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"Sung-Jong Hong"

Brief Communications

Identification of an Opisthorchis viverrini-like liver fluke from Myanmar: Metacercariae recovered from snakehead fish and adults from an experimentally infected hamster
Woon-Mok Sohn, Bong-Kwang Jung, Keon-Hoon Lee, Sung-Jong Hong, Seung-Hwan Seo, Thi Thi Htoon, Htay Htay Tin, Eun-Hee Shin, Jong-Yil Chai
Parasites Hosts Dis 2025;63(2):174-181.
Published online May 26, 2025
DOI: https://doi.org/10.3347/PHD.24063
A novel fluke species, morphologically resembling Opisthorchis viverrini, was discovered in the Yangon Region, Myanmar. Metacercariae were found in the muscle tissue of 2 snakehead fish species, Mi and Channa striata. The metacercariae were elliptical (average 165×122 μm, n=10), having 2 suckers and a large excretory bladder. Experimental infection of a hamster resulted in the recovery of adult flukes from the bile ducts at day 50 post-infection. Adult flukes were lanceolate, with dimensions of 3.8–6.0 (average 5.1) mm by 1.1–1.2 (1.2) mm (n=10). Morphological characteristics included an oral sucker slightly smaller than the ventral sucker, a long uterus not extending anterior to the ventral sucker, vitelline follicles reaching the anterior ovary level, and 2 deeply lobed testes (4 lobes anteriorly, 5 posteriorly). Eggs were ovoid to elliptical, measuring 26.3–27.5 (26.9) μm in length and 13.8–15.0 (14.6) μm in width (n=10). Despite the close morphological resemblance to O. viverrini, our specimens displayed significant differences, including a more spiraled seminal vesicle, a longer uterus occupying 50%–60% of the body length, a less distinct grouping of vitelline follicles (forming 7–8 groups on each side in O. viverrini), vitelline follicles restricted to the ovary level (beyond the posterior end of the ovary or at anterior testis level in O. viverrini), and smaller metacercariae. We tentatively categorize our specimens as an O. viverrini-like liver fluke potentially parasitizing mammals or birds, highlighting the need for further research. Rigorous molecular analyses and identification of natural definitive hosts are essential to clarify the taxonomic status of this novel parasite.

Citations

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  • Toward resolving cryptic diversity in opisthorchiid flukes: Molecular clarification of an Opisthorchis viverrini-like parasite in Myanmar is urgently needed
    Schawanya Kaewpitoon Rattanapitoon, Chutharat Thanchonnang, Nathkapach Kaewpitoon Rattanapitoon
    Parasites, Hosts and Diseases.2025; 63(3): 284.     CrossRef
  • 2,375 View
  • 85 Download
  • 1 Web of Science
  • Crossref
Standard- and large-sized eggs of Trichuris trichiura in the feces of schoolchildren in the Yangon Region, Myanmar: Morphological and molecular analyses
Seungwan Ryoo, Bong-Kwang Jung, Sooji Hong, Hyejoo Shin, Hyemi Song, Hyun-Seung Kim, Jin-Youp Ryu, Woon-Mok Sohn, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
Parasites Hosts Dis 2023;61(3):317-324.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.23059
Standard- and large-sized eggs of Trichuris trichiura were found in the feces of schoolchildren in Yangon, Myanmar during epidemiological surveys and mass deworming with albendazole in 2017-2019. The standard-sized eggs were identified as those of T. trichiura, but it was necessary to exclude the possibility of the large-sized eggs belonging to Trichuris vulpis, a dog whipworm. We conducted morphological and molecular studies to determine the species of the 2 types of Trichuris eggs. Individual eggs of both sizes were isolated from Kato-Katz fecal smears (n=20) and mechanically destroyed using a 23G injection needle. Nuclear DNA was extracted, and the 18S rRNA region was sequenced in 15 standard-sized eggs and 15 large-sized eggs. The average size of standard-sized eggs (T. trichiura) was 55.2×26.1 μm (range: 51.7-57.6×21.3-28.0 μm; n=97), whereas the size of large-sized eggs was 69.3×32.0 μm (range: 65.1-76.4×30.1-34.5 μm; n=20), slightly smaller than the known size of T. vulpis. Regarding standard-sized eggs, the 18S rRNA nucleotide sequences exhibited 100% homology with T. trichiura deposited in GenBank and 88.6-90.5% homology with T. vulpis. Regarding large-sized eggs, the nucleotide sequences showed 99.8-100% homology with T. trichiura in GenBank and 89.6-90.7% homology with T. vulpis. Both standard- and large-sized eggs of Trichuris spp. found in Myanmar schoolchildren during 2017-2019 were morphologically and molecularly confirmed to belong to T. trichiura. The conversion of eggs from smaller to large sizes might be due to anthelmintic treatments with albendazole.

Citations

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  • Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea
    Jong-Yil Chai, Min Seo, Dong Hoon Shin
    Parasites, Hosts and Diseases.2023; 61(4): 345.     CrossRef
  • 10,228 View
  • 102 Download
  • 3 Web of Science
  • Crossref

Original Articles

Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar
Sooji Hong, Bong-Kwang Jung, Hyemi Song, Jaeeun Cho, Woon-Mok Sohn, Sung-Jong Hong, Jin-Youp Ryu, Hyun-Seung Kim, Mun-Hyoo Jeong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
Korean J Parasitol 2021;59(6):607-613.
Published online December 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.6.607
Soil-transmitted helminth (STH) infections are still a considerable challenge in Myanmar. We undertook a control program for STH infections (especially Trichuris trichiura) among schoolchildren in Myanmar using mass drug administration (MDA) and health education. Around 1,700 schoolchildren from 15 primary schools in 3 suburban districts (Shwe Pyi Thar, Twantay, and Kyauktan) of the Yangon Region were subjected in this study during 2017-2019. All of the schoolchildren in each school were orally administered albendazole (400 mg in a single dose) 2, 3, and 4 times a year in 2017, 2018, and 2019, respectively. The results revealed that the egg positive rate of any intestinal helminths (including STH) was reduced from 37.6% (649/1,724) in 2017 to 22.8% (352/1,542) in 2019. The egg positive rate of Ascaris lumbricoides was decreased remarkably from 23.3% (402/1,724) in 2017 to 3.6% (56/1,542) in 2019. However, that of T. trichiura was only slightly reduced from 26.9% (464/1,724) in 2017 to 20.2% (312/1,542) in 2019. The intensity of infection with A. lumbricoides and T. trichiura was both more or less reduced, and the proportion of light infection cases with A. lumbricoides and T. trichiura increased from 35.6% in 2017 to 64.3% in 2019 and from 70.3% in 2017 to 81.7% in 2019, respectively. The results indicated that repeated MDAs (2-4 times a year for 3 years) using albendazole on schoolchildren in Myanmar failed to control T. trichiura infection. For a successful control of trichuriasis in Myanmar, new MDA strategies, using a modified albendazole regimen (multiple daily doses for 2 or 3 days) or an alternative anthelmintic drug, such as oxantel pamoate, is strongly recommended.

Citations

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  • Assessing soil-transmitted helminths and Schistosoma mansoni infections using parasitological indicators after seven years of preventive chemotherapy among school-age children in Mizan-Aman town
    Mitiku Abera, Tariku Belay, Daniel Emana, Zeleke Mekonnen, Uwem Friday Ekpo
    PLOS Neglected Tropical Diseases.2025; 19(5): e0013058.     CrossRef
  • Standard- and large-sized eggs of Trichuris trichiura in the feces of schoolchildren in the Yangon Region, Myanmar: Morphological and molecular analyses
    Seungwan Ryoo, Bong-Kwang Jung, Sooji Hong, Hyejoo Shin, Hyemi Song, Hyun-Seung Kim, Jin-Youp Ryu, Woon-Mok Sohn, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
    Parasites, Hosts and Diseases.2023; 61(3): 317.     CrossRef
  • 4,818 View
  • 100 Download
  • 2 Web of Science
  • Crossref
Recent Spatial and Temporal Trends of Malaria in Korea
Yeong Hoon Kim, Hye-Jin Ahn, Dongjae Kim, Sung-Jong Hong, Tong-Soo Kim, Ho-Woo Nam
Korean J Parasitol 2021;59(6):585-593.
Published online December 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.6.585
This study was done to provide an analytical overview on the latest malaria infection clusters by evaluating temporal trends during 2010-2019 in Korea. Incheon was the most likely cluster (MLC) for all cases of malaria during the total period. MLCs for P. falciparum, vivax, malariae, ovale, and clinically diagnosed malaria without parasitological confirmation were Jeollanam-do, Incheon, Gangwon-do, Gyeongsangnam-do, and Jeollabuk-do, respectively. Malaria was decreasing in most significant clusters, but Gwangju showed an increase for all cases of malaria, P. vivax and clinically diagnosed cases. Malaria overall, P. falciparum and P. vivax seem to be under control thanks to aggressive health measures. This study might provide a sound scientific basis for future control measures against malaria in Korea.

Citations

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  • List of occupational diseases among farmers in Korea: a literature review
    Hansoo Song, Seok-Ju Yoo, Won-Ju Park, Seunghyeon Cho, Ki Soo Park, Joo Hyun Sung, Sang Jin Park, Seong-yong Yoon, Kyeongsoo Kim, Dong-phil Choi, Hye-min Kim, Bounggyun Ju, Kanwoo Youn
    Ann Occup Environ Med.2025; 37: e2.     CrossRef
  • 2024년 수도권역 말라리아 환자 및 군집사례 발생 현황
    미정 고, 윤정 서, 현미 김, 경원 황
    Public Health Weekly Report.2025; 18(47): 1867.     CrossRef
  • Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea
    Jiseung Jeon, Heung Chul Kim, Terry A. Klein, Kwang Shik Choi
    Scientific Reports.2023;[Epub]     CrossRef
  • Spatio‐temporal incidence of malaria patients in Incheon Metropolitan City
    Jung‐A An, Jeong Hyeon Lee, MyungDeok Kim-Jeon, Sung‐Jong Hong, Hyung Wook Kwon
    Entomological Research.2023; 53(12): 609.     CrossRef
  • 5,781 View
  • 135 Download
  • 3 Web of Science
  • Crossref

Brief Communication

Prevalence and Intensity of Opisthorchis viverrini Metacercarial Infection in Fish from Phnom Penh, Takeo, and Kandal Provinces, Cambodia
Woon-Mok Sohn, Seung-Ho Choi, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Taehee Chang, Keon Hoon Lee, Byoung-Kuk Na, Sung-Jong Hong, Virak Khieu, Jong-Yil Chai
Korean J Parasitol 2021;59(5):531-536.
Published online October 22, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.5.531
The prevalence and intensity of Opisthorchis viverrini metacercariae (OvMc) were investigated in fish from 3 southern administrative regions along the Mekong River in Cambodia, i.e., Phnom Penh, Takeo, and Kandal Provinces from 2017 to 2020. A total of 295 freshwater fish (24 species) were transported to our laboratory with ice and examined using the artificial digestion method. In Phnom Penh, among 4 fish species positive for OvMc, 9 (23.7%) of 38 specimens examined were infected, and their intensity of infection averaged 4.3 metacercariae per infected fish. In Takeo Province, among 10 fish species positive for OvMc, 24 (38.1%) out of 63 fish examined were infected, and their intensity of infection was av. 14.4 metacercariae per infected fish. In particular, all of 3 Osteochilus schlegelii fish examined were infected, and their infection intensity was high, 34.7 metacercariae per fish. In Kandal Province, among 6 fish species positive for OvMc, 46 (90.2%) out of 51 specimens examined were infected, and their infection intensity was 24.0 metacercaraie per infected fish. All fish of Systomus orphoides (n=17), Barbonymus altus (n=14), and Rasbora aurotaenia (n=2) were infected, and their intensity of infection averaged 37.7, 21.6, and 18.5 metacercariae per fish, respectively. Metacercariae of Haplochis yokogawai, Haplorchis taichui, and Centrocestus formosanus were detected in fish from Takeo and Kandal Provinces. From these results, it has been confirmed that a variety of fish species from Phnom Penh, Takeo, and Kandal Provinces are commonly infected with OvMc, and preventive measures to avoid human O. viverrini infection should be performed in Cambodia.

Citations

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  • Biological Hazards and Indicators Found in Products of Animal Origin in Cambodia from 2000 to 2022: A Systematic Review
    Shwe Phue San, Rortana Chea, Delia Grace, Kristina Roesel, Sothyra Tum, Stephen Young, Tumnoon Charaslertrangsi, Nazanin Zand, Shetty Seetharama Thombathu, Ra Thorng, Leab Kong, Kuok Fidero, Linda Nicolaides
    International Journal of Environmental Research and Public Health.2024; 21(12): 1621.     CrossRef
  • Re‐evaluation of certain aspects of the EFSA Scientific Opinion of April 2010 on risk assessment of parasites in fishery products, based on new scientific data. Part 2
    Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panag
    EFSA Journal.2024;[Epub]     CrossRef
  • 5,991 View
  • 110 Download
  • 2 Web of Science
  • Crossref

Original Articles

Electrophysiological Properties of Ion Channels in Ascaris suum Tissue Incorporated into Planar Lipid Bilayers
Kwon Moo Park, Sun-Don Kim, Jin Bong Park, Sung-Jong Hong, Pan Dong Ryu
Korean J Parasitol 2021;59(4):329-339.
Published online August 18, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.4.329
Ion channels are important targets of anthelmintic agents. In this study, we identified 3 types of ion channels in Ascaris suum tissue incorporated into planar lipid bilayers using an electrophysiological technique. The most frequent channel was a large-conductance cation channel (209 pS), which accounted for 64.5% of channels incorporated (n=60). Its open-state probability (Po) was ~0.3 in the voltage range of –60~+60 mV. A substate was observed at 55% of the main-state. The permeability ratio of Cl- to K+ (PCl/PK) was ~0.5 and PNa/PK was 0.81 in both states. Another type of cation channel was recorded in 7.5% of channels incorporated (n=7) and discriminated from the large-conductance cation channel by its smaller conductance (55.3 pS). Its Po was low at all voltages tested (~0.1). The third type was an anion channel recorded in 27.9% of channels incorporated (n=26). Its conductance was 39.0 pS and PCl/PK was 8.6±0.8. Po was ~1.0 at all tested potentials. In summary, we identified 2 types of cation and 1 type of anion channels in Ascaris suum. Gating of these channels did not much vary with voltage and their ionic selectivity is rather low. Their molecular nature, functions, and potentials as anthelmintic drug targets remain to be studied further.
  • 4,809 View
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Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
Korean J Parasitol 2021;59(3):251-256.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.251
We find out the clusters with high toxoplasmosis risk to discuss the geographical pattern in Gyodong-myeon and Samsan-myeon of Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea. Seroepidemiological data of toxoplasmosis surveyed using rapid diagnostic tests for the residents in the areas in 2019 were analyzed to detect clusters of the infection. The cluster was investigated using the SaTScan program which is based on Kulldorff’s scan statistic. The clusters were found with P-values in each region analyzed in the program, and the risk and patient incidence of specific areas can be examined by the values such as relative risk and log likelihood ratio. Jiseok-ri and Insa-ri were found to be a cluster in Gyodong-myeon and Seokmo-ri was the cluster in Samsan-myeon. Yangji-ri and Igil-ri were found to be a cluster in Cheorwon-gun and Madal-ri and Baebong-ri were the cluster in Goseong-gun. This findings can be used to monitor and prevent toxoplasmosis infections occurring in vulnerable areas.

Citations

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  • Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China
    Yu-bin Guan, Xiao-xiao Sun, Shao-lian Chen, Xiao-ting Zhu, Zhi-hua Zeng, Han-wei Lu, Hong-mei Feng, Yu Guo, Wen-gong Jiang, Kui Xiong, Xiao-rong Yang, Ho-Woo Nam, Zhao-shou Yang, Pan Li
    PLOS ONE.2023; 18(7): e0286430.     CrossRef
  • 4,508 View
  • 85 Download
  • 1 Web of Science
  • Crossref

Mini Review

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Jong-Yil Chai, Bong-Kwang Jung, Sung-Jong Hong
Korean J Parasitol 2021;59(3):189-225.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.189
The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule systems of parasites and mammalian cells leading to inhibition of glucose uptake and transport and finally cell death. Eventually they exhibit ovicidal, larvicidal, and vermicidal effects on parasites, and tumoricidal effects on hosts. Albendazole and mebendazole are most frequently prescribed for treatment of intestinal nematode infections (ascariasis, hookworm infections, trichuriasis, strongyloidiasis, and enterobiasis) and can also be used for intestinal tapeworm infections (taeniases and hymenolepiasis). However, these drugs also exhibit considerable therapeutic effects against tissue nematode/cestode infections (visceral, ocular, neural, and cutaneous larva migrans, anisakiasis, trichinosis, hepatic and intestinal capillariasis, angiostrongyliasis, gnathostomiasis, gongylonemiasis, thelaziasis, dracunculiasis, cerebral and subcutaneous cysticercosis, and echinococcosis). Albendazole is also used for treatment of filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis, and dirofilariasis) alone or in combination with other drugs, such as ivermectin or diethylcarbamazine. Albendazole was tried even for treatment of trematode (fascioliasis, clonorchiasis, opisthorchiasis, and intestinal fluke infections) and protozoan infections (giardiasis, vaginal trichomoniasis, cryptosporidiosis, and microsporidiosis). These drugs are generally safe with few side effects; however, when they are used for prolonged time (>14-28 days) or even only 1 time, liver toxicity and other side reactions may occur. In hookworms, Trichuris trichiura, possibly Ascaris lumbricoides, Wuchereria bancrofti, and Giardia sp., there are emerging issues of drug resistance. It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have been shown to be active in vitro and in vivo (animals) against liver, lung, ovary, prostate, colorectal, breast, head and neck cancers, and melanoma. Two clinical reports for albendazole and 2 case reports for mebendazole have revealed promising effects of these drugs in human patients having variable types of cancers. However, because of the toxicity of albendazole, for example, neutropenia due to myelosuppression, if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.

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    Mohammed A.O. Basubaih, Nahla S Zidan, Hany M.Abd El-Lateef, Mai M. Khalaf, Aly Abdou
    Journal of Molecular Structure.2026; 1352: 144411.     CrossRef
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  • 10.1016/s1155-1968(23)45969-x

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Original Article

Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
Korean J Parasitol 2021;59(1):9-14.
Published online February 19, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.1.9
Toxoplasma gondii seroprevalence have been rapidly increasing in some parts of Korea. We analyzed prevalence of anti-Toxoplasma gondii antibodies, using a rapid diagnostic test (RDT), in the sera of 552 residents in Ganghwa-gun, 661 ones in Cheorwon-gun, and 305 ones in Goseong-gun, Korea in 2019. IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), glutathione-S-transferase-linker-SAG1A, were applied to the sera. IgG seroprevalence was 28.1% in Ganghwa-gun, 19.5% in Cheorwon-gun and 35.7% in Goseong-gun. Odds ratios comparing Cheorwon vs Ganghwa was 0.63 (P=0.001) and Goesong versus Ganghwa was 1.47 (P=0.01) adjusting age and sex. Goseong had highest seroprevalence among the 3 counties both in crude rates and logistic regression. Although Cheorwon and Goseong are adjacent to the demilitarized zone (DMZ) in Korea, seroprevalence rate was much higher in Goseong. Further investigation on other DMZ-closed areas is necessary whether they have high prevalence rates compared to the other areas. T. gondii prevalence in Korea is still persists; proper health policy should be established.

Citations

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  • Molecular survey of Toxoplasma gondii B1 gene in pigs from various localities in Korea
    Dongmi Kwak, Min-Goo Seo
    Parasites, Hosts and Diseases.2024; 62(3): 294.     CrossRef
  • 5,510 View
  • 180 Download
  • 2 Web of Science
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Brief Communications

Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar
Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2020;58(6):701-707.
Published online December 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.6.701
A survey was performed to investigate the infection status of zoonotic helminth larvae in fish from a local market of North Dagon District in Yangon City, Myanmar. A total of 486 fish in 13 species were collected 8 times from December 2015 to December 2019. All fish were transported under ice to a laboratory in Korea and examined for helminth larvae using artificial digestion method. Larval gnathostomes and metacercariae of more than 8 zoonotic trematode species, i.e., Opisthorchis viverrini, Haplorchis taichui, H. pumilio, H. yokogawai, Centrocestus spp., Stellantchasmus falcatus, Pygidiopsis cambodiensis, and Procerovum sp., were detected. Larval gnathostomes were found in 58 (16.0%) out of 362 fish of 6 species, with mean intensity of 2.8 per fish infected. Metacercariae of O. viverrini were detected in 10 (2.9%) out of 349 fish of 5 species, with mean intensity of 16.9 per fish infected. Metacercarial prevalences of 4 intestinal flukes, H. taichui, H. pumilio, H. yokogawai, and Centrocestus spp., were 16.8%, 26.0%, 12.5%, and 15.0% in the positive fish species, respectively, and mean metacercarial intensity was 63.3, 26.8, 86.2, and 8.7 per fish infected. Metacercariae of S. falcatus and P. cambodiensis were detected only from the mullet, Chelon macrolepis. Metacercariae of Procerovum sp. were found in Channa striata and Anabas testudineus. Collectively, it was confirmed that the fish were infected with gnathostome larvae and metacercariae of O. viverrini and intestinal flukes in Yangon City, Myanmar.

Citations

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  • Identification of an Opisthorchis viverrini-like liver fluke from Myanmar: Metacercariae recovered from snakehead fish and adults from an experimentally infected hamster
    Woon-Mok Sohn, Bong-Kwang Jung, Keon-Hoon Lee, Sung-Jong Hong, Seung-Hwan Seo, Thi Thi Htoon, Htay Htay Tin, Eun-Hee Shin, Jong-Yil Chai
    Parasites, Hosts and Diseases.2025; 63(2): 174.     CrossRef
  • Exploring the second intermediate hosts and morphology of human- and cat-specific Opisthorchis viverrini-like populations
    Vania Agustina, Prasert Saichua, Thewarach Laha, Sirikachorn Tangkawatana, Suksanti Prakobwong, Nonglak Laoprom, Wanrak Kamphasri, Chonteera Chareonchai, David Blair, Sutas Suttiprapa
    International Journal for Parasitology.2024; 54(10): 497.     CrossRef
  • Re‐evaluation of certain aspects of the EFSA Scientific Opinion of April 2010 on risk assessment of parasites in fishery products, based on new scientific data. Part 2
    Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panag
    EFSA Journal.2024;[Epub]     CrossRef
  • Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia
    Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 519.     CrossRef
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Infection Status of Gnathostoma spinigerum Larvae in Asian Swamp Eels, Monopterus albus, Purchased from Local Markets in Cambodia
Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Sung-Jong Hong, Virak Khieu, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2020;58(6):695-699.
Published online December 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.6.695
Present study was performed to know the infection status of Gnathostoma sp. larvae in swamp eels from Cambodia. We purchased total 30 Asian swamp eels, Monopterus albus, from local markets in Pursat and Takeo Provinces and Phnom Penh on May and November 2017 and May 2018. All collected eels were transferred to our laboratory with ice and each of them was examined by artificial digestion method. A total of 15 larval gnathostomes (1-5 larvae) were detected from 55.6% (5/9) swamp eels in Pursat Province. No larval gnathostomes were found in 21 swamp eels in Takeo Province and Phnom Penh. The advanced third-stage larvae (AdL3) detected were 2.575-3.825 (3.250) mm in length and 0.375-0.425 (0.386) mm in width. They had the characteristic head bulb (av. 0.104×0.218 mm) with 4 rows of hooklets, long muscular esophagus (1.048 mm), and 2 pairs of cervical sacs (0.615 mm). The number of hooklets in 4 rows on the head bulb was 41, 44, 47, and 50. In scanning electron microscopy, characteristic features were 4 rows of hooklets on the head bulb, cervical papillae, tegumental spines regularly arranged in transverse striations, and anus. The larval gnathostomes were identified as AdL3 of Gnathostoma spinigerum based on the morphological characters. By the present study, it has been confirmed that G. spinigerum larvae are infected in Asian swamp eels, M. albus, in Pursat Province, Cambodia.

Citations

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  • Biological Hazards and Indicators Found in Products of Animal Origin in Cambodia from 2000 to 2022: A Systematic Review
    Shwe Phue San, Rortana Chea, Delia Grace, Kristina Roesel, Sothyra Tum, Stephen Young, Tumnoon Charaslertrangsi, Nazanin Zand, Shetty Seetharama Thombathu, Ra Thorng, Leab Kong, Kuok Fidero, Linda Nicolaides
    International Journal of Environmental Research and Public Health.2024; 21(12): 1621.     CrossRef
  • Intracameral Gnathostomiasis: A Case Report and Literature Review
    Wijak Kongwattananon, Thanaporn Wiriyabanditkul, Waraluck Supwatjariyakul, Thanapong Somkijrungroj
    Ocular Immunology and Inflammation.2023; 31(5): 1092.     CrossRef
  • Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia
    Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 519.     CrossRef
  • 5,709 View
  • 121 Download
  • 2 Web of Science
  • Crossref

Original Articles

Cluster of Parasite Infections by the Spatial Scan Analysis in Korea
Kyoung-Eun Bae, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
Korean J Parasitol 2020;58(6):603-608.
Published online December 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.6.603
This study was performed to find out the clusters with high parasite infection risk to discuss the geographical pattern. Clusters were detected using SatScan software, which is a statistical spatial scan program using Kulldorff’s scan statistic. Information on the parasitic infection cases in Korea 2011-2019 were collected from the Korea Centers for Disease Control and Prevention. Clusters of Ascaris lumbricoides infection were detected in Jeollabuk-do, and T. trichiura in Ulsan, Busan, and Gyeongsangnam-do. C. sinensis clusters were detected in Ulsan, Daegu, Busan, Gyeongsangnam-do, and Gyeongsangbuk-do. Clusters of intestinal trematodes were detected in Ulsan, Busan, and Gyeongsangnam-do. P. westermani cluster was found in Jeollabuk-do. E. vermicularis clusters were distributed in Gangwon-do, Jeju-do, Daegu, Daejeon, and Gwangju. This clustering information can be referred for surveillance and control on the parasitic infection outbreak in the infection-prone areas.
  • 4,871 View
  • 117 Download
Monitoring Insecticide Resistance and Target Site Mutations of L1014 Kdr And G119 Ace Alleles in Five Mosquito Populations in Korea
Seo Hye Park, Hojong Jun, Seong Kyu Ahn, Jinyoung Lee, Sung-Lim Yu, Sung Keun Lee, Jung-Mi Kang, Hyunwoo Kim, Hee-Il Lee, Sung-Jong Hong, Byoung-Kuk Na, Young Yil Bahk, Tong-Soo Kim
Korean J Parasitol 2020;58(5):543-550.
Published online October 22, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.5.543
Mosquitoes are globally distributed and important vectors for the transmission of many human diseases. Mosquito control is a difficult task and the cost of preventing mosquito-borne diseases is much lower than that for curing the associated diseases. Thus, chemical control remains the most effective tool for mosquito. Due to the long-term intensive use of insecticides to control mosquito vectors, resistance to most chemical insecticides has been reported. This study aimed to investigate the relationship between insecticide resistance and target site mutation of L1014 kdr and G119 ace alleles in 5 species/species group of mosquitoes (Aedes vexans, Ae. albopictus, Anopheles spp., Culex pipiens complex, and Cx. tritaeniorhynchus) obtained from 6 collection sites. For Anopheles spp., the proportion of mosquitoes with mutated alleles in L1014 was 88.4%, homozygous resistant genotypes were observed in 46.7%, and heterozygous resistant genotypes were observed in 41.8%. For the Cx. pipiens complex and Cx. tritaeniorhynchus species, homozygous resistant genotypes were found in 25.9% and 9.8%, respectively. However, target site mutation of L1014 in the Ae. vexans nipponii and Ae. albopictus species was not observed. Anopheles spp., Cx. pipiens complex, and Cx. tritaeniorhynchus mosquitoes were resistant to deltamethrin and chlorpyriphos, whereas Ae. vexans nipponii and Ae. albopictus were clearly susceptible. We also found a correlation between the resistance phenotype and the presence of the L1014 kdr and G119 ace mutations only in the Anopheles spp. population. In this study, we suggest that insecticide resistance poses a growing threat and resistance management must be integrated into all mosquito control programs.

Citations

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  • Seasonal fluctuation of insecticide resistance mutation frequencies in field populations of Anopheles and Culex species in Korea
    Do Eun Lee, Heung-Chul Kim, Terry A Klein, Si Hyeock Lee, Ju Hyeon Kim, Alec Gerry
    Journal of Medical Entomology.2025; 62(1): 155.     CrossRef
  • Insecticide resistance mutations of Anopheles species in the Republic of Korea
    Jiseung Jeon, Heung Chul Kim, Terry A. Klein, Hojong Jun, Kwang Shik Choi, Jean-philippe David
    PLOS Neglected Tropical Diseases.2025; 19(1): e0012748.     CrossRef
  • Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors
    Nikhil Bharadwaj, Rohit Sharma, Muthukumaravel Subramanian, Gnanasekar Ragini, Shriram Ananganallur Nagarajan, Manju Rahi
    International Journal of Molecular Sciences.2025; 26(5): 1854.     CrossRef
  • Distribution and frequency of ace-1 and kdr mutations of Culex pipiens subgroup in the Republic of Korea
    Jiseung Jeon, Jihun Ryu, Kwang Shik Choi
    Acta Tropica.2024; 249: 107058.     CrossRef
  • Investigating insecticide resistance, kdr mutation, and morphology of the coastal mosquito Aedes (Ochlerotatus) zammitii (Theobald, 1903) (Diptera: Culicidae)
    Fatma Bursalı
    Turkish Journal of Entomology.2024; 48(2): 213.     CrossRef
  • Inference of selection pressures that drive insecticide resistance in Anopheles and Culex mosquitoes in Korea
    Do Eun Lee, Jeewoo Shin, Young Ho Kim, Kwang Shik Choi, Hyeyeong Choe, Kwang Pum Lee, Si Hyeock Lee, Ju Hyeon Kim
    Pesticide Biochemistry and Physiology.2023; 194: 105520.     CrossRef
  • CDC Bottle Bioassays for Detection of Insecticide Resistance in Culex pipiens, Aedes albopictus, and Aedes koreicus Collected on US Army Garrisons, Republic of Korea
    Craig A. Stoops, Myong Sun Kim, Sanjeev Mahabir, Sung Tae Chong, Stephanie S. Cinkovich, Jennifer B. Carder
    Journal of the American Mosquito Control Association.2023; 39(3): 208.     CrossRef
  • Reduction of mosquito communities using the mass trapping method
    Su Mi Na, Dong Gun Kim
    Entomological Research.2023; 53(12): 600.     CrossRef
  • 7,343 View
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Bile Ductal Transcriptome Identifies Key Pathways and Hub Genes in Clonorchis sinensis-Infected Sprague-Dawley Rats
Won Gi Yoo, Jung-Mi Kang, Huong Giang L?, Jhang Ho Pak, Sung-Jong Hong, Woon-Mok Sohn, Byoung-Kuk Na
Korean J Parasitol 2020;58(5):513-525.
Published online October 22, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.5.513
Clonorchis sinensis is a food-borne trematode that infects more than 15 million people. The liver fluke causes clonorchiasis and chronical cholangitis, and promotes cholangiocarcinoma. The underlying molecular pathogenesis occurring in the bile duct by the infection is little known. In this study, transcriptome profile in the bile ducts infected with C. sinensis were analyzed using microarray methods. Differentially expressed genes (DEGs) were 1,563 and 1,457 at 2 and 4 weeks after infection. Majority of the DEGs were temporally dysregulated at 2 weeks, but 519 DEGs showed monotonically changing expression patterns that formed seven distinct expression profiles. Protein-protein interaction (PPI) analysis of the DEG products revealed 5 sub-networks and 10 key hub proteins while weighted co-expression network analysis (WGCNA)-derived gene-gene interaction exhibited 16 co-expression modules and 13 key hub genes. The DEGs were significantly enriched in 16 Kyoto Encyclopedia of Genes and Genomes pathways, which were related to original systems, cellular process, environmental information processing, and human diseases. This study uncovered a global picture of gene expression profiles in the bile ducts infected with C. sinensis, and provided a set of potent predictive biomarkers for early diagnosis of clonorchiasis.

Citations

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  • Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression
    Shitao Li, Yiqi Jiang, Jun Kawanokuchi, Xueling Deng, Yuhong Wu, Yu Chen, Lixia Zeng, Ganghuan Deng, Damian Li, Tingzheng Zhan, Dengyu Liu, Ning Ma, Zeli Tang
    Parasites & Vectors.2025;[Epub]     CrossRef
  • Liver Fluke-Derived Molecules Accelerate Skin Repair Processes in a Mouse Model of Type 2 Diabetes Mellitus
    Anna Kovner, Yaroslav Kapushchak, Oxana Zaparina, Dmitry Ponomarev, Maria Pakharukova
    International Journal of Molecular Sciences.2024; 25(22): 12002.     CrossRef
  • Comparative liver transcriptome analysis in hamsters infected with food-borne trematodes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis
    Ekaterina A. Lishai, Oxana G. Zaparina, Yaroslav K. Kapushchak, Banchob Sripa, Sun-Jong Hong, Guofeng Cheng, Maria Y. Pakharukova, Feng Xue
    PLOS Neglected Tropical Diseases.2024; 18(12): e0012685.     CrossRef
  • Current status of Clonorchis sinensis and clonorchiasis in Korea: epidemiological perspectives integrating the data from human and intermediate hosts
    Won Gi Yoo, Woon-Mok Sohn, Byoung-Kuk Na
    Parasitology.2022; 149(10): 1296.     CrossRef
  • Transcriptomic profiling of three-dimensional cholangiocyte spheroids long term exposed to repetitive Clonorchis sinensis excretory-secretory products
    Jung-Woong Kim, Junyeong Yi, Jinhong Park, Ji Hoon Jeong, Jinho Kim, Jihee Won, Seok Chung, Tong-Soo Kim, Jhang Ho Pak
    Parasites & Vectors.2021;[Epub]     CrossRef
  • 6,682 View
  • 125 Download
  • 5 Web of Science
  • Crossref
Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
Korean J Parasitol 2020;58(5):493-497.
Published online October 22, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.5.493
The purpose of this study is to find out the clusters with high toxoplasmosis risk to discuss the geographical pattern in 2 islands of Gyodong-myeon and Samsan-myeon in Ganghwa-gun, Korea. Seroepidemiological data of toxoplasmosis surveyed using rapid diagnostic tests for the residents in 2 islands from 2010 to 2013 were analyzed to detect clusters of the infection. The cluster was investigated using the SatScan program which is based on Kulldorff’s scan statistic. The clusters were found with P-values in each region analyzed in the program, and the risk and patient incidence of specific areas can be examined by the values such as relative risk and log likelyhood ratio. Jiseok-ri was found to be a cluster in Gyodong-myeon and Ha-ri was the cluster in Samsan-myeon. This findings can be used to monitor and prevent toxoplasmosis infections occurring in vulnerable areas.
  • 4,502 View
  • 97 Download

Brief Communications

Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection
Jong-Yil Chai, Bong-Kwang Jung, Jin-Youp Ryu, Hyun-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2020;58(4):467-473.
Published online August 25, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.4.467
Chinese edible frogs, Hoplobatrachus rugulosus, were examined to estimate the potential risks of human gnathostomiasis and sparganosis in Myanmar. A total of 20 frogs were purchased in a local market of Yangon and examined with naked eyes and the artificial digestion method after skin peeling in June 2018 and June 2019. Larvae of gnathostomes and Spirometra (=spargana) were detected in 15 (75.0%) and 15 (75.0%) frogs with average intensities of 10.5 and 6.3 larvae per infected frog, respectively. Gnathostome larvae were 2.75-3.80 (av. 3.30) mm long and 0.29-0.36 (0.33) mm wide. They had a characteristic head bulb with 4 rows of hooklets, a muscular long esophagus, and 2 pairs of cervical sac. The mean number of hooklets were 41, 44, 47, and 50 on the 1st, 2nd, 3rd, and 4th row, respectively. Collected spargana were actively moving, particularly with the scolex part, and have ivory-white color and variable in size. Conclusively, it has been first confirmed that Chinese edible frogs, H. rugulosus, are highly infected with larval gnathostomes and spargana in this study. Consuming these frogs is considered a potential risk of human gnathostomiasis and sparganosis in Myanmar.

Citations

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  • A Global Review of the Zoonotic Potential and Disease Risks of Amphibian Parasites in Bullfrog Aquaculture
    Meiqi Weng, Xinhua Liu, Chenxi Zhang, Rui Shu, Andrew Wang, Haotian Zhang, Xingqiang Wang, Huirong Yang, Jinyong Zhang
    Reviews in Aquaculture.2025;[Epub]     CrossRef
  • Parasitic helminths of alien invasive anurans in Butuan City, Northeastern Mindanao, Philippines
    CA. V. Torralba, E. F. Gamalinda, L. A. Estaño
    Helminthologia.2023; 60(4): 385.     CrossRef
  • Echinostoma mekongi: Discovery of Its Metacercarial Stage in Snails, Filopaludina martensi cambodjensis, in Pursat Province, Cambodia
    Jong-Yil Chai, Woon-Mok Sohn, Jaeeun Cho, Bong-Kwang Jung, Taehee Chang, Keon Hoon Lee, Virak Khieu, Rekol Huy
    The Korean Journal of Parasitology.2021; 59(1): 47.     CrossRef
  • Detection of Gnathostoma spinigerum Advanced 3rd-Stage Larvae in the Chinese Edible Frog, Hoplobatrachus rugulosus, from Local Markets in Phnom Penh, Cambodia
    Woon-Mok Sohn, Bong-Kwang Jung, Sooji Hong, Seungwan Ryoo, Keon Hoon Lee, Virak Khieu, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(5): 519.     CrossRef
  • Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar
    Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(6): 701.     CrossRef
  • 7,209 View
  • 102 Download
  • 4 Web of Science
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High Prevalence of Clonorchis sinensis and Other Zoonotic Trematode Metacercariae in Fish from a Local Market in Yen Bai Province, Northern Vietnam
Fuhong Dai, Sung-Jong Hong, Jhang Ho Pak, Thanh Hoa Le, Seung-Ho Choi, Byoung-Kuk Na, Woon-Mok Sohn
Korean J Parasitol 2020;58(3):333-338.
Published online June 26, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.3.333
A small survey was performed to investigate the recent infection status of Clonorchis sinensis and other zoonotic trematode metacercariae in freshwater fish from a local market of Yen Bai city, Yen Bai province, northern Vietnam. A total of 118 fish in 7 species were examined by the artificial digestion method on March 2016. The metacercariae of 4 species of zoonotic trematodes, i.e., C. sinensis, Haplorchis pumilio, Haplorchis taichui, and Centrocestus formosanus, were detected. The metacercariae of C. sinensis were found in 62 (69.7%) out of 89 fish (5 species), and their intensity of infection was very high, 81.2 per fish infected. Prevalences of 3 intestinal flukes, H. pumilio, H. taichui and C. formosanus, were 75.0%, 47.6%, and 31.7% in positive fish species, respectively, with the metacercarial intensities of 15.5, 10.3, and 2.2 per fish infected. From the above results, it has been confirmed that various species of freshwater fish continue to play the role of the infection source of C. sinensis and other zoonotic trematodes in Yen Bai city, Yen Bai province, northern Vietnam. It is of particular note that the prevalence and intensity of C. sinensis metacercariae are much higher than those reported in previous studies in fish in northern Vietnam.

Citations

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  • Hydropower reservoirs – their potential association with transmission of trematodes in Vietnam
    A.H. Le, H.V. Nguyen, H. Van Hoang, T.A. Tran, C.N. Nguyen, B.N. Nguyen, H.T. Nguyen, S.E. Greiman, J.R. Stauffer, H. Madsen, M.H. Nguyen
    Journal of Helminthology.2025;[Epub]     CrossRef
  • Infection with Clonorchis sinensis (Cobbold, 1875) Metacercariae in Fish from the East Lake of Wuhan: Freshwater Fish in Urban Lakes May Act as Infection Sources of Liver Fluke
    Jia-Nan Jiang, Hui-Fen Dong, Hou-Da Cheng, Hong Zou, Ming Li, Wen-Xiang Li, Gui-Tang Wang
    Microorganisms.2024; 12(5): 898.     CrossRef
  • An overview of human helminthioses in Vietnam: Their prevention, control and lessons learnt
    Hung Manh Nguyen, Dung Trung Do, Stephen E. Greiman, Ha Van Nguyen, Hien Van Hoang, Toan Quoc Phan, Phuc Pham-Duc, Henry Madsen
    Acta Tropica.2023; 238: 106753.     CrossRef
  • Parasite Diversity in a Freshwater Ecosystem
    Amana Shafiq, Farzana Abbas, Muhammad Hafeez-ur-Rehman, Bushra Nisar Khan, Ayesha Aihetasham, Iffat Amin, Hmidullah, Ramzi A. Mothana, Mohammed S. Alharbi, Imran Khan, Atif Ali Khan Khalil, Bashir Ahmad, Nimra Mubeen, Muneeba Akram
    Microorganisms.2023; 11(8): 1940.     CrossRef
  • A relatively high zoonotic trematode prevalence in Orientogalba ollula and the developmental characteristics of isolated trematodes by experimental infection in the animal model
    Jian Li, Yijing Ren, Lei Yang, Jiani Guo, Haiying Chen, Jiani Liu, Haoqiang Tian, Qingan Zhou, Weiyi Huang, Wei Hu, Xinyu Feng
    Infectious Diseases of Poverty.2022;[Epub]     CrossRef
  • Helminth infections in fish in Vietnam: A systematic review
    Trang Huyen Nguyen, Pierre Dorny, Thanh Thi Giang Nguyen, Veronique Dermauw
    International Journal for Parasitology: Parasites and Wildlife.2021; 14: 13.     CrossRef
  • Optimization of tools for the detection and identification of Cryptocotyle metacercariae in fish: Digestion method and viability studies
    Maureen Duflot, Graziella Midelet, Odile Bourgau, Kurt Buchmann, Mélanie Gay
    Journal of Fish Diseases.2021; 44(11): 1777.     CrossRef
  • Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection
    Xin-He Zhang, Die Huang, Yi-Ling Li, Bing Chang
    World Journal of Clinical Cases.2021; 9(23): 6639.     CrossRef
  • Current status of human liver fluke infections in the Greater Mekong Subregion
    Banchob Sripa, Apiporn T. Suwannatrai, Somphou Sayasone, Dung Trung Do, Virak Khieu, Yichao Yang
    Acta Tropica.2021; 224: 106133.     CrossRef
  • 6,827 View
  • 144 Download
  • 10 Web of Science
  • Crossref

Original Article

Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea
Yeojin Park, Jinhyeong Noh, Hyun-Ji Seo, Keun-Ho Kim, Subin Min, Mi-Sun Yoo, Bo-Ram Yun, Jong-Ho Kim, Eun-Jin Choi, Doo-Sung Cheon, Sung-Jong Hong, Soon-Seek Yoon, Yun Sang Cho
Korean J Parasitol 2020;58(3):257-265.
Published online June 26, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.3.257
The outbreak of human toxoplasmosis can be attributed to ingestion of food contaminated with Toxoplasma gondii. Toxoplasmosis recently increased in domestic and stray dogs and cats. It prompted studies on the zoonotic infectious diseases transmitted via these animals. Sero- and antigen prevalences of T. gondii in dogs and cats were surveyed using ELISA and PCR, and B1 gene phylogeny was analyzed in this study. Toxoplasmosis antibodies were measured on sera of 403 stray cats, 947 stray dogs, 909 domestic cats, and 2,412 domestic dogs collected at nationwide regions, Korea from 2017 to 2019. In addition, whole blood, feces, and tissue samples were also collected from stray cats (1,392), stray dogs (686), domestic cats (3,040), and domestic dogs (1,974), and T. gondii-specific B1 gene PCR was performed. Antibody prevalence of stray cats, stray dogs, domestic cats, and domestic dogs were 14.1%, 5.6%, 2.3%, and 0.04%, respectively. Antigen prevalence of these animals was 0.5%, 0.2%, 0.1%, and 0.4%, respectively. Stray cats revealed the highest infection rate of toxoplasmosis, followed by stray dogs, domestic cats, and domestic dogs. B1 gene positives were 5 of stray cats, and identified to high/moderate pathogenic Type I/III group. These findings enforce that preventive hygienic measure should be strengthened at One Health level in dogs and cats, domestic and stray, to minimize human toxoplasmosis infections.

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    Min-Goo Seo, Dongmi Kwak
    Parasites, Hosts and Diseases.2025; 63(1): 66.     CrossRef
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    Sooji Hong, Hyejoo Shin, Seungwan Ryoo, Chung-Won Lee, Jae-Young Park, Jong-Yil Chai, Bong-Kwang Jung
    Parasites, Hosts and Diseases.2025; 63(2): 182.     CrossRef
  • Toxoplasma gondii in owned and stray dogs from a Northwestern region of São Paulo State, Brazil: Seroprevalence and geospatial distribution from a One Health perspective
    Fernando Henrique Antunes Murata, Jessica Priscilla Barboza, Fernanda Follis Tasso, Tainara Souza Pinho, Tiago Henrique, Janine Fusco Alves, Carlos Alexandre Guimarães de Souza, Daniel Abrahão, Ubirajara Leoncy de Lavor, Luiz Carlos de Mattos, Chunlei Su,
    One Health.2025; 21: 101222.     CrossRef
  • A 20-year serological survey of Toxoplasma gondii and Neospora caninum infection in dogs with neuromuscular disorders from urban areas in Argentina
    María Laura Gos, María Cecilia Venturini, Lorena De Felice, Andrea Dellarupe, Magdalena Rambeaud, Lais Pardini, Lucía María Campero, Mariana Bernstein, Diana Bacigalupe, Walter Basso, Gastón Moré, Juan Manuel Unzaga
    Veterinary Parasitology.2024; 330: 110235.     CrossRef
  • Seroprevalence and risk factors for Toxoplasma gondii infection in shelter cats in Erzurum province of Turkey
    Başak HANEDAN, Cahit BABÜR, Muhammed Sertaç EROĞLU, Selin Sinem SÜMBÜL, Ömer ALKAN
    Etlik Veteriner Mikrobiyoloji Dergisi.2023; 34(2): 151.     CrossRef
  • Prevalence of Toxoplasma gondii Measured by Western Blot, ELISA and DNA Analysis, by PCR, in Cats of Western Mexico
    María de la Luz Galván-Ramírez, Claudia Charles-Niño, César Pedroza-Roldán, Carolina Salazar-Reveles, Karen Lissete Ocampo-Figueroa, Laura Roció Rodríguez-Pérez, Varinia Margarita Paez-Magallán
    Pathogens.2022; 11(1): 109.     CrossRef
  • Seroprevalence of Toxoplasma gondii in outdoor dogs and cats in Bangkok, Thailand
    Ana Huertas-López, Woraporn Sukhumavasi, Gema Álvarez-García, Silvia Martínez-Subiela, David Cano-Terriza, Sonia Almería, Jitender P. Dubey, Ignacio García-Bocanegra, José Joaquín Cerón, Carlos Martínez-Carrasco
    Parasitology.2021; 148(7): 843.     CrossRef
  • Genetic Analysis of Zoonotic Gastrointestinal Protozoa and Microsporidia in Shelter Cats in South Korea
    Dongmi Kwak, Min-Goo Seo
    Pathogens.2020; 9(11): 894.     CrossRef
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  • 163 Download
  • 7 Web of Science
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Brief Communication

Effect of Mass Drug Administration with a Single Dose of Albendazole on Ascaris lumbricoides and Trichuris trichiura Infection among Schoolchildren in Yangon Region, Myanmar
Jong-Yil Chai, Woon-Mok Sohn, Sung-Jong Hong, Bong-Kwang Jung, Sooji Hong, Seon Cho, Jong-Bok Park, In-Sung Kim, Sunkyoung Kim, Keon-Hoon Lee, Hoo-Gn Jeoung, Thi Thi Htoon, Htay Htay Tin
Korean J Parasitol 2020;58(2):195-200.
Published online April 30, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.2.195
Soil-transmitted helminths, including Ascaris lumbricoides and Trichuris trichiura, are important intestinal parasites mostly affecting younger people in developing countries. In 2014-2015, we performed mass fecal examinations targeting a total of 2,227 schoolchildren in 3 districts (South Dagon, North Dagon, and Hlaing-thar-yar) of Yangon Region, Myanmar, using the Kato-Katz thick smear technique. The egg positive children were subjected to a mass drug administration (MDA) using a single oral dose of 400 mg albendazole. The pre-treatment egg positive rate (EPG/person) of A. lumbricoides averaged 17.2% (15,532); it was 25.2% (21,796), 14.2% (11,816), and 12.8% (12,983) in 3 districts, respectively, and that of T. trichiura averaged 19.4% (1,074), and was 24.1% (1,040), 12.3% (852), and 21.2% (1,330) in 3 districts, respectively. Follow-up fecal examinations performed 4 months post-MDA revealed considerable decreases of A. lumbricoides prevalence (EPG/person) to av. 8.3% (12,429), and 13.7% (17,640), 8.0% (7,797), and 4.5% (11,849) in 3 districts, respectively. However, T. trichiura did not show any recognizable decrease in the prevalence (EPG/person) remaining at av. 18.2% (862), and 18.5% (888), 11.5% (812), and 23.3% (887) in 3 districts, respectively. The results demonstrated difficulty in short-term control of T. trichiura by MDA using albendazole and suggested necessity of either a long-term MDA (>10 years) or changing the albendazole regimen into 2~3-day course (total 800 or 1,200 mg), or using an alternative drug/drug combination.

Citations

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  • In the realm of microbiology, a quality stool sample is as valuable as gold
    Nikunja Kumar Das, Sahjid Mukhida, Sriram Kannuri, Sameena Khan, Rajashri Patil
    MRIMS Journal of Health Sciences.2025; 13(1): 29.     CrossRef
  • Malnutrition among children under 7 years of age linked to ascariasis: evidence from West Sumba, Indonesia, despite ongoing deworming program
    Rizqiani Amalia Kusumasari, Hanindyo Adi, Tri Baskoro Tunggul Satoto, Abdul Wahab, E. Elsa Herdiana Murhandarwati
    BMC Public Health.2025;[Epub]     CrossRef
  • Epidemiology of soil-transmitted helminthiasis among school-aged children in pastoralist communities of Kenya: A cross-sectional study
    Richelle W. Kihoro, Damaris Mulewa, Collins Okoyo, Dominic Ayaa, Agnes Korir, Doris W. Njomo, Charles Mwandawiro, Janet Masaku, Emmanuel Timmy Donkoh
    PLOS ONE.2024; 19(5): e0304266.     CrossRef
  • Standard- and large-sized eggs of Trichuris trichiura in the feces of schoolchildren in the Yangon Region, Myanmar: Morphological and molecular analyses
    Seungwan Ryoo, Bong-Kwang Jung, Sooji Hong, Hyejoo Shin, Hyemi Song, Hyun-Seung Kim, Jin-Youp Ryu, Woon-Mok Sohn, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
    Parasites, Hosts and Diseases.2023; 61(3): 317.     CrossRef
  • Parasitic Infections of the Gastrointestinal Track and Liver
    Annie L. Braseth, David E. Elliott, M. Nedim Ince
    Gastroenterology Clinics of North America.2021; 50(2): 361.     CrossRef
  • Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
    Jong-Yil Chai, Bong-Kwang Jung, Sung-Jong Hong
    The Korean Journal of Parasitology.2021; 59(3): 189.     CrossRef
  • Occurrence of gastrointestinal helminths and the first molecular detection of Ancylostoma ceylanicum, Trichuris trichiura, and Trichuris vulpis in dogs in Myanmar
    Lat Lat Htun, Sandar Thu Rein, Shwe Yee Win, Nyein Chan Soe, Su Su Thein, Yadanar Khaing, Yu Nandi Thaw, Hla Myet Chel, Myint Myint Hmoon, Saw Bawm
    Parasitology Research.2021; 120(10): 3619.     CrossRef
  • Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar
    Sooji Hong, Bong-Kwang Jung, Hyemi Song, Jaeeun Cho, Woon-Mok Sohn, Sung-Jong Hong, Jin-Youp Ryu, Hyun-Seung Kim, Mun-Hyoo Jeong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(6): 607.     CrossRef
  • Necrotizing pancreatitis due to Ascaris lumbricoides: Causes, diagnosis, and current treatment
    Silvia Carolina Barbosa Valenzuela, Maite Lubian Nieto del Río, Daniela Ramirez, José Ariza Daza, Wilmar Montañez Coronado, Laura Alvarado
    Revista colombiana de Gastroenterología.2021; 36(4): 514.     CrossRef
  • Larval Gnathostomes and Zoonotic Trematode Metacercariae in Fish from a Local Market in Yangon City, Myanmar
    Jong-Yil Chai, Bong-Kwang Jung, Keon Hoon Lee, Jin-Youp Ryu, Hyeon-Seung Kim, Sung-Jong Hong, Thi Thi Htoon, Htay Htay Tin, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2020; 58(6): 701.     CrossRef
  • 7,054 View
  • 157 Download
  • 9 Web of Science
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Original Articles

Diagnostic Performance of Three Rapid Diagnostic Test Kits for Malaria Parasite Plasmodium falciparum
Seo Hye Park, Seung Jegal, Seong Kyu Ahn, Haneul Jung, Jinyoung Lee, Byoung-Kuk Na, Sung-Jong Hong, Young Yil Bahk, Tong-Soo Kim
Korean J Parasitol 2020;58(2):147-152.
Published online April 30, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.2.147
Malaria is a potent burden on public healthcare worldwide due to requiring rapid diagnosis and treatment. Nowadays, prompt diagnosis with rapid diagnostic tests (RDTs) has been widely accepted as an effective diagnostic technique in malaria-endemic countries, primarily due to their easy operation, fast output, and straightforward interpretation. The global availability and use of RDTs have gradually grown over recent decades as field-applicable diagnostic tests for the reliable confirmation of malaria infection and proper case management. This study was conducted to evaluate diagnostic performance of 3 commercially available malaria RDT kits : BIOCREDITTM Malaria Ag Pf(pLDH), Malaria Ag Pf(pLDH/pHRPII), and Malaria Ag Pf/Pv(pLDH/pLDH) (where pLDH and pHRPII stand for plasmodium lactate dehydrogenase and histidine-rich protein 2, respectively) for the specific detection of Plasmodium falciparum. A total of 1,129 blood samples including 95 blood samples, confirmed as vivax malaria infection by microscopic examinations and a nested-PCR method, were tested for falciparum malaria infection. The overall sensitivity and specificity of Malaria Ag Pf(pLDH/pHRPII), Malaria Ag Pf/Pv(pLDH/pLDH), and Pf(pLDH) for P. falciparum were 99.0% and 100%, 95.8% and 100%, and 100% and 100%, respectively. It is proposed that the 3 RDT kits perform reliable level of diagnostic accuracy of detection for P. falciparum parasites.

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  • Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal
    Babacar Souleymane Sambe, Stephanie Zobrist, William Sheahan, Divya Soni, Aissatou Diagne, Ibrahima Sarr, Arona Sabene Diatta, Serigne Ousmane Mbacke Diaw, Allison Golden, Hannah Slater, Ihn Kyung Jang, Nerie Roa, Sampa Pal, Fatoumata Diene Sarr, Joseph F
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    Rahma Abdi Moussa, Nasserdine Papa Mze, Houssein Yonis Arreh, Aicha Abdillahi Hamoud, Kahiya Mohamed Alaleh, Fatouma Mohamed Aden, Abdoul-Razak Yonis Omar, Warsama Osman Abdi, Samatar Kayad Guelleh, Abdoul-Ilah Ahmed Abdi, Leonardo K. Basco, Bouh Abdi Kha
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  • Comparison of three rapid diagnostic tests for Plasmodium falciparum diagnosis in Ghana
    Tolulope Adeyemi Kayode, Agyapong Kofi Addo, Thomas Kwame Addison, Austine Tweneboah, Stephen Opoku Afriyie, Dawood Ackom Abbas, Ayesha Seth, Abraham K. Badu-Tawiah, Kingsley Badu, Cristian Koepfli
    Malaria Journal.2024;[Epub]     CrossRef
  • Performance of highly sensitive and conventional rapid diagnostic tests for clinical and subclinical Plasmodium falciparum infections, and hrp2/3 deletion status in Burundi
    David Niyukuri, Denis Sinzinkayo, Emma V. Troth, Colins O. Oduma, Mediatrice Barengayabo, Mireille Ndereyimana, Aurel Holzschuh, Claudia A. Vera-Arias, Yilekal Gebre, Kingsley Badu, Joseph Nyandwi, Dismas Baza, Elizabeth Juma, Cristian Koepfli, Sarah Aubu
    PLOS Global Public Health.2022; 2(7): e0000828.     CrossRef
  • Diagnostic accuracy and limit of detection of ten malaria parasite lactate dehydrogenase-based rapid tests for Plasmodium knowlesi and P. falciparum
    Angelica F. Tan, Sitti Saimah binti Sakam, Giri S. Rajahram, Timothy William, Mohammad Faruq Abd Rachman Isnadi, Sylvia Daim, Bridget E. Barber, Steven Kho, Colin J. Sutherland, Nicholas M. Anstey, Seda Yerlikaya, Donelly A. van Schalkwyk, Matthew J. Grig
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
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    Michael J. Kavanaugh, Steven E. Azzam, David M. Rockabrand
    Diagnostics.2021; 11(5): 768.     CrossRef
  • Recent Spatial and Temporal Trends of Malaria in Korea
    Yeong Hoon Kim, Hye-Jin Ahn, Dongjae Kim, Sung-Jong Hong, Tong-Soo Kim, Ho-Woo Nam
    The Korean Journal of Parasitology.2021; 59(6): 585.     CrossRef
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  • 8 Web of Science
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Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis
Jung-Mi Kang, Won-Gi Yoo, H??ng Giang L?, Th? Lam Th?i, Sung-Jong Hong, Woon-Mok Sohn, Byoung-Kuk Na
Korean J Parasitol 2019;57(6):671-680.
Published online December 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.6.671
Cathepsin D (CatD, EC 3.4.23.5) is a member belonging to the subfamily of aspartic endopeptidases, which are classified into the MEROPS clan AA, family A1. Helminth parasites express a large set of different peptidases that play pivotal roles in parasite biology and pathophysiology. However, CatD is less well known than the other classes of peptidases in terms of biochemical properties and biological functions. In this study, we identified 2 novel CatDs (CsCatD1 and CsCatD2) of Clonorchis sinensis and partially characterized their properties. Both CsCatDs represent typical enzymes sharing amino acid residues and motifs that are tightly conserved in the CatD superfamily of proteins. Both CsCatDs showed similar patterns of expression in different developmental stages of C. sinensis, but CsCatD2 was also expressed in metacercariae. CsCatD2 was mainly expressed in the intestines and eggs of C. sinensis. Sera obtained from rats experimentally infected with C. sinensis reacted with recombinant CsCatD2 beginning 2 weeks after infection and the antibody titers were gradually increased by maturation of the parasite. Structural analysis of CsCatD2 revealed a bilobed enzyme structure consisting of 2 antiparallel β-sheet domains packed against each other forming a homodimeric structure. These results suggested a plausible biological role of CsCatD2 in the nutrition and reproduction of parasite and its potential utility as a serodiagnostic antigen in clonorchiasis.

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  • Clonorchis sinensis excretory/secretory proteins ameliorate inflammation in rheumatoid arthritis and ankylosing spondylitis
    Moon-Ju Kim, Hee Min Yoo, Yu Jeong Lee, Hyun Hee Jang, Seung Cheol Shim, Eun Jeong Won, Tae-Jong Kim
    Parasites & Vectors.2025;[Epub]     CrossRef
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    Timothy K. Wu, Qin Fu, Janice L. Liotta, Dwight D. Bowman
    Veterinary Parasitology.2024; 332: 110331.     CrossRef
  • An insight into the functional genomics and species classification of Eudiplozoon nipponicum (Monogenea, Diplozoidae), a haematophagous parasite of the common carp Cyprinus carpio
    Jiří Vorel, Nikol Kmentová, Christoph Hahn, Petr Bureš, Martin Kašný
    BMC Genomics.2023;[Epub]     CrossRef
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    Víctor Caña-Bozada, Martha Chapa-López, Rubén D. Díaz-Martín, Alejandra García-Gasca, José Ángel Huerta-Ocampo, Guillermo de Anda-Jáuregui, F. Neptalí Morales-Serna
    Infection, Genetics and Evolution.2021; 93: 104931.     CrossRef
  • pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of Clonorchis sinensis
    Jung-Mi Kang, Hương Giang Lê, Byoung-Kuk Na, Won Gi Yoo
    Pathogens.2021; 10(9): 1128.     CrossRef
  • Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production
    Fuhong Dai, Jin-Ho Song, Yeon Pyo Hong, Xuelian Bai, Woon-Mok Sohn, Sung-Jong Hong, jong-Yil Chai
    PLOS Neglected Tropical Diseases.2020; 14(3): e0008220.     CrossRef
  • Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis
    Yunliang Shi, Kai Yu, Anli Liang, Yan Huang, Fangqi Ou, Haiyan Wei, Xiaoling Wan, Yichao Yang, Weiyu Zhang, Zhihua Jiang
    Frontiers in Microbiology.2020;[Epub]     CrossRef
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  • 8 Web of Science
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Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components
Jhang Ho Pak, Ji-Yun Lee, Bo Young Jeon, Fuhong Dai, Won Gi Yoo, Sung-Jong Hong
Korean J Parasitol 2019;57(4):379-387.
Published online August 31, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.4.379
Clonorchis sinensis is a carcinogenic human liver fluke that promotes hepatic inflammatory environments via direct contact or through their excretory-secretory products (ESPs), subsequently leading to cholangitis, periductal fibrosis, liver cirrhosis, and even cholangiocarcinoma (CCA). This study was conducted to examine the host inflammatory responses to C. sinensis ESPs and their putative protein components selected from C. sinensis expressed sequenced tag (EST) pool databases, including TGF-β receptor interacting protein 1(CsTRIP1), legumain (CsLeg), and growth factor binding protein 2 (CsGrb2). Treatment of CCA cells (HuCCT1) with the ESPs or bacterial recombinant C. sinensis proteins differentially promoted the secretion of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) as well as anti-inflammatory cytokines (IL-10, TGF-β1, and TGF-β2) in a time-dependent manner. In particular, recombinant C. sinensis protein treatment resulted in increase (at maximum) of ~7-fold in TGF-β1, ~30-fold in TGF-β2, and ~3-fold in TNF-α compared with the increase produced by ESPs, indicating that CsTrip1, CsLeg, and CsGrb2 function as strong inducers for secretion of these cytokines in host cells. These results suggest that C. sinensis ESPs contribute to the immunopathological response in host cells, leading to clonorchiasis-associated hepatobiliary abnormalities of greater severity.

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  • Immunogenomics of cholangiocarcinoma
    Virag Gehl, Colm J. O’Rourke, Jesper B. Andersen
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    Wen-Min Lu, Jin Yan, Zhao-Ji Liu, Yong Wu, Qian-Ru Cui, Ji Feng, Yu Chen, Guang-Zhi Zhu, Tao Peng, Jing Zhou, Guo-Dong Lu
    Parasites & Vectors.2025;[Epub]     CrossRef
  • The crosstalk between cholangiocytes and hepatic stellate cells promotes the progression of epithelial-mesenchymal transition and periductal fibrosis during Clonorchis sinensis infection
    Junyeong Yi, Ji Hoon Jeong, Jihee Won, Seok Chung, Jhang Ho Pak
    Parasites & Vectors.2024;[Epub]     CrossRef
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    Feng Li, Yanli Zhang, Chunfu Li, Fenqi Li, Baojiang Gan, Hong Yu, Jian Li, Xinyu Feng, Wei Hu
    Parasite.2024; 31: 53.     CrossRef
  • Up-regulation of MDSCs accumulation and Th2 biased response to co-stimulation of CsESP from Clonorchis sinensis and HBeAg in vitro
    Qiannan Liu, Nian Wang, Hengchang Sun, Huimin Dong, Xuerong Li, Xinbing Yu, Yan Huang
    Acta Tropica.2024; 260: 107405.     CrossRef
  • The expression of sICAM-1 influenced by Clonorchis sinensis co-infection in CHB patients
    J. Qiu, M. Shang, W. Li, H. Zhang, Y. Liao, H. Dong
    Journal of Helminthology.2024;[Epub]     CrossRef
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    Guoyang Huang, Xiaohong Peng
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    Qing He, Xiaowen Pan, Yingxuan Yin, Anyuan Xu, Xueqing Yi, Yinjuan Wu, Xuerong Li
    Parasites & Vectors.2023;[Epub]     CrossRef
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    Parasites & Vectors.2023;[Epub]     CrossRef
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    Niccolò Fonti, Francesca Parisi, Francesca Mancianti, Giulia Freer, Alessandro Poli
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    International Journal of Molecular Sciences.2022; 23(15): 8173.     CrossRef
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    Frontiers in Immunology.2022;[Epub]     CrossRef
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    Pathogens.2021; 10(2): 124.     CrossRef
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    Elisabeth Digifico, Silvia Balinzo, Cristina Belgiovine
    International Journal of Molecular Sciences.2021; 22(3): 1224.     CrossRef
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    Menghua Zhou, Chaoqun Wang, Shounan Lu, Yanan Xu, Zihao Li, Hongchi Jiang, Yong Ma
    EBioMedicine.2021; 67: 103375.     CrossRef
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    Antioxidants.2021; 10(7): 1017.     CrossRef
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    Byoung-Kuk Na, Jhang Ho Pak, Sung-Jong Hong
    Acta Tropica.2020; 203: 105309.     CrossRef
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    Hongli Guan, Jiacong Peng, Liping Jiang, Gang Mo, Xiang Li, Xiaohong Peng
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  • Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production
    Fuhong Dai, Jin-Ho Song, Yeon Pyo Hong, Xuelian Bai, Woon-Mok Sohn, Sung-Jong Hong, jong-Yil Chai
    PLOS Neglected Tropical Diseases.2020; 14(3): e0008220.     CrossRef
  • Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis
    Yunliang Shi, Kai Yu, Anli Liang, Yan Huang, Fangqi Ou, Haiyan Wei, Xiaoling Wan, Yichao Yang, Weiyu Zhang, Zhihua Jiang
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Bile Ductal Transcriptome Identifies Key Pathways and Hub Genes in Clonorchis sinensis-Infected Sprague-Dawley Rats
    Won Gi Yoo, Jung-Mi Kang, Huong Giang Lê, Jhang Ho Pak, Sung-Jong Hong, Woon-Mok Sohn, Byoung-Kuk Na
    The Korean Journal of Parasitology.2020; 58(5): 513.     CrossRef
  • 7,845 View
  • 142 Download
  • 23 Web of Science
  • Crossref
Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
Korean J Parasitol 2018;56(5):437-446.
Published online October 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.5.437
To investigate the prevalence of Toxoplasma gondii in pork on the market in Korea, an in-house enzyme-linked immunosorbent assay for tissue fluid (CAU-tf-ELISA) was developed using a soluble extract of T. gondii RH strain tachyzoites. As the standard positive controls, the piglets were experimentally infected with T. gondii: Group A (1,000 cysts-containing bradyzoites), Group B (500 cysts-containing bradyzoites) and Group C (1.0×103 or 1.0×104 tachyzoites). The CAU-tf-ELISA demonstrated infection intensity-dependent positivity toward tissue fluids with average cut-off value 0.15: 100% for Group A, 93.8% for Group B and 40.6% for Group C. When tissue-specific cut-off values 0.066-0.199 were applied, CAU-tf-ELISA showed 96.7% sensitivity, 100% specificity, 100% positive and 90.0% negative predictive values. When compared with the same tissue fluids, performance of CAU-tf-ELISA was better than that of a commercial ELISA kit. Of the 583 Korea domestic pork samples tested, anti-T. gondii antibodies were detected from 9.1% of whole samples and 37.9% from skirt meat highest among pork parts. In the 386 imported frozen pork samples, 1.8% (skirt meat and shoulder blade) were positive for anti-T. gondii antibodies. In Korea, prevalence of anti-T. gondii antibodies in the pork on retail markets appeared high, suggesting that regulations on pig farming and facilities are necessary to supply safe pork on the tables.

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  • Molecular survey of Toxoplasma gondii B1 gene in pigs from various localities in Korea
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    Pathogens.2021; 10(5): 605.     CrossRef
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    Jitender P. Dubey, Camila K. Cerqueira-Cézar, Fernando H.A. Murata, Oliver C.H. Kwok, Dolores Hill, Yurong Yang, Chunlei Su
    Veterinary Parasitology.2020; 288: 109185.     CrossRef
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    Jitender P. Dubey, Camila K. Cerqueira-Cézar, Fernando H.A. Murata, Oliver C.H. Kwok, Dolores Hill, Yurong R. Yang, Chunlei Su
    Veterinary Parasitology.2020; : 109182.     CrossRef
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  • 4 Web of Science
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Survey on Intestinal Helminthic Infection Status of Students in Two Counties, Hadong-gun and Goseong-gun, Korea
Young Yil Bahk, Yun-Kyu Park, Byoung-Kuk Na, Woon-Mok Sohn, Sung-Jong Hong, Jong-Yil Chai, Tong-Soo Kim
Korean J Parasitol 2018;56(4):335-339.
Published online August 31, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.4.335
This study was conducted to investigate the prevalence of intestinal parasites among students from Goseonggun, Gangwon-do and Hadong-gun, Gyeongsangnam-do as typical low and high endemic counties. From May to July 2017, a total of 2,033 fecal samples were collected at 27 elementary, 10 junior high, and 8 high schools from 2 counties and examined by the Kato-Katz technique for egg-positive surveys (Collection rate: 37.02% [2,033/5,492]). Of the participants examined, 13 (0.64%) were found to harbor eggs of 3 parasitic species, Trichuris trichiura, Clonorchis sinensis and Metagonimus yokogawai. Based on the regional distribution, the egg-positive rate in Goseong-gun was 0% (0/550) and that in Hadong-gun was 0.88% (13/1,483). The positive rates for C. sinensis, M. yokogawai, and T. trichiura in Hadonggun were 0.20% (3/1,483), 0.61% (9/1,483), and 0.07% (1/1,483), respectively. The present survey showed that the prevalence of parasitic infection among students is currently very low even in remote, previously endemic areas, and the present status of parasitic diseases can be summarized as some transmission of fish/food-borne trematodes. Thus, it is necessary to carefully, continuously monitor the trematode infection status, particularly of C. sinensis and M. yokogawai.

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  • The spatial-temporal risk profiling of Clonorchis sinensis infection over 50 years implies the effectiveness of control programs in South Korea: a geostatistical modeling study
    Hai-Yan Xiao, Jong-Yil Chai, Yue-Yi Fang, Ying-Si Lai
    The Lancet Regional Health - Western Pacific.2023; 33: 100697.     CrossRef
  • Global prevalence of 4 neglected foodborne trematodes targeted for control by WHO: A scoping review to highlight the gaps
    Rachel Tidman, Kaushi S. T. Kanankege, Mathieu Bangert, Bernadette Abela-Ridder, Paul R. Torgerson
    PLOS Neglected Tropical Diseases.2023; 17(3): e0011073.     CrossRef
  • Risk Factors for Clonorchis sinensis Infection in Residents of Binyang, Guangxi: A Cross-Sectional and Logistic Analysis Study
    Meng Xu, Yanyan Jiang, Jianhai Yin, Shengkui Cao, Yujuan Shen, Jianping Cao
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review
    Ganna Saelens, Sarah Gabriël
    Pathogens.2020; 9(1): 47.     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • Blood Pressure and the Risk of Death From Non-cardiovascular Diseases: A Population-based Cohort Study of Korean Adults
    Jeoungbin Choi, Jieun Jang, Yoonsuk An, Sue K. Park
    Journal of Preventive Medicine and Public Health.2018; 51(6): 298.     CrossRef
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  • 6 Web of Science
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Genetic and Morphologic Identification of Spirometra ranarum in Myanmar
Hyeong-Kyu Jeon, Hansol Park, Dongmin Lee, Seongjun Choe, Yeseul Kang, Mohammed Mebarek Bia, Sang-Hwa Lee, Woon-Mok Sohn, Sung-Jong Hong, Jong-Yil Chai, Keeseon S. Eom
Korean J Parasitol 2018;56(3):275-280.
Published online June 30, 2018
DOI: https://doi.org/10.3347/kjp.2018.56.3.275
In the present study, we identified a Spirometra species of Myanmar origin (plerocercoid) by molecular analysis using mitochondrial cox1 and nad1 genes, as well as by morphological observations of an adult tapeworm. Spargana specimens were collected from a paddy-field in Taik Kyi Township Tarkwa Village, Yangon, Myanmar in December 2017. A total of 5 spargana were obtained from 20 frogs Hoplobatrachus rugulosus; syn: Rana rugulosa (Wiegmann, 1834) or R. tigrina (Steindachner, 1867). The plerocercoids were used for experimental infection of a dog. After 4 weeks of infection, an adult tapeworm was recovered from the intestine of the dog. Morphologically, the distinct features of Spirometra sp. (Myanmar origin) relative to S. erinaceieuropaei and S. decipiens include a uterine morphology comprising posterior uterine coils that larger than the terminal uterine ball and coiling of the uteri diagonally (swirling) rather than spirally. The cox1 sequences (1,566 bp) of the Myanmar-origin Spirometra species showed 97.9% similarity to a reference sequence of S. decipiens (GenBank no. KJ599679) and 90.5% similarity to a reference sequence of S. erinaceieuropaei (GenBank no. KJ599680). Phylogenetic tree topologies were identical and presented high confidence level of values for the 3 major branches of the 3 Spirometra species in cox1 and nad1 genes. These results indicated that Myanmar-origin Spirometra species coincided with those of S. ranarum and may be considered as a valid species.

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    Meiqi Weng, Xinhua Liu, Chenxi Zhang, Rui Shu, Andrew Wang, Haotian Zhang, Xingqiang Wang, Huirong Yang, Jinyong Zhang
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    Ryanka Edila, Seongjun Choe, Mustofa Helmi Effendi, Lucia Tri Suwanti, John Yew Huat Tang
    International Journal for Parasitology: Parasites and Wildlife.2025; 28: 101150.     CrossRef
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    Parasitology International.2024; 98: 102798.     CrossRef
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    Acta Parasitologica.2024; 69(1): 574.     CrossRef
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    Hyeong-Kyu Jeon, Sun Huh, Woon-Mok Sohn, Jong-Yil Chai, Keeseon S. Eom
    The Korean Journal of Parasitology.2018; 56(4): 359.     CrossRef
  • 11,699 View
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Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
Korean J Parasitol 2017;55(4):385-389.
Published online August 31, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.4.385
Seroprevalence of Toxoplasma gondii infection among the residents of Cheorwon-gun, Gangwon-do, Korea, which partly includes the demilitarized zone (DMZ), were surveyed for 4 years and evaluated by RDT using recombinant fragment of major surface antigen (SAG1A). Sera from 1336, 583, 526, and 583 adult residents were collected on a yearly basis from 2010 to 2013, respectively. The total positive seroprevalence was 19.3, 21.9, 23.4, and 26.8% from 2010 to 2013, respectively. The positive seroprevalence in men (23.6, 27.5, 29.5, 34.6%) was far higher than women (14.1, 18.3, 19.4, 21.4%), from 2010 to 2013, respectively. This high seroprevalence of toxoplasmosis in Cheorwon-gun may have been influenced in part by its geographical locality of the area as it includes the DMZ, where civilian access is strictly limited, thus creating a relatively isolated area that is a well-preserved habitat. Further research is necessary to study the epidemiology of toxoplasmosis in this area.

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  • Is the incidence of congenital toxoplasmosis declining?
    Gregory Colin Milne, Joanne P. Webster, Martin Walker
    Trends in Parasitology.2023; 39(1): 26.     CrossRef
  • Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China
    Yu-bin Guan, Xiao-xiao Sun, Shao-lian Chen, Xiao-ting Zhu, Zhi-hua Zeng, Han-wei Lu, Hong-mei Feng, Yu Guo, Wen-gong Jiang, Kui Xiong, Xiao-rong Yang, Ho-Woo Nam, Zhao-shou Yang, Pan Li
    PLOS ONE.2023; 18(7): e0286430.     CrossRef
  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
    Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Distribution of toxoplasmosis among different groups of the population of the Оmsk Region
    O.Yu. Starostina, Yu.I. Patsula, A.Kh. Nurpeisova
    ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2019; : 51.     CrossRef
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Brief Communication

Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
Korean J Parasitol 2017;55(3):347-350.
Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.347
An epidemiological study was performed to know the recent infection status of Paragonimus westermani metacercariae (PwMc) in freshwater crayfish, Cambaroides similis, from 2 streams in Jeollanam-do, Republic of Korea. Crayfish were collected from creeks in Bogil-do (Island), Wando-gun, and in a creek near Daeheung Temple in Haenam-gun. The infection rate of crayfish with PwMc in Bogil-do was 89.8%, and the metacercarial burden was 37 PwMc per the infected crayfish. Crayfish in a creek near Daeheung Temple were larger and twice heavier than those in Bogil-do. Of them, 96.5% were infected with PwMc. An average of 140 metacercariae was found in the infected crayfish, almost quadruple to those of Bogil-do. There was a strong correlation between the number of PwMc and body weight of the crayfish. These results suggest that P. westermani metacercariae are still prevalent in crayfish of the 2 regions in Jeollanam-do, Korea.

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  • Physical habitat characteristics of freshwater crayfish Cambaroides similis (Koelbel, 1892) (Arthropoda, Decapoda) in South Korea
    Jin-Young Kim, Yong Ju Kwon, Ye Ji Kim, Yeong-Deok Han, Jung Soo Han, Chae Hui An, Yong Su Park, Dongsoo Kong
    Journal of Ecology and Environment.2023;[Epub]     CrossRef
  • Morphological and Molecular Characterization of Paragonimus skrjabini Complex from Yunnan, China: A Brief Report
    Qiu-Hong Shu, Shu-De Li, Ming Tian, Yong Meng, Shu-Mei-Qi He, Min Zhu, Miao-Miao Wang, Wen-Lin Wang
    Acta Parasitologica.2022; 67(1): 316.     CrossRef
  • What Findings on Chest CTs Can Delay Diagnosis of Pleuropulmonary Paragonimiasis?
    Kai Ke Li, Gong Yong Jin, Keun Sang Kwon
    Tomography.2022; 8(3): 1493.     CrossRef
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    Xiao-Juan Zhou, Qian Yang, Qi-Hong Tan, Li-Yanyang Zhang, Lin-Bo Shi, Jie-Xin Zou
    Acta Tropica.2021; 223: 106094.     CrossRef
  • Morphological and Molecular Characterization of Paragonimus Species Isolated from Freshwater Crabs in Southern Yunnan, China
    Qiu-Hong Shu, Yang Yang, Miao-Miao Wang, Shu-De Li, Ming Tian, Wen-Wei Bai, Yong Meng, Shu-Mei-Qi He, Wen-Lin Wang, Maoshui Wang
    Journal of Tropical Medicine.2021; 2021: 1.     CrossRef
  • Paragonimus and paragonimiasis in Asia: An update
    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
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  • A Case of Pulmonary Paragonimiasis with Chronic Abdominal Pain and Erythematous Rash in a 6-year-old Girl
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  • 8 Web of Science
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Original Articles

Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
Korean J Parasitol 2017;55(3):247-254.
Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.247
ELISA has been used for the diagnosis of toxoplasmosis, but it is being gradually replaced by a rapid diagnostic test (RDT). We compared and analyzed ELISA and RDT results using the sera collected during 4 consecutive years from residents of Gyodong-do (Island), Incheon-city, Korea. Sera from 921, 993, 940, and 838 adult residents were collected on a yearly basis (2010-2013). ELISA was performed by using a crude extract of T. gondii RH strain antigen and IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), GST-linker-SAG1A, were applied to the sera. Comparison between groups was analyzed by the Student’s t-test. The positive seroprevalence surged from 14.7% (135/921, 2010), 23.1% (231/993, 2011), 23.6% (222/940, 2012), and 32.1% (269/838, 2013) by ELISA. In contrast, RDT showed a more moderate increasing trend from 21.7% (200/921, 2010), 25.5% (253/993, 2011), 28.9% (272/940, 2012) and 33.1% (277/838, 2013). Discrepancies between ELISA and RDT were noted near the cut-off value. At the OD 0.15-0.24 range, RDT could detect 16.1% (169/1051) more positives, which suggests an early or acute toxoplasmosis, but at the OD 0.25-0.34 range, ELISA could detect 35.9% (92/256) more positives of possible chronic infections. Over the OD > 0.35 ELISA and RDT agreed in the majority of the cases. This surge in seroprevalence may be caused by the organic agriculture in addition to eating behavior or increase in pets among Koreans. These facts may be applied on a full-scale national survey using RDT to supplement ELISA to define the characteristics of the infection.

Citations

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  • Is the incidence of congenital toxoplasmosis declining?
    Gregory Colin Milne, Joanne P. Webster, Martin Walker
    Trends in Parasitology.2023; 39(1): 26.     CrossRef
  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
    Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
    Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2020; 58(5): 493.     CrossRef
  • Evaluation of a Newly Designed Immunochromatographic Test using Gold Nanoparticles and Recombinant Antigen gra7 for Rapid Diagnosis of Human Toxoplasmosis
    Hassan Morovati, Seyyed javad Seyyedtabaei, Mehrdad Gholamzad
    Iranian Journal of Medical Microbiology.2020; 14(1): 101.     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
    Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
    The Korean Journal of Parasitology.2018; 56(5): 437.     CrossRef
  • 11,679 View
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High Seroprevalence of Toxoplasmosis Detected by RDT among the Residents of Seokmo-do (Island) in Ganghwa-Gun, Incheon City, Korea
Yeong Hoon Kim, Jihoo Lee, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
Korean J Parasitol 2017;55(1):9-13.
Published online February 28, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.1.9
Seroprevalence of Toxoplasma gondii infection among the residents of Seokmo-do (Island) in Ganghwa-gun, Incheon, Korea was surveyed for 4 years by a rapid diagnostic test (RDT) using recombinant fragment of major surface antigen (SAG1), GST-linker-SAG1A. Sera from 312, 343, 390, and 362 adult residents were collected on a yearly basis from 2010 to 2013, respectively. Total positive seroprevalence regardless of gender was 29.2, 35.3, 38.7, and 45.3% from 2010 to 2013, respectively. Positive seroprevalence in male adults was 43.9, 48.2, 45.4, and 55.3%, which was far higher than that of the corresponding female adults which was 20.7, 29.2, 33.9, and 38.9%, from 2010 to 2013, respectively. This high seroprevalence of toxoplasmosis in Seokmo-do may have been caused in part by peculiar changes in the toxoplasmic environment of the island as it is a relatively isolated area preserving its natural habitat while also being connected by a bridge to the mainland. Further study is necessary to find out symptomatic patients and to confirm the risk factors.

Citations

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  • Clinical characteristics of toxoplasmosis patients in Korea: A retrospective study using health insurance review and assessment service data and electronic medical records
    Do-Won Ham, Bong-Kwang Jung, Ji-Hun Shin, Yong Joon Kim, Kyoung Yul Seo, Seung Mi Lee, Jae Hyoung Im, Jeong-Ran Kwon, Ho-Sung Lee, Kyung-Won Hwang, Eun-Hee Shin
    Parasites, Hosts and Diseases.2024; 62(4): 424.     CrossRef
  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
    Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals
    Amjad Hayat Khan, Rahmah Noordin
    European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(1): 19.     CrossRef
  • Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
    Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2020; 58(5): 493.     CrossRef
  • 9,762 View
  • 159 Download
  • 5 Web of Science
  • Crossref
Identification and Molecular Characterization of Parkin in Clonorchis sinensis
Xuelian Bai, Tae Im Kim, Ji-Yun Lee, Fuhong Dai, Sung-Jong Hong
Korean J Parasitol 2015;53(1):65-75.
Published online February 27, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.1.65

Clonorchis sinensis habitating in the bile duct of mammals causes clonorchiasis endemic in East Asian countries. Parkin is a RING-between-RING protein and has E3-ubiquitin ligase activity catalyzing ubiquitination and degradation of substrate proteins. A cDNA clone of C. sinensis was predicted to encode a polypeptide homologous to parkin (CsParkin) including 5 domains (Ubl, RING0, RING1, IBR, and RING2). The cysteine and histidine residues binding to Zn2+ were all conserved and participated in formation of tertiary structural RINGs. Conserved residues were also an E2-binding site in RING1 domain and a catalytic cysteine residue in the RING2 domain. Native CsParkin was determined to have an estimated molecular weight of 45.7 kDa from C. sinensis adults by immunoblotting. CsParkin revealed E3-ubiquitin ligase activity and higher expression in metacercariae than in adults. CsParkin was localized in the locomotive and male reproductive organs of C. sinensis adults, and extensively in metacercariae. Parkin has been found to participate in regulating mitochondrial function and energy metabolism in mammalian cells. From these results, it is suggested that CsParkin play roles in energy metabolism of the locomotive organs, and possibly in protein metabolism of the reproductive organs of C. sinensis.

Citations

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  • Characterization of a novel organic solute transporter homologue from Clonorchis sinensis
    Yanyan Lu, Won Gi Yoo, Fuhong Dai, Ji-Yun Lee, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong, John Pius Dalton
    PLOS Neglected Tropical Diseases.2018; 12(4): e0006459.     CrossRef
  • Molecular and structural characteristics of multidrug resistance-associated protein 7 in Chinese liver fluke Clonorchis sinensis
    Fuhong Dai, Won Gi Yoo, Ji-Yun Lee, Yanyan Lu, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 953.     CrossRef
  • 14,292 View
  • 98 Download
  • 3 Web of Science
  • Crossref
Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR
Hwang-Yong Kim, In-Wook Choi, Yeon-Rok Kim, Juan-Hua Quan, Hassan Ahmed Hassan Ahmed Ismail, Guang-Ho Cha, Sung-Jong Hong, Young-Ha Lee
Korean J Parasitol 2014;52(6):645-652.
Published online December 23, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.6.645

Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

Citations

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  • Distribution and Fasciola infection rates of Lymnaea snails and cattle in high-salinity areas of Mekong Delta, Vietnam
    Dang Thi LOAN, Lam Thanh NGUYEN, Tran Ngoc BICH, Nguyen Thuy Y VI, Yasunobu MATSUMOTO
    Journal of Veterinary Medical Science.2025; 87(3): 291.     CrossRef
  • Susceptibility of lymnaeid snails to Fasciola hepatica and Fasciola gigantica (Digenea: Fasciolidae): a systematic review and meta-analysis
    Philile Ignecious Ngcamphalala, Ignore Nyagura, Mokgadi Pulane Malatji, Samson Mukaratirwa
    PeerJ.2025; 13: e18976.     CrossRef
  • Green vegetable juice as a potential source of human fascioliasis in Korea
    Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
    One Health.2022; 15: 100441.     CrossRef
  • Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods
    Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
    Infectious Diseases of Poverty.2018;[Epub]     CrossRef
  • Morphological Characterization of Emerging Cercariae among Lymnaeid Snails from Barangay Cawongan, Padre Garcia, Batangas, Philippines
    Gregorio L. Martin I, Esperanza C. Cabrera
    Journal of Parasitology Research.2018; 2018: 1.     CrossRef
  • A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea
    Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong
    The Korean Journal of Parasitology.2018; 56(4): 375.     CrossRef
  • Monitoring of Fasciola Species Contamination in Water Dropwort by COX1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
    In-Wook Choi, Hwang-Yong Kim, Juan-Hua Quan, Jae-Gee Ryu, Rubing Sun, Young-Ha Lee
    The Korean Journal of Parasitology.2015; 53(5): 641.     CrossRef
  • Ectopic Human <i>Fasciola hepatica</i> Infection by an Adult Worm in the Mesocolon
    Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park
    The Korean Journal of Parasitology.2015; 53(6): 725.     CrossRef
  • 12,099 View
  • 139 Download
  • 9 Web of Science
  • Crossref

Brief Communication

Seroprevalence of Toxoplasmosis in the Residents of Cheorwon-gun, Gangwon-do, Korea
Hye-Jin Ahn, Pyo Yun Cho, Seong Kyu Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam
Korean J Parasitol 2012;50(3):225-227.
Published online August 13, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.3.225

The seroepidemiological status of toxoplasmosis was surveyed among the residents of Cheorwon-gun, Gangwon-do by means of ELISA using a crude extract antigen of Toxoplasma gondii. The sera of 1,661 adult residents (866 males and 795 females) were collected and checked for IgG antibody titers, which showed 17.0% positive rate (282 sera). The positive rate was significantly different between the sex; 20.6% for males and 13.1% for females (P<0.05). The positive rates were higher in fifties of males (28.7%) and forties of females (20.0%). This positive rate of toxoplasmosis in Cheorwon-gun residents is regarded as the highest among the surveys of different geographical regions of Korea. This high positive rate may due in part to peculiar geographical locality of the surveyed area near the naturally well preserved demilitarized zone (DMZ) or presumably consumption of the pork imported from high endemic nations. Therefore, it is necessary to study further the epidemiology of toxoplasmosis in Cheorwon-gun.

Citations

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    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea
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    The Korean Journal of Parasitology.2020; 58(3): 257.     CrossRef
  • Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
    Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2020; 58(5): 493.     CrossRef
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    Davood Anvari, Mehdi Sharif, Shahabeddin Sarvi, Sargis A. Aghayan, Shirzad Gholami, Abdol Sattar Pagheh, Seyed Abdollah Hosseini, Reza Saberi, Tooran Nayeri Chegeni, Zahra Hosseininejad, Ahmad Daryani
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  • Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
    Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(3): 247.     CrossRef
  • Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
    Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(4): 385.     CrossRef
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    Mehdi Sharif, Ahmad Daryani, Zahra Ebrahimnejad, Shirzad Gholami, Ehsan Ahmadpour, Samaneh Borhani, Narges Lamsechi
    Journal of Infection and Public Health.2016; 9(1): 75.     CrossRef
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    Journal of Parasitology.2014; 100(5): 692.     CrossRef
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    Ma de la Luz Galván-Ramírez, Laura Verónica Sánchez-Orozco, Laura Rocío Rodríguez, Saúl Rodríguez, Enrique Roig-Melo, Rogelio Troyo Sanromán, Erwin Chiquete, Juan Armendáriz-Borunda
    Parasites & Vectors.2013;[Epub]     CrossRef
  • Clinical Features and Treatment of Ocular Toxoplasmosis
    Young-Hoon Park, Ho-Woo Nam
    The Korean Journal of Parasitology.2013; 51(4): 393.     CrossRef
  • Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
    Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2012; 50(4): 287.     CrossRef
  • A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea
    Zhaoshou Yang, Pyo Yun Cho, Seong Kyu Ahn, Hye-Jin Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam
    The Korean Journal of Parasitology.2012; 50(3): 191.     CrossRef
  • 9,775 View
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Original Article

A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea
Zhaoshou Yang, Pyo Yun Cho, Seong Kyu Ahn, Hye-Jin Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam
Korean J Parasitol 2012;50(3):191-197.
Published online August 13, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.3.191

Seroepidemiological changes of Toxoplasma gondii infection among the residents of the islands of Gangwha-gun, Incheon for 2 years were surveyed and evaluated by ELISA using a crude extract antigen. In 2010, sera of 919 adult residents in Gyodong-myeon and 313 adults in Samsan-myeon were collected and checked for IgG antibody titers, which showed 14.5% (133 sera) and 19.8% (62 sera) positive rates, respectively. In 2011, sera of 955 adults in Gyodong-myeon and 341 adults in Samsan-myeon were examined, which showed an increase of positive rates to 23.8% (227 sera) and 31.7% (108 sera), respectively. Totally, the seroprevalence of the first year was 15.8% and it increased rapidly to 25.8% in the second year. The positive rates of both sexes increased simultaneously with the significant ratio of males to females by 1.7-2.2 fold (P<0.05). In both myeons, 661 sera were collected every year and showed changes in optical density (OD) in 177 sera; newly found as positives in 73 persons (11.0%), negative conversion in 10 persons (1.5%), and maintained or increased in 94 persons (14.2%). This rapid increase in the prevalence of toxoplasmosis in Gangwha islands may be due to in part peculiar changes in the toxoplasmic environment of the islands and presumably the consumption of the pork bred domestically within the islands or imported from high endemic nations. It is necessary to find out symptomatic toxoplasmic patients and confirm the risk factors for further infection in the islands of Gangwha-gun.

Citations

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  • Is the incidence of congenital toxoplasmosis declining?
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    Trends in Parasitology.2023; 39(1): 26.     CrossRef
  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
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    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Cross-sectional survey for Toxoplasma gondii infection in humans in Fernando de Noronha island, Brazil
    Maria da Conceição Carvalho, Müller Ribeiro-Andrade, Renata Pimentel Bandeira de Melo, Dandara Matias Guedes, José Wilton Pinheiro Junior, Erika Fernanda Torres Samico Fernandes Cavalcanti, Fernando Jorge Rodrigues Magalhães, Rinaldo Aparecido Mota
    Revista Brasileira de Parasitologia Veterinária.2021;[Epub]     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea
    Mi Hae Chung, Chan Ok Shin, Juyoung Lee
    Korean Journal of Pediatrics.2018; 61(4): 114.     CrossRef
  • Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
    Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
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  • Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
    Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(3): 247.     CrossRef
  • Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
    Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(4): 385.     CrossRef
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  • Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
    Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
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  • 9,826 View
  • 78 Download
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Brief Communication

Maintained Seroprevalence of Toxoplasmosis among the Residents of Jeju Island, Korea
Sung-Jong Hong, Chom-Kyu Chong, Kyutaeg Lee, Tong-Soo Kim, Yeon-Pyo Hong, Hye-Jin Ahn, Hak-Yong Kim, A-Ra Ko, Yong-Joo Kim, Ho-Woo Nam
Korean J Parasitol 2011;49(3):309-311.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.309

Seroepidemiological status of toxoplasmosis among the residents of Jeju island was surveyed and evaluated by ELISA with crude extract of Toxoplasma gondii. The sera of 2,348 residents (male 1,157 and female 1,191) were collected and checked for the IgG antibody titers, which showed 13.2% positive rate (309 sera). The positive rates were increasing gradually according to the age from 4.3% in teenage to 20.6% in seventies. The positive rates were significantly different between the sex by 16.2% for male and 10.2% for female (P<0.05). This positive rate of toxoplasmosis in Jeju island residents is regarded relatively higher than any other regions of Korea. And the high positive rate may be maintained continuously among Jeju island residents without any clear reasons until now but due to some parts peculiar socio-cultural tradition of Jeju island. Therefore, it is necessary to study further the epidemiology of toxoplasmosis of Jeju island.

Citations

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  • Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea
    Jeehi Jung, Jinyoung Lee, Yoon Kyung Chang, Seong Kyu Ahn, Seo Hye Park, Sung-Jong Hong, Jihoo Lee, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam, Tong-Soo Kim, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(1): 9.     CrossRef
  • Clusters of Toxoplasmosis in Ganghwa-gun, Cheorwon-gun, and Goseong-gun, Korea
    Jihye Yu, Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2021; 59(3): 251.     CrossRef
  • Cross-sectional survey for Toxoplasma gondii infection in humans in Fernando de Noronha island, Brazil
    Maria da Conceição Carvalho, Müller Ribeiro-Andrade, Renata Pimentel Bandeira de Melo, Dandara Matias Guedes, José Wilton Pinheiro Junior, Erika Fernanda Torres Samico Fernandes Cavalcanti, Fernando Jorge Rodrigues Magalhães, Rinaldo Aparecido Mota
    Revista Brasileira de Parasitologia Veterinária.2021;[Epub]     CrossRef
  • Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea
    Yeojin Park, Jinhyeong Noh, Hyun-Ji Seo, Keun-Ho Kim, Subin Min, Mi-Sun Yoo, Bo-Ram Yun, Jong-Ho Kim, Eun-Jin Choi, Doo-Sung Cheon, Sung-Jong Hong, Soon-Seek Yoon, Yun Sang Cho
    The Korean Journal of Parasitology.2020; 58(3): 257.     CrossRef
  • Clusters of Toxoplasmosis in Gyodong-Myeon and Samsan-Myeon, Ganghwa-Gun, Korea
    Woojin Kim, Yoon Kyung Chang, Tong-Soo Kim, Sung-Jong Hong, Hye-Jin Ahn, Ho-Woo Nam, Dongjae Kim
    The Korean Journal of Parasitology.2020; 58(5): 493.     CrossRef
  • Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
    Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
    The Korean Journal of Parasitology.2018; 56(5): 437.     CrossRef
  • Seroprevalence of Toxoplasmosis with ELISA and Rapid Diagnostic Test among Residents in Gyodong-do, Inchon city, Korea: A Four-Year Follow-up
    Yeong Hoon Kim, Ji hoo Lee, Seong kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(3): 247.     CrossRef
  • Seroprevalence of Toxoplasmosis Detected by RDT in Residents near the DMZ (demilitarized zone) of Cheorwon-gun, Gangwon-do, Korea
    Yeong Hoon Kim, Jihoo Lee, Young-Eun Kim, Seongkyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
    The Korean Journal of Parasitology.2017; 55(4): 385.     CrossRef

  • Koki Yakushiji
    JOURNAL OF WATER AND ENVIRONMENTAL ISSUES.2015; 28(1): 82.     CrossRef
  • Mesial Temporal Lobe Epilepsy in Congenital Toxoplasmosis: A Case Report
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    Journal of Epilepsy Research.2015; 5(1): 25.     CrossRef
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    The Korean Journal of Parasitology.2013; 51(5): 503.     CrossRef
  • Serologic Survey of Toxoplasmosis in Seoul and Jeju-do, and a Brief Review of Its Seroprevalence in Korea
    Hyemi Lim, Sang-Eun Lee, Bong-Kwang Jung, Min-Ki Kim, Mi Youn Lee, Ho-Woo Nam, Jong-Gyun Shin, Cheong-Ha Yun, Han-Ik Cho, Eun-Hee Shin, Jong-Yil Chai
    The Korean Journal of Parasitology.2012; 50(4): 287.     CrossRef
  • A Surge in the Seroprevalence of Toxoplasmosis among the Residents of Islands in Gangwha-gun, Incheon, Korea
    Zhaoshou Yang, Pyo Yun Cho, Seong Kyu Ahn, Hye-Jin Ahn, Tong-Soo Kim, Chom-Kyu Chong, Sung-Jong Hong, Seok Ho Cha, Ho-Woo Nam
    The Korean Journal of Parasitology.2012; 50(3): 191.     CrossRef
  • Seroprevalence of Toxoplasmosis in the Residents of Cheorwon-gun, Gangwon-do, Korea
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    The Korean Journal of Parasitology.2012; 50(3): 225.     CrossRef
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Original Article

Development and Clinical Evaluation of a Rapid Serodiagnostic Test for Toxoplasmosis of Cats Using Recombinant SAG1 Antigen
Chom-Kyu Chong, Wooseog Jeong, Hak-Yong Kim, Dong-Jun An, Hye-Young Jeoung, Jeong-Eun Ryu, A-Ra Ko, Yong-Joo Kim, Sung-Jong Hong, Zhaoshou Yang, Ho-Woo Nam
Korean J Parasitol 2011;49(3):207-212.
Published online September 30, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.3.207

Rapid serodiagnostic methods for Toxoplasma gondii infection in cats are urgently needed for effective control of transmission routes toward human infections. In this work, 4 recombinant T. gondii antigens (SAG1, SAG2, GRA3, and GRA6) were produced and tested for the development of rapid diagnostic test (RDT). The proteins were expressed in Escherichia coli, affinity-purified, and applied onto the nitrocellulose membrane of the test strip. The recombinant SAG1 (rSAG1) showed the strongest antigenic activity and highest specificity among them. We also performed clinical evaluation of the rSAG1-loaded RDT in 182 cat sera (55 household and 127 stray cats). The kit showed 0.88 of kappa value comparing with a commercialized ELISA kit, which indicated a significant correlation between rSAG1-loaded RDT and the ELISA kit. The overall sensitivity and specificity of the RDT were 100% (23/23) and 99.4% (158/159), respectively. The rSAG1-loaded RDT is rapid, easy to use, and highly accurate. Thus, it would be a suitable diagnostic tool for rapid detection of antibodies in T. gondii-infected cats under field conditions.

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    Nicoletta Formenti, Alessandra Gaffuri, Tiziana Trogu, Roberto Viganò, Nicola Ferrari, Paolo Lanfranchi
    Parasitology Research.2016; 115(5): 2115.     CrossRef
  • Opportunities and challenges for the application of microfluidic technologies in point-of-care veterinary diagnostics
    Valentina Busin, Beth Wells, Maïwenn Kersaudy-Kerhoas, Wenmaio Shu, Stewart T.G. Burgess
    Molecular and Cellular Probes.2016; 30(5): 331.     CrossRef
  • Synthesis and characterization of latex-protein complexes from different antigens ofToxoplasma gondiifor immunoagglutination assays
    Leandro E. Peretti, Verónica D. G. Gonzalez, Juan G. Costa, Iván S. Marcipar, Luis M. Gugliotta
    International Journal of Polymeric Materials and Polymeric Biomaterials.2016; 65(18): 938.     CrossRef
  • Toxoplasma gondii Infection in Alpine Red Deer (Cervus elaphus): Its Spread and Effects on Fertility
    Nicoletta Formenti, Tiziana Trogu, Luca Pedrotti, Alessandra Gaffuri, Paolo Lanfranchi, Nicola Ferrari, Guido Favia
    PLOS ONE.2015; 10(9): e0138472.     CrossRef
  • Latex–protein complexes from an acute phase recombinant antigen of Toxoplasma gondii for the diagnosis of recently acquired toxoplasmosis
    Leandro E. Peretti, Verónica D.G. Gonzalez, Iván S. Marcipar, Luis M. Gugliotta
    Colloids and Surfaces B: Biointerfaces.2014; 120: 88.     CrossRef
  • A Rapid Diagnostic Test for Toxoplasmosis using Recombinant Antigenic N-terminal Half of SAG1 Linked with Intrinsically Unstructured Domain of GRA2 Protein
    Kyoung Ju Song, Zhaoshou Yang, Chom-Kyu Chong, Jin-Soo Kim, Kyung Chan Lee, Tong-Soo Kim, Ho-Woo Nam
    The Korean Journal of Parasitology.2013; 51(5): 503.     CrossRef
  • Evaluation of an indirect ELISA using a tachyzoite surface antigen SAG1 for diagnosis of Toxoplasma gondii infection in cats
    M. Hosseininejad
    Experimental Parasitology.2012; 132(4): 556.     CrossRef
  • 10,773 View
  • 121 Download
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Brief Communication

Molecular Identification of Taenia Tapeworms by Cox1 Gene in Koh Kong, Cambodia
Hyeong-Kyu Jeon, Tai-Soon Yong, Woon-Mok Sohn, Jong-Yil Chai, Sung-Jong Hong, Eun-Taek Han, Hoo-Gn Jeong, Tep Chhakda, Muth Sinuon, Duong Socheat, Keeseon S. Eom
Korean J Parasitol 2011;49(2):195-197.
Published online June 14, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.2.195

We collected fecal samples from 21 individuals infected with Taenia tapeworms in Koh Kong Province, Cambodia, and performed nucleotide sequencing of the cox1 gene and multiplex PCR on the eggs for DNA differential diagnosis of human Taenia tapeworms. Genomic DNA was extracted from the eggs of a minimum number of 10 isolated from fecal samples. Using oligonucleotide primers Ta7126F, Ts7313F, Tso7466F, and Rev7915, the multiplex PCR assay proved useful for differentially diagnosing Taenia solium, Taenia saginata, and Taenia asiatica based on 706, 629, and 474 bp bands, respectively. All of the Taenia specimens from Kho Kong, Cambodia, were identified as either T. saginata (n=19) or T. solium (n=2) by cox1 sequencing and multiplex PCR.

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  • Taenia

    CABI Compendium.2022;[Epub]     CrossRef
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    Yi Liu, Zijian Dong, Jianda Pang, Mingyuan Liu, Xuemin Jin
    Parasitology Research.2021; 120(12): 4145.     CrossRef
  • Occurrence of a Hybrid Between Taenia saginata and Taenia asiatica Tapeworms in Cambodia
    Taehee Chang, Bong-Kwang Jung, Sooji Hong, Hyejoo Shin, Seungwan Ryoo, Jeonggyu Lee, Keon Hoon Lee, Hansol Park, Keeseon S. Eom, Virak Khieu, Rekol Huy, Woon-Mok Sohn, Jong-Yil Chai
    The Korean Journal of Parasitology.2021; 59(2): 179.     CrossRef
  • Recent advances in nucleic acid-based methods for detection of helminth infections and the perspective of biosensors for future development
    Hanif Ullah, Abdul Qadeer, Muhammad Rashid, Muhammad Imran Rashid, Guofeng Cheng
    Parasitology.2020; 147(4): 383.     CrossRef
  • Epidemiology of Taenia saginata taeniosis/cysticercosis: a systematic review of the distribution in East, Southeast and South Asia
    Ramon M. Eichenberger, Lian F. Thomas, Sarah Gabriël, Branco Bobić, Brecht Devleesschauwer, Lucy J. Robertson, Anastasios Saratsis, Paul R. Torgerson, Uffe C. Braae, Veronique Dermauw, Pierre Dorny
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Cysticercosis/taeniasis endemicity in Southeast Asia: Current status and control measures
    Hai-Wei Wu, Akira Ito, Lin Ai, Xiao-Nong Zhou, Luz P. Acosta, Arve Lee Willingham III
    Acta Tropica.2017; 165: 121.     CrossRef
  • Needs of exploring the burden of recent onset seizures due to neurocysticercosis and challenges in southeast Asia focusing on scenario in Malaysia
    Priyadarshi S. Sahu, Yvonne A.L. Lim, Rohela Mahmud, Sushela D. Somanath, Chong T. Tan, C.P. Ramachandran
    Asian Pacific Journal of Tropical Medicine.2017; 10(4): 332.     CrossRef
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    Shane Byrne, Jennifer M.B. Robson
    Pathology.2015; 47(3): 234.     CrossRef
  • Intestinal Parasite Infections in Symptomatic Children Attending Hospital in Siem Reap, Cambodia
    Catrin E. Moore, Phot Nget, Mao Saroeun, Suy Kuong, Seng Chanthou, Varun Kumar, Rachel Bousfield, Johanna Nader, J. Wendi Bailey, Nicholas J. Beeching, Nicholas P. Day, Christopher M. Parry, William A Paxton
    PLOS ONE.2015; 10(5): e0123719.     CrossRef
  • Evolution, molecular epidemiology and perspectives on the research of taeniid parasites with special emphasis on Taenia solium
    Raúl J. Bobes, Gladis Fragoso, Agnès Fleury, Martín García-Varela, Edda Sciutto, Carlos Larralde, Juan P. Laclette
    Infection, Genetics and Evolution.2014; 23: 150.     CrossRef
  • The Parasitological, Immunological, and Molecular Diagnosis of Human Taeniasis with Special Emphasis on Taenia solium Taeniasis
    Kabemba E. Mwape, Sarah Gabriël
    Current Tropical Medicine Reports.2014; 1(4): 173.     CrossRef
  • Comparative analysis of the miRNA profiles from Taenia solium and Taenia asiatica adult
    Ai Lin, Chen Mu-Xin, Zhang Yong-Nian, Chen Shao-Hong, Zhou Xiao-Nong, Chen Jia-Xu
    African Journal of Microbiology Research.2014; 8(9): 895.     CrossRef
  • Prevalence of Intestinal Helminths among Inhabitants of Cambodia (2006-2011)
    Tai-Soon Yong, Jong-Yil Chai, Woon-Mok Sohn, Keeseon S. Eom, Hoo-Gn Jeoung, Eui-Hyug Hoang, Cheong-Ha Yoon, Bong-Kwang Jung, Soon-Hyung Lee, Muth Sinuon, Duong Socheat
    The Korean Journal of Parasitology.2014; 52(6): 661.     CrossRef
  • Epidemiology and genetic diversity of Taenia asiatica: a systematic review
    Anita Ale, Bjorn Victor, Nicolas Praet, Sarah Gabriël, Niko Speybroeck, Pierre Dorny, Brecht Devleesschauwer
    Parasites & Vectors.2014;[Epub]     CrossRef
  • Molecular Testing for Clinical Diagnosis and Epidemiological Investigations of Intestinal Parasitic Infections
    Jaco J. Verweij, C. Rune Stensvold
    Clinical Microbiology Reviews.2014; 27(2): 371.     CrossRef
  • Molecular Approaches to Taenia asiatica
    Hyeong-Kyu Jeon, Keeseon S. Eom
    The Korean Journal of Parasitology.2013; 51(1): 1.     CrossRef
  • 10,233 View
  • 118 Download
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Mini Review

Functional Genes and Proteins of Clonorchis sinensis
Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong
Korean J Parasitol 2009;47(Suppl):S59.
Published online October 27, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.S.S59

During the past several decades, researches on parasite genetics have progressed from biochemical and serodiagnostic studies to protein chemistry, molecular biology, and functional gene studies. Nowadays, bioinformatics, genomics, and proteomics approaches are being applied by Korean parasitology researchers. As for Clonorchis sinensis, investigations have been carried out to identify its functional genes using forward and reverse genetic approaches and to characterize the biochemical and biological properties of its gene products. The authors review the proteins of cloned genes, which include antigenic proteins, physiologic and metabolic enzymes, and the gene expression profile of Clonorchis sinensis.

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  • Clonorchis sinensis ESPs enhance the activation of hepatic stellate cells by a cross-talk of TLR4 and TGF-β/Smads signaling pathway
    Bo Li, Chao Yan, Jing Wu, Koda Stephane, Xin Dong, Yu-Zhao Zhang, Yu Zhang, Qian Yu, Kui-Yang Zheng
    Acta Tropica.2020; 205: 105307.     CrossRef
  • Serodiagnostic antigens of Clonorchis sinensis identified and evaluated by high-throughput proteogenomics
    Pyo Yun Cho, Ji-Yun Lee, Tae Im Kim, Jin-Ho Song, Sung-Jong Hong, Won Gi Yoo, Takafumi Tsuboi, Kwon-Soo Ha, Jae-Wan Jung, Satoru Takeo, Eun-Taek Han, Banchob Sripa, Sung-Tae Hong, Jong-Yil Chai, Ho-Woo Nam, Jhang Ho Pak, Tong-Soo Kim, Krystyna Cwiklinski
    PLOS Neglected Tropical Diseases.2020; 14(12): e0008998.     CrossRef
  • Clonorchiasis
    Men-Bao Qian, Jürg Utzinger, Jennifer Keiser, Xiao-Nong Zhou
    The Lancet.2016; 387(10020): 800.     CrossRef
  • Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
    Ze-Li Tang, Yan Huang, Xin-Bing Yu
    Infectious Diseases of Poverty.2016;[Epub]     CrossRef
  • Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review
    Tong-Soo Kim, Jhang Ho Pak, Jong-Bo Kim, Young Yil Bahk
    BMB Reports.2016; 49(11): 590.     CrossRef
  • Clonorchis sinensis acetoacetyl-CoA thiolase: identification and characterization of its potential role in surviving in the bile duct
    Jinsi Lin, Hongling Qu, Guishan Chen, Lei He, Yanquan Xu, Zhizhi Xie, Mengyu Ren, Jiufeng Sun, Shan Li, Wenjun Chen, Xueqing Chen, Xiaoyun Wang, Xuerong Li, Chi Liang, Yan Huang, Xinbing Yu
    Parasites & Vectors.2015;[Epub]     CrossRef
  • Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells
    Qiang Mao, Zhizhi Xie, Xiaoyun Wang, Wenjun Chen, Mengyu Ren, Mei Shang, Huali Lei, Yanli Tian, Shan Li, Pei Liang, Tingjin Chen, Chi Liang, Jin Xu, Xuerong Li, Yan Huang, Xinbing Yu
    Parasitology Research.2015; 114(2): 659.     CrossRef
  • Biochemical and immunological characterization of annexin B30 from Clonorchis sinensis excretory/secretory products
    Lei He, Mengyu Ren, Xueqing Chen, Xiaoyun Wang, Shan Li, Jinsi Lin, Chi Liang, Pei Liang, Yue Hu, Huali Lei, Meng Bian, Yan Huang, Zhongdao Wu, Xuerong Li, Xinbing Yu
    Parasitology Research.2014; 113(7): 2743.     CrossRef
  • Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis
    Pei Liang, Lei He, Yanquan Xu, Xueqing Chen, Yan Huang, Mengyu Ren, Chi Liang, Xuerong Li, Jin Xu, Gang Lu, Xinbing Yu
    Parasitology Research.2014; 113(10): 3621.     CrossRef
  • Proteomic identification of potential Clonorchis sinensis excretory/secretory products capable of binding and activating human hepatic stellate cells
    Xiaoyun Wang, Fengyu Hu, Xuchu Hu, Wenjun Chen, Yan Huang, Xinbing Yu
    Parasitology Research.2014; 113(8): 3063.     CrossRef
  • Characterization of the secreted cathepsin B cysteine proteases family of the carcinogenic liver fluke Clonorchis sinensis
    Wenjun Chen, Xiaoyun Wang, Xiaoli Lv, Yanli Tian, Yanquan Xu, Qiang Mao, Mei Shang, Xuerong Li, Yan Huang, Xinbing Yu
    Parasitology Research.2014; 113(9): 3409.     CrossRef
  • ClonorESTdb: a comprehensive database for Clonorchis sinensis EST sequences
    Dae-Won Kim, Won Gi Yoo, Sanghyun Lee, Myoung-Ro Lee, Yu-Jung Kim, Shin-Hyeong Cho, Won-Ja Lee, Jung-Won Ju
    BMC Research Notes.2014;[Epub]     CrossRef
  • Adult Opisthorchis felineus major protein fractions deduced from transcripts: Comparison with liver flukes Opisthorchis viverrini and Clonorchis sinensis
    Mikhail Pomaznoy, Sergey Tatkov, Alexey Katokhin, Dmitry Afonnikov, Vladimir Babenko, Dagmara Furman, Ilya Brusentsov, Pavel Belavin, Alexandr Najakshin, Sergey Guselnikov, Gennady Vasiliev, Anton Sivkov, Egor Prokhortchouk, Konstantin Skryabin, Viatchesl
    Experimental Parasitology.2013; 135(2): 297.     CrossRef
  • Biochemical characterization and functional analysis of fructose-1,6-bisphosphatase from Clonorchis sinensis
    Pei Liang, Jiufeng Sun, Yan Huang, Fan Zhang, Juanjuan Zhou, Yue Hu, Xiaoyun Wang, Chi Liang, Minghui Zheng, Yanquan Xu, Qiang Mao, Xuchu Hu, Xuerong Li, Jin Xu, Gang Lu, Xinbing Yu
    Molecular Biology Reports.2013; 40(7): 4371.     CrossRef
  • Genetic diversity of nuclear ITS1–5.8S–ITS2 rDNA sequence in Clonorchis sinensis Cobbold, 1875 (Trematoda: Opisthorchidae) from the Russian Far East
    Yulia V. Tatonova, Galina N. Chelomina, Vladimir V. Besprosvannykh
    Parasitology International.2012; 61(4): 664.     CrossRef
  • Genomics and molecular genetics of Clonorchis sinensis: Current status and perspectives
    Si-Yang Huang, Guang-Hui Zhao, Bao-Quan Fu, Min-Jun Xu, Chun-Ren Wang, Song-Ming Wu, Feng-Cai Zou, Xing-Quan Zhu
    Parasitology International.2012; 61(1): 71.     CrossRef
  • Molecular characterization of Clonorchis sinensis tetraspanin 2 extracellular loop 2
    Tae Yun Kim, Eun Joo Chung, Woon-Mok Sohn, Sung-Hong Hong, Tai-Soon Yong
    Parasitology Research.2012; 110(2): 707.     CrossRef
  • Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, Clonorchis sinensis
    Won Gi Yoo, Dae-Won Kim, Jung-Won Ju, Pyo Yun Cho, Tae Im Kim, Shin-Hyeong Cho, Sang-Haeng Choi, Hong-Seog Park, Tong-Soo Kim, Sung-Jong Hong, Banchob Sripa
    PLoS Neglected Tropical Diseases.2011; 5(6): e1208.     CrossRef
  • Fish-borne Parasitic Diseases
    Jong-Yil Chai
    Hanyang Medical Reviews.2010; 30(3): 223.     CrossRef
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  • 87 Download
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Brief Communication

Metacercarial proteins interacting with WD40-repeat protein of Clonorchis sinensis
Pyo Yun Cho, Tae Im Kim, Shunyu Li, Sung-Jong Hong, Min-Ho Choi, Sung-Tae Hong, Yong Je Chung
Korean J Parasitol 2007;45(3):229-232.
Published online September 20, 2007
DOI: https://doi.org/10.3347/kjp.2007.45.3.229

The WD40-repeat proteins serve as a platform coordinating partner proteins and are involved in a range of regulatory cellular functions. A WD40-repeat protein (CsWD1) of Clonorchis sinensis previously cloned is expressed stage-specifically in the tegumental syncytium of C. sinensis metacercariae. In the present study, interacting proteins with the CsWD1 protein was purified by immunoprecipitation and 2 dimension gel electrophoresis from the C. sinensis metacercaria soluble extract, and tryptic peptides were analyzed by LC/ESI-MS. Putative partner proteins were annotated to be actin-2, glyceraldehyde-3-phosphate dehydrogenase, and hypothetical and unmanned proteins. The CsWD1 protein was predicted to contain 3 conserved actin-interacting residues on its functional surface. With these results, the CsWD1 protein is suggested to be an actin-interacting protein of C. sinensis.

Citations

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  • Clonorchis sinensis and clonorchiasis, an update
    Sung-Tae Hong, Yueyi Fang
    Parasitology International.2012; 61(1): 17.     CrossRef
  • 7,265 View
  • 67 Download
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Case Report

A human infection of Echinostoma hortense in duodenal bulb diagnosed by endoscopy
Young-Doo Chang, Woon-Mok Sohn, Jae-Hwa Ryu, Shin-Yong Kang, Sung-Jong Hong
Korean J Parasitol 2005;43(2):57-60.
Published online June 20, 2005
DOI: https://doi.org/10.3347/kjp.2005.43.2.57

As gastroduodenoscopy performed more frequently, case reports of human echinostomiasis are increasing in Korea. A Korean woman presented at a local clinic with complaints of abdominal pain and discomfort that had persisted for 2 weeks. Under gastroduodenoscopy, two motile flukes were found attached on the duodenal bulb, and retrieved with endoscopic forceps. She had history of eating raw frog meat. The two flukes were identified as Echinostoma hortense by egg morphology, 27 collar spines with 4 end-group spines, and surface ultrastructural characters. This report may prove frogs to be a source of human echinostome infections.

Citations

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  • Clonorchis sinensis and Echinostoma hortense detected by endoscopy and molecular characterization: two case reports and update on diagnosis
    Lijia Wen, Benhe Wang, Hui Zhang
    Frontiers in Medicine.2025;[Epub]     CrossRef
  • Rare Case of Echinostoma cinetorchis Infection, South Korea
    Sooji Hong, Hyejoo Shin, Yoon-Hee Lee, Sung-Jong Hong, So-Ri Kim, Youn-Kyoung Kim, Young-Jin Son, Jeong-Gil Song, Jong-Yil Chai, Bong-Kwang Jung
    Emerging Infectious Diseases.2024;[Epub]     CrossRef
  • Type of cercaria in freshwater snails at Tunggu Pampang Reservoir, Makassar City, Indonesia
    Arif Rahman Jabal, Dian Mutiasari, Hairil Akbar, M. Arfah, Marhani Marhani, Rini Rini, Nur Alam Sobak, Anggit Julianingsih Pisu, Agnes Immanuela Toemon, Arini Ratnasari
    Russian Journal of Infection and Immunity.2023; 12(4): 765.     CrossRef
  • Neglected food-borne trematodiases: echinostomiasis and gastrodiscoidiasis
    Rafael Toledo, María Álvarez-Izquierdo, J. Guillermo Esteban, Carla Muñoz-Antoli
    Parasitology.2022; 149(10): 1319.     CrossRef
  • Morphology and Molecular Identification of Echinostoma revolutum and Echinostoma macrorchis in Freshwater Snails and Experimental Hamsters in Upper Northern Thailand
    Preeyaporn Butboonchoo, Chalobol Wongsawad, Pheravut Wongsawad, Jong-Yil Chai
    The Korean Journal of Parasitology.2020; 58(5): 499.     CrossRef
  • Fasciola hepatica infection in children actively detected in a survey in rural areas of Mardan district, Khyber Pakhtunkhawa province, northern Pakistan
    Asma W. Qureshi, Aurang Zeb, Abu Mansoor, Azam Hayat, Santiago Mas-Coma
    Parasitology International.2019; 69: 39.     CrossRef
  • Infection Status of Isthmiophora hortensis Metacercariae in Dark Sleepers, Odontobutis Species, from Some Water Systems of the Republic of Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju
    The Korean Journal of Parasitology.2018; 56(6): 633.     CrossRef
  • New Definitive Hosts and Differential Body Indices of Isthmiophora hortensis (Digenea: Echinostomatidae)
    Woon-Mok Sohn, Byoung-Kuk Na, Sung-Shik Shin
    The Korean Journal of Parasitology.2017; 55(3): 287.     CrossRef
  • Echinostoma macrorchis (Digenea: Echinostomatidae): Metacercariae in Cipangopaludina chinensis malleata Snails and Adults from Experimental Rats in Korea
    Woon-Mok Sohn, Byoung-Kuk Na
    The Korean Journal of Parasitology.2017; 55(5): 541.     CrossRef
  • Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan
    Asma W. Qureshi, Akhtar Tanveer, Santiago Mas-Coma
    Acta Tropica.2016; 156: 157.     CrossRef
  • An update on human echinostomiasis
    R. Toledo, J. G. Esteban
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2016; 110(1): 37.     CrossRef
  • A Case of Echinostoma cinetorchis (Trematoda: Echinostomatidae) Infection Diagnosed by Colonoscopy
    Woon Tae Jung, Kyeong Ju Lee, Hong Jun Kim, Tae Hyo Kim, Byoung-Kuk Na, Woon-Mok Sohn
    The Korean Journal of Parasitology.2014; 52(3): 287.     CrossRef
  • Echinostoma hortense Infection with Enteritis Diagnosed by Upper Gastrointestinal Endoscopy in a Dog
    Hiroki OKANISHI, Jun MATSUMOTO, Sadao NOGAMI, Yumiko KAGAWA, Toshihiro WATARI
    Journal of Veterinary Medical Science.2013; 75(7): 991.     CrossRef
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    Nguyen Lan Anh Thi, Henry Madsen, Dao Thanh Ha, Eric Hoberg, Anders Dalsgaard, K. Darwin Murrell
    Parasitology Research.2012; 111(3): 1045.     CrossRef
  • Proteomics of foodborne trematodes
    Rafael Toledo, M. Dolores Bernal, Antonio Marcilla
    Journal of Proteomics.2011; 74(9): 1485.     CrossRef
  • Echinostoma hortense and Heterophyid Metacercariae Encysted in Yellowfin Goby, Acanthogobius flavimanus, from Shinan-gun and Muan-gun (Jeollanam-do), Korea
    Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho
    The Korean Journal of Parasitology.2009; 47(3): 307.     CrossRef
  • Foodborne Intestinal Flukes in Southeast Asia
    Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
    The Korean Journal of Parasitology.2009; 47(Suppl): S69.     CrossRef
  • ECHINOSTOMA HORTENSE ASADA INFECTION IN THE DUODENUM: INCIDENTAL FINDINGS DURING ROUTINE GASTROINTESTINAL ENDOSCOPY
    Toshiaki Tanaka, Tomoari Kamada, Hideki Koga, Aki Tanaka, Noriaki Manabe, Jiro Hata, Hiroaki Kusunoki, Manabu Ishii, Motonori Sato, Kenichi Tarumi, Akiko Shiotani, Tetsuya Okino, Ken Haruma
    Digestive Endoscopy.2008; 20(2): 87.     CrossRef
  • Eosinophilia: Causes and pathobiology in persons with prior exposures in tropical areas with an emphasis on parasitic infections
    Yae-Jean Kim, Thomas B. Nutman
    Current Infectious Disease Reports.2006; 8(1): 43.     CrossRef
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  • 95 Download
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Original Articles

Developmental surface ultrastructure of Macroorchis spinulosus in albino rats
Sung-Jong Hong, Ho-Chun Woo, Oh Sil Kwon
Korean J Parasitol 2004;42(4):151-157.
Published online December 20, 2004
DOI: https://doi.org/10.3347/kjp.2004.42.4.151

Developmental surface ultrastructure of Macroorchis spinulosus was studied by scanning electron microscopy. One-day-old juvenile fluke was leaf-shaped and bent ventrally. Body surface was covered densely with peg-like spines and with cobblestone-like cytoplasmic processes. Ciliated sensory papillae were concentrated around oral sucker. Several unciliated sensory papillae occurred equidistantly on oral sucker and acetabulum. The ciliated papillae appeared in two longitudinal lines symmetric bilaterally on dorsal surface. On adult flukes, tegumantal spines became wider in middle of the body surface. The cytoplasmic processes differentiated into more fine velvety form. It is likely that the differentiated fine cytoplasmic processes are an increased absorptive surface to adult M. spinulosus. It is suggested that single pointed tegumental spines on anterior half of the body may be supportive for this fluke to migration.

Citations

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  • Evaluation of the effect of larval metamorphosis of some digenetic parasites within the digestive gland tissues of the freshwater ampullariid snails, Lanistes carinatus (Olivier, 1804)
    Mohammed E. El-Zeiny, Ola A. Abu Samak, Shereen A. Fahmy, Abdel Aziz A. Khidr
    Parasitology International.2025; 108: 103078.     CrossRef
  • Lethal effects of praziquantel and albendazole, on the cercariae of Echinochasmus sp. (Dietz, 1909) in-vitro
    Mohammed E. El-Zeiny, Ola A. Abu Samak, Shereen A. Fahmy, Abdel Aziz A. Khidr
    Journal of Parasitic Diseases.2024; 48(2): 320.     CrossRef
  • Molecular Description of Macroorchis spinulosus (Digenea: Nanophyetidae) Based on ITS1 Sequences
    Eun Jeong Won, Deok-Gyu Kim, Jaeeun Cho, Bong-Kwang Jung, Min-Jae Kim, Yong Woon Yun, Jong-Yil Chai, Dong Wook Ryang
    The Korean Journal of Parasitology.2016; 54(1): 109.     CrossRef
  • Surface ultrastructure of Plagiorchis muris growth and developmental stages in rats, the final host
    Sung-Jong Hong
    Parasitology Research.2009; 105(4): 1077.     CrossRef
  • Surface ultrastructure of the plagiorchid trematode Glossidium pedatum Looss, 1899 from bagrid fish in Egypt
    Mohammed Hasan Ibraheem
    Acta Zoologica.2007; 88(2): 173.     CrossRef
  • MORPHOLOGICAL OBSERVATIONS OF ECHINOCHASMUS JAPONICUS CERCARIAE AND THE IN VITRO MAINTENANCE OF ITS LIFE CYCLE FROM CERCARIAE TO ADULTS
    Min-Ho Choi, Sae Hoon Kim, Jong-Hoon Chung, Hye-Jin Jang, Joon-Ho Eom, Byung-Suk Chung, Woon-Mok Sohn, Jong-Yil Chai, Sung-Tae Hong
    Journal of Parasitology.2006; 92(2): 236.     CrossRef
  • 7,409 View
  • 65 Download
  • Crossref
Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense
Eun-Hee Shin, Tae-Heung Kim, Sung-Jong Hong, Jae-Hwan Park, Sang-Mee Guk, Jong-Yil Chai
Korean J Parasitol 2003;41(2):81-87.
Published online June 20, 2003
DOI: https://doi.org/10.3347/kjp.2003.41.2.81

The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine (a histamine receptor H1 blocker), cimetidine (a H2 blocker), cyclosporin-A (a helper T-cell suppressant), and prednisolone (a T- and B-cell suppressant). Infected, but untreated controls, and uninfected controls, were prepared. Worm recovery rate and intestinal mastocytosis were measured on weeks 1, 2, 3, 5, and 7 post-infection. Compared with the infected controls, worm expulsion was significantly (P < 0.05) delayed in hydroxyzine- and cimetidine-treated rats, despite mastocytosis being equally marked in the duodenum of all three groups. In the cyclosporin-A- and prednisolone-treated groups, mastocytosis was suppressed, but worm expulsion was only slightly delayed, without statistical significance. Our results suggest that binding of histamine to its receptors on intestinal smooth muscles is more important in terms of the expulsion of N. seoulense from rats than the levels of histamine alone, or mastocytosis.

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  • Immune pathogenesis in pigeons during experimental Prohemistomum vivax infection
    Asmaa M. I. Abuzeid, Mahmoud M. Hefni, Yue Huang, Long He, Tingting Zhuang, Guoqing Li
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
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    Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai
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    Rebecca K Martin, Sheinei J Saleem, Lauren Folgosa, Hannah B Zellner, Sheela R Damle, Giang-Kim T Nguyen, John J Ryan, Harry D Bear, Anne-Marie Irani, Daniel H Conrad
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    Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
    The Korean Journal of Parasitology.2009; 47(Suppl): S69.     CrossRef
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  • 81 Download
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Recovery, growth and development of Macroorchis spinulosus in albino rats
Ho-Chun Woo, Jong-Yil Chai, Sung-Jong Hong
Korean J Parasitol 2003;41(1):27-33.
Published online March 20, 2003
DOI: https://doi.org/10.3347/kjp.2003.41.1.27

The developmental features, growth and organogenesis of Macroorchis spinulosus were observed in albino rats. Globular and thick walled metacercariae, possessed a stylet, Y-shaped excretory bladder and extracecal testes. In albino rats, M. spinulosus showed habitat shifting. The majority of M. spinulosus reside in the jejunum for the first four days post infection (p.i.) and migrate to the duodenum at the later stage of infection. M. spinulosus grew rapidly during the first four days and reached full maturity at 14 days p.i. and later reduced in size. The ovary was separated from the genital primodium at one day p.i. The seminal vesicle appeared on the third day and divided into two sacs on the fourth day p.i. and intrauterine eggs and sperm mass were produced on the fourth day. Organogenesis and enlargement of reproductive organs governed the growth of M. spinulosus. The similarity of related species of the genus Macroorchis to M. spinulosus was discussed in consideration to developmental features.

Citations

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  • Molecular Description of Macroorchis spinulosus (Digenea: Nanophyetidae) Based on ITS1 Sequences
    Eun Jeong Won, Deok-Gyu Kim, Jaeeun Cho, Bong-Kwang Jung, Min-Jae Kim, Yong Woon Yun, Jong-Yil Chai, Dong Wook Ryang
    The Korean Journal of Parasitology.2016; 54(1): 109.     CrossRef
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    Mohammed Hasan Ibraheem
    Acta Zoologica.2007; 88(2): 173.     CrossRef
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    Sung-Jong Hong, Ho-Chun Woo, Oh Sil Kwon
    The Korean Journal of Parasitology.2004; 42(4): 151.     CrossRef
  • 7,270 View
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Ultrastructural localization of 28 kDa glutathione S-transferase in adult Clonorchis sinensis
Sung-Jong Hong, Jae-Ran Yu, Shin-Yong Kang
Korean J Parasitol 2002;40(4):173-176.
Published online December 30, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.4.173

Glutathione S-transferase (28GST) with molecular mass of 28 kDa is an anti-oxidant enzyme abundant in Clonorchis sinensis. In adult C. sinensis, 28GST was localized in tegumental syncytium, cytons, parenchyma, and sperm tails examined by immunoelectron microscopy. C. sinensis 28GST was earlier found to neutralize bio-reactive compounds and to be rich in eggs. Accordingly, it is suggested that 28GST plays important roles in phase II defense system and physiological roles in worm fecundity of C. sinensis.

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    Ho Yin Pekkle Lam, Ting-Hua Yang, Ting-Ruei Liang, Po-Ching Cheng, Kai-Chih Chang, Shih-Yi Peng
    Acta Tropica.2021; 222: 106033.     CrossRef
  • Adult Opisthorchis felineus major protein fractions deduced from transcripts: Comparison with liver flukes Opisthorchis viverrini and Clonorchis sinensis
    Mikhail Pomaznoy, Sergey Tatkov, Alexey Katokhin, Dmitry Afonnikov, Vladimir Babenko, Dagmara Furman, Ilya Brusentsov, Pavel Belavin, Alexandr Najakshin, Sergey Guselnikov, Gennady Vasiliev, Anton Sivkov, Egor Prokhortchouk, Konstantin Skryabin, Viatchesl
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    Y.-A. BAE, S.-H. KIM, E.-G. LEE, W.-M. SOHN, Y. KONG
    Parasitology.2011; 138(9): 1143.     CrossRef
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    Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Bronwyn E. Campbell, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser
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    Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong
    The Korean Journal of Parasitology.2009; 47(Suppl): S59.     CrossRef
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    Viktor Cvilink, Jiri Lamka, Lenka Skálová
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    Nopporn Chutiwitoonchai, Yan Shen, Huajun Zheng, Hui Xiong, Guoping Zhao, Kanokwan Imtawil, Pewpan M. Intapan, Sopit Wongkham, Chaisiri Wongkham
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Mini Review

Tegumental ultrastructure of Echinoparyphium recurvatum according to developmental stages
Woon-Mok Sohn, Ho-Choon Woo, Sung-Jong Hong
Korean J Parasitol 2002;40(2):67-73.
Published online June 30, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.2.67

The present study was performed to observe tegumental ultrastructure of Echinoparyphium recurvatum according to developmental stages. Worms (1, 3, 5 and 15-day old) were recovered from chicks experimentally infected with metacercariae from Radix auricularia coreana. One-day old worms were elongated and ventrally concave, and covered with peg-like tegumental spines except the adjacent areas of the head crown and excretory pore. Type I sensory papillae were distributed on the lip of the oral sucker, and grouped ciliated papillae were around the oral sucker. Peg-like tegumental spines were densely distributed on the anterior surface of the ventral sucker level. The ventral sucker had an aspinous tegument and no sensory papillae. Tegumental spines on the posterior surface of the ventral sucker level were sparsely distributed and disappeared posteriorly. In 3 and 5-day old worms, the tegument around the oral sucker was aspinose and wrinkled concentrically. The ventral sucker had a wrinkled tegument and many bulbous papillae. Type I sensory papillae were distributed between the bulbous papillae. Tegumental spines were spade-shaped with a terminal tip. A total of 45 collar spines including 4 end group ones on both ventral corners was alternately arranged in 2 rows. The 15-day old worms were very stout and their tegumental spines were tongue-shaped without a terminal tip. From the above results, it is confirmed that the surface ultrastructure of E. recurvatum was generally similar to that of other echinostomatid flukes. However, some features, i.e., morphological change of tegumental spines and appearence of sensory papillae on the ventral sucker according to development, and number, shape and arrangement of collar spines, were characteristic, which may be of taxonomic and bioecological significance.

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    S.A. Denisova, S.V. Shchenkov
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    Jane Huffman, Bernard Fried
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    Eun-Taek Han, Moon-Seok Choi, Sung-Yil Choi, Jong-Yil Chai
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    A.M. McCarthy
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    J. SOTILLO, L. VALERO, M. M. SÁNCHEZ DEL PINO, B. FRIED, J. G. ESTEBAN, A. MARCILLA, R. TOLEDO
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    David Bruce Conn, Cameron P. Goater, Douglas Bray
    Journal of Parasitology.2008; 94(3): 635.     CrossRef
  • Developmental and Functional Ultrastructure of Ornithodiplostomum ptychocheilus Diplostomula (Trematoda: Strigeoidea) during Invasion of the Brain of the Fish Intermediate Host, Pimephales promelas
    David Bruce Conn, Cameron P. Goater, Douglas Bray
    Journal of Parasitology.2008; 94(3): 635.     CrossRef
  • FIRST RECORD AND DESCRIPTION OF METACERCARIAE OF CURTUTERIA ARGUINAE N. SP. (DIGENEA: ECHINOSTOMATIDAE), PARASITE OF COCKLES CERASTODERMA EDULE (MOLLUSCA: BIVALVIA) IN ARCACHON BAY, FRANCE
    Céline Desclaux, Fernanda Russell-Pinto, Xavier de Montaudouin, Guy Bachelet
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    Min-Ho Choi, Sae Hoon Kim, Jong-Hoon Chung, Hye-Jin Jang, Joon-Ho Eom, Byung-Suk Chung, Woon-Mok Sohn, Jong-Yil Chai, Sung-Tae Hong
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    Eun-Taek Han, Kye-Young Han, Jong-Yil Chai
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Original Articles

Antigenic profile and localization of Clonorchis sinensis proteins in the course of infection
Sung-Jong Hong, Tae Yun Kim, Kye-Yong Song, Woon-Mok Sohn, Shin-Yong Kang
Korean J Parasitol 2001;39(4):307-312.
Published online December 31, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.4.307

In the course of Clonorchis sinensis infection, antigens presented to the hosts may be in a close relation to growth of the fluke. The antigenic proteins stimulating IgG antibody production were chronologically identified by immunoblot and localized by immunohistochemical staining. In the early stage of infection until 12 weeks post-infection (PI), antigens were proteins with molecular mass larger than 34 kDa which were derived from the tegument, testes and intrauterine eggs. After 20 weeks PI, antigens recognized were 29, 27 and 26 kDa proteins from the intestine, excretory bladder and reproductive organs. It is suggested that the tegumental proteins are the most potent antigens and the excretory-secretory proteins with middle molecular mass of 26-45 kDa contribute to the high level production of antibodies after 20 weeks of the C. sinensis infection.

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    Peng Li, Yongjian Shao, Ke Xu, Xiaohui Qiu
    Review of Scientific Instruments.2021;[Epub]     CrossRef
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    Xiao-Xiao Ma, Yang-Yuan Qiu, Zhi-Guang Chang, Jun-Feng Gao, Rui-Ruo Jiang, Chun-Lin Li, Chun-Ren Wang, Qiao-Cheng Chang
    Frontiers in Cellular and Infection Microbiology.2021;[Epub]     CrossRef
  • Mapping of the putative epitope domain of Clonorchis sinensis paramyosin (CsPmy) recognized by CsPmy-specific immunoglobulin G in sera of human clonorchiasis
    Jung-Mi Kang, Hye-Lim Ju, Jinyoung Lee, Tae Im Kim, Shin-Hyeong Cho, Tong-Soo Kim, Woon-Mok Sohn, Byoung-Kuk Na
    Molecular and Biochemical Parasitology.2015; 201(1): 66.     CrossRef
  • Coproantigen capture ELISA for detection of Clonorchis sinensis infection in experimentally infected rats
    S.M. Mazidur Rahman, Min-Ho Choi, Young Mee Bae, Sung-Tae Hong
    Parasitology International.2012; 61(1): 203.     CrossRef
  • Functional Genes and Proteins of Clonorchis sinensis
    Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong
    The Korean Journal of Parasitology.2009; 47(Suppl): S59.     CrossRef
  • Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms
    Jung‐Won Ju, Hyun‐Na Joo, Myoung‐Ro Lee, Shin‐Hyeong Cho, Hyeng‐Il Cheun, Jung‐Yeon Kim, Young‐Hee Lee, Kwang‐Jun Lee, Woon‐Mok Sohn, Dong‐Min Kim, Il‐Chul Kim, Byoung Chul Park, Tong‐Soo Kim
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    Yan Huang, Zhenwen Zhou, Xuchu Hu, Quande Wei, Jin Xu, Zhongdao Wu, Xinbing Yu
    Parasitology Research.2007; 102(1): 77.     CrossRef
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    Shunyu Li, Byung-Suk Chung, Min-Ho Choi, Sung-Tae Hong
    The Korean Journal of Parasitology.2004; 42(4): 169.     CrossRef
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    Ke-Xia Wang, Rong-Bo Zhang, Yu-Bao Cui, Ye Tian, Ru Cai, Chao-Pin Li
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  • Use of a recombinant Clonorchis sinensis pore-forming peptide, clonorin, for serological diagnosis of clonorchiasis
    Ji-Yun Lee, Tae Yun Kim, Xiao-Xian Gan, Shin-Yong Kang, Sung-Jong Hong
    Parasitology International.2003; 52(2): 175.     CrossRef
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Molecular cloning and characterization of an antigenic protein with a repeating region from Clonorchis sinensis
Tae Yun Kim, Shin-Yong Kang, Il-Young Ahn, Seung-Yull Cho, Sung-Jong Hong
Korean J Parasitol 2001;39(1):57-66.
Published online March 31, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.1.57

In the course of immunoscreening of Clonorchis sinensis cDNA library, a cDNA CsRP12 containing a tandem repeat was isolated. The cDNA CsRP12 encodes two putative peptides of open reading frames (ORFs) 1 and 2 (CsRP12-1 and -2). The repetitive region is composed of 15 repeats of 10 amino acids. Of the two putative peptides, CsRP12-1 was proline-rich and found to have homologues in several organisms. Recombinant proteins of the putative peptides were bacterially produced and purified by an affinity chromatography. Recombinant CsRP12-1 protein was recognized by sera of clonorchiasis patients and experimental rabbits, but recombinant CsRP12-2 was not. One of the putative peptide, CsRP12-1, is designated CsPRA, proline-rich antigen of C. sinensis. Both the C-termini of CsRP12-1 and -2 were bacterially produced and analysed to show no antigenicity. Recombinant CsPRA protein showed high sensitivity and specificity. In experimental rabbits, IgG antibodies to CsPRA was produced between 4 and 8 weeks after the infection and decreased thereafter over one year. These results indicate that CsPRA is equivalent to a natural protein and a useful antigenic protein for serodiagnosis of human clonorchiasis.

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    Jose Ma. M. Angeles, Atcharaphan Wanlop, Minh-Anh Dang-Trinh, Masashi Kirinoki, Shin-ichiro Kawazu, Aya Yajima
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    Na Cheng, Xue-Nian Xu, Yan Zhou, Yu-Ting Dong, Yi-Fang Bao, Bin Xu, Wei Hu, Zheng Feng, Maria Elena Bottazzi
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    Eun Joo Chung, Young-Il Jeong, Myoung-Ro Lee, Yu Jung Kim, Sang-Eun Lee, Shin-Hyeong Cho, Won-Ja Lee, Mi-Yeoun Park, Jung-Won Ju
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    Yu-Jung Kim, Won Yoo, Myoung-Ro Lee, Jung-Mi Kang, Byoung-Kuk Na, Shin-Hyeong Cho, Mi-Yeoun Park, Jung-Won Ju
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    Shuqi Wang, Wei Hu
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  • Genomics and molecular genetics of Clonorchis sinensis: Current status and perspectives
    Si-Yang Huang, Guang-Hui Zhao, Bao-Quan Fu, Min-Jun Xu, Chun-Ren Wang, Song-Ming Wu, Feng-Cai Zou, Xing-Quan Zhu
    Parasitology International.2012; 61(1): 71.     CrossRef
  • Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis
    Shunyu Li, Jung Guk Shin, Pyo Yun Cho, Tae Im Kim, Sung-Tae Hong, Sung-Jong Hong
    Parasitology Research.2011; 108(5): 1295.     CrossRef
  • Human Antibody Response to Thioredoxin Peroxidase-1 and Tandem Repeat Proteins as Immunodiagnostic Antigen Candidates for Schistosoma japonicum Infection
    Shin-ichiro Kawazu, Masashi Kirinoki, Pilarita Tongol-Rivera, Yasuyuki Goto, Lydia Leonardo, Elena Villacorte, Yuichi Chigusa, Noboru Inoue, Jose Ma. Angeles
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    Tae Im Kim, Sung-Jong Hong
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  • Functional Genes and Proteins of Clonorchis sinensis
    Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong
    The Korean Journal of Parasitology.2009; 47(Suppl): S59.     CrossRef
  • Molecular cloning and phylogenetic analysis of Clonorchis sinensis elongation factor-1α
    Tae Yun Kim, Pyo Yun Cho, Jong Won Na, Sung-Jong Hong
    Parasitology Research.2007; 101(6): 1557.     CrossRef
  • Clonorchiasis: an update
    H.-J. Rim
    Journal of Helminthology.2005; 79(3): 269.     CrossRef
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    S. Wongratanacheewin, R.W. Sermswan, S. Sirisinha
    Acta Tropica.2003; 88(3): 195.     CrossRef
  • Use of a recombinant Clonorchis sinensis pore-forming peptide, clonorin, for serological diagnosis of clonorchiasis
    Ji-Yun Lee, Tae Yun Kim, Xiao-Xian Gan, Shin-Yong Kang, Sung-Jong Hong
    Parasitology International.2003; 52(2): 175.     CrossRef
  • Analysis of the genes expressed in Clonorchis sinensis adults using the expressed sequence tag approach
    Ji-Sook Lee, Jongweon Lee, Soon-Jung Park, Tai-Soon Yong
    Parasitology Research.2003; 91(4): 283.     CrossRef
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Intestinal histopathology and in situ postures of Gymnophalloides seoi in experimentally infected mice
Jong-Yil Chai, Hong-Soon Lee, Sung-Jong Hong, Jae Hyung Yoo, Sang-Mee Guk, Min Seo, Min-Ho Choi, Soon-Hyung Lee
Korean J Parasitol 2001;39(1):31-41.
Published online March 31, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.1.31

The intestinal histopathology and in situ postures of Gymnophalloides seoi (Digenea: Gymnophallidae) were studied using C3H/HeN and C57BL/6 mice as experimental hosts; the effects of immunosuppression were also observed. The metacercariae isolated from naturally infected oysters, 300 or 1,000 in number, were infected orally to each mouse, and the mice were killed at days 3-21 post-infection (PI). In immunocompetent (IC) mice, only a small number of flukes were found in the mucosa of the duodenum and jejunum during days 3-7 PI, with their large oral suckers pinching and sucking the root of villi. The intestinal mucosa showed mild villous atrophy, crypt hyperplasia, and inflammations in the villous stroma and crypt, with remarkable goblet cell hyperplasia. These mucosal changes were almost restored after days 14-21 PI. In immunosuppressed (IS) mice, displacement as well as complete loss of villi adjacent to the flukes was frequently encountered, otherwise the histopathology was generally mild, with minimal goblet cell hyperplasia. In these mice, numerous flukes were found, and it seemed that they were actively moving and rotating in situ. Several flukes were found to have invaded into the submucosa, almost facing the serosa. These results indicate that in IC mice the intestinal histopathology caused by G. seoi is generally mild, and the flukes do not penetrate beyond the mucosa, however, in IS mice, the flukes can cause severe destruction of neighboring villi, and some of them invade into the submucosa.

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    Asmaa M. I. Abuzeid, Mahmoud M. Hefni, Yue Huang, Long He, Tingting Zhuang, Guoqing Li
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    Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
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    Jae-Hwan Park, Sang-Mee Guk, Eun-Hee Shin, Hyo-Jin Kim, Jae-Lip Kim, Min Seo, Yun-Kyu Park, Jong-Yil Chai
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    Min Seo, Hokyung Chun, Geunghwan Ahn, Kee-Taek Jang, Sang-Mee Guk, Jong-Yil Chai
    The Korean Journal of Parasitology.2006; 44(1): 87.     CrossRef
  • Gymnophalloides seoi: a new human intestinal trematode
    Jong-Yil Chai, Min-Ho Choi, Jae-Ran Yu, Soon-Hyung Lee
    Trends in Parasitology.2003; 19(3): 109.     CrossRef
  • Food-borne intestinal trematode infections in the Republic of Korea
    Jong-Yil Chai, Soon-Hyung Lee
    Parasitology International.2002; 51(2): 129.     CrossRef
  • A review of Gymnophalloides seoi (Digenea: Gymnophallidae) and human infections in the Republic of Korea
    Soon-Hyung Lee, Jong-Yil Chai
    The Korean Journal of Parasitology.2001; 39(2): 85.     CrossRef
  • 9,549 View
  • 75 Download
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Case Reports

A case of chronic cerebral paragonimiasis westermani
Shin-Yong Kang, Tae-Kwon Kim, Tae Yun Kim, Young-Il Ha, Sun-Wook Choi, Sung-Jong Hong
Korean J Parasitol 2000;38(3):167-171.
Published online September 30, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.3.167

We report a chronic cerebral paragonimiasis from a 41-year-old Korean man who complains a headache and weakness of left motor neuron components. Magnetic resonance images of the brain revealed conglomerates of multiple ring-like enhancements in temporo-occipital and frontal lobes of the right hemisphere. An intradermal test for paragonimiasis westermani was positive. The patient was born near an endemic area of paragonimiasis and used to eat boiled or grilled freshwater crayfish in his childhood. Nodules in the brain were resected through craniotomies. The eggs of P. westermani were identified pathologically and parasitologically in the calcified necrotic lesions. Examinations on sputum and fecal specimens for the eggs of P. westermani were shown to be negative and a chest radiograph was normal. It is presumed that the brain lesions were formed by P. westermani approximately 30 years ago.

Citations

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  • Imaging of infectious and inflammatory cystic lesions of the brain, a narrative review
    Anna Cervantes-Arslanian, Hector H Garcia, Otto Rapalino
    Expert Review of Neurotherapeutics.2023; 23(3): 237.     CrossRef
  • Cerebral Paragonimiasis Presenting with Dementia
    Seok Woo Moon, Taeho Kim
    The Korean Journal of Parasitology.2022; 60(5): 353.     CrossRef
  • Inactivation of Paragonimus westermani metacercariae in soy sauce-marinated and frozen freshwater crabs
    Tae Im Kim, Se-Ra Oh, Fuhong Dai, Hyun-Jong Yang, Sang-Do Ha, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 1003.     CrossRef
  • Cerebral Paragonimiasis Presenting with Sudden Death
    Gary W. Procop, Annie Cowell, Sharon L. Reed, Deirdre E. Amaro, Marion J. Tuohy, Jacquelyn Morhaime
    The American Journal of Tropical Medicine and Hygiene.2016; 95(6): 1424.     CrossRef
  • Overview of the Effect and Epidemiology of Parasitic Central Nervous System Infections in African Children
    Macpherson Mallewa, Jo M. Wilmshurst
    Seminars in Pediatric Neurology.2014; 21(1): 19.     CrossRef
  • Cerebral Infarction and Cranial Venous Sinus Thrombosis Caused by Paragonimiasis
    Jia‐Yan Wu, Bao‐Rong Zhang, Guo‐Hua Zhao
    CNS Neuroscience & Therapeutics.2013; 19(9): 734.     CrossRef
  • The Return of an Old Worm: Cerebral Paragonimiasis Presenting with Intracerebral Hemorrhage
    Eun Jung Koh, Seung-Ki Kim, Kyu-Chang Wang, Jong-Yil Chai, Sangjoon Chong, Sung-Hye Park, Jung-Eun Cheon, Ji Hoon Phi
    Journal of Korean Medical Science.2012; 27(11): 1428.     CrossRef
  • Excretory–secretory products from Paragonimus westermani increase nitric oxide production in microglia in PKC-dependent and -independent manners
    Youngnam Jin, In Young Choi, Chunsook Kim, Suyoung Hong, Won-Ki Kim
    Neuroscience Research.2009; 65(2): 141.     CrossRef
  • Update on Eosinophilic Meningoencephalitis and Its Clinical Relevance
    Carlos Graeff-Teixeira, Ana Cristina Arámburu da Silva, Kentaro Yoshimura
    Clinical Microbiology Reviews.2009; 22(2): 322.     CrossRef
  • Parasitoses et atteinte neurologique
    André Paugam
    Revue Francophone des Laboratoires.2008; 2008(399): 41.     CrossRef
  • Imaging Manifestations of Tropical Parasitic Infections
    Carlos S. Restrepo, Abhijit A. Raut, Roy Riascos, Santiago Martinez, Jorge Carrillo, Srinivasa R. Prasad
    Seminars in Roentgenology.2007; 42(1): 37.     CrossRef
  • Excretory-Secretory Products Produced by Paragonimus westermani Differentially Regulate the Nitric Oxide Production and Viability of Microglial Cells
    Youngnam Jin, Jae-Chul Lee, In Young Choi, Eun A. Kim, Myeong Heon Shin, Won-Ki Kim
    International Archives of Allergy and Immunology.2006; 139(1): 16.     CrossRef
  • Granulomatous Diseases of the Central Nervous System
    Antonio José da Rocha, Antonio Carlos Martins Maia, Nelson Paes Diniz Fortes Ferreira, Lázaro Luís Faria do Amaral
    Topics in Magnetic Resonance Imaging.2005; 16(2): 155.     CrossRef
  • Paragonimiasis: a view from Columbia
    Iván D Vélez, Jorge E Ortega, Luz E Velásquez
    Clinics in Chest Medicine.2002; 23(2): 421.     CrossRef
  • Paragonimiasis: a Japanese perspective
    Fukumi Nakamura-Uchiyama, Hiroshi Mukae, Yukifumi Nawa
    Clinics in Chest Medicine.2002; 23(2): 409.     CrossRef
  • 10,236 View
  • 100 Download
  • Crossref
A human case of Stellantchasmus falcatus infection in Korea
Sung-Jong Hong
Korean J Parasitol 2000;38(1):25-27.
Published online March 31, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.1.25

In an attempt to find the worm producing unidentified egg, one minute fluke was collect from a Korean patient after praziquantel administration. The fluke was identified to be Stellantchasmus falcatus by the expulsor. Brackish water fish was suggested to be a probable source of the infection.

Citations

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  • Digestive tract trematodiases caused by members of the Heterophyidae
    S. B. Chuelov, A. L. Rossina
    CHILDREN INFECTIONS.2021; 20(1): 39.     CrossRef
  • Epidemiological situation and molecular identification of cercarial stage in freshwater snails in Chao-Phraya Basin, Central Thailand
    Sothorn Anucherngchai, Thanawan Tejangkura, Thapana Chontananarth
    Asian Pacific Journal of Tropical Biomedicine.2016; 6(6): 539.     CrossRef
  • Stellantchasmus falcatus (Digenea: Heterophyidae) in Cambodia: Discovery of Metacercariae in Mullets and Recovery of Adult Flukes in an Experimental Hamster
    Jong-Yil Chai, Woon-Mok Sohn, Byoung-Kuk Na, Hoo-Gn Jeoung, Muth Sinuon, Duong Socheat
    The Korean Journal of Parasitology.2016; 54(4): 537.     CrossRef
  • Digenean metacercariae of fishes from the lagoon flats of Palmyra Atoll, Eastern Indo-Pacific
    V.M. Vidal-Martínez, M.L. Aguirre-Macedo, J.P. McLaughlin, R.F. Hechinger, A.G. Jaramillo, J.C. Shaw, A.K. James, A.M. Kuris, K.D. Lafferty
    Journal of Helminthology.2012; 86(4): 493.     CrossRef
  • 6,906 View
  • 77 Download
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Original Article
Infection status of dragonflies with Plagiorchis muris metacercariae in Korea
Sung-Jong Hong, Ho-Chun Woo, Soo-Ung Lee, Sun Huh
Korean J Parasitol 1999;37(2):65-70.
Published online June 30, 1999
DOI: https://doi.org/10.3347/kjp.1999.37.2.65

Plagiorchis muris has been found in both house and field rats as well as in humans. The infection status of the second intermediate hosts of P. muris is prerequisite in understanding their biological features in an ecosystem. Six species of dragonflies were caught in a wide range of areas in Korea; and they were Sympetrum darwinianum, S. eroticum, S. pedomontanum, S. infuscatum, Pantala flavoscens, Calopteryx atrata, and Orthetrum albistylum speciosum. The occurrence of P. muris metacercariae in dragonflies was nationwide with various infection rates. The metacercarial burden of P. muris in the surveyed areas was the highest in S. eroticum followed by S. darwinianum, S. pedomontanum, and C. atrata. The highest infection rate by P. muris metacercariae was found in S. darwinianum followed by S. eroticum. The metacercarial burden was particularly heavy in the dragonflies found in Hamyang-gun and Kosong-gun, Kyongsangnam-do. It is, therefore, likely that dragonflies play a significant role as the second intermediate host in the life cycle of P. muris in Korea.

Citations

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  • Survey of the Prosthogonimus spp. metacercariae infection in the second intermediate host dragonfly in Heilongjiang Province, China
    Ben Li, Zhuo Lan, Xin-Ru Guo, Ai-Hui Zhang, Wei Wei, Ye Li, Zhen-Hua Jin, Zhong-Yan Gao, Xian-Guang Zhang, Bai Li, Jun-Feng Gao, Chun-Ren Wang
    Parasitology Research.2023; 122(12): 2859.     CrossRef
  • Odonata (Insecta) Larvae as the Second Intermediate Hosts of the Trematodes of Genus Plagiorchis in the Basin of Chany Lake, Western Siberia
    N. M. Ponomareva, O. N. Popova, N. I. Yurlova
    Contemporary Problems of Ecology.2022; 15(6): 631.     CrossRef
  • Influences of habitat and arthropod density on parasitism in two co-occurring host taxa
    J. Koprivnikar, T.M.Y. Urichuk, D. Szuroczki
    Canadian Journal of Zoology.2017; 95(8): 589.     CrossRef
  • A molecular and ecological analysis of the trematodePlagiorchis elegansin the wood mouseApodemus sylvaticusfrom a periaquatic ecosystem in the UK
    K. Boyce, G. Hide, P.S. Craig, C. Reynolds, M. Hussain, A.J. Bodell, H. Bradshaw, A. Pickles, M.T. Rogan
    Journal of Helminthology.2014; 88(3): 310.     CrossRef
  • Trematodes and nematodes parasitizing the benthic insect community of an Andean Patagonian stream, with emphasis on plagiorchiid metacercariae
    Gustavo D. Mariluan, Gustavo P. Viozzi, Ricardo J. Albariño
    Invertebrate Biology.2012; 131(4): 285.     CrossRef
  • Plagiorchis muris infection in Apodemus agrarius from northern Gyeonggi-do (Province) near the demilitarized zone
    Jong-Yil Chai, Jae-Hwan Park, Sang-Mee Guk, Jae-Lip Kim, Hyo-Jin Kim, Won-Hee Kim, Eun-Hee Shin, Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jin-Won Song, Luck-Ju Baek
    The Korean Journal of Parasitology.2007; 45(2): 153.     CrossRef
  • The occurrence of the trematodePlagiorchis murisin the wood mouseApodemus sylvaticusin North Yorkshire, UK
    M.T. Rogan, P.S. Craig, G. Hide, S. Heath, A. Pickles, D.M. Storey
    Journal of Helminthology.2007; 81(1): 57.     CrossRef
  • A Human Case of Plagiorchis vespertilionis (Digenea: Plagiorchiidae) Infection in the Republic of Korea
    S-M. Guk, J-L. Kim, J-H. Park, J-Y. Chai
    Journal of Parasitology.2007; 93(5): 1225.     CrossRef
  • Molecular phylogenic location of the Plagiorchis muris (Digenea, Plagiorchiidae) based on sequences of partial 28S D1 rDNA and mitochondrial cytochrome C oxidase subunit I
    Soo-Ung Lee, Sun Huh, Woon-Mok Sohn
    The Korean Journal of Parasitology.2004; 42(2): 71.     CrossRef
  • Food-borne intestinal trematode infections in the Republic of Korea
    Jong-Yil Chai, Soon-Hyung Lee
    Parasitology International.2002; 51(2): 129.     CrossRef
  • 8,527 View
  • 71 Download
  • Crossref
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PHD : Parasites, Hosts and Diseases