang, China
    Baoping Guo, Li Zhao, Lu Zhao, Rongsheng Mi, Xu Zhang, Bingjie Wang, Gang Guo, Yuan Ren, Wenjing Qi, Zhuangzhi Zhang
    Pathogens.2023; 12(1): 134.     CrossRef
  • Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences
    Nigus Abebe Shumuye, Li Li, John Asekhaen Ohiolei, Sayed Ajmal Qurishi, Wen-Hui Li, Nian-Zhang Zhang, Yan-Tao Wu, Yao-Dong Wu, Sheng-Zhi Gao, Fu-Heng Zhang, Xue-Qi Tian, Wen-Jun Tian, Yong Fu, Xie-Zhong Wang, Yong-Hong Pan, Fang Zhan, Lin-Sheng Zhang, Min
    Parasitology Research.2023; 122(5): 1107.     CrossRef
  • Echinococcus granulosus sensu lato Genotypes in Different Hosts Worldwide: A Systematic Review
    Carlos Manterola, Armando Totomoch-Serra, Claudio Rojas, Ángela L. Riffo-Campos, Nayely García-Méndez
    Acta Parasitologica.2022; 67(1): 161.     CrossRef
  • Genetic diversity of Echinococcus granulosus sensu lato in China: Epidemiological studies and systematic review
    Rui‐Qi Hua, Xiao‐Di Du, Xue He, Xiao‐Bin Gu, Yue Xie, Ran He, Jing Xu, Xue‐Rong Peng, Guang‐You Yang
    Transboundary and Emerging Diseases.2022;[Epub]     CrossRef
  • Genetic structure and phylogeography of Echinococcus granulosus sensu stricto genotypes G1 and G3 in Pakistan and other regions of the world based on nad5 gene
    Naunain Mehmood, Hira Muqaddas, Muhammad Irfan Ullah, Urmas Saarma, Antonio Varcasia
    Infection, Genetics and Evolution.2022; 98: 105223.     CrossRef
  • Meta-analysis on the prevalence of bovine hydatid disease in China from 2000 to 2021
    Shijie Fan, Hailong Dong, Hongcai Ma, Bingyi Wang, Mujahid Iqbal, Minghao Zou, Ming Qi, Zhipeng Cao
    Microbial Pathogenesis.2022; 168: 105586.     CrossRef
  • A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess
    Yan Li, Yaohui Yu, Qian Liu, Haicheng Qi, Shan Li, Juan Xin, Yan Xing
    Parasitology Research.2022; 121(12): 3393.     CrossRef
  • Genetic diversity and haplotype analysis of yak and sheep echinococcal cysts isolates from the mitochondrial cox1 gene in parts of Tibet, China
    Shijie Fan, Xialing Zhao, Danqulamu, Bin Shi, Wenqiang Tang, Hailong Dong, Chenyang Xia
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
  • Genotyping and phylogenetic analysis of hydatid cysts isolated from livestock in Bushehr province, Iran
    Zahra Babaei, Reza Taherkhani, Afshin Barazesh, Marzieh Taherzadeh, Soleiman Khorami, Moradali Fouladvand
    Journal of Parasitic Diseases.2021; 45(1): 197.     CrossRef
  • Meta-Analysis of the Prevalence of Echinococcus in Sheep in China From 1983 to 2020
    Yang Gao, Wei Wang, Chuang Lyu, Xin-Yu Wei, Yu Chen, Quan Zhao, Zhi-Guang Ran, You-Qing Xia
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process
    Junjie Fan, Hongye Wu, Kai Li, Xunuo Liu, Qingqing Tan, Wenqiao Cao, Bo Liang, Bin Ye
    The Korean Journal of Parasitology.2020; 58(3): 287.     CrossRef
  • Tacrolimus, a rapamycin target protein inhibitor, exerts anti-cystic echinococcosis effects both in vitro and in vivo
    Muzhabaier Muhedier, Jintian Li, Hui Liu, Guizhi Ma, Kuerbannisha Amahong, Renyong Lin, Guodong Lü
    Acta Tropica.2020; 212: 105708.     CrossRef
  • 8,190 View
  • 125 Download
  • 21 Web of Science
  • Crossref

Brief Communications

Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep
Liu Tianli, Wang Xifeng, Tian Zhenzhong, Wang Lixia, Zhang Xingxing, Qiao Jun, Meng Qingling, Gong Shasha, Chen Ying, Cai Xuepeng
Korean J Parasitol 2019;57(1):61-67.
Published online February 26, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.1.61
Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep.

Citations

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  • Rapid and non‐invasive detection of cystic echinococcosis in sheep based on serum fluorescence spectrum combined with machine learning algorithms
    Shengke Xu, Wubulitalifu Dawuti, Maierhaba Maimaitiaili, Jingrui Dou, Malike Aizezi, Kalibixiati Aimulajiang, Xiaoyi Lü, Guodong Lü
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • Recombinant multiepitope proteins expressed in Escherichia coli cells and their potential for immunodiagnosis
    Ana Alice Maia Gonçalves, Anna Julia Ribeiro, Carlos Ananias Aparecido Resende, Carolina Alves Petit Couto, Isadora Braga Gandra, Isabelle Caroline dos Santos Barcelos, Jonatas Oliveira da Silva, Juliana Martins Machado, Kamila Alves Silva, Líria Souza Si
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    Yang Xianwei, Wang Tao, Chen Yin, Wang Wentao
    Parasitology.2024; 151(13): 1458.     CrossRef
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    Wubulitalifu Dawuti, Jingrui Dou, Xiangxiang Zheng, Xiaoyi Lü, Hui Zhao, Lingfei Yang, Renyong Lin, Guodong Lü
    Journal of Biophotonics.2023;[Epub]     CrossRef
  • Evaluation of a novel Echinococcus granulosus recombinant fusion B-EpC1 antigen for the diagnosis of human cystic echinococcosis using indirect ELISA in comparison with a commercial diagnostic ELISA kit
    Enayat Darabi, Elahe Motevaseli, Mehdi Mohebali, Mohammad Bagher Rokni, Mohammad Reza Khorramizadeh, Farzaneh Zahabiun, Soudabeh Heidari, Eshrat Beigom Kia
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  • Detection of Echinococcus granulosus sensu lato infection by using extracts derived from a protoscoleces G1 cell line
    Andrea Maglioco, Jorge Gentile, Melisa S. Barbery Venturi, Oscar Jensen, Claudia Hernández, María Laura Gertiser, Verónica Poggio, Gabriela Canziani, Alicia Graciela Fuchs
    Parasite Immunology.2019;[Epub]     CrossRef
  • 7,521 View
  • 130 Download
  • 6 Web of Science
  • Crossref
Genetic Diversity of Echinococcus granulosus Genotype G1 in Xinjiang, Northwest of China
Bin Yan, Xiafei Liu, Junyuan Wu, Shanshan Zhao, Wumei Yuan, Baoju Wang, Hazi Wureli, Changchun Tu, Chuangfu Chen, Yuanzhi wang
Korean J Parasitol 2018;56(4):391-396.
Published online August 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.4.391
Cystic echinococcosis (CE) caused by E. granulosus is a serious helminthic zoonosis in humans, livestock and wildlife. Xinjiang is one of high endemic province for CE in China. A total of 55 sheep and cattle livers containing echinococcal cysts were collected from slaughterhouses in Changji and Yining City, northern region of Xinjiang. PCR was employed for cloning 2 gene fragments, 12S rRNA and CO1 for analysis of phylogenetic diversity of E. granulosus. The results showed that all the samples collected were identified as G1 genotype of E. granulosus. Interestingly, YL5 and CJ75 strains were the older branches compared to those strains from France, Argentina, Australia. CO1 gene fragment showed 20 new genotype haploids and 5 new genotype haplogroups (H1-H5) by the analysis of Network 5.0 software, and the YLY17 strain was identified as the most ancestral haplotype. The major haplotypes, such as CJ75 and YL5 strains, showed identical to the isolates from Middle East. The international and domestic trade of livestock might contribute to the dispersal of different haplotypes for E. granulosus evolution.

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    Sumeeta Khurana, Reena Yadav, Anupma Dhaka, Abhishek Mewara, Lileshwar Kaman, Ajay Duseja, Naveen Kalra
    Diagnostic Microbiology and Infectious Disease.2025; 113(2): 116904.     CrossRef
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    Heliyon.2024; 10(7): e28812.     CrossRef
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    Wulijiang Kamali, Si-Yun Wang, Wei-Dong Luo, Shuai Liu, Li Zhao, Xing-Yu Pan, Bing-Jie Wang, Yong-Hui Mu, Tuoliehuojia Jiawuti, Kadierding Aierken, Zhuang-Zhi Zhang, Wan-Li Ban
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  • Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences
    Nigus Abebe Shumuye, Li Li, John Asekhaen Ohiolei, Sayed Ajmal Qurishi, Wen-Hui Li, Nian-Zhang Zhang, Yan-Tao Wu, Yao-Dong Wu, Sheng-Zhi Gao, Fu-Heng Zhang, Xue-Qi Tian, Wen-Jun Tian, Yong Fu, Xie-Zhong Wang, Yong-Hong Pan, Fang Zhan, Lin-Sheng Zhang, Min
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  • Molecular characterization of cattle and sheep isolates of Echinococcus granulosus from Elazig province in Turkey and expression analysis of the non-coding RNAs, egr-miR-7, egr-miR-71 and egr-miR-96
    Bunyamin Irehan, Figen Celik, Ergun Koroglu, Ahmet Tektemur, Sami Simsek
    Experimental Parasitology.2023; 251: 108551.     CrossRef
  • Echinococcus granulosus sensu lato Genotypes in Different Hosts Worldwide: A Systematic Review
    Carlos Manterola, Armando Totomoch-Serra, Claudio Rojas, Ángela L. Riffo-Campos, Nayely García-Méndez
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    Gaelle Joanny, Maria Grazia Cappai, Francesca Nonnis, Claudia Tamponi, Giorgia Dessì, Naunain Mehmood, Julien Dahdah, Chadi Hosri, Antonio Scala, Antonio Varcasia
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    Mughees Aizaz Alvi, Abdullah F. Alsayeqh
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
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  • Multiple haplotypes of Echinococcus granulosus sensu stricto in single naturally infected intermediate hosts
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    N.M. AL-Mutairi, H.A. Taha, A.H. Nigm
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A Retrospective Analysis on the Cystic Echinococcosis Cases Occured in Northeastern Punjab Province, Pakistan
Aisha Khan, Sarmad Zahoor, Haroon Ahmed, Uzma Malik, Rabia Amin Butt, Muhammad Sultanul Muzam, Seyma Gunyakti Kilinc, Noorulain Noor, Saroosh Zahoor, Muhammad Sohail Afzal, Hamza Mansur, Shumaila Irum, Sami Simsek
Korean J Parasitol 2018;56(4):385-390.
Published online August 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.4.385
A retrospective study was performed to report the case occurrence of cystic echinococcosis (CE) in three hospitals of north-eastern region in Punjab Province, Pakistan. We reviewed retrospectively the clinical records of patients in 4 hospitals which were diagnosed with CE during 2012-2017. A total of 198 cases, 82 (41.4%) male and 116 (58.6%) females were detected as CE. The most Highest incidence was revealed in.... 21-30 years-old group (24.2%) followed by 41-50 (22.7%), 31-40 (16.2%), 11-20 (13.6%), 51-60 (8.1%), below 10 (5.5%), over 71 (5.1%) and 61-70 year-old group (4.5%). CE was detected in various organs of infected individuals. However, most of CE cases were detected in the liver (47.4%) and lung (18.6%). The present study indicated that CE is more or less prevalent in surveyed areas and one of the most important public health problems in Punjab Province, Pakistan.

Citations

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  • Prevalence and molecular characterization of cystic echinococcosis in livestock in the Hazara Division, Pakistan
    Safia Arbab, Hanif Ullah, Inam Ul Hassan, Suleman, Weiwei Wang, Abdul Qadeer, Jiya Zhang
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    Pathogens.2022; 11(2): 194.     CrossRef
  • Design of highly sensitive nano-biosensor for diagnosis of hydatid cyst based on gold nanoparticles
    Fariba Jafari, Amir Hossein Maghsood, Mohammad Fallah, Ahmad Jalilvand, Mohammad Matini, Bahram Amini
    Photodiagnosis and Photodynamic Therapy.2022; 38: 102786.     CrossRef
  • Seropozitifity of Anti-Echinococcus granulosus in Patients with of Clinical Prediagnosis Cystic Echinococcosis at Kafkas University Health Research and Application Hospital
    Mükremin Özkan Arslan, Neriman Mor, Hilal Bedir
    Turkish Journal of Parasitology.2022; 46(2): 129.     CrossRef
  • Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA
    Aisha Khan, Gérald Umhang, Zaib Ullah, Franck Boué, Vanessa Bastid, Ikram Ullah, Sajid Mahmood, Muhammad Sohail Afzal, Haroon Ahmed
    Parasitology Research.2021; 120(2): 731.     CrossRef
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    Vishal Farid Raza, Dawood Arshad, Sajeel Ahmad, Khalid Javeed Khan
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  • A review of the diagnosis and management of liver hydatid cyst
    Ester Ferrer-Inaebnit, Francesc Xavier Molina-Romero, Juan José Segura-Sampedro, Xavier González-Argenté, José Miguel Morón Canis
    Revista Española de Enfermedades Digestivas.2021;[Epub]     CrossRef
  • Demographics of cystic echinococcosis patients treated surgically in Lahore, Pakistan: A single centre study from 2007 – 2018
    Q. Rasib, A. Khan, H. Ahmed, S. Nizamuddin, F. Asif, M. S. Afzal, S. Simsek, F. Khurshid, S. Irum, N. Hussain, S. Riaz, S. S. Khan, C. M. Budke
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  • Echinococcoses in Iran, Turkey, and Pakistan: Old Diseases in the New Millennium
    Mehdi Borhani, Saeid Fathi, Enayat Darabi, Fatemeh Jalousian, Sami Simsek, Haroon Ahmed, Harun Kaya Kesik, Seyed Hossein Hosseini, Thomas Romig, Majid Fasihi Harandi, Iraj Mobedi
    Clinical Microbiology Reviews.2021;[Epub]     CrossRef
  • Clinical and pathogenetic aspects of the complications after surgical treatment of hepatic echinococcosis
    F. G. Nazyrov, A. Kh. Babadjanov, F. R. Yakubov
    Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery.2021; 26(4): 51.     CrossRef
  • Detection of Anti-Echinococcus granulosus Antibodies in Humans: An Update from Pakistan
    Huma Khan, Haroon Ahmed, Muhammad Sohail Afzal, Usman Ayub Awan, Muhammad Khurram, Sami Simsek, Jianping Cao
    Pathogens.2021; 11(1): 29.     CrossRef
  • Cystic echinococcosis: a 10-year experience from a middle-income country
    Ayesha Butt, Javaid Ahmed Khan
    Tropical Doctor.2020; 50(2): 117.     CrossRef
  • First report of Echinococcus canadensis (G6/G7) by sequence analysis from the Khyber Pakhtunkhwa province of Pakistan
    Aisha Khan, Haroon Ahmed, Huma Khan, Sami Simsek, Seyma Gunyakti Kilinc, Harun Kaya Kesik, Guan Yayi, Figen Celik, Muhammad Sohail Afzal, Christine M. Budke
    Acta Tropica.2020; 209: 105559.     CrossRef
  • Human cystic echinococcosis in southwest Iran: a 15-year retrospective epidemiological study of hospitalized cases
    Reza Shahriarirad, Amirhossein Erfani, Mehrdad Eskandarisani, Mohammad Rastegarian, Hajar Taghizadeh, Bahador Sarkari
    Tropical Medicine and Health.2020;[Epub]     CrossRef
  • Cystic Echinococcosis in Pakistan: A Review of Reported Cases, Diagnosis, and Management
    Aisha Khan, Haroon Ahmed, Huma Khan, Sadia Saleem, Sami Simsek, Enrico Brunetti, Muhammad Sohail Afzal, Tommaso Manciulli, Christine M. Budke
    Acta Tropica.2020; 212: 105709.     CrossRef
  • Management Outcome in Simple and Complex Hydatid Cysts of Lung
    Pratikshya Thapaliya, Tanveer Ahmad, Ambreen Abid, Nazish Sikander, Misauq Mazcuri, Nadir Ali
    Cureus.2020;[Epub]     CrossRef
  • Retrospective Study of Cystic Echinococcosis (CE) Based on Hospital Record from Five Major Metropolitan Cities of Pakistan
    Hira Muqaddas, Muhammad Arshad, Haroon Ahmed, Naunain Mehmood, Aisha Khan, Sami Simsek
    Acta Parasitologica.2019; 64(4): 866.     CrossRef
  • 8,483 View
  • 157 Download
  • 16 Web of Science
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Original Article

Analysis of Lethality in Echinococcal Disease
Anna S. Khachatryan
Korean J Parasitol 2017;55(5):549-553.
Published online October 31, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.5.549
The information on mortality from echinococcosis is important not only for a better understanding of the severity of the disease, but also for evaluating the effectiveness of public health interventions. The aim of this research was to study the causes of mortality from echinococcosis. We have collected and analyzed the materials of 1,470 patients in 10 age - groups in the Republic of Armenia (from 2000 to 2016). To find out the causes of mortality from echinococcosis, we have analyzed the medical histories and protocols of postmortem examinations of 19 deaths from echinococcosis and 17 deaths due to other indirect causes not associated with the parasite. The average annual death rate from echinococcosis is 0.007 per 10,000 population, and the mortality is 1.29 (per 100 patients). The highest mortality occurs in people aged 70-79. Mortality from echinococcosis is also recorded among the unoperated children. The rupture of the parasitic cyst and hepatic insufficiency are major among the direct causes of mortality. Sometimes the hydatid cysts unrecognized during the life were first diagnosed at autopsy. Insufficient qualification of doctors in the field of helminthology, as well as the latent course of the disease or manifestation of minor symptoms in echinococcosis over a long period often led to medical errors. Further decline in mortality can be achieved by early diagnosis, timely hospitalization and treatment before the development of severe complications worsening the prognosis and outcomes of surgical intervention.

Citations

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  • Narrowing the region of candidate genes that control the development of protoscoleces of Echinococcus multilocularis in the mouse liver
    Keisuke Sato, Naritaka Hikosaka, Hirokazu Kouguchi, Takao Irie, Masami Morimatsu, Takashi Agui
    Infection, Genetics and Evolution.2025; 127: 105704.     CrossRef
  • Epidemiological profile and treatment of cystic echinococcosis hospitalized cases in Morocco between 2011 and 2021
    Ilham Benmoujjane, Souad Bouhout, Aicha mehdioui, Houda Chebli, Meryem Zabarra, Mohammed Akrim, Hassan Chrifi, Touria Benamar
    Clinical Epidemiology and Global Health.2025; 33: 102035.     CrossRef
  • A Rare Case of Hepatic Echinococcus granulosus Infection Diagnosed by Autopsy in Japan
    Akira Asai, Hisato Kawashima, Tomomi Hirota, Ryota Masutani, Shuichi Asano, Soo Ki Kim, Hiroki Nishikawa, Naomune Yamamoto
    Internal Medicine.2025;[Epub]     CrossRef
  • Surgical treatment outcomes of hepatic cystic echinococcosis in HIV-positive and HIV-negative patients: a South African cohort study.
    Kate Couzens-Bohlin, Sanju Sobnach, Jake Krige, Urda Kotze, Christo Kloppers, Marc Bernon, Stefano Cacciatore, Eduard Jonas
    HPB.2025;[Epub]     CrossRef
  • Assessment of Echinococcosis spp. Surveillance System through SWOT Analysis in Armenia
    A. H. Manukyan
    Medical Science of Armenia.2024; : 142.     CrossRef
  • Complicated Liver Cystic Echinococcosis—A Comprehensive Literature Review and a Tale of Two Extreme Cases
    Valentin Calu, Octavian Enciu, Elena-Adelina Toma, Radu Pârvuleţu, Dumitru Cătălin Pîrîianu, Adrian Miron
    Tomography.2024; 10(6): 922.     CrossRef
  • Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project
    Adriano Casulli, Bernadette Abela-Ridder, Daniele Petrone, Massimo Fabiani, Branko Bobić, David Carmena, Barbara Šoba, Enver Zerem, Maria João Gargaté, Gordana Kuzmanovska, Cristian Calomfirescu, Iskra Rainova, Smaragda Sotiraki, Vera Lungu, Balázs Dezsén
    The Lancet Infectious Diseases.2023; 23(3): e95.     CrossRef
  • α-Mangostin Exhibits a Therapeutic Effect on Spinal Cystic Echinococcosis by Affecting Glutamine Metabolism
    Sibo Wang, Haohao Sun, Shan Wang, Qian Ren, Yi Dai, Meipeng Zhu, Yayun Zhang, Honglei Kang, Jing Li, Jun Xiao, Yimin Dong, Weishan Wang
    Antimicrobial Agents and Chemotherapy.2023;[Epub]     CrossRef
  • Endoscopic Endonasal Surgery for a Pterygopalatine Fossa Hydatid Cyst
    Vjerislav Peterković, Marcel Marjanović Kavanagh, Hrvoje Barić, Niko Njirić, Mirjana Balen-Topić, Relja Beck, Klaudija Višković
    Journal of Maxillofacial and Oral Surgery.2022; 21(1): 93.     CrossRef
  • Status and prospect of novel treatment options toward alveolar and cystic echinococcosis
    Sibo Wang, Yibo Ma, Weishan Wang, Yi Dai, Haohao Sun, Jing Li, Shan Wang, Feng Li
    Acta Tropica.2022; 226: 106252.     CrossRef
  • Echinococcosis in immunocompromised patients: A systematic review
    Hamidreza Ghasemirad, Nasrin Bazargan, Armita Shahesmaeili, Majid Fasihi Harandi
    Acta Tropica.2022; 232: 106490.     CrossRef
  • Mathematical modelling of echinococcosis in human, dogs and sheep with intervention
    Birhan Getachew Bitew, Justin Manango W. Munganga, Adamu Shitu Hassan
    Journal of Biological Dynamics.2022; 16(1): 439.     CrossRef
  • Reasons for late diagnosis of pulmonary echinococcosis in a non-endemic area
    I. A. Krylova, S. N. Levitsky, I. A. Shabalina, A. V. Semenova, I. A. Turabov
    Translational Medicine.2022; 9(3): 81.     CrossRef
  • Advances in research on echinococcoses epidemiology in China
    Mei-Hua Fu, Xu Wang, Shuai Han, Ya-Yi Guan, Robert Bergquist, Wei-Ping Wu
    Acta Tropica.2021; 219: 105921.     CrossRef
  • Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro
    Fatima Zahran, Hayam Mohamed Ezz El-Din, Mai Abdel Sameaa Shehata
    Journal of Parasitic Diseases.2020; 44(2): 411.     CrossRef
  • A pilot comparative study between serological and genetic investigations in relationship to clinical outcomes on patients with cystic echinococcosis
    Nu. Altintas, S. A. Karamil, O. Turkum, M. Akil, A. Sakarya, H. Bozkaya, J. Šoltys, Na. Altintas
    Helminthologia.2020; 57(2): 91.     CrossRef
  • Laparoscopic adrenal resection for primary echinococcosis
    A. A. Kovalev, Z. Kh. Osmanov, A. E. Neimark, I. N. Danilov
    Endoskopicheskaya khirurgiya.2018; 24(5): 51.     CrossRef
  • 8,451 View
  • 161 Download
  • 17 Web of Science
  • Crossref

Case Report

Unusual Location of Hydatid Cysts: Report of Two Cases in the Heart and Hip Joint of Romanian Patients
Simona Gurzu, Marius Alexandru Beleaua, Emeric Egyed-Zsigmond, Ioan Jung
Korean J Parasitol 2017;55(4):429-431.
Published online August 31, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.4.429
Hydatid cyst is usually located in the liver and lungs, rare cases showing localization in other organs or tissues. In the unusual location, echinococcosis is an excluding diagnosis that is established only after microscopic evaluation. Our first case occurred in a 67-year-old female previously diagnosed with pulmonary tuberculosis and hospitalized with persistent pain in the hip joint. The clinical diagnosis was tuberculosis of the joint, but the presence of the specific acellular membrane indicated a hydatid cyst of the synovial membrane, without bone involvement. Fewer than 25 cases of joint hydatidosis have been reported in literature to date. In the second case, the intramural hydatid cyst was incidentally discovered at autopsy, in the left heart ventricle of a 52-year-old male hospitalized for a fatal brain hemorrhage, as a result of rupture of an anterior communicating artery aneurysm. The conclusion of our paper is that echinococcosis should be taken into account for the differential diagnosis of cystic lesions, independently from their location.

Citations

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  • Unusual primary hydatid cysts of the body without liver and lung involvement
    Yener Aydin, Ali Bilal Ulas, Suat Eren, Gurkan Ozturk, Kamber Kasali, Yilmaz Aksoy, Mehmet Kursat Karadag, Eyup Senocak, Abdurrahim Colak
    Journal of Parasitic Diseases.2025;[Epub]     CrossRef
  • Cardiac cystic echinococcosis—A systematic review and analysis of the literature
    Simone Bumann, Esther Kuenzli, Raffaella Lissandrin, Enrico Brunetti, Sam Goblirsch, Lars Henning, Francesca Tamarozzi, Andreas Neumayr, Adriano Casulli
    PLOS Neglected Tropical Diseases.2024; 18(5): e0012183.     CrossRef
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    Ali Azari, Leila Bigdelu, Ossama Maadarani, Zouheir Bitar
    European Journal of Case Reports in Internal Medicine.2023;[Epub]     CrossRef
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    Xiyi Wei, Jinyong Tian, Jianyu Diao, Gulinuer Aibibula, Maimaitijiang Dawuti, Yiliyasi Tuerxun, Mhtaer Wubuli, Yujie Zhang, Ninghong Song, Jie Yang
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  • Cardiac hydatid cysts in a young man: A case report and a literature review
    Mircea Bajdechi, Dalia Manolache, Adrian Tudor, Mihnea Orghidan, Adriana Gurghean
    Experimental and Therapeutic Medicine.2022;[Epub]     CrossRef
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    Ayesha Butt, Javaid Ahmed Khan
    Tropical Doctor.2020; 50(2): 117.     CrossRef
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    Reza Shahriarirad, Amirhossein Erfani, Mehrdad Eskandarisani, Mohammad Rastegarian, Bahador Sarkari
    Surgery Research and Practice.2020; 2020: 1.     CrossRef
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    Rong-Xing Zhou, Hai-Jie Hu, Wen-Jie Ma, Yong Jiang, Fu-Yu Li
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  • 7,440 View
  • 170 Download
  • 6 Web of Science
  • Crossref

Original Articles

Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock
Jianrong Ye, Qin Zhang, Yan Xuan, Siyu Chen, Long Ma, Yongqiang Zhang, Hong Zheng
Korean J Parasitol 2016;54(6):769-775.
Published online December 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.6.769
This retrospective case-control study explored the factors associated with anaphylactic shock during surgery for cystic echinococcosis (CE) at the First Affiliated Hospital of Xinjiang Medical University between October 2008 and September 2013. Patients who suffered from anaphylactic shock (n=16) were age-matched 3:1 to patients who did not (n=43). Multivariate analysis suggested that IL-4 levels (odds ratio=1.096; 95% confidence interval=1.015-1.185; P=0.02) and cyst size (odds ratio=3.028, 95% confidence interval=1.259-7.283, P=0.013) were independently associated with CE-induced perioperative anaphylactic shock. Using the receiver operating characteristic (ROC) curves and a cut-off value of 415.7 ng/ml, IL-4 showed an area under the ROC (AUC) of 0.926, sensitivity of 75.0%, and specificity of 97.7%. Using a cut-off value of 7.8 cm, cyst size showed an AUC of 0.828, sensitivity of 81.3%, and specificity of 76.7%. In conclusion, results suggest that levels of IL-4 and cyst size were independently associated with echinococcosis-induced perioperative anaphylactic shock. These results could help identifying patients with echinococcosis at risk of anaphylactic shock in whom appropriate prophylaxis could be undertaken.

Citations

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  • Impact of Echinococcus granulosus Cyst Fluid on the Phenotypic Dynamics and Degranulation of RBL-2H3 Mast Cells
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    P. Gundappa, D. Prakash, N. Palankar, S. Karanth
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    Ergin Erginöz, Sefa Ergün, Emre Tunç, Salih Pekmezci
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  • The regulatory role of differential microRNA expressions on cellular inflammatory factors IL‐6 and IL‐10 in Echinococcus granulosus‐induced anaphylaxis
    Chun‐sheng Wang, Tao Yu, Xilizhati Kulaixi, Jing‐ru Zhou, Xianyidan Abulajiang, Jia‐ling Wang, Si‐jia Wang, Jian‐rong Ye
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  • The role of memory T cells in Echinococcus granulosus‐induced sensitization
    Jing‐Ru Zhou, Xiao‐Xuan Du, Xianyidan Abulajiang, Wuer Geli, Xue‐Li Pu, Subi Tailaiti, Jia‐Ying Lin, Yu‐Qian Li, Jian‐Rong Ye
    Immunity, Inflammation and Disease.2023;[Epub]     CrossRef
  • Peri‐operative refractory anaphylactic shock during hepatic hydatid cyst surgery
    P. Gundappa, D. Prakash, N. Palankar, S. Karanth
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    Christiane Bayerl
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    Xiaodong Yu, Yali Yasen, Chunsheng Wang, Meng Li, Zhiyuan Fang, Jialing Wang, Jianrong Ye
    Acta Tropica.2021; 224: 106120.     CrossRef
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    African Journal of Urology.2021;[Epub]     CrossRef
  • Endoscopic excision of hydatid cyst: A case of delayed anaphylaxis in postoperative period - “The risk is not over until it is over”
    Aakriti Gupta, Neerja Bhardwaj, Soumya Sarkar, Ravi P. Kanojia
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  • Should Pediatricians Be Aware of Cystic Echinococcosis? A Literature Review
    Chiara Tersigni, Elisabetta Venturini, Carlotta Montagnani, Leila Bianchi, Elena Chiappini, Maurizio de Martino, Luisa Galli
    Journal of Pediatric Gastroenterology and Nutrition.2019; 68(2): 161.     CrossRef
  • Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients
    Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
    Medicine.2017; 96(42): e7632.     CrossRef
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Molecular Cloning and Characterization of a P38-Like Mitogen-Activated Protein Kinase from Echinococcus granulosus
Guodong L?, Jing Li, Chuanshan Zhang, Liang Li, Xiaojuan Bi, Chaowang Li, Jinliang Fan, Xiaomei Lu, Dominique A. Vuitton, Hao Wen, Renyong Lin
Korean J Parasitol 2016;54(6):759-769.
Published online December 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.6.759
Cystic echinococcosis (CE) treatment urgently requires a novel drug. The p38 mitogen-activated protein kinases (MAPKs) are a family of Ser/Thr protein kinases, but still have to be characterized in Echinococcus granulosus. We identified a 1,107 bp cDNA encoding a 368 amino acid MAPK protein (Egp38) in E. granulosus. Egp38 exhibits 2 distinguishing features of p38-like kinases: a highly conserved T-X-Y motif and an activation loop segment. Structural homology modeling indicated a conserved structure among Egp38, EmMPK2, and H. sapiens p38α, implying a common binding mechanism for the ligand domain and downstream signal transduction processing similar to that described for p38α. Egp38 and its phosphorylated form are expressed in the E. granulosus larval stages vesicle and protoscolices during intermediate host infection of an intermediate host. Treatment of in vitro cultivated protoscolices with the p38-MAPK inhibitor ML3403 effectively suppressed Egp38 activity and led to significant protoscolices death within 5 days. Treatment of in vitro-cultivated protoscolices with TGF-β1 effectively induced Egp38 phosphorylation. In summary, the MAPK, Egp38, was identified in E. granulosus, as an anti-CE drug target and participates in the interplay between the host and E. granulosus via human TGF-β1.

Citations

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  • Echinococcus granulosus promotes MAPK pathway-mediated osteoclast differentiation by inhibiting Nrf2 in osseous echinococcosis
    Yaqing Liu, Jing Li, Zhendong Zhang, Qi Li, Yanhu Tian, Sibo Wang, Chenhui Shi, Haohao Sun
    Veterinary Research.2025;[Epub]     CrossRef
  • In vitro Scolicidal Efficacy of 5-Fluorouracil and Radiation Against Protoscoleces of Echinococcus granulosus Sensu Lato
    Pengfei Lu, Jun Li, Rui Mao, Hongzhi Qi, Liping Yang, Qin Zhou, Mengxiao Tian, Wenbao Zhang, Yongxing Bao
    Acta Parasitologica.2022; 67(2): 820.     CrossRef
  • Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
    Yingfang Yu, Jun Li, Weisi Wang, Tian Wang, Wenjing Qi, Xueting Zheng, Lei Duan, Jiaxu Chen, Shizhu Li, Xiumin Han, Wenbao Zhang, Liping Duan
    BMC Genomics.2021;[Epub]     CrossRef
  • Knock Down the Egp38 and Combine with Radiation to Increase Its Inhibitory Effect on Echinococcus granulosus
    Pengfei Lu, Mengxiao Tian, Na Yi, Rui Mao, Hongzhi Qi, Liping Yang, Qin Zhou, Jun Li, Wenbao Zhang, Yongxing Bao
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and
    Chuanshan Zhang, Jing Li, Tuerganaili Aji, Liang Li, Xiaojuan Bi, Ning Yang, Zhide Li, Hui Wang, Rui Mao, Guodong Lü, Yingmei Shao, Dominique A. Vuitton, Hao Wen, Renyong Lin
    Antimicrobial Agents and Chemotherapy.2019;[Epub]     CrossRef
  • Echinococcosis: Advances in the 21st Century
    Hao Wen, Lucine Vuitton, Tuerhongjiang Tuxun, Jun Li, Dominique A. Vuitton, Wenbao Zhang, Donald P. McManus
    Clinical Microbiology Reviews.2019;[Epub]     CrossRef
  • 9,561 View
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Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus
Ebrahim Saedi Dezaki, Mohammad Mehdi Yaghoobi, Elham Taheri, Pooya Ghaseminejad Almani, Farideh Tohidi, Bruno Gottstein, Majid Fasihi Harandi
Korean J Parasitol 2016;54(5):653-658.
Published online October 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.5.653
This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

Citations

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  • Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective
    Yan Lv, Xuan Pang, Zhonghong Cao, Changping Song, Baohua Liu, Weiwei Wu, Qiuxiang Pang
    International Journal of Molecular Sciences.2024; 25(6): 3322.     CrossRef
  • Echinococcus multilocularis delta/notch signalling components are expressed in post-mitotic cells
    Chris Speicher, Monika Bergmann, Klaus Brehm
    Parasitology Research.2024;[Epub]     CrossRef
  • Notch signaling pathway involved in Echinococcus granulosus infection regulates dendritic cell development and differentiation
    Mingxia Wang, Zailing Shang, Fei Qiao, Junhu Hei, Xueling Ma, Yana Wang
    Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
  • Proteomic profiling of hydatid fluid from pulmonary cystic echinococcosis
    Guilherme Brzoskowski dos Santos, Edileuza Danieli da Silva, Eduardo Shigueo Kitano, Maria Eduarda Battistella, Karina Mariante Monteiro, Jeferson Camargo de Lima, Henrique Bunselmeyer Ferreira, Solange Maria de Toledo Serrano, Arnaldo Zaha
    Parasites & Vectors.2022;[Epub]     CrossRef
  • The Genomes of Two Strains of Taenia crassiceps the Animal Model for the Study of Human Cysticercosis
    Raúl J. Bobes, Karel Estrada, Diana G. Rios-Valencia, Arturo Calderón-Gallegos, Patricia de la Torre, Julio C. Carrero, Alejandro Sanchez-Flores, Juan P. Laclette
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation
    Jian Gao, Xuan Zhou, Ling Liu, Guodong Lv, Qiulian Hou, Xiaofan Zhang, Yujuan Shen
    Parasites & Vectors.2022;[Epub]     CrossRef
  • Screening, construction, and serological identification of the diagnostic antigen molecule EG-06283 for the diagnosis of Echinococcus granulosus
    Yazhou Zhu, Tingrui Zhang, Yinqi Zhao, Yin Wang, Yongxue Lv, Shasha Li, Songhao Yang, Mingxing Zhu, Wei Zhao, Qiang Wang
    Parasitology Research.2021; 120(7): 2557.     CrossRef
  • Evolutionary Transformations of the Metazoan Body Plan: Genomic-Morphogenetic Correlations
    V. V. Isaeva, S. V. Rozhnov
    Paleontological Journal.2021; 55(7): 811.     CrossRef
  • In vitro effects of glutathione on Transforming Growth Factor beta and Epidermal Growth Factor Receptor genes expression in the protoscoleces and strobilated worms of Echinococcus granulosus
    Seyyed Jafar Nosratabadi, Nasim Hayati Roodbari, Ali Afgar, Mohammad Hossein Modarressi, Alireza Farsinejad, Majid Fasihi Harandi
    Gene Reports.2020; 20: 100786.     CrossRef
  • Transcriptomic profile of two developmental stages of the cestode parasite Mesocestoides corti
    T. Basika, G.P. Paludo, F.M. Araujo, A.C. Salim, F. Pais, L. Maldonado, N. Macchiaroli, J. Camargo de Lima, M. Rosenzvit, G.C. Oliveira, L. Kamenetzky, H.B. Ferreira
    Molecular and Biochemical Parasitology.2019; 229: 35.     CrossRef
  • Calmodulin-specific small interfering RNA induces consistent expression suppression and morphological changes in Echinococcus granulosus
    Seyed Mohammad Mousavi, Ali Afgar, Mohammad Ali Mohammadi, Seifollah Mortezaei, Balal Sadeghi, Majid Fasihi Harandi
    Scientific Reports.2019;[Epub]     CrossRef
  • The effect of albendazole sulfoxide on the expression of miR-61 and let-7 in different in vitro developmental stages of Echinococcus granulosus
    Seifollah Mortezaei, Ali Afgar, Mohammad Ali Mohammadi, Seyed Mohammad Mousavi, Balal Sadeghi, Majid Fasihi Harandi
    Acta Tropica.2019; 195: 97.     CrossRef
  • Comparative Transcriptomic Analysis of the Larval and Adult Stages of Taenia pisiformis
    Shaohua Zhang
    Genes.2019; 10(7): 507.     CrossRef
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Brief Communication

Environmental Contamination by Echinococcus granulosus sensu lato Eggs in Relation to Slaughterhouses in Urban and Rural Areas in Tunisia
Raja Cha?bane-Banaoues, Myriam Oudni-M’rad, Selim M’rad, Habib Mezhoud, Hamouda Babba
Korean J Parasitol 2016;54(1):113-118.
Published online February 26, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.1.113
Hydatidosis has become a real concern for health care institutions and animal rearers in Tunisia. The Tunisian endemicity is aggravated by the growing number of dogs and the difficulty of getting rid of contaminated viscera because of the lack of equipment in most slaughterhouses. Therefore, microscopic and molecular tools were applied to evaluate the role of slaughterhouses in canine infection and Echinococcus granulosus sensu lato (s. l.) egg dissemination. Exposure risk to E. granulosus s. l. eggs in urban and rural areas was explored in order to implant preventive and adapted control strategies. Microscopic examinations detected taeniid eggs in 152 amongst 553 fecal samples. The copro-PCR demonstrated that 138 of 152 taeniid samples analyzed were positive for E. granulosus s. l. DNA. PCR-RFLP demonstrated that all isolated samples belonged to E. granulosus sensu stricto (s. s.). An important environmental contamination index (25.0%) by E. granulosus s. l. eggs was demonstrated. The average contamination index from the regions around slaughterhouses (23.3%; 95% CI: 17.7-28.9%) was in the same range as detected in areas located far from slaughterhouses (26.0%, 95% CI: 21.3-30.8%). Echinococcosis endemic areas were extended in both rural (29.9%, 95% CI: 24.8-34.9%) and urban locations (18.1%, 95% CI: 13.0-22.9%). The pathogen dissemination is related neither to the presence/absence of slaughterhouses nor to the location in urban or rural areas, but is probably influenced by human activities (home slaughtering) and behavior towards the infected viscera.

Citations

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  • Zoonotic threat of cystic echinococcosis in Tunisia: insights into livestock prevalence and identification of the G1 genotype
    Mohamed Hedi Abdelghani, Selim M’rad, Raja Chaâbane-Banaoues, Sayadi Taoufik, Mohamed Ali Charfedine, Lamia Zemzemi, Ines Kamoun, Hamouda Babba, Myriam Oudni-M’rad
    Frontiers in Veterinary Science.2025;[Epub]     CrossRef
  • Synthetic rEg.P29 Peptides Induce Protective Immune Responses Against Echinococcus granulosus in Mice
    Yongxue Lv, Jing Tang, Tao Li, Yinqi Zhao, Changyou Wu, Wei Zhao
    Vaccines.2025; 13(3): 266.     CrossRef
  • Environmental contamination with feces of free-roaming dogs and the risk of transmission of Echinococcus and Taenia species in urban regions of southeastern Iran
    Saeedeh Shamsaddini, Carina Schneider, Sonja Dumendiak, Hossein Aghassi, Hossein Kamyabi, Elham Akhlaghi, Marion Wassermann, Majid Fasihi Harandi, Peter Deplazes, Thomas Romig
    Parasites & Vectors.2024;[Epub]     CrossRef
  • Global distribution of Echinococcus granulosus genotypes in domestic and wild canids: a systematic review and meta-analysis
    Morteza Shams, Sasan Khazaei, Razi Naserifar, Seyyed Ali Shariatzadeh, Davood Anvari, Fattaneh Montazeri, Majid Pirestani, Hamidreza Majidiani
    Parasitology.2022; 149(9): 1147.     CrossRef
  • Detection of Echinococcus granulosus sensu lato in Environmental Samples from Ibadan, Oyo State, South West Nigeria
    Emmanuel Jolaoluwa Awosanya, Adeola Olagbaju, Angela Peruzzu, Gabriella Masu, Giovanna Masala, Piero Bonelli
    Veterinary Sciences.2022; 9(12): 679.     CrossRef
  • Human and animal cystic echinococcosis in Tataouine governorate: hypoendemic area in a hyperendemic country, myth or reality?
    Selim M’rad, Raja Chaâbane-Banaoues, Massaouda Ghrab, Hamouda Babba, Myriam Oudni-M’rad
    Parasites & Vectors.2021;[Epub]     CrossRef
  • Dispersion of Echinococcus granulosus eggs from infected dogs under natural conditions in Patagonia, Argentina
    P. Sánchez Thevenet, H.M. Alvarez, C. Torrecillas, O. Jensen, J.A. Basualdo
    Journal of Helminthology.2020;[Epub]     CrossRef
  • Molecular identification of Echinococcus granulosus sensu lato by mitochondrial COX1 and SSU-rDNA markers in dogs in the west of Iran
    Seyed-Reza Mirbadie, Masoomeh Zivdari, Hamed Kalani, Mohammad-Reza Vafaei, Shahrokh Izadi, Zahra Jabalameli, Mohsen Mohammadi, Ganesh Yadagiri, Peyman Heydarian, Farzaneh Mirzaei, Mohammad-Ali Mohaghegh
    Gene Reports.2020; 19: 100616.     CrossRef
  • Reinventing the Wheel of Echinococcus granulosus sensu lato Transmission to Humans
    Francesca Tamarozzi, Peter Deplazes, Adriano Casulli
    Trends in Parasitology.2020; 36(5): 427.     CrossRef
  • Parasitological Contamination of Vegetables Sold in Tunisian Retail Markets with Helminth Eggs and Protozoan Cysts
    Selim M'rad, Raja Chaabane-Banaoues, Ibtissem Lahmar, Hamza Oumaima, Habib Mezhoud, Hamouda Babba, Myriam Oudni-M'rad
    Journal of Food Protection.2020; 83(7): 1104.     CrossRef
  • Environmental, climatic and host population risk factors of human cystic echinococcosis in southwest of Iran
    Mohammad Amin Ghatee, Koorosh Nikaein, Walter Robert Taylor, Mehdi Karamian, Hasan Alidadi, Zahra Kanannejad, Faezeh Sehatpour, Fateme Zarei, Gholamreza Pouladfar
    BMC Public Health.2020;[Epub]     CrossRef
  • Molecular phylodiagnosis of Echinococcus granulosus sensu lato and Taenia hydatigena determined by mitochondrial Cox1 and SSU-rDNA markers in Iranian dogs: Indicating the first record of pig strain (G7) in definitive host in the Middle East
    Seyed Reza Mirbadie, Abbas Najafi Nasab, Mohammad Ali Mohaghegh, Pirasteh Norouzi, Mehdi Mirzaii, Adel Spotin
    Comparative Immunology, Microbiology and Infectious Diseases.2019; 65: 88.     CrossRef
  • Molecular characterization of Echinococcus species in dogs from four regions of Kenya
    Erastus Mulinge, Japhet Magambo, David Odongo, Sammy Njenga, Eberhard Zeyhle, Cecilia Mbae, Dorothy Kagendo, Francis Addy, Dennis Ebi, Marion Wassermann, Peter Kern, Thomas Romig
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  • Preliminary studies on the prevalence and genotyping of Echinococcus granulosus infection in stray dogs in Van Province, Turkey
    Bekir Oguz, Nalan Ozdal, Ozlem Orunc Kilinc, M. Serdar Deger
    Journal of Veterinary Research.2018; 62(4): 497.     CrossRef
  • Hydatid Recurrence Medically Treated by Albendazole
    Imen Khammari, Mohamed Amine El Ghali, Salsabil Nasri, Imen Dhib, Hamed Chouaieb, Alia Yaacoub, Moncef Ben Said, Rached Letaief, Akila Fathallah
    The Open Parasitology Journal.2018; 6(1): 1.     CrossRef
  • First molecular identification of Echinococcus vogeli and Echinococcus granulosus (sensu stricto) G1 revealed in feces of domestic dogs (Canis familiaris) from Acre, Brazil
    Leandro Batista das Neves, Paulo Eduardo Ferlini Teixeira, Sidnei Silva, Fernanda Bittencourt de Oliveira, Daniel Daipert Garcia, Fernanda Barbosa de Almeida, Rosângela Rodrigues-Silva, José Roberto Machado-Silva
    Parasites & Vectors.2017;[Epub]     CrossRef
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    Tommaso Manciulli, M. Mariconti, A. Vola, R. Lissandrin, E. Brunetti
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  • Analysis of Lethality in Echinococcal Disease
    Anna S. Khachatryan
    The Korean Journal of Parasitology.2017; 55(5): 549.     CrossRef
  • 11,405 View
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  • 14 Web of Science
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Original Article

Prevalence of Serum IgG Antibodies to Cystic Echinococcus Antigen among Patients in an Uzbekistan Emergency Hospital
Se Jin Park, Sung Sik Han, Khikmat Anvarov, Abdukhakim Khajibaev, Min-Ho Choi, Sung-Tae Hong
Korean J Parasitol 2015;53(6):699-703.
Published online December 31, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.6.699
Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.271-0.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P=0.181), and women were 4.4% while men were 3.1% positive (P=0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.

Citations

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  • Comparison of Methods in the Serologic Diagnosis of Cystic Echinococcosis
    Sidre Erganis, Fakhriddin Sarzhanov, Funda Doğruman Al, Kayhan Cağlar
    Acta Parasitologica.2024; 69(2): 1122.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • Kistik Ekinokokoz’un serolojik tanısında Indirekt Hemaglütinasyon, İndirekt Floresan Antikor ve Enzim İmmuno Assay testlerinin etkinliğinin değerlendirilmesi
    Sadık AKGÜN, Hakan Sezgin SAYİNER, Tekin KARSLIGİL
    Journal of Contemporary Medicine.2017;[Epub]     CrossRef
  • 8,296 View
  • 85 Download
  • 3 Web of Science
  • Crossref

Brief Communication

Prevalence of Cystic Echinococcosis in Slaughtered Sheep as an Indicator to Assess Control Progress in Emin County, Xinjiang, China
Shijie Yang, Weiping Wu, Tian Tian, Jiangshan Zhao, Kang Chen, Qinyan Wang, Zheng Feng
Korean J Parasitol 2015;53(3):355-359.
Published online June 30, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.3.355
Hydatid disease imposing serious threat on human health and great loss in live?stock pastoralism remains a major public health problem in western China. To assess and monitor the effect of control program on transmission dynamics, we used the prevalence of cystic echinococcosis in slaughtered sheep at slaughterhouse as an indicator during the period of 2007 to 2013 in Emin County, Xinjiang Uygur Autonomous Region, China. The results showed a significant decline trend of prevalence in all age groups during the 7 years when the control program was implemented; particularly, the rate was reduced by 72% after first 3 years. Among the sheep slaughtered, the age distribution evidenced that the prevalence increased significantly as the sheep grew older. The baseline data indicated that the rate was 4.5% at the age <1, 6.7% at age 2~, and reached to the highest 17.9% at age ≥4 years. Earlier response to the intervention pressure was seen in the sheep at the younger age. Significant decline started from 2008 at the age <1, from 2009 at age of 1~, 2010 at 2~ to 3~, and the latest, in 2012 at age ≥4. This study demonstrated that the prevalence of cystic echinococcosis in slaughtered sheep may be used as an indicator to assess and monitor the transmission status during and after control program providing information for betterment of performance to sustain control strength.

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  • Epidemiological and genotypic assessment of cystic echinococcosis in ruminant populations of Northern Punjab, Pakistan: a neglected zoonotic disease
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    Parasitology Research.2025;[Epub]     CrossRef
  • Zoonotic threat of cystic echinococcosis in Tunisia: insights into livestock prevalence and identification of the G1 genotype
    Mohamed Hedi Abdelghani, Selim M’rad, Raja Chaâbane-Banaoues, Sayadi Taoufik, Mohamed Ali Charfedine, Lamia Zemzemi, Ines Kamoun, Hamouda Babba, Myriam Oudni-M’rad
    Frontiers in Veterinary Science.2025;[Epub]     CrossRef
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    Faten A. M. Abo-Aziza
    Journal of Parasitic Diseases.2025; 49(4): 917.     CrossRef
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    Fang Yin, Wenrui Meng, Peiwei Fan, Yue Shi, Shuai Chen, Yongchun Liang, Jianyi Yao, Yeping Wang, Chuizhao Xue, Shuai Han, Mengmeng Hao, Qian Wang, Ze Meng, Jun Zhuo, Kai Sun, Yongqing Bai, Tingting Kang, Zhenyu Wang, Lei Liu, Dong Jiang, Liqun Fang, Canju
    PLOS Neglected Tropical Diseases.2025; 19(7): e0013182.     CrossRef
  • The role of cattle in the transmission of cystic echinococcosis in a highly endemic area of the Peruvian Andes
    J. Raúl Lucas, Miguel Cabrera, Néstor Falcón, Orlando Lucas, Alejandro Rodríguez, Daphne Ramos, Cesar Gavidia
    Veterinary Parasitology: Regional Studies and Reports.2024; 51: 101021.     CrossRef
  • Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences
    Nigus Abebe Shumuye, Li Li, John Asekhaen Ohiolei, Sayed Ajmal Qurishi, Wen-Hui Li, Nian-Zhang Zhang, Yan-Tao Wu, Yao-Dong Wu, Sheng-Zhi Gao, Fu-Heng Zhang, Xue-Qi Tian, Wen-Jun Tian, Yong Fu, Xie-Zhong Wang, Yong-Hong Pan, Fang Zhan, Lin-Sheng Zhang, Min
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Original Article

Scolicidal Effects of Black Cumin Seed (Nigella sativa) Essential Oil on Hydatid Cysts
Hossein Mahmoudvand, Ebrahim Saedi Dezaki, Farnaz Kheirandish, Behrouz Ezatpour, Sareh Jahanbakhsh, Majid Fasihi Harandi
Korean J Parasitol 2014;52(6):653-659.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.653

Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal effect of Nigella sativa (Ranunculaceae) essential oil and also its active principle, thymoquinone, against protoscolices of hydatid cysts. Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (0.01-10 mg/ml) and thymoquinone (0.125-1.0 mg/ml) were used for 5 to 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Furthermore, the components of the N. sativa essential oil were identified by gas chromatography/mass spectroscopy (GC/MS). Our study revealed that the essential oil of N. sativa at the concentration of 10 mg/ml and its main component, thymoquinone, at the concentration of 1 mg/ml had potent scolicidal activities against protoscolices of Echinococcus granulosus after 10 min exposure. Moreover, thymoquinone (42.4%), p-cymene (14.1%), carvacrol (10.3%), and longifolene (6.1%) were found to be the major components of N. sativa essential oil by GC/MS analysis. The results of this study indicated the potential of N. sativa as a natural source for production of a new scolicidal agent for use in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking the essential oil and its active component in in vivo models.

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Case Report

Primary Renal Hydatid Cyst: Mis-Interpretation as a Renal Malignancy
Hoon Choi, Jae Young Park, Jae-Heon Kim, Du Geon Moon, Jeong-Gu Lee, Jae Hyun Bae
Korean J Parasitol 2014;52(3):295-298.
Published online June 26, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.3.295

Primary renal echinococcosis, a rare disease involving the kidney, accounts for 2-3% of human echinococcosis. A 64-year-old female patient from Uzbekistan presented with complaints of left flank pain. A CT scan revealed a cystic mass in the upper to midpole of the left kidney. We regarded this lesion as a renal malignancy and hand-assisted laparoscopic radical nephrectomy was performed to remove the renal mass. The mass consisted of a large unilocular cyst and multiple smaller cysts without any grossly visible renal tissue. The final pathologic diagnosis was a renal hydatid cyst. For patients from endemic areas, hydatid cyst should be included in the differential diagnosis. Here, we present a case of renal hydatid cyst in a female patient who relocated from Uzbekistan to Korea.

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Brief Communication

Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
Korean J Parasitol 2013;51(5):595-597.
Published online October 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.5.595

In December 2011, we reported an autochthonous case of Echinococcus multilocularis infection in a 42-year-old woman in Korea. The diagnosis was based on histopathological findings of the surgically resected liver cyst. In the present study, we evaluated the serological and molecular characteristics of this Korean E. multilocularis case. The patient's serum strongly reacted with affinity-purified native Em18 and recombinant Em18 antigens (specific for E. multilocularis) but negative for recombinant antigen B8/1 (reactive for Echinococcus granulosus). In immunoaffinity chromatography, the serum also strongly reacted with E. multilocularis and only weakly positive for E. granulosus. We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia. The Korean case showed 99.8-99.9% similarity with isolates from Asia (the highest similarity with an isolate from Sichuan, China), whereas the similarity with European isolates ranged from 99.5 to 99.6%.

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  • Assessment of the global pattern of genetic diversity in Echinococcus multilocularis inferred by mitochondrial DNA sequences
    Adel Spotin, Belgees Boufana, Ehsan Ahmadpour, Adriano Casulli, Mahmoud Mahami-Oskouei, Soheila Rouhani, Amirreza Javadi-Mamaghani, Firooz Shahrivar, Paria Khoshakhlagh
    Veterinary Parasitology.2018; 262: 30.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • 8,872 View
  • 98 Download
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Case Report

A Case of Budd-Chiari Syndrome Associated with Alveolar Echinococcosis
Erol ?akmak, Hakan Alagozlu, Cesur Gumus, Celiks?z Al?
Korean J Parasitol 2013;51(4):475-477.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.475

Although alveolar echinococcosis (AE) can cause a serious disease with high mortality and morbidity similar to malign neoplasms. A 62-year-old woman admitted to a hospital located in Sivas, Turkey, with the complaints of fatigue and right upper abdominal pain. On contrast abdominal CT, a 54×70×45 mm sized cystic lesion was detected in the left lobe of the liver that was seen to extend to the posterior mediastinum and invade the diaphragm, esophagus, and pericardium. The cystic lesion was seen to be occluding the inferior vena cava and left hepatic vein at the level where the hepatic veins poured into the inferior vena cava. Bilateral pleural effusion was also detected. We discussed this secondary Budd-Chiari Syndrome (BCS) case, resulting from the AE occlusion of the left hepatic vein and inferior vena cava, in light of the information in literature.

Citations

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  • A Case Series and Literature Review of Alveolar Echinococcosis in Kashmir, India: An Emerging Endemic Zone for Echinococcus multilocularis
    Mohammad Sultan Khuroo, Naira Sultan Khuroo, Ajaz Ahmad Rather
    Life.2024; 14(7): 794.     CrossRef
  • Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis
    Paul Calame, Mathieu Weck, Andreas Busse-Cote, Eleonore Brumpt, Carine Richou, Celia Turco, Alexandre Doussot, Solange Bresson-Hadni, Eric Delabrousse
    Insights into Imaging.2022;[Epub]     CrossRef
  • Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study
    Tilmann Graeter, Rong Shi, Haihua Bao, Wenya Liu, Weixia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer
    Acta Radiologica.2021; 62(8): 997.     CrossRef
  • Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis
    Tilmann Graeter, Hai-Hua Bao, Rong Shi, Wen-Ya Liu, Wei-Xia Li, Yi Jiang, Julian Schmidberger, Eleonore Brumpt, Eric Delabrousse, Wolfgang Kratzer, the XUUB Consortium
    World Journal of Gastroenterology.2020; 26(29): 4302.     CrossRef
  • Left trisectionectomy and supra-hepatic caval reconstruction with vascular prosthesis for chronic Budd-Chiari syndrome caused by hepatic alveolar echinococcosis
    Bo Ran, Tie-Min Jiang, Aimaiti Yasen, Abudusalamu Aini, Qiang Guo, Rui-Qing Zhang, Ying-Mei Shao, Hao Wen, Aji Tuerganaili
    Chinese Medical Journal.2019; 132(23): 2886.     CrossRef
  • A report on three patients with Echinococcus multilocularis: Lessons learned
    Nalini Bansal, Vivek Vij, Mukul Rastogi, Manav Wadhawan, Ajay Kumar
    Indian Journal of Gastroenterology.2018; 37(4): 353.     CrossRef
  • Diagnosis and treatment guidelines for aberrant portal hemodynamics

    Hepatology Research.2017; 47(5): 373.     CrossRef
  • Recurrent multiple-organ involvement of disseminated alveolar echinococcosis in 3 patients
    Leilei Xu, Sikandaer Siyiti, Xinghua Song, Hao Wen, Liwen Ding, Akbar Yunus, Zheng Tian, Chong Wang, Jiangtao Chen
    Medicine.2017; 96(42): e7632.     CrossRef
  • Orage pour ce foie mais pas de désespoir…
    C. Bernard, F. Bailly, F. Craigherot, B. Bancel, M. Brevet, C. Broussolle, P. Sève, P. Bélénotti
    La Revue de Médecine Interne.2015; 36(10): 706.     CrossRef
  • Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study
    Tilmann Graeter
    World Journal of Gastroenterology.2015; 21(16): 4925.     CrossRef
  • 8,589 View
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Original Articles

Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications
Djurdja Bracanovic, Marija Djuric, Jelena Sopta, Danijela Djonic, Nenad Lujic
Korean J Parasitol 2013;51(4):453-459.
Published online August 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.4.453

Although Serbia is recognized as an endemic country for echinococcosis, no information about precise incidence in humans has been available. The aim of this study was to investigate the skeletal manifestations of hydatid disease in Serbia. This retrospective study was conducted by reviewing the medical database of Institute for Pathology (Faculty of Medicine in Belgrade), a reference institution for bone pathology in Serbia. We reported a total of 41 patients with bone cystic echinococcosis (CE) during the study period. The mean age of 41 patients was 40.9±18.8 years. In 39% of patients, the fracture line was the only visible radiological sign, followed by cyst and tumefaction. The spine was the most commonly involved skeletal site (55.8%), followed by the femur (18.6%), pelvis (13.9%), humerus (7.0%), rib (2.3%), and tibia (2.3%). Pain was the symptom in 41.5% of patients, while some patients demonstrated complications such as paraplegia (22.0%), pathologic fracture (48.8%), and scoliosis (9.8%). The pathological fracture most frequently affected the spine (75.0%) followed by the femur (20.0%) and tibia (5.0%). However, 19.5% of patients didn't develop any complication or symptom. In this study, we showed that bone CE is not uncommon in Serbian population. As reported in the literature, therapy of bone CE is controversial and its results are poor. In order to improve the therapy outcome, early diagnosis, before symptoms and complications occur, can be contributive.

Citations

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  • Vertebral and pelvic echinococcosis in northwestern China
    Laihong Yang, Pahati Tuxunjiang, Wenya Liu, Hui Guo
    International Orthopaedics.2023; 47(5): 1153.     CrossRef
  • Complete excision of giant clavicular hydatid cyst: a case report
    Xin Wang, Jinyong Huang, Liping Su, Qian Ma, Chao Ma, Zengru Xie
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Hydatid disease of bone
    Hui Guo, Pahati Tuxunjiang, Laihong Yang, Wenya Liu
    Radiology of Infectious Diseases.2022; 9(1): 18.     CrossRef
  • Cystic Echinococcosis of the Bone: A European Multicenter Study
    Letizia Cattaneo, Tommaso Manciulli, Carmen-Michaela Cretu, Maria Teresa Giordani, Andrea Angheben, Alessandro Bartoloni, Lorenzo Zammarchi, Filippo Bartalesi, Joachim Richter, Peter Chiodini, Gauri Godbole, Thomas Junghanss, Marija Stojkovic, Luigi Samma
    The American Journal of Tropical Medicine and Hygiene.2019; 100(3): 617.     CrossRef
  • Human hydatid disease and its effect on bones and joints: edital
    MA Gracio
    MOJ Public Health.2019; 8(4): 121.     CrossRef
  • Cystic Echinococcosis of the Bone in Kazakhstan
    Tommaso Manciulli, Aigerim Mustapayeva, Konrad Juszkiewicz, Ekaterina Sokolenko, Zhaksylik Maulenov, Ambra Vola, Mara Mariconti, Gani Serikbaev, Amangul Duisenova, Enrico Brunetti, Zhamilya Zholdybay
    Case Reports in Infectious Diseases.2018; 2018: 1.     CrossRef
  • Fractures de côtes non traumatiques
    Yves Maugars, Marguerite Mary-Chemel, Christelle Laffite-Darrieutort, Pascale Guillot, Joëlle Glémarec, Jean-Marie Berthelot, Benoit Le Goff
    Revue du Rhumatisme Monographies.2015; 82(2): 109.     CrossRef
  • Giant hydatid cyst of the pelvis, femur and retroperitoneal space: surgical treatment with extended hemipelvectomy
    Panagiotis Tsagozis, Otte Brosjö
    BMJ Case Reports.2015; 2015: bcr2015209715.     CrossRef
  • Reports of four cyst hydatid cases in different size and location
    Elif Tukenmez Tigen, Buket Erturk Sengel, Huseyin Bilgin, Serra Ozel, Lutfiye Mulazimoglu
    Asian Pacific Journal of Tropical Disease.2014; 4(5): 408.     CrossRef
  • Bone cyst: Case report and implications for the anaesthesiologist
    Chhavi Sawhney, Ghansham Biyani, Sadik Mohammed, Pallavi Shende
    Indian Journal of Anaesthesia.2014; 58(6): 767.     CrossRef
  • 10,149 View
  • 96 Download
  • Crossref
Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
Korean J Parasitol 2013;51(3):313-317.
Published online June 30, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.3.313

According to increase of travel, the cases of imported echinococcosis have been increasing in Korea. The present study was undertaken to develop a serodiagnostic system for echinococcosis in Korea. For diagnosis of echinococcosis, the fluid of Echinococcus granulosus hydatid cysts was collected from naturally infected sheep in Uzbekistan. Also serum samples of infected patients who were surgically confirmed were collected in a hospital in Tashkent, Uzbekistan. According to the absorbance of 59 echinococcosis positive and 39 negative control serum samples, the cut-off value was determined as 0.27. The sensitivity and specificity of ELISA with hydatid fluid antigen were 91.5% and 96%, respectively. The antigen cross-reacted with the serum of some cysticercosis or clonorchiasis patients. However, immunoblot analysis on the cystic fluid recognized antigenic proteins of 7-, 16-, and 24-kDa bands in their dominant protein quantity and strong blotting reactivity. In conclusion, the present ELISA system using hydatid cyst fluid antigen from Uzbekistan sheep is sensitive and specific for diagnosis of echinococcosis cases.

Citations

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  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Human and camel cystic echinococcosis – a polyclonal antibody-based sandwich ELISA for its serodiagnosis with molecular identification
    A. Maher, N. I. Toaleb, R. M. Shaapan, D. Aboelsoued, M. B. Salman, S. Zaky
    Veterinary Research Communications.2024; 48(4): 2193.     CrossRef
  • Past and present of diagnosis of echinococcosis: A review (1999–2021)
    Mughees Aizaz Alvi, Rana Muhammad Athar Ali, Sadiq Khan, Muhammad Saqib, Warda Qamar, Li Li, Bao-Quan Fu, Hong-Bin Yan, Wan-Zhong Jia
    Acta Tropica.2023; 243: 106925.     CrossRef
  • A Novel Designed Sandwich ELISA for the Detection of Echinococcus granulosus Antigen in Camels for Diagnosis of Cystic Echinococcosis
    Nagwa I. Toaleb, Dina Aboelsoued, Kadria N. Abdel Megeed, Sahar Hussein Abdalla Hekal
    Tropical Medicine and Infectious Disease.2023; 8(8): 400.     CrossRef
  • A simple and efficient purification method of native immunoreactive antigen for diagnosis of camel hydatidosis
    Nagwa I. Toaleb, Mohamed S. Helmy, Eman E. El Shanawany, Eman H. Abdel-Rahman
    Veterinary World.2020; 13(1): 141.     CrossRef
  • Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep
    Liu Tianli, Wang Xifeng, Tian Zhenzhong, Wang Lixia, Zhang Xingxing, Qiao Jun, Meng Qingling, Gong Shasha, Chen Ying, Cai Xuepeng
    The Korean Journal of Parasitology.2019; 57(1): 61.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • Serological diagnosis of cystic echinococcosis in cattle
    Aitbay K. Bulashev, Zhanbolat A. Suranshiev, Orken S. Akibekov, Zhanara Zh. Akanova, Gulmira A. Abulgazimova
    Folia Parasitologica.2017;[Epub]     CrossRef
  • Diagnostic value of semi-purified antigens of hydatid cyst fluid in human cystic echinococcosis
    Wissal Iraqi
    Acta Parasitologica.2016;[Epub]     CrossRef
  • Presumptive case of sparganosis manifesting as a hepatic mass: A case report and literature review
    Gyeong Deok Jo, Jae Young Lee, Sung-Tae Hong, Jung Hoon Kim, Joon Koo Han
    World Journal of Radiology.2016; 8(10): 846.     CrossRef
  • Prevalence of Serum IgG Antibodies to Cystic <i>Echinococcus</i> Antigen among Patients in an Uzbekistan Emergency Hospital
    Se Jin Park, Sung Sik Han, Khikmat Anvarov, Abdukhakim Khajibaev, Min-Ho Choi, Sung-Tae Hong
    The Korean Journal of Parasitology.2015; 53(6): 699.     CrossRef
  • Infection Status of Hydatid Cysts in Humans and Sheep in Uzbekistan
    Sung-Tae Hong, Yan Jin, Khikmat Anvarov, Abdukhakim Khadjibaev, Samin Hong, Yusufjon Ahmedov, Utkir Otaboev
    The Korean Journal of Parasitology.2013; 51(3): 383.     CrossRef
  • 9,066 View
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Case Reports
An Imported Case of Cystic Echinococcosis in the Liver
Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
Korean J Parasitol 2012;50(4):357-360.
Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.357

A 25-year-old Uzbek male presented with right upper abdominal pain for 20 days. On radiologic studies, a huge cystic mass was noticed in the right liver which was suspected as parasitic. The patient received right hepatic segmentectomy (segment 7), and the surgically resected mass was confirmed as cystic echinococcosis (CE), measuring 10.5 cm in its diameter. The inner surface of the cyst was bile-stained. The patient was discharged on the 8th hospital day, and was rechecked 6 months after the surgical intervention without any evidence of recurrence. The present report describes findings of an imported case of CE which represented ultrasound images of the 'ball of wool'.

Citations

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  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Hepatic Hydatid Cyst: A Case Report
    Wan Chul Kim, Jae Uk Shin, Su Sin Jin
    The Korean Journal of Gastroenterology.2021; 77(1): 35.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • Medical treatment of tropical parasitic diseases
    Joon Sup Yeom, Yoon Kong
    Journal of the Korean Medical Association.2016; 59(9): 721.     CrossRef
  • Primary Renal Hydatid Cyst: Mis-Interpretation as a Renal Malignancy
    Hoon Choi, Jae Young Park, Jae-Heon Kim, Du Geon Moon, Jeong-Gu Lee, Jae Hyun Bae
    The Korean Journal of Parasitology.2014; 52(3): 295.     CrossRef
  • Lateral Flow Test Using Echinococcus granulosus Native Antigen B and Comparison of IgG and IgG4 Dipsticks for Detection of Human Cystic Echinococcosis
    Sabariah Osman, Akbar Khalilpour, Rahmah Noordin, Seyed Mahmoud Sadjjadi, Muhammad Hafiznur Yunus, Zohreh Kazemi Moghadam, Nor Dyana Zakaria
    The American Journal of Tropical Medicine and Hygiene.2014; 91(5): 994.     CrossRef
  • Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
    Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(3): 313.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
  • Infection Status of Hydatid Cysts in Humans and Sheep in Uzbekistan
    Sung-Tae Hong, Yan Jin, Khikmat Anvarov, Abdukhakim Khadjibaev, Samin Hong, Yusufjon Ahmedov, Utkir Otaboev
    The Korean Journal of Parasitology.2013; 51(3): 383.     CrossRef
  • 9,567 View
  • 90 Download
  • Crossref
Recurrent Hepatic Alveolar Echinococcosis: Report of The First Case in Korea with Unproven Infection Route
Su-Jin Kim, Jong-Han Kim, Sang-Young Han, Young-Hoon Kim, Jin-Han Cho, Jong-Yil Chai, Jin-Sook Jeong
Korean J Parasitol 2011;49(4):413-418.
Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.413

Human alveolar echinococcosis (AE), a hepatic disorder that resembles liver cancer, is a highly aggressive and lethal zoonotic infection caused by the larval stage of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is widely distributed in the northern hemisphere; the disease-endemic area stretches from north America through Europe to central and east Asia, including northern parts of Japan, but it has not been reported in Korea. Herein, we represent a first case of AE in Korea. A 41-year-old woman was found to have a large liver mass on routine medical examination. The excised mass showed multinodular, necrotic, and spongiform appearance with small irregular pseudocystic spaces. Microscopically, the mass was composed of chronic granulomatous inflammation with extensive coagulation necrosis and parasite-like structure, which was revealed as parasitic vesicles and laminated layer delineated by periodic acid-Schiff (PAS) stain. Clinical and histologic features were consistent with AE. After 8 years, a new liver mass and multiple metastatic pulmonary nodules were found and the recurred mass showed similar histologic features to the initial mass. She had never visited endemic areas of AE, and thus the exact infection route is unclear.

Citations

Citations to this article as recorded by  Crossref logo
  • Delayed Diagnosis of Imported Cystic Echinococcosis and Successful Treatment With Percutaneous Drainage and Albendazole in Korea: A Case Report
    Won Jun Choi, Hanna Jin, Hyeon Jae Jo, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Min-Ho Choi
    Journal of Korean Medical Science.2025;[Epub]     CrossRef
  • Imported parasitic diseases in the Republic of Korea: status and issues
    Jong-Yil Chai
    Journal of the Korean Medical Association.2025; 68(1): 52.     CrossRef
  • Comparative analysis of host immune responses to Hydatid cyst in human and ovine hepatic cystic Echinococcosis
    Bnar S. Hamad, Bushra H. Shnawa, Rafal A. Alrawi, Mukhtar H. Ahmed
    Veterinary Immunology and Immunopathology.2024; 273: 110775.     CrossRef
  • Investigation of Echinococcus multilocularis in foxes and dogs in Pakistan by detection of copro-DNA
    Aisha Khan, Gérald Umhang, Zaib Ullah, Franck Boué, Vanessa Bastid, Ikram Ullah, Sajid Mahmood, Muhammad Sohail Afzal, Haroon Ahmed
    Parasitology Research.2021; 120(2): 731.     CrossRef
  • Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century
    Sven Baumann, Rong Shi, Wenya Liu, Haihua Bao, Julian Schmidberger, Wolfgang Kratzer, Weixia Li, Thomas F. E. Barth, Sven Baumann, Johannes Bloehdorn, Iris Fischer, Tilmann Graeter, Natalja Graf, Beate Gruener, Doris Henne-Bruns, Andreas Hillenbrand, Tanj
    Infection.2019; 47(5): 703.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • The echinococcoses in Asia: The present situation
    Akira Ito, Christine M. Budke
    Acta Tropica.2017; 176: 11.     CrossRef
  • Alveolar Echinococcosis of the Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble S. Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthruimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2016; 45(1): 80.     CrossRef
  • Alveolar Echinococcosis of Liver: A Diagnostic Problem in a Nonendemic Area
    Kumble Seetharama Madhusudhan, Deep N. Srivastava, Nihar R. Dash, Arun Venuthurimilli, Raju Sharma, Shivanand Gamanagatti, Arun K. Gupta
    Current Problems in Diagnostic Radiology.2015; 44(2): 221.     CrossRef
  • Serological and Molecular Characteristics of the First Korean Case of Echinococcus multilocularis
    Jin-Sook Jeong, Sang-Young Han, Young-Hoon Kim, Yasuhito Sako, Tetsuya Yanagida, Akira Ito, Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(5): 595.     CrossRef
  • Serodiagnosis of Echinococcosis by ELISA Using Cystic Fluid from Uzbekistan Sheep
    Yan Jin, Khikmat Anvarov, Abdukhakim Khajibaev, Samin Hong, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(3): 313.     CrossRef
  • In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes
    Tatiana Küster, Nadja Kriegel, David W. Boykin, Chad E. Stephens, Andrew Hemphill
    Antimicrobial Agents and Chemotherapy.2013; 57(8): 3829.     CrossRef
  • An Imported Case of Cystic Echinococcosis in the Liver
    Keun Soo Ahn, Sung-Tae Hong, Yu Na Kang, Jung Hyeok Kwon, Mi Jeong Kim, Tae Jun Park, Yong Hoon Kim, Tae Jin Lim, Koo Jeong Kang
    The Korean Journal of Parasitology.2012; 50(4): 357.     CrossRef
  • 10,357 View
  • 109 Download
  • Crossref